FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1749, 252 aa 1>>>pF1KE1749 252 - 252 aa - 252 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4331+/-0.000298; mu= 14.9274+/- 0.019 mean_var=89.3475+/-18.149, 0's: 0 Z-trim(118.9): 173 B-trim: 402 in 1/53 Lambda= 0.135685 statistics sampled from 32116 (32324) to 32116 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.379), width: 16 Scan time: 6.750 The best scores are: opt bits E(85289) XP_005273311 (OMIM: 120831) PREDICTED: C4b-binding ( 252) 1796 361.0 1.2e-99 NP_000707 (OMIM: 120831) C4b-binding protein beta ( 252) 1796 361.0 1.2e-99 NP_001017365 (OMIM: 120831) C4b-binding protein be ( 252) 1796 361.0 1.2e-99 NP_001017367 (OMIM: 120831) C4b-binding protein be ( 252) 1796 361.0 1.2e-99 NP_001017366 (OMIM: 120831) C4b-binding protein be ( 251) 1779 357.6 1.2e-98 NP_001017364 (OMIM: 120831) C4b-binding protein be ( 251) 1779 357.6 1.2e-98 XP_005273312 (OMIM: 120831) PREDICTED: C4b-binding ( 227) 982 201.6 1e-51 XP_011533056 (OMIM: 608397) PREDICTED: CUB and sus (2238) 455 99.3 6.3e-20 XP_011533055 (OMIM: 608397) PREDICTED: CUB and sus (2595) 455 99.3 7e-20 XP_016869220 (OMIM: 608397) PREDICTED: CUB and sus (3327) 455 99.4 8.4e-20 XP_011533054 (OMIM: 608397) PREDICTED: CUB and sus (3549) 455 99.5 8.8e-20 NP_150094 (OMIM: 608397) CUB and sushi domain-cont (3564) 455 99.5 8.8e-20 XP_016855679 (OMIM: 608398) PREDICTED: CUB and sus (3362) 393 87.3 3.8e-16 XP_016855678 (OMIM: 608398) PREDICTED: CUB and sus (3506) 393 87.3 3.9e-16 XP_016855683 (OMIM: 608398) PREDICTED: CUB and sus (3566) 393 87.3 4e-16 XP_016855677 (OMIM: 608398) PREDICTED: CUB and sus (3567) 393 87.3 4e-16 XP_016855676 (OMIM: 608398) PREDICTED: CUB and sus (3606) 393 87.3 4e-16 XP_016855674 (OMIM: 608398) PREDICTED: CUB and sus (3607) 393 87.3 4e-16 XP_016855675 (OMIM: 608398) PREDICTED: CUB and sus (3607) 393 87.3 4e-16 XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 375 83.6 3.2e-15 XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 375 83.8 4.5e-15 XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 375 83.8 4.5e-15 NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 375 83.8 4.5e-15 XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 375 83.8 4.6e-15 XP_011515118 (OMIM: 608399) PREDICTED: CUB and sus (3603) 375 83.8 4.6e-15 XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 375 83.8 4.6e-15 NP_937757 (OMIM: 608399) CUB and sushi domain-cont (3667) 375 83.8 4.7e-15 XP_016868497 (OMIM: 608399) PREDICTED: CUB and sus (3681) 375 83.8 4.7e-15 NP_937756 (OMIM: 608399) CUB and sushi domain-cont (3707) 375 83.8 4.7e-15 NP_443128 (OMIM: 608398) CUB and sushi domain-cont (3487) 371 83.0 7.7e-15 NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 344 77.7 3.1e-13 XP_005245497 (OMIM: 147050,173610) PREDICTED: P-se ( 768) 298 68.1 5.1e-11 NP_001268885 (OMIM: 608398) CUB and sushi domain-c (3631) 305 70.1 6.2e-11 NP_001701 (OMIM: 138470,612924,615489,615561) comp ( 764) 292 67.0 1.1e-10 XP_011507508 (OMIM: 120650,240500,610927,614699) P ( 969) 280 64.7 6.9e-10 NP_001006659 (OMIM: 120650,240500,610927,614699) c (1092) 280 64.8 7.6e-10 NP_000564 (OMIM: 120620,607486,611162) complement (2039) 277 64.4 1.8e-09 XP_006711229 (OMIM: 120620,607486,611162) PREDICTE (2459) 277 64.5 2.1e-09 NP_000642 (OMIM: 120620,607486,611162) complement (2489) 277 64.5 2.1e-09 XP_011507507 (OMIM: 120620,607486,611162) PREDICTE (2554) 277 64.5 2.1e-09 XP_005273308 (OMIM: 120830) PREDICTED: C4b-binding ( 597) 267 62.0 2.8e-09 XP_005273309 (OMIM: 120830) PREDICTED: C4b-binding ( 597) 267 62.0 2.8e-09 NP_000706 (OMIM: 120830) C4b-binding protein alpha ( 597) 267 62.0 2.8e-09 NP_000033 (OMIM: 138700) beta-2-glycoprotein 1 pre ( 345) 261 60.6 4.3e-09 NP_000441 (OMIM: 131210,145500) E-selectin precurs ( 610) 263 61.2 4.9e-09 NP_110414 (OMIM: 608593,614809) complement factor ( 569) 253 59.2 1.8e-08 XP_011508322 (OMIM: 608593,614809) PREDICTED: comp ( 572) 253 59.2 1.8e-08 NP_001868 (OMIM: 120650,240500,610927,614699) comp (1033) 255 59.8 2.2e-08 XP_011507588 (OMIM: 134580,613235) PREDICTED: coag ( 628) 246 57.9 5.1e-08 NP_001985 (OMIM: 134580,613235) coagulation factor ( 661) 246 57.9 5.3e-08 >>XP_005273311 (OMIM: 120831) PREDICTED: C4b-binding pro (252 aa) initn: 1796 init1: 1796 opt: 1796 Z-score: 1910.0 bits: 361.0 E(85289): 1.2e-99 Smith-Waterman score: 1796; 100.0% identity (100.0% similar) in 252 aa overlap (1-252:1-252) 10 20 30 40 50 60 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL 190 200 210 220 230 240 250 pF1KE1 ELKKAELKAKLL :::::::::::: XP_005 ELKKAELKAKLL 250 >>NP_000707 (OMIM: 120831) C4b-binding protein beta chai (252 aa) initn: 1796 init1: 1796 opt: 1796 Z-score: 1910.0 bits: 361.0 E(85289): 1.2e-99 Smith-Waterman score: 1796; 100.0% identity (100.0% similar) in 252 aa overlap (1-252:1-252) 10 20 30 40 50 60 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL 190 200 210 220 230 240 250 pF1KE1 ELKKAELKAKLL :::::::::::: NP_000 ELKKAELKAKLL 250 >>NP_001017365 (OMIM: 120831) C4b-binding protein beta c (252 aa) initn: 1796 init1: 1796 opt: 1796 Z-score: 1910.0 bits: 361.0 E(85289): 1.2e-99 Smith-Waterman score: 1796; 100.0% identity (100.0% similar) in 252 aa overlap (1-252:1-252) 10 20 30 40 50 60 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL 190 200 210 220 230 240 250 pF1KE1 ELKKAELKAKLL :::::::::::: NP_001 ELKKAELKAKLL 250 >>NP_001017367 (OMIM: 120831) C4b-binding protein beta c (252 aa) initn: 1796 init1: 1796 opt: 1796 Z-score: 1910.0 bits: 361.0 E(85289): 1.2e-99 Smith-Waterman score: 1796; 100.0% identity (100.0% similar) in 252 aa overlap (1-252:1-252) 10 20 30 40 50 60 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL 190 200 210 220 230 240 250 pF1KE1 ELKKAELKAKLL :::::::::::: NP_001 ELKKAELKAKLL 250 >>NP_001017366 (OMIM: 120831) C4b-binding protein beta c (251 aa) initn: 1777 init1: 1637 opt: 1779 Z-score: 1892.1 bits: 357.6 E(85289): 1.2e-98 Smith-Waterman score: 1779; 99.6% identity (99.6% similar) in 252 aa overlap (1-252:1-251) 10 20 30 40 50 60 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 MFFWCACCLMVAWRVSASD-EHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL 180 190 200 210 220 230 250 pF1KE1 ELKKAELKAKLL :::::::::::: NP_001 ELKKAELKAKLL 240 250 >>NP_001017364 (OMIM: 120831) C4b-binding protein beta c (251 aa) initn: 1777 init1: 1637 opt: 1779 Z-score: 1892.1 bits: 357.6 E(85289): 1.2e-98 Smith-Waterman score: 1779; 99.6% identity (99.6% similar) in 252 aa overlap (1-252:1-251) 10 20 30 40 50 60 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_001 MFFWCACCLMVAWRVSASD-EHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL 180 190 200 210 220 230 250 pF1KE1 ELKKAELKAKLL :::::::::::: NP_001 ELKKAELKAKLL 240 250 >>XP_005273312 (OMIM: 120831) PREDICTED: C4b-binding pro (227 aa) initn: 1001 init1: 840 opt: 982 Z-score: 1049.5 bits: 201.6 E(85289): 1e-51 Smith-Waterman score: 982; 99.3% identity (99.3% similar) in 136 aa overlap (1-136:1-135) 10 20 30 40 50 60 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: XP_005 MFFWCACCLMVAWRVSASD-EHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV :::::::::::::::: XP_005 CLEDHTWAPPFPICKSIPQTRPLPFQPCSPLFLFLLRQSLALFPRLECSGRILAHCNLHL 120 130 140 150 160 170 >>XP_011533056 (OMIM: 608397) PREDICTED: CUB and sushi d (2238 aa) initn: 435 init1: 351 opt: 455 Z-score: 478.8 bits: 99.3 E(85289): 6.3e-20 Smith-Waterman score: 455; 35.3% identity (64.7% similar) in 204 aa overlap (26-226:1301-1498) 10 20 30 40 50 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHL .:: :.: . : : . ..: :: : XP_011 WRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLT-VYGAT-AIFTCNTGYTL 1280 1290 1300 1310 1320 60 70 80 90 100 110 pF1KE1 VGKKTLFCNASKEWDNTTTECRLGHC--PDPVLVNGEFSSSGPVNVSDKITFMCNDHYIL ::... : :. :... :.: ::: :::. :::..:..: . : ....:: . : XP_011 VGSHVRECLANGLWSGSETRCLAGHCGSPDPI-VNGHISGDG-FSYRDTVVYQCNPGFRL 1330 1340 1350 1360 1370 1380 120 130 140 150 160 170 pF1KE1 KGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVG :.. ::.:: :. :.: : ::::.::. .:..:.:...... :. : : : XP_011 VGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQG 1390 1400 1410 1420 1430 1440 180 190 200 210 220 230 pF1KE1 VQEQQC-VDGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMT :.. :: .:.::: ::.:.... . :.:. :. :. :..: :. : XP_011 VSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQ--NFPESFEYGMSILYHCKKG 1450 1460 1470 1480 1490 1500 240 250 pF1KE1 MEELKYSLELKKAELKAKLL XP_011 FYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSES 1510 1520 1530 1540 1550 1560 >-- initn: 380 init1: 193 opt: 292 Z-score: 306.4 bits: 67.4 E(85289): 2.5e-10 Smith-Waterman score: 292; 27.0% identity (55.7% similar) in 185 aa overlap (23-201:1771-1953) 10 20 30 40 50 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKG ::. :::.:. ... . .: :. : XP_011 YVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDG 1750 1760 1770 1780 1790 1800 60 70 80 90 100 110 pF1KE1 YHLVGKKTLFCNASKEWDNTTTECRLGHCPDP-VLVNGEFSSSGPVNVSDKITFMCNDHY :.: . : :.. : . .: : :: . ..:..:... . .... :.:.. . XP_011 YQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKS-FTYKSEVFFQCKSPF 1810 1820 1830 1840 1850 120 130 140 150 160 pF1KE1 ILKGSNRSQCLEDHTWAPPFPIC---KSRDCDPPGNPVHGYFEGN-NFTLGSTISYYCED :: ::.: : : ::. : : : ::.: : ... .. .:::. . :. XP_011 ILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRK 1860 1870 1880 1890 1900 1910 170 180 190 200 210 220 pF1KE1 RYYLVGVQEQQCVDG-EWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQL :.. : . :. . ::. : . . .:: XP_011 GYHIQGSTTRTCLANLTWSGIQTEC-IPHACRQPETPAHADVRAIDLPTFGYTLVYTCHP 1920 1930 1940 1950 1960 1970 230 240 250 pF1KE1 KESGMTMEELKYSLELKKAELKAKLL XP_011 GFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTKTPVPSDVFFVNSLWKGYYEY 1980 1990 2000 2010 2020 2030 >-- initn: 420 init1: 171 opt: 271 Z-score: 284.1 bits: 63.3 E(85289): 4.4e-09 Smith-Waterman score: 271; 28.3% identity (55.3% similar) in 152 aa overlap (47-194:1618-1769) 20 30 40 50 60 70 pF1KE1 ASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTEC . : :..: :. : . :.. : XP_011 GNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVC 1590 1600 1610 1620 1630 1640 80 90 100 110 120 130 pF1KE1 RLGHCPDP-VLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICK . : .: . .:: . :: . :... . : . : .: .: . ::. : : XP_011 EAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCT 1650 1660 1670 1680 1690 1700 140 150 160 170 180 190 pF1KE1 SRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQ--QCV-DGEWSSALPVCK .: ::. ..: :..::...:.:: :. : . .: .:. ::.:. . :::: XP_011 IISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCK 1710 1720 1730 1740 1750 1760 200 210 220 230 240 250 pF1KE1 LIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELKAKLL . XP_011 AVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPV 1770 1780 1790 1800 1810 1820 >-- initn: 243 init1: 128 opt: 206 Z-score: 215.4 bits: 50.5 E(85289): 2.9e-05 Smith-Waterman score: 222; 29.3% identity (52.0% similar) in 123 aa overlap (47-161:1499-1616) 20 30 40 50 60 70 pF1KE1 ASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTEC : : ::..:.:...: : :. :: . .: XP_011 NCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC 1470 1480 1490 1500 1510 1520 80 90 100 110 120 130 pF1KE1 RLGHCPDP-----VLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPF : : ....::. . : : . . : : :.. : :: :. . XP_011 LAISCGHPGVPANAVLTGELFTYGAV-----VHYSCRGSESLIGNDTRVCQEDSHWSGAL 1530 1540 1550 1560 1570 1580 140 150 160 170 180 pF1KE1 PICKSRD---CDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSAL : : . . : ::.:.:: :..: : . XP_011 PHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGL 1590 1600 1610 1620 1630 1640 190 200 210 220 230 240 pF1KE1 PVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELK XP_011 QPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTA 1650 1660 1670 1680 1690 1700 >>XP_011533055 (OMIM: 608397) PREDICTED: CUB and sushi d (2595 aa) initn: 435 init1: 351 opt: 455 Z-score: 477.9 bits: 99.3 E(85289): 7e-20 Smith-Waterman score: 455; 35.3% identity (64.7% similar) in 204 aa overlap (26-226:1658-1855) 10 20 30 40 50 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHL .:: :.: . : : . ..: :: : XP_011 WRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLT-VYGAT-AIFTCNTGYTL 1630 1640 1650 1660 1670 1680 60 70 80 90 100 110 pF1KE1 VGKKTLFCNASKEWDNTTTECRLGHC--PDPVLVNGEFSSSGPVNVSDKITFMCNDHYIL ::... : :. :... :.: ::: :::. :::..:..: . : ....:: . : XP_011 VGSHVRECLANGLWSGSETRCLAGHCGSPDPI-VNGHISGDG-FSYRDTVVYQCNPGFRL 1690 1700 1710 1720 1730 1740 120 130 140 150 160 170 pF1KE1 KGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVG :.. ::.:: :. :.: : ::::.::. .:..:.:...... :. : : : XP_011 VGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQG 1750 1760 1770 1780 1790 1800 180 190 200 210 220 230 pF1KE1 VQEQQC-VDGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMT :.. :: .:.::: ::.:.... . :.:. :. :. :..: :. : XP_011 VSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQ--NFPESFEYGMSILYHCKKG 1810 1820 1830 1840 1850 1860 240 250 pF1KE1 MEELKYSLELKKAELKAKLL XP_011 FYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSES 1870 1880 1890 1900 1910 1920 >-- initn: 380 init1: 193 opt: 292 Z-score: 305.5 bits: 67.4 E(85289): 2.8e-10 Smith-Waterman score: 292; 27.0% identity (55.7% similar) in 185 aa overlap (23-201:2128-2310) 10 20 30 40 50 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKG ::. :::.:. ... . .: :. : XP_011 YVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDG 2100 2110 2120 2130 2140 2150 60 70 80 90 100 110 pF1KE1 YHLVGKKTLFCNASKEWDNTTTECRLGHCPDP-VLVNGEFSSSGPVNVSDKITFMCNDHY :.: . : :.. : . .: : :: . ..:..:... . .... :.:.. . XP_011 YQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKS-FTYKSEVFFQCKSPF 2160 2170 2180 2190 2200 2210 120 130 140 150 160 pF1KE1 ILKGSNRSQCLEDHTWAPPFPIC---KSRDCDPPGNPVHGYFEGN-NFTLGSTISYYCED :: ::.: : : ::. : : : ::.: : ... .. .:::. . :. XP_011 ILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRK 2220 2230 2240 2250 2260 2270 170 180 190 200 210 220 pF1KE1 RYYLVGVQEQQCVDG-EWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQL :.. : . :. . ::. : . . .:: XP_011 GYHIQGSTTRTCLANLTWSGIQTEC-IPHACRQPETPAHADVRAIDLPTFGYTLVYTCHP 2280 2290 2300 2310 2320 2330 230 240 250 pF1KE1 KESGMTMEELKYSLELKKAELKAKLL XP_011 GFFLAGGSEHRTCKADMKWTGKSPVCKSKGVREVNETVTKTPVPSDVFFVNSLWKGYYEY 2340 2350 2360 2370 2380 2390 >-- initn: 420 init1: 171 opt: 271 Z-score: 283.3 bits: 63.3 E(85289): 4.9e-09 Smith-Waterman score: 271; 28.3% identity (55.3% similar) in 152 aa overlap (47-194:1975-2126) 20 30 40 50 60 70 pF1KE1 ASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTEC . : :..: :. : . :.. : XP_011 GNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVC 1950 1960 1970 1980 1990 2000 80 90 100 110 120 130 pF1KE1 RLGHCPDP-VLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICK . : .: . .:: . :: . :... . : . : .: .: . ::. : : XP_011 EAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCT 2010 2020 2030 2040 2050 2060 140 150 160 170 180 190 pF1KE1 SRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQ--QCV-DGEWSSALPVCK .: ::. ..: :..::...:.:: :. : . .: .:. ::.:. . :::: XP_011 IISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCK 2070 2080 2090 2100 2110 2120 200 210 220 230 240 250 pF1KE1 LIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELKAKLL . XP_011 AVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPV 2130 2140 2150 2160 2170 2180 >-- initn: 243 init1: 128 opt: 206 Z-score: 214.5 bits: 50.6 E(85289): 3.3e-05 Smith-Waterman score: 222; 29.3% identity (52.0% similar) in 123 aa overlap (47-161:1856-1973) 20 30 40 50 60 70 pF1KE1 ASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTEC : : ::..:.:...: : :. :: . .: XP_011 NCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC 1830 1840 1850 1860 1870 1880 80 90 100 110 120 130 pF1KE1 RLGHCPDP-----VLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPF : : ....::. . : : . . : : :.. : :: :. . XP_011 LAISCGHPGVPANAVLTGELFTYGAV-----VHYSCRGSESLIGNDTRVCQEDSHWSGAL 1890 1900 1910 1920 1930 1940 140 150 160 170 180 pF1KE1 PICKSRD---CDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSAL : : . . : ::.:.:: :..: : . XP_011 PHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGL 1950 1960 1970 1980 1990 2000 190 200 210 220 230 240 pF1KE1 PVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELK XP_011 QPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTA 2010 2020 2030 2040 2050 2060 >>XP_016869220 (OMIM: 608397) PREDICTED: CUB and sushi d (3327 aa) initn: 417 init1: 351 opt: 455 Z-score: 476.5 bits: 99.4 E(85289): 8.4e-20 Smith-Waterman score: 455; 35.3% identity (64.7% similar) in 204 aa overlap (26-226:2627-2824) 10 20 30 40 50 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHL .:: :.: . : : . ..: :: : XP_016 WRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLT-VYGAT-AIFTCNTGYTL 2600 2610 2620 2630 2640 2650 60 70 80 90 100 110 pF1KE1 VGKKTLFCNASKEWDNTTTECRLGHC--PDPVLVNGEFSSSGPVNVSDKITFMCNDHYIL ::... : :. :... :.: ::: :::. :::..:..: . : ....:: . : XP_016 VGSHVRECLANGLWSGSETRCLAGHCGSPDPI-VNGHISGDG-FSYRDTVVYQCNPGFRL 2660 2670 2680 2690 2700 2710 120 130 140 150 160 170 pF1KE1 KGSNRSQCLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVG :.. ::.:: :. :.: : ::::.::. .:..:.:...... :. : : : XP_016 VGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQG 2720 2730 2740 2750 2760 2770 180 190 200 210 220 230 pF1KE1 VQEQQC-VDGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMT :.. :: .:.::: ::.:.... . :.:. :. :. :..: :. : XP_016 VSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQ--NFPESFEYGMSILYHCKKG 2780 2790 2800 2810 2820 2830 240 250 pF1KE1 MEELKYSLELKKAELKAKLL XP_016 FYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSES 2840 2850 2860 2870 2880 2890 >-- initn: 380 init1: 193 opt: 293 Z-score: 305.1 bits: 67.7 E(85289): 2.9e-10 Smith-Waterman score: 293; 27.7% identity (55.9% similar) in 177 aa overlap (23-193:3097-3272) 10 20 30 40 50 pF1KE1 MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKG ::. :::.:. ... . .: :. : XP_016 YVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDG 3070 3080 3090 3100 3110 3120 60 70 80 90 100 110 pF1KE1 YHLVGKKTLFCNASKEWDNTTTECRLGHCPDP-VLVNGEFSSSGPVNVSDKITFMCNDHY :.: . : :.. : . .: : :: . ..:..:... . .... :.:.. . XP_016 YQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEGRLSGKS-FTYKSEVFFQCKSPF 3130 3140 3150 3160 3170 3180 120 130 140 150 160 pF1KE1 ILKGSNRSQCLEDHTWAPPFPIC---KSRDCDPPGNPVHGYFEGN-NFTLGSTISYYCED :: ::.: : : ::. : : : ::.: : ... .. .:::. . :. XP_016 ILVGSSRRVCQADGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTVFFRCRK 3190 3200 3210 3220 3230 3240 170 180 190 200 210 220 pF1KE1 RYYLVGVQEQQCVDG-EWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQL :.. : . :. . ::. : : XP_016 GYHIQGSTTRTCLANLTWSGIQTECILWFPRTGSITIGWTLGCEGCSQAPSLTLNQSLWR 3250 3260 3270 3280 3290 3300 >-- initn: 420 init1: 171 opt: 271 Z-score: 281.9 bits: 63.4 E(85289): 5.8e-09 Smith-Waterman score: 271; 28.3% identity (55.3% similar) in 152 aa overlap (47-194:2944-3095) 20 30 40 50 60 70 pF1KE1 ASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTEC . : :..: :. : . :.. : XP_016 GNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVC 2920 2930 2940 2950 2960 2970 80 90 100 110 120 130 pF1KE1 RLGHCPDP-VLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPFPICK . : .: . .:: . :: . :... . : . : .: .: . ::. : : XP_016 EAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCT 2980 2990 3000 3010 3020 3030 140 150 160 170 180 190 pF1KE1 SRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQ--QCV-DGEWSSALPVCK .: ::. ..: :..::...:.:: :. : . .: .:. ::.:. . :::: XP_016 IISCGDPGTLANGIQFGTDFTFNKTVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCK 3040 3050 3060 3070 3080 3090 200 210 220 230 240 250 pF1KE1 LIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELKAKLL . XP_016 AVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCLPV 3100 3110 3120 3130 3140 3150 >-- initn: 243 init1: 128 opt: 206 Z-score: 213.1 bits: 50.7 E(85289): 3.9e-05 Smith-Waterman score: 222; 29.3% identity (52.0% similar) in 123 aa overlap (47-161:2825-2942) 20 30 40 50 60 70 pF1KE1 ASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKTLFCNASKEWDNTTTEC : : ::..:.:...: : :. :: . .: XP_016 NCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKC 2800 2810 2820 2830 2840 2850 80 90 100 110 120 130 pF1KE1 RLGHCPDP-----VLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQCLEDHTWAPPF : : ....::. . : : . . : : :.. : :: :. . XP_016 LAISCGHPGVPANAVLTGELFTYGAV-----VHYSCRGSESLIGNDTRVCQEDSHWSGAL 2860 2870 2880 2890 2900 140 150 160 170 180 pF1KE1 PICKSRD---CDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCVDGEWSSAL : : . . : ::.:.:: :..: : . XP_016 PHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSWSGL 2910 2920 2930 2940 2950 2960 190 200 210 220 230 240 pF1KE1 PVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSLELKKAELK XP_016 QPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTA 2970 2980 2990 3000 3010 3020 252 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:40:22 2016 done: Sun Nov 6 18:40:23 2016 Total Scan time: 6.750 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]