FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7962, 397 aa 1>>>pF1KB7962 397 - 397 aa - 397 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6007+/-0.000389; mu= 20.0067+/- 0.025 mean_var=237.3276+/-51.663, 0's: 0 Z-trim(120.2): 368 B-trim: 0 in 0/54 Lambda= 0.083253 statistics sampled from 34721 (35195) to 34721 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.755), E-opt: 0.2 (0.413), width: 16 Scan time: 9.710 The best scores are: opt bits E(85289) NP_064589 (OMIM: 606066) LIM/homeobox protein Lhx9 ( 397) 2730 340.8 3.3e-93 NP_001014434 (OMIM: 606066) LIM/homeobox protein L ( 388) 2590 324.0 3.8e-88 XP_011508083 (OMIM: 606066) PREDICTED: LIM/homeobo ( 403) 2590 324.0 3.9e-88 XP_016857338 (OMIM: 606066) PREDICTED: LIM/homeobo ( 378) 2585 323.4 5.7e-88 XP_005245407 (OMIM: 606066) PREDICTED: LIM/homeobo ( 336) 2041 258.0 2.5e-68 XP_006717386 (OMIM: 603759) PREDICTED: LIM/homeobo ( 314) 1029 136.4 9.5e-32 NP_004780 (OMIM: 603759) LIM/homeobox protein Lhx2 ( 406) 1029 136.6 1.1e-31 NP_665804 (OMIM: 609481) insulin gene enhancer pro ( 359) 514 74.6 4.2e-13 XP_016877994 (OMIM: 609481) PREDICTED: insulin gen ( 534) 514 74.9 5.1e-13 NP_002193 (OMIM: 600366) insulin gene enhancer pro ( 349) 475 69.9 1.1e-11 XP_005263467 (OMIM: 221750,600577) PREDICTED: LIM/ ( 386) 468 69.1 2e-11 NP_055379 (OMIM: 221750,600577) LIM/homeobox prote ( 402) 457 67.8 5.1e-11 XP_011519065 (OMIM: 180386) PREDICTED: LIM domain ( 145) 451 66.3 5.3e-11 NP_001001395 (OMIM: 180386) LIM domain only protei ( 145) 451 66.3 5.3e-11 XP_006719174 (OMIM: 180386) PREDICTED: LIM domain ( 145) 451 66.3 5.3e-11 NP_001230538 (OMIM: 180386) LIM domain only protei ( 145) 451 66.3 5.3e-11 NP_061110 (OMIM: 180386) LIM domain only protein 3 ( 145) 451 66.3 5.3e-11 XP_011519064 (OMIM: 180386) PREDICTED: LIM domain ( 145) 451 66.3 5.3e-11 NP_001230539 (OMIM: 180386) LIM domain only protei ( 145) 451 66.3 5.3e-11 XP_006719173 (OMIM: 180386) PREDICTED: LIM domain ( 145) 451 66.3 5.3e-11 NP_001230540 (OMIM: 180386) LIM domain only protei ( 156) 451 66.4 5.4e-11 NP_001230541 (OMIM: 180386) LIM domain only protei ( 163) 451 66.4 5.5e-11 NP_835258 (OMIM: 221750,600577) LIM/homeobox prote ( 397) 454 67.5 6.5e-11 XP_016870657 (OMIM: 221750,600577) PREDICTED: LIM/ ( 373) 453 67.3 6.9e-11 NP_203129 (OMIM: 262700,602146) LIM/homeobox prote ( 390) 451 67.1 8.3e-11 XP_006718291 (OMIM: 186921) PREDICTED: rhombotin-1 ( 193) 444 65.7 1.1e-10 NP_002306 (OMIM: 186921) rhombotin-1 isoform a [Ho ( 156) 440 65.1 1.4e-10 NP_001257357 (OMIM: 186921) rhombotin-1 isoform b ( 155) 438 64.8 1.6e-10 NP_001229263 (OMIM: 608215) LIM/homeobox protein L ( 363) 436 65.2 2.8e-10 NP_001229262 (OMIM: 608215) LIM/homeobox protein L ( 366) 436 65.3 2.8e-10 NP_954629 (OMIM: 608215) LIM/homeobox protein Lhx6 ( 377) 436 65.3 2.9e-10 XP_011516824 (OMIM: 608215) PREDICTED: LIM/homeobo ( 378) 436 65.3 2.9e-10 NP_055183 (OMIM: 608215) LIM/homeobox protein Lhx6 ( 392) 436 65.3 2.9e-10 XP_005251973 (OMIM: 608215) PREDICTED: LIM/homeobo ( 230) 433 64.5 2.9e-10 XP_011516823 (OMIM: 608215) PREDICTED: LIM/homeobo ( 407) 436 65.3 3e-10 XP_011518400 (OMIM: 186921) PREDICTED: rhombotin-1 ( 145) 428 63.6 3.6e-10 XP_011518401 (OMIM: 186921) PREDICTED: rhombotin-1 ( 145) 428 63.6 3.6e-10 NP_006760 (OMIM: 603129) LIM domain transcription ( 165) 426 63.4 4.5e-10 XP_005271348 (OMIM: 603129) PREDICTED: LIM domain ( 165) 426 63.4 4.5e-10 NP_071758 (OMIM: 605992) LIM/homeobox protein Lhx5 ( 402) 426 64.1 6.8e-10 NP_005559 (OMIM: 601999) LIM/homeobox protein Lhx1 ( 406) 422 63.7 9.5e-10 XP_016873222 (OMIM: 180385) PREDICTED: rhombotin-2 ( 158) 348 54.0 2.9e-07 XP_016873219 (OMIM: 180385) PREDICTED: rhombotin-2 ( 158) 348 54.0 2.9e-07 XP_005252978 (OMIM: 180385) PREDICTED: rhombotin-2 ( 158) 348 54.0 2.9e-07 XP_016873216 (OMIM: 180385) PREDICTED: rhombotin-2 ( 158) 348 54.0 2.9e-07 XP_016873221 (OMIM: 180385) PREDICTED: rhombotin-2 ( 158) 348 54.0 2.9e-07 XP_016873218 (OMIM: 180385) PREDICTED: rhombotin-2 ( 158) 348 54.0 2.9e-07 NP_001135787 (OMIM: 180385) rhombotin-2 isoform 2 ( 158) 348 54.0 2.9e-07 XP_016873217 (OMIM: 180385) PREDICTED: rhombotin-2 ( 158) 348 54.0 2.9e-07 XP_016873220 (OMIM: 180385) PREDICTED: rhombotin-2 ( 158) 348 54.0 2.9e-07 >>NP_064589 (OMIM: 606066) LIM/homeobox protein Lhx9 iso (397 aa) initn: 2730 init1: 2730 opt: 2730 Z-score: 1794.3 bits: 340.8 E(85289): 3.3e-93 Smith-Waterman score: 2730; 100.0% identity (100.0% similar) in 397 aa overlap (1-397:1-397) 10 20 30 40 50 60 pF1KB7 MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNGRDAGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNGRDAGM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 PPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 PPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 KEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 VYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 NYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 NYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 AQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTAT 310 320 330 340 350 360 370 380 390 pF1KB7 TLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF ::::::::::::::::::::::::::::::::::::: NP_064 TLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF 370 380 390 >>NP_001014434 (OMIM: 606066) LIM/homeobox protein Lhx9 (388 aa) initn: 2590 init1: 2590 opt: 2590 Z-score: 1703.5 bits: 324.0 E(85289): 3.8e-88 Smith-Waterman score: 2590; 100.0% identity (100.0% similar) in 379 aa overlap (19-397:10-388) 10 20 30 40 50 60 pF1KB7 MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNGRDAGM :::::::::::::::::::::::::::::::::::::::::: NP_001 MLNGTTLEAAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNGRDAGM 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 PPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYC 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 KEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB7 VYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB7 NYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQL 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB7 AQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTAT 300 310 320 330 340 350 370 380 390 pF1KB7 TLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF ::::::::::::::::::::::::::::::::::::: NP_001 TLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF 360 370 380 >>XP_011508083 (OMIM: 606066) PREDICTED: LIM/homeobox pr (403 aa) initn: 2590 init1: 2590 opt: 2590 Z-score: 1703.3 bits: 324.0 E(85289): 3.9e-88 Smith-Waterman score: 2590; 100.0% identity (100.0% similar) in 379 aa overlap (19-397:25-403) 10 20 30 40 50 pF1KB7 MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLN :::::::::::::::::::::::::::::::::::: XP_011 MQTLQTPSPLRMKPASSRVSGPQEAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 GRDAGMPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRDAGMPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 DGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 GMKDSLVYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GMKDSLVYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 LGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 KDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALT 310 320 330 340 350 360 360 370 380 390 pF1KB7 PPGTATTLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF ::::::::::::::::::::::::::::::::::::::::::: XP_011 PPGTATTLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF 370 380 390 400 >>XP_016857338 (OMIM: 606066) PREDICTED: LIM/homeobox pr (378 aa) initn: 2585 init1: 2585 opt: 2585 Z-score: 1700.3 bits: 323.4 E(85289): 5.7e-88 Smith-Waterman score: 2585; 100.0% identity (100.0% similar) in 378 aa overlap (20-397:1-378) 10 20 30 40 50 60 pF1KB7 MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNGRDAGM ::::::::::::::::::::::::::::::::::::::::: XP_016 MLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNGRDAGM 10 20 30 40 70 80 90 100 110 120 pF1KB7 PPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYC 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 KEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSL 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 VYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 NYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQL 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB7 AQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALTPPGTAT 290 300 310 320 330 340 370 380 390 pF1KB7 TLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF ::::::::::::::::::::::::::::::::::::: XP_016 TLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF 350 360 370 >>XP_005245407 (OMIM: 606066) PREDICTED: LIM/homeobox pr (336 aa) initn: 2041 init1: 2041 opt: 2041 Z-score: 1347.6 bits: 258.0 E(85289): 2.5e-68 Smith-Waterman score: 2041; 100.0% identity (100.0% similar) in 294 aa overlap (19-312:25-318) 10 20 30 40 50 pF1KB7 MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLN :::::::::::::::::::::::::::::::::::: XP_005 MQTLQTPSPLRMKPASSRVSGPQEAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 GRDAGMPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GRDAGMPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 DGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGSIYCKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 GMKDSLVYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GMKDSLVYCRAHFETLLQGEYPPQLSYTELAAKSGGLALPYFNGTGTVQKGRPRKRKSPA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 LGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGVDIVNYNSGCNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRTMKSYFAINHNPDA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 KDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTSLPAPPSADSGALT :::::::::::::::::: XP_005 KDLKQLAQKTGLTKRVLQGEQILGHYSQTSRRLKIP 310 320 330 >>XP_006717386 (OMIM: 603759) PREDICTED: LIM/homeobox pr (314 aa) initn: 1422 init1: 924 opt: 1029 Z-score: 691.0 bits: 136.4 E(85289): 9.5e-32 Smith-Waterman score: 1565; 73.7% identity (87.2% similar) in 312 aa overlap (20-312:1-311) 10 20 30 40 50 pF1KB7 MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNG-RDAG ::::..:: ...:...::.::.:.:: ..: : .. XP_006 MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETT 10 20 30 40 60 70 80 90 100 110 pF1KB7 MPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIY :: .: .. ::::::::::::::::::::::::.:::::::::: ::::::::.:::::: XP_006 MPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIY 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 CKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDS :::::::::::::::::::::::::::::::: ::::.::::.:::: :::::::::::: XP_006 CKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDS 110 120 130 140 150 160 180 190 200 210 220 pF1KB7 LVYCRAHFETLLQGEYPPQLSYTELAA--------KSGGLA--------LPYFNGTGTVQ ::::: :::.::::::: .......:: ::.::. :::.::.:::: XP_006 LVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQ 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 KGRPRKRKSPALGVDIVNYNSG--CNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRT ::::::::::. :.:.. ::.. ::::.:.:::::: ::: :::::::::::::::::: XP_006 KGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQ-PYPSSQKTKRMRTSFKHHQLRT 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 MKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTS ::::::::::::::::::::::::::::::: XP_006 MKSYFAINHNPDAKDLKQLAQKTGLTKRVLQASL 290 300 310 350 360 370 380 390 pF1KB7 LPAPPSADSGALTPPGTATTLTDLTNPTITVVTSVTSNMDSHESGSPSQTTLTNLF >>NP_004780 (OMIM: 603759) LIM/homeobox protein Lhx2 [Ho (406 aa) initn: 1824 init1: 930 opt: 1029 Z-score: 690.0 bits: 136.6 E(85289): 1.1e-31 Smith-Waterman score: 1891; 70.3% identity (85.5% similar) in 407 aa overlap (20-397:1-406) 10 20 30 40 50 pF1KB7 MEIVGCRAEDNSCPFRPPAMLFHGISGGHIQGIMEEMERRSKTEARLAKGAQLNG-RDAG ::::..:: ...:...::.::.:.:: ..: : .. NP_004 MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETT 10 20 30 40 60 70 80 90 100 110 pF1KB7 MPPLSPEKPALCAGCGGKISDRYYLLAVDKQWHLRCLKCCECKLALESELTCFAKDGSIY :: .: .. ::::::::::::::::::::::::.:::::::::: ::::::::.:::::: NP_004 MPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIY 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 CKEDYYRRFSVQRCARCHLGISASEMVMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDS :::::::::::::::::::::::::::::::: ::::.::::.:::: :::::::::::: NP_004 CKEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDS 110 120 130 140 150 160 180 190 200 210 220 pF1KB7 LVYCRAHFETLLQGEYPPQLSYTELAA--------KSGGLA--------LPYFNGTGTVQ ::::: :::.::::::: .......:: ::.::. :::.::.:::: NP_004 LVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNGVGTVQ 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 KGRPRKRKSPALGVDIVNYNSG--CNENEADHLDRDQQPYPPSQKTKRMRTSFKHHQLRT ::::::::::. :.:.. ::.. ::::.:.:::::: ::: :::::::::::::::::: NP_004 KGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQ-PYPSSQKTKRMRTSFKHHQLRT 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 MKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENGGVDKADGTS :::::::::::::::::::::::::::::::::::::::::::::::::: ::::. .. NP_004 MKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAA 290 300 310 320 330 340 350 360 370 380 390 pF1KB7 L----PAPPSAD--SGALTPPGTATTLTDLTNPTI----TVVTSVTSNMDSHESGSPSQT : :. :... ...:.: .: :::::::.::. .:.::: .:...:: ::::: NP_004 LQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHSPSQT 350 360 370 380 390 400 pF1KB7 TLTNLF :::::: NP_004 TLTNLF >>NP_665804 (OMIM: 609481) insulin gene enhancer protein (359 aa) initn: 412 init1: 250 opt: 514 Z-score: 356.2 bits: 74.6 E(85289): 4.2e-13 Smith-Waterman score: 621; 37.3% identity (62.4% similar) in 287 aa overlap (60-342:14-267) 30 40 50 60 70 80 pF1KB7 IQGIMEEMERRSKTEARLAKGAQLNGRDAGMPPLSPEKP--ALCAGCGGKISDRYYL-LA : : .:: :.:.:::..: :.. : .. NP_665 MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVS 10 20 30 40 90 100 110 120 130 140 pF1KB7 VDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMV : .:: :::: ::. :. :::..::. :::.:: : :.. .::.:..:.:.:..: NP_665 PDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGI-KCAKCQVGFSSSDLV 50 60 70 80 90 100 150 160 170 180 190 200 pF1KB7 MRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSLVYCRAHFETLLQGEYPPQLSYTELAA :::::::::. :: ::.:.. : ::.:.... . ::: ::. . . NP_665 MRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLE-------RAAAGSP 110 120 130 140 150 210 220 230 240 250 260 pF1KB7 KSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPSQK .: : :: : . : :. ::: :. .. ..: NP_665 RSPG-PLPGARGLHLPDAGSGRQ---PAL---------------RPHVHKQ------TEK 160 170 180 190 270 280 290 300 310 320 pF1KB7 TKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAK-FRRN : :.:: ....::.:... .: : ::: .::.. :::. ::..::::: : : ... NP_665 TTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKS 200 210 220 230 240 250 330 340 350 360 370 380 pF1KB7 LLRQENGGVDKADGTSLPAPPSADSGALTPPGTATTLTDLTNPTITVVTSVTSNMDSHES .: .. ...: ::: NP_665 ILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQ 260 270 280 290 300 310 >>XP_016877994 (OMIM: 609481) PREDICTED: insulin gene en (534 aa) initn: 412 init1: 250 opt: 514 Z-score: 354.7 bits: 74.9 E(85289): 5.1e-13 Smith-Waterman score: 621; 37.3% identity (62.4% similar) in 287 aa overlap (60-342:14-267) 30 40 50 60 70 80 pF1KB7 IQGIMEEMERRSKTEARLAKGAQLNGRDAGMPPLSPEKP--ALCAGCGGKISDRYYL-LA : : .:: :.:.:::..: :.. : .. XP_016 MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVS 10 20 30 40 90 100 110 120 130 140 pF1KB7 VDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMV : .:: :::: ::. :. :::..::. :::.:: : :.. .::.:..:.:.:..: XP_016 PDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGI-KCAKCQVGFSSSDLV 50 60 70 80 90 100 150 160 170 180 190 200 pF1KB7 MRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSLVYCRAHFETLLQGEYPPQLSYTELAA :::::::::. :: ::.:.. : ::.:.... . ::: ::. . . XP_016 MRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLE-------RAAAGSP 110 120 130 140 150 210 220 230 240 250 260 pF1KB7 KSGGLALPYFNGTGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPSQK .: : :: : . : :. ::: :. .. ..: XP_016 RSPG-PLPGARGLHLPDAGSGRQ---PAL---------------RPHVHKQ------TEK 160 170 180 190 270 280 290 300 310 320 pF1KB7 TKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAK-FRRN : :.:: ....::.:... .: : ::: .::.. :::. ::..::::: : : ... XP_016 TTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKS 200 210 220 230 240 250 330 340 350 360 370 380 pF1KB7 LLRQENGGVDKADGTSLPAPPSADSGALTPPGTATTLTDLTNPTITVVTSVTSNMDSHES .: .. ...: ::: XP_016 ILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQ 260 270 280 290 300 310 >>NP_002193 (OMIM: 600366) insulin gene enhancer protein (349 aa) initn: 421 init1: 259 opt: 475 Z-score: 331.0 bits: 69.9 E(85289): 1.1e-11 Smith-Waterman score: 604; 34.5% identity (61.7% similar) in 313 aa overlap (57-356:3-281) 30 40 50 60 70 80 pF1KB7 GGHIQGIMEEMERRSKTEARLAKGAQLNGRDAGMPPLSPEKPALCAGCGGKISDRYYL-L : : :: . . .::.:::..: :.: : . NP_002 MGDMGDPPKKKRLISLCVGCGNQIHDQYILRV 10 20 30 90 100 110 120 130 140 pF1KB7 AVDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEM . : .:: :::: ::. :. :::..::. :::.:: : ... .::.: .:.: ... NP_002 SPDLEWHAACLKCAECNQYLDESCTCFVRDGKTYCKRDYIRLYGI-KCAKCSIGFSKNDF 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB7 VMRARDSVYHLSCFTCSTCNKTLTTGDHFGMKDSLVYCRAHFETLLQGEYPPQLSYTELA :::::..:::. :: : .:.. : ::.:..... ..::: ... : : NP_002 VMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVV------------ERA 100 110 120 130 210 220 230 240 250 260 pF1KB7 AKSGGLALPYFNGTGTVQ-KGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPS . ..: : .. . .: ..: . ..::: :. . :: NP_002 SLGAGDPLSPLHPARPLQMAAEPISARQPAL---------------RPHVHK--QP---- 140 150 160 170 270 280 290 300 310 320 pF1KB7 QKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAK-FR .:: :.:: ....::.:... .: : ::: .::.. :::. ::..::::: : : . NP_002 EKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKK 180 190 200 210 220 230 330 340 350 360 370 pF1KB7 RNLLR---QENGGVDKAD-----GTSLPA--PPSADSGALTPPGTATTLTDLTNPTITVV :... :.. ::.. :: . : : :.: . : NP_002 RSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGGLQANPVEVQSYQPPWKVLSDFA 240 250 260 270 280 290 380 390 pF1KB7 TSVTSNMDSHESGSPSQTTLTNLF NP_002 LQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQLPDTPNSMVASPIEA 300 310 320 330 340 397 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:31:09 2016 done: Sun Nov 6 05:31:11 2016 Total Scan time: 9.710 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]