FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1659, 176 aa 1>>>pF1KE1659 176 - 176 aa - 176 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4679+/-0.000343; mu= 11.2034+/- 0.021 mean_var=56.4682+/-11.086, 0's: 0 Z-trim(113.8): 15 B-trim: 0 in 0/54 Lambda= 0.170676 statistics sampled from 23351 (23366) to 23351 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.274), width: 16 Scan time: 5.690 The best scores are: opt bits E(85289) NP_061194 (OMIM: 605619) interleukin-20 precursor ( 176) 1154 292.1 3.2e-79 XP_005273209 (OMIM: 605619) PREDICTED: interleukin ( 261) 1154 292.1 4.6e-79 NP_037503 (OMIM: 605687) interleukin-19 isoform 2 ( 177) 457 120.4 1.5e-27 NP_715639 (OMIM: 605687) interleukin-19 isoform 1 ( 215) 457 120.4 1.8e-27 XP_011507752 (OMIM: 605687) PREDICTED: interleukin ( 207) 328 88.7 6.3e-18 XP_016855610 (OMIM: 604136) PREDICTED: interleukin ( 179) 292 79.8 2.6e-15 XP_011507403 (OMIM: 604136) PREDICTED: interleukin ( 179) 292 79.8 2.6e-15 NP_006841 (OMIM: 604136) interleukin-24 isoform 1 ( 206) 292 79.8 2.9e-15 NP_001172085 (OMIM: 604136) interleukin-24 isoform ( 207) 292 79.8 2.9e-15 NP_000563 (OMIM: 124092,180300,609423,614395) inte ( 178) 213 60.3 1.8e-09 NP_060872 (OMIM: 605679) interleukin-26 precursor ( 171) 125 38.7 0.0058 >>NP_061194 (OMIM: 605619) interleukin-20 precursor [Hom (176 aa) initn: 1154 init1: 1154 opt: 1154 Z-score: 1543.3 bits: 292.1 E(85289): 3.2e-79 Smith-Waterman score: 1154; 100.0% identity (100.0% similar) in 176 aa overlap (1-176:1-176) 10 20 30 40 50 60 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 DIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIK 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 KDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 KDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE 130 140 150 160 170 >>XP_005273209 (OMIM: 605619) PREDICTED: interleukin-20 (261 aa) initn: 1154 init1: 1154 opt: 1154 Z-score: 1540.4 bits: 292.1 E(85289): 4.6e-79 Smith-Waterman score: 1154; 100.0% identity (100.0% similar) in 176 aa overlap (1-176:86-261) 10 20 30 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNL :::::::::::::::::::::::::::::: XP_005 SDSELRPEIFSSREAWQFFLLLWSPDFRPKMKASSLAFSLLSAAFYLLWTPSTGLKTLNL 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE1 GSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLY 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE1 LDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFE 180 190 200 210 220 230 160 170 pF1KE1 KLEPQAAVVKALGELDILLQWMEETE :::::::::::::::::::::::::: XP_005 KLEPQAAVVKALGELDILLQWMEETE 240 250 260 >>NP_037503 (OMIM: 605687) interleukin-19 isoform 2 prec (177 aa) initn: 436 init1: 403 opt: 457 Z-score: 615.7 bits: 120.4 E(85289): 1.5e-27 Smith-Waterman score: 457; 40.2% identity (72.4% similar) in 174 aa overlap (1-174:1-169) 10 20 30 40 50 60 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNI :: . ... ::.. . : . . ::. :.:.:....:...:.::. ..:::: NP_037 MKLQCVSLWLLGTILILCSVDNHGLRR-----CLISTDMHHIEESFQEIKRAIQAKDTFP 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 DIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIK .. :: :.:: :: . ::. ..:: .:.:::::..: :. ::::::.::::: .. NP_037 NVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQ 60 70 80 90 100 110 130 140 150 160 170 pF1KE1 KDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE : :: :. . ::: .:: . : .....:: .::..:.:::::..: :... NP_037 KTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMF 120 130 140 150 160 170 NP_037 SA >>NP_715639 (OMIM: 605687) interleukin-19 isoform 1 [Hom (215 aa) initn: 436 init1: 403 opt: 457 Z-score: 614.3 bits: 120.4 E(85289): 1.8e-27 Smith-Waterman score: 457; 40.2% identity (72.4% similar) in 174 aa overlap (1-174:39-207) 10 20 30 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNL :: . ... ::.. . : . . ::. NP_715 HRSACSLPLTHVHTHIHVCVPVLWGSVPRGMKLQCVSLWLLGTILILCSVDNHGLRR--- 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 GSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLY :.:.:....:...:.::. ..:::: .. :: :.:: :: . ::. ..:: .: NP_715 --CLISTDMHHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFY 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 LDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFE .:::::..: :. ::::::.::::: ..: :: :. . ::: .:: . : .... NP_715 VDRVFKDHQEPNPKILRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYD 130 140 150 160 170 180 160 170 pF1KE1 KLEPQAAVVKALGELDILLQWMEETE .:: .::..:.:::::..: :... NP_715 QLEVHAAAIKSLGELDVFLAWINKNHEVMFSA 190 200 210 >>XP_011507752 (OMIM: 605687) PREDICTED: interleukin-19 (207 aa) initn: 291 init1: 274 opt: 328 Z-score: 442.9 bits: 88.7 E(85289): 6.3e-18 Smith-Waterman score: 328; 41.1% identity (71.3% similar) in 129 aa overlap (1-129:1-124) 10 20 30 40 50 60 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNI :: . ... ::.. . : . . ::. :.:.:....:...:.::. ..:::: XP_011 MKLQCVSLWLLGTILILCSVDNHGLRR-----CLISTDMHHIEESFQEIKRAIQAKDTFP 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 DIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIK .. :: :.:: :: . ::. ..:: .:.:::::..: :. ::::::.::::: .. XP_011 NVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQ 60 70 80 90 100 110 130 140 150 160 170 pF1KE1 KDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE : :: : .: XP_011 KTLRQCVSHWVRIPASAPCLPKERPGSAGPHRPPDMVLGVKGNSLRTSTGRTVENLSQWP 120 130 140 150 160 170 >>XP_016855610 (OMIM: 604136) PREDICTED: interleukin-24 (179 aa) initn: 251 init1: 149 opt: 292 Z-score: 396.0 bits: 79.8 E(85289): 2.6e-15 Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (17-174:14-175) 10 20 30 40 50 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIRNGFSEIRGSVQAKD :::. .: . ...: : . . :.. ..: .. ..::.: XP_016 MQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQD 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQ--TPDHYTLRKISSLANS . . :.:.. : ::... :. : :.. ::..:: :::::. : . ::...:.:::. XP_016 NITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 FLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEET :. : ..:. . . . : ... . :..:. .::..:::::.:::: ::.. XP_016 FVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKF 120 130 140 150 160 170 pF1KE1 E XP_016 YKL >>XP_011507403 (OMIM: 604136) PREDICTED: interleukin-24 (179 aa) initn: 251 init1: 149 opt: 292 Z-score: 396.0 bits: 79.8 E(85289): 2.6e-15 Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (17-174:14-175) 10 20 30 40 50 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIRNGFSEIRGSVQAKD :::. .: . ...: : . . :.. ..: .. ..::.: XP_011 MQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQD 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQ--TPDHYTLRKISSLANS . . :.:.. : ::... :. : :.. ::..:: :::::. : . ::...:.:::. XP_011 NITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 FLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEET :. : ..:. . . . : ... . :..:. .::..:::::.:::: ::.. XP_011 FVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKF 120 130 140 150 160 170 pF1KE1 E XP_011 YKL >>NP_006841 (OMIM: 604136) interleukin-24 isoform 1 prec (206 aa) initn: 251 init1: 149 opt: 292 Z-score: 395.0 bits: 79.8 E(85289): 2.9e-15 Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (17-174:41-202) 10 20 30 40 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIR :::. .: . ...: : . . :.. NP_006 WTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLW 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE1 NGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQ--TP ..: .. ..::.:. . :.:.. : ::... :. : :.. ::..:: :::::. : NP_006 EAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTV 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 DHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKA . ::...:.:::.:. : ..:. . . . : ... . :..:. .::..:: NP_006 EVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKA 130 140 150 160 170 180 170 pF1KE1 LGELDILLQWMEETE :::.:::: ::.. NP_006 LGEVDILLTWMQKFYKL 190 200 >>NP_001172085 (OMIM: 604136) interleukin-24 isoform 3 p (207 aa) initn: 251 init1: 149 opt: 292 Z-score: 395.0 bits: 79.8 E(85289): 2.9e-15 Smith-Waterman score: 292; 33.1% identity (68.1% similar) in 163 aa overlap (17-174:42-203) 10 20 30 40 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLK--TLNLGSCVIATNL-QEIR :::. .: . ...: : . . :.. NP_001 TLASRPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLW 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE1 NGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQ--TP ..: .. ..::.:. . :.:.. : ::... :. : :.. ::..:: :::::. : NP_001 EAFWAVKDTMQAQDNITSARLLQQ-EVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTV 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE1 DHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKA . ::...:.:::.:. : ..:. . . . : ... . :..:. .::..:: NP_001 EVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKA 140 150 160 170 180 190 170 pF1KE1 LGELDILLQWMEETE :::.:::: ::.. NP_001 LGEVDILLTWMQKFYKL 200 >>NP_000563 (OMIM: 124092,180300,609423,614395) interleu (178 aa) initn: 168 init1: 78 opt: 213 Z-score: 290.9 bits: 60.3 E(85289): 1.8e-09 Smith-Waterman score: 213; 27.0% identity (64.2% similar) in 159 aa overlap (20-173:19-169) 10 20 30 40 50 pF1KE1 MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCV-----IATNLQEIRNGFSEIRGSVQA .:. : .. : ::. . . :...:..::... : NP_000 MHSSALLCCLVLLTGVRASPGQGTQSEN--SCTHFPGNLPNMLRDLRDAFSRVKTFFQM 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 KDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANS :: ..: .:... :.: : : : .....::..:. . .. : ...::... NP_000 KD-QLDNLLLKESL-LEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGEN 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 FLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEET . :.. :: :: . : :. : :. . :.::. . .. ::..:.::.....: NP_000 LKTLRLRLRRCHRFLPC---ENKSKAVEQVKNAFNKLQ-EKGIYKAMSEFDIFINYIEAY 120 130 140 150 160 170 pF1KE1 E NP_000 MTMKIRN 176 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:41:36 2016 done: Sun Nov 6 18:41:37 2016 Total Scan time: 5.690 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]