FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1991, 569 aa 1>>>pF1KE1991 569 - 569 aa - 569 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1951+/-0.000349; mu= 20.5527+/- 0.022 mean_var=88.3583+/-16.952, 0's: 0 Z-trim(117.1): 154 B-trim: 89 in 1/49 Lambda= 0.136443 statistics sampled from 28589 (28799) to 28589 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.338), width: 16 Scan time: 9.810 The best scores are: opt bits E(85289) NP_110414 (OMIM: 608593,614809) complement factor ( 569) 4094 816.1 0 XP_011508322 (OMIM: 608593,614809) PREDICTED: comp ( 572) 3977 793.0 0 NP_000177 (OMIM: 126700,134370,235400,609814,61069 (1231) 1661 337.5 1.6e-91 NP_001188480 (OMIM: 605337) complement factor H-re ( 577) 1370 279.9 1.6e-74 NP_001188479 (OMIM: 605337) complement factor H-re ( 578) 1317 269.4 2.2e-71 XP_006711192 (OMIM: 605337) PREDICTED: complement ( 570) 1316 269.2 2.5e-71 NP_002104 (OMIM: 134371,235400,603075) complement ( 330) 1133 233.0 1.2e-60 XP_011507586 (OMIM: 134580,613235) PREDICTED: coag ( 675) 939 195.1 6.2e-49 NP_005657 (OMIM: 600889) complement factor H-relat ( 270) 929 192.7 1.3e-48 XP_011507760 (OMIM: 600889) PREDICTED: complement ( 266) 925 191.9 2.2e-48 XP_011507588 (OMIM: 134580,613235) PREDICTED: coag ( 628) 924 192.1 4.5e-48 NP_001985 (OMIM: 134580,613235) coagulation factor ( 661) 924 192.1 4.7e-48 XP_011507585 (OMIM: 134580,613235) PREDICTED: coag ( 676) 924 192.1 4.8e-48 XP_016855603 (OMIM: 605337) PREDICTED: complement ( 387) 877 182.6 2e-45 XP_016855599 (OMIM: 605337) PREDICTED: complement ( 519) 861 179.6 2.1e-44 XP_011507761 (OMIM: 600889) PREDICTED: complement ( 250) 851 177.3 5e-44 NP_006675 (OMIM: 605337) complement factor H-relat ( 331) 719 151.5 4e-36 NP_001160096 (OMIM: 235400,603075,605336) compleme ( 269) 710 149.6 1.2e-35 XP_011507759 (OMIM: 134371,235400,603075) PREDICTE ( 265) 685 144.7 3.6e-34 NP_066303 (OMIM: 235400,603075,605336) complement ( 330) 684 144.6 4.8e-34 XP_005245170 (OMIM: 600889) PREDICTED: complement ( 205) 638 135.3 1.8e-31 XP_016856598 (OMIM: 600889) PREDICTED: complement ( 211) 629 133.6 6.3e-31 XP_011507762 (OMIM: 600889) PREDICTED: complement ( 201) 627 133.2 8e-31 NP_001299601 (OMIM: 600889) complement factor H-re ( 146) 563 120.4 4e-27 XP_011533056 (OMIM: 608397) PREDICTED: CUB and sus (2238) 475 104.2 4.5e-21 XP_011533055 (OMIM: 608397) PREDICTED: CUB and sus (2595) 475 104.3 5e-21 XP_011533054 (OMIM: 608397) PREDICTED: CUB and sus (3549) 475 104.4 6.3e-21 NP_150094 (OMIM: 608397) CUB and sushi domain-cont (3564) 475 104.4 6.3e-21 XP_016869220 (OMIM: 608397) PREDICTED: CUB and sus (3327) 474 104.2 6.8e-21 XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 471 103.4 7.6e-21 XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 471 103.6 1.1e-20 XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 471 103.6 1.1e-20 NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 471 103.7 1.1e-20 XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 471 103.7 1.1e-20 XP_011515118 (OMIM: 608399) PREDICTED: CUB and sus (3603) 471 103.7 1.1e-20 XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 471 103.7 1.1e-20 NP_937757 (OMIM: 608399) CUB and sushi domain-cont (3667) 471 103.7 1.1e-20 XP_016868497 (OMIM: 608399) PREDICTED: CUB and sus (3681) 471 103.7 1.1e-20 NP_937756 (OMIM: 608399) CUB and sushi domain-cont (3707) 471 103.7 1.1e-20 XP_016855678 (OMIM: 608398) PREDICTED: CUB and sus (3506) 470 103.5 1.2e-20 XP_016855676 (OMIM: 608398) PREDICTED: CUB and sus (3606) 470 103.5 1.3e-20 XP_016855674 (OMIM: 608398) PREDICTED: CUB and sus (3607) 470 103.5 1.3e-20 XP_016855675 (OMIM: 608398) PREDICTED: CUB and sus (3607) 470 103.5 1.3e-20 NP_001268885 (OMIM: 608398) CUB and sushi domain-c (3631) 470 103.5 1.3e-20 XP_016855602 (OMIM: 605337) PREDICTED: complement ( 458) 448 98.3 5.8e-20 XP_016855601 (OMIM: 605337) PREDICTED: complement ( 468) 448 98.3 5.9e-20 XP_016855600 (OMIM: 605337) PREDICTED: complement ( 519) 448 98.3 6.4e-20 NP_443128 (OMIM: 608398) CUB and sushi domain-cont (3487) 457 100.9 7.2e-20 NP_001014975 (OMIM: 126700,134370,235400,609814,61 ( 449) 415 91.8 5.2e-18 XP_016856597 (OMIM: 126700,134370,235400,609814,61 ( 446) 413 91.4 6.8e-18 >>NP_110414 (OMIM: 608593,614809) complement factor H-re (569 aa) initn: 4094 init1: 4094 opt: 4094 Z-score: 4356.9 bits: 816.1 E(85289): 0 Smith-Waterman score: 4094; 100.0% identity (100.0% similar) in 569 aa overlap (1-569:1-569) 10 20 30 40 50 60 pF1KE1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 RVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 RVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 FIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 FIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 YAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 YAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 DIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 DIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 YLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 YLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 FYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_110 FYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQ 490 500 510 520 530 540 550 560 pF1KE1 CKFPHKAMISSPPFRAICQEGKFEYPICE ::::::::::::::::::::::::::::: NP_110 CKFPHKAMISSPPFRAICQEGKFEYPICE 550 560 >>XP_011508322 (OMIM: 608593,614809) PREDICTED: compleme (572 aa) initn: 3977 init1: 3977 opt: 3977 Z-score: 4232.4 bits: 793.0 E(85289): 0 Smith-Waterman score: 3977; 100.0% identity (100.0% similar) in 550 aa overlap (20-569:23-572) 10 20 30 40 50 pF1KE1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEY :::::::::::::::::::::::::::::::::::::: XP_011 MVKPLRQKRNQENVVFHRPCEAGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 NFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 YSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 NLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 NPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNC 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE1 RNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRY 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE1 RCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE1 KENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYR 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE1 CQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAV 490 500 510 520 530 540 540 550 560 pF1KE1 EFQCKFPHKAMISSPPFRAICQEGKFEYPICE :::::::::::::::::::::::::::::::: XP_011 EFQCKFPHKAMISSPPFRAICQEGKFEYPICE 550 560 570 >>NP_000177 (OMIM: 126700,134370,235400,609814,610698) c (1231 aa) initn: 2082 init1: 1465 opt: 1661 Z-score: 1764.3 bits: 337.5 E(85289): 1.6e-91 Smith-Waterman score: 1661; 46.2% identity (70.9% similar) in 519 aa overlap (53-566:475-981) 30 40 50 60 70 80 pF1KE1 CDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPK :.:. ..:. . ::: ..::: : NP_000 VKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPT 450 460 470 480 490 500 90 100 110 120 130 140 pF1KE1 CLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGY--SLQNNEKNISCVERGWSTPPIC :.. :..: :...... .::.. :. :: . .. .: : ::: ::: NP_000 CIKSCDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPIC 510 520 530 540 550 560 150 160 170 180 190 200 pF1KE1 SFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPT . . ::..: ..... . ::..::::.::::::. .. :: .:::::.:: ::..: NP_000 -YER-ECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPI 570 580 590 600 610 620 210 220 230 240 250 260 pF1KE1 CKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLP :: ::.::::::.: ::.::: ::::::.::::: ::: :...::.::::::::::::: NP_000 CKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLP 630 640 650 660 670 680 270 280 290 300 310 320 pF1KE1 TCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELP .:. . .::: :::::.:..: : ::: .: ::: :: . ..:::. ::::.:.::.:: NP_000 VCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQLP 690 700 710 720 730 740 330 340 350 360 370 380 pF1KE1 MCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVD .::: .::.:: ... : . :::.::: ::::: . :.:::::.:.:::. NP_000 QCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVN 750 760 770 780 790 800 390 400 410 420 430 440 pF1KE1 CTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLP :. . :.:::::::::..:::::.::.:::::.:::.::::. :..::.::::::::.: NP_000 CSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIP 810 820 830 840 850 860 450 460 470 480 490 pF1KE1 RCVESTAYCGPPPSINNGDTTSFPLS--VYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWS :::. :. ::.:..: .: : : :. ..: :.. .... .:: .:: NP_000 LCVEKIP-CSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCYMGKWS 870 880 890 900 910 920 500 510 520 530 540 550 pF1KE1 EPPRCLD-PCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAI ::.: :: : . .. .:. : :. : ..: : . :..: . : NP_000 SPPQCEGLPCKSPPEISHGVVAHM---SDSYQY---GEEVTYKC-FEGFG-IDGPAI-AK 930 940 950 960 970 560 pF1KE1 CQEGKFEYPICE : :. .: NP_000 CLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTC 980 990 1000 1010 1020 1030 >-- initn: 884 init1: 631 opt: 713 Z-score: 755.8 bits: 150.8 E(85289): 2.3e-35 Smith-Waterman score: 713; 38.8% identity (65.9% similar) in 255 aa overlap (320-568:982-1228) 290 300 310 320 330 340 pF1KE1 GVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKE- : :. : : .. .... . .. :. NP_000 GEEVTYKCFEGFGIDGPAIAKCLGEKWSHPPSCIKTD----C-LSLPSFENAIPMGEKKD 960 970 980 990 1000 350 360 370 380 390 400 pF1KE1 -FNHNSRIRYRCSDIFRY---RHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTT .. . .. : :. ... . .:::..:. . : :. : :: . :: .. NP_000 VYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTC---RDTSCVNPPTVQNAYIVSRQ 1010 1020 1030 1040 1050 1060 410 420 430 440 450 460 pF1KE1 VN-YQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSF .. : .::.: :. : . .:..: .: : :.: .::. ::::: :.::: ::: NP_000 MSKYPSGERVRYQCRSPYEMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSF 1070 1080 1090 1100 1110 1120 470 480 490 500 510 520 pF1KE1 PLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKW ::::: :.:.: :.::..:.:.:. .:::: ::::::.:: :::.:.: :.. :: :.: NP_000 PLSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRW 1130 1140 1150 1160 1170 1180 530 540 550 560 pF1KE1 RNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE :::..::..::: :: .. : .:. : .::.::: : NP_000 TAKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 1190 1200 1210 1220 1230 >-- initn: 475 init1: 413 opt: 413 Z-score: 436.6 bits: 91.8 E(85289): 1.4e-17 Smith-Waterman score: 413; 39.8% identity (70.3% similar) in 118 aa overlap (23-140:325-442) 10 20 30 40 50 pF1KE1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFY ::.: :.:: :: :. :. : .:. . NP_000 RNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYS 300 310 320 330 340 350 60 70 80 90 100 110 pF1KE1 YSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQI : :. .: .:: :.: .: ::..::::. ::: : ::...::.... : ..: .... NP_000 YYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDV 360 370 380 390 400 410 120 130 140 150 160 170 pF1KE1 ICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLK :. ::.: . . ...:.: ::: : : NP_000 ACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSKSSIDIENGFISESQYTYALKEKAK 420 430 440 450 460 470 >>NP_001188480 (OMIM: 605337) complement factor H-relate (577 aa) initn: 1182 init1: 629 opt: 1370 Z-score: 1458.9 bits: 279.9 E(85289): 1.6e-74 Smith-Waterman score: 1370; 36.5% identity (62.4% similar) in 595 aa overlap (1-569:1-577) 10 20 30 40 50 60 pF1KE1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV ::::..::: ::: ..:. ::::.:.:: :: . . . .:. . : :. ::: NP_001 MLLLINVILTLWVSCANGQVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFV 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 SPSKSFWTRITCTEEGWSPTPKCLRMCSFP--FVKNGHSESSGLIHLEGDTVQIICNTGY .:: :.: : ::..::::: ::: :: ..:: :. :.. .. .: :. :: NP_001 TPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPGY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 SLQ--NNEKNISCVERGWSTPPIC-SFTKGECHVPILEANVDAQPKKESYKVGDVLKFSC . :. .:.:.. :::: ::: .: : .:..: : :. . .:. :.: . : NP_001 ATAEGNSSGSITCLQNGWSTQPICIKF----CDMPVFE-NSRAKSNGMWFKLHDTLDYEC 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 RKNL-IRVG--SDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEV . : .::. : . ::: ..::: .. ..::::: .:::.. . .. : NP_001 YDGYESSYGNTTDSIVCGEDGWS-HLPTCYNSSENCGPPPPISNGDTTSFPQKVYLPWSR 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 VEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYG--YVQPSVPPY--- :::.:. . ..: : . : .:.:. : :. ..: : . ::...: : . . :: NP_001 VEYQCQSYYELQGSKYVTCSNGDWSEPPRCI-SMKPCEF-PEIQHGHLYYENTRRPYFPV 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE1 QHGVSVEVNCRNEYAMIGN---NMITCINGIWTELPMCVATHQLKRCKIAGVNIKT-LLK : : : .... .. ..: : . : : :. :. . ..:.. ... NP_001 ATGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPC-----LRTCSKSDIEIENGFIS 300 310 320 330 340 350 360 370 380 390 pF1KE1 LSGKEFNHNSRIRYRCSDIFRYRHS------VCINGKWNPEVDCTEKREQFCPPPPQIPN :.. . :..:.:.:. . . .:... :. . : .:: : . : NP_001 ESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICI----KFCDMPV-FEN 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE1 AQNMTTTVNYQDGEKVAVLCKENYLLPEAKE---IVCKDGRWQSLPRCVESTAYCGPPPS .. .. . .. . . : ..: . .. ::: . :. .: : .:. ::::: NP_001 SRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPP 410 420 430 440 450 460 460 470 480 490 500 510 pF1KE1 INNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENM :.::::::: :.:: : : : :.:::.:.:::: ::: : .:::::::. ::...:::: NP_001 ISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENM 470 480 490 500 510 520 520 530 540 550 560 pF1KE1 NKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE :::::::: ..: : ::::::..::.::. ..: : :.:.:.:: ::: :: NP_001 NKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE 530 540 550 560 570 >>NP_001188479 (OMIM: 605337) complement factor H-relate (578 aa) initn: 1055 init1: 629 opt: 1317 Z-score: 1402.5 bits: 269.4 E(85289): 2.2e-71 Smith-Waterman score: 1362; 36.6% identity (62.2% similar) in 596 aa overlap (1-569:1-578) 10 20 30 40 50 pF1KE1 MLLLFSVILISWVSTVGG-EGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNF ::::..::: ::: ..: : ::::.:.:: :: . . . .:. . : :. :: NP_001 MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 VSPSKSFWTRITCTEEGWSPTPKCLRMCSFP--FVKNGHSESSGLIHLEGDTVQIICNTG :.:: :.: : ::..::::: ::: :: ..:: :. :.. .. .: :. : NP_001 VTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 YSLQ--NNEKNISCVERGWSTPPIC-SFTKGECHVPILEANVDAQPKKESYKVGDVLKFS :. :. .:.:.. :::: ::: .: : .:..: : :. . .:. :.: . NP_001 YATAEGNSSGSITCLQNGWSTQPICIKF----CDMPVFE-NSRAKSNGMWFKLHDTLDYE 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 CRKNL-IRVG--SDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNE : . : .::. : . ::: ..::: .. ..::::: .:::.. . .. : NP_001 CYDGYESSYGNTTDSIVCGEDGWS-HLPTCYNSSENCGPPPPISNGDTTSFPQKVYLPWS 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 VVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYG--YVQPSVPPY-- :::.:. . ..: : . : .:.:. : :. ..: : . ::...: : . . :: NP_001 RVEYQCQSYYELQGSKYVTCSNGDWSEPPRCI-SMKPCEF-PEIQHGHLYYENTRRPYFP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE1 -QHGVSVEVNCRNEYAMIGN---NMITCINGIWTELPMCVATHQLKRCKIAGVNIKT-LL : : : .... .. ..: : . : : :. :. . ..:.. .. NP_001 VATGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPC-----LRTCSKSDIEIENGFI 300 310 320 330 340 350 360 370 380 390 pF1KE1 KLSGKEFNHNSRIRYRCSDIFRYRHS------VCINGKWNPEVDCTEKREQFCPPPPQIP . :.. . :..:.:.:. . . .:... :. . : .:: : . NP_001 SESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICI----KFCDMPV-FE 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE1 NAQNMTTTVNYQDGEKVAVLCKENYLLPEAKE---IVCKDGRWQSLPRCVESTAYCGPPP :.. .. . .. . . : ..: . .. ::: . :. .: : .:. ::::: NP_001 NSRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPP 410 420 430 440 450 460 460 470 480 490 500 510 pF1KE1 SINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEEN :.::::::: :.:: : : : :.:::.:.:::: ::: : .:::::::. ::...::: NP_001 PISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEEN 470 480 490 500 510 520 520 530 540 550 560 pF1KE1 MNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE ::::::::: ..: : ::::::..::.::. ..: : :.:.:.:: ::: :: NP_001 MNKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE 530 540 550 560 570 >>XP_006711192 (OMIM: 605337) PREDICTED: complement fact (570 aa) initn: 1084 init1: 629 opt: 1316 Z-score: 1401.5 bits: 269.2 E(85289): 2.5e-71 Smith-Waterman score: 1316; 35.8% identity (61.7% similar) in 595 aa overlap (1-569:1-570) 10 20 30 40 50 60 pF1KE1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV ::::..::: ::: ..:. .:.:: :: . . . .:. . : :. ::: XP_006 MLLLINVILTLWVSCANGQ-------EIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNFV 10 20 30 40 50 70 80 90 100 110 pF1KE1 SPSKSFWTRITCTEEGWSPTPKCLRMCSFP--FVKNGHSESSGLIHLEGDTVQIICNTGY .:: :.: : ::..::::: ::: :: ..:: :. :.. .. .: :. :: XP_006 TPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDVEIENGFISESSSIYILNEETQYNCKPGY 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 SLQ--NNEKNISCVERGWSTPPIC-SFTKGECHVPILEANVDAQPKKESYKVGDVLKFSC . :. .:.:.. :::: ::: .: : .:..: : :. . .:. :.: . : XP_006 ATAEGNSSGSITCLQNGWSTQPICIKF----CDMPVFE-NSRAKSNGMWFKLHDTLDYEC 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 RKNL-IRVG--SDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEV . : .::. : . ::: ..::: .. ..::::: .:::.. . .. : XP_006 YDGYESSYGNTTDSIVCGEDGWS-HLPTCYNSSENCGPPPPISNGDTTSFPQKVYLPWSR 170 180 190 200 210 220 240 250 260 270 280 pF1KE1 VEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYG--YVQPSVPPY--- :::.:. . ..: : . : .:.:. : :. ..: : . ::...: : . . :: XP_006 VEYQCQSYYELQGSKYVTCSNGDWSEPPRCI-SMKPCEF-PEIQHGHLYYENTRRPYFPV 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 QHGVSVEVNCRNEYAMIGN---NMITCINGIWTELPMCVATHQLKRCKIAGVNIKT-LLK : : : .... .. ..: : . : : :. :. . ..:.. ... XP_006 ATGQSYSYYCDQNFVTPSGSYWDYIHCTQDGWLPTVPC-----LRTCSKSDIEIENGFIS 290 300 310 320 330 340 350 360 370 380 390 pF1KE1 LSGKEFNHNSRIRYRCSDIFRYRHS------VCINGKWNPEVDCTEKREQFCPPPPQIPN :.. . :..:.:.:. . . .:... :. . : .:: : . : XP_006 ESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNGWSAQPICI----KFCDMPV-FEN 350 360 370 380 390 400 410 420 430 440 450 pF1KE1 AQNMTTTVNYQDGEKVAVLCKENYLLPEAKE---IVCKDGRWQSLPRCVESTAYCGPPPS .. .. . .. . . : ..: . .. ::: . :. .: : .:. ::::: XP_006 SRAKSNGMRFKLHDTLDYECYDGYEISYGNTTGSIVCGEDGWSHFPTCYNSSEKCGPPPP 400 410 420 430 440 450 460 470 480 490 500 510 pF1KE1 INNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENM :.::::::: :.:: : : : :.:::.:.:::: ::: : .:::::::. ::...:::: XP_006 ISNGDTTSFLLKVYVPQSRVEYQCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENM 460 470 480 490 500 510 520 530 540 550 560 pF1KE1 NKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE :::::::: ..: : ::::::..::.::. ..: : :.:.:.:: ::: :: XP_006 NKNNIQLKGKSDIKYYAKTGDTIEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE 520 530 540 550 560 570 >>NP_002104 (OMIM: 134371,235400,603075) complement fact (330 aa) initn: 1639 init1: 1031 opt: 1133 Z-score: 1209.9 bits: 233.0 E(85289): 1.2e-60 Smith-Waterman score: 1133; 51.7% identity (68.4% similar) in 329 aa overlap (1-322:1-327) 10 20 30 40 50 60 pF1KE1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV : :: :::::: .:.::::.:.::::::.::.::::: :.:::::::::::::::::::: NP_002 MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL :::::::::::::::::::::::::.: ::::.:::::::: ::::::::::::::: : NP_002 SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRKNL ::::.::::::::::::: : : : : :. .. : : :. ... ::. NP_002 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 IRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNP :.. :.: . .:. : :: .. .::::: ..::.. . :. :::.:. NP_002 EMFGDEEVMCLNGNWTEP-PQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 NFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPE---LEYGYVQPSVPPYQHGVSVEVN . ..: :.: : .:.:. : :.. : : . .. . . : :.: NP_002 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 CRNEYAMIGNNMI---TCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNS :. : . . . :: .: : : : NP_002 CKRGYRLSSRSHTLRTTCWDGK-LEYPTCAKR 300 310 320 330 >>XP_011507586 (OMIM: 134580,613235) PREDICTED: coagulat (675 aa) initn: 937 init1: 496 opt: 939 Z-score: 999.5 bits: 195.1 E(85289): 6.2e-49 Smith-Waterman score: 939; 31.2% identity (59.5% similar) in 504 aa overlap (87-568:25-514) 60 70 80 90 100 pF1KE1 YNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNG------HSESSGLIHLEGDT- :.:: :.:: .. .: . . : XP_011 MRLKNLTFIIILIISGELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKK 10 20 30 40 50 110 120 130 140 150 160 pF1KE1 VQIICNTGYSLQNN--EKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKV ....: .::. ... :.. .:. .::: : : : : : : : .: . : ::. XP_011 LSFFCLAGYTTESGRQEEQTTCTTEGWSPEPRC-FKK--CTKPDL-SNGYISDVKLLYKI 60 70 80 90 100 110 170 180 190 200 210 220 pF1KE1 GDVLKFSCRKNLIRVGS---DSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRK . ....: .. .:. . ::: . ::: . :::. . ..: : .: ::. . .: XP_011 QENMRYGCASGYKTTGGKDEEVVQCLSDGWSSQ-PTCRKEHETCLAP-ELYNGNYSTTQK 120 130 140 150 160 230 240 250 260 270 280 pF1KE1 EEYGHNEVVEYDCNPNFIINGPKK---IQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQ . .. :.:.: .. : :: ..:. :. : :. ..: :. . .: :: . XP_011 T-FKVKDKVQYECATGYYTAGGKKTEEVECLTYGWSLTPKCT-KLK-CSSLRLIENGYFH 170 180 190 200 210 220 290 300 310 320 330 340 pF1KE1 PSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIW-TELPMCVATHQLKRCKIAGVNIKT : :..: :. :...: . :...: : : : : :.: . .. :: . :.. XP_011 PVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRN--RCPPPPLPINS 230 240 250 260 270 280 350 360 370 380 390 pF1KE1 LLKLSGKEFNHNSRIRYRCSDIFRYRHSV---CINGKWNPEVDCTEKREQFCPPPPQIPN .. . . :. .. .: :. . :. : .:::. : ... : :: : : XP_011 KIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIGQEKVACEEPPFIEN 290 300 310 320 330 340 400 410 420 430 440 450 pF1KE1 -AQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSIN : :. . . : .:.::. :: .::: ..::.:. :.: :.:::.. : :: . XP_011 GAANLHSKI-YYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVENNENCKHPPVVM 350 360 370 380 390 400 460 470 480 490 500 510 pF1KE1 NGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNK :: ... :. : ::.: :::. .: :.:: :.. .:: :: ::.::.:. . ::. XP_011 NGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNR 410 420 430 440 450 460 520 530 540 550 560 pF1KE1 NNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSP--PFRAICQEGKFEYPICE :::..::. .::. :: ..: :: . .: . . :..:. .::.: XP_011 NNIEMKWKYEGKVLH--GDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRKESK 470 480 490 500 510 520 XP_011 GMCTSPPLIKHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEP 530 540 550 560 570 580 >-- initn: 406 init1: 283 opt: 337 Z-score: 359.1 bits: 76.6 E(85289): 2.9e-13 Smith-Waterman score: 337; 36.7% identity (66.4% similar) in 128 aa overlap (444-568:518-645) 420 430 440 450 460 470 pF1KE1 AVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGST :: ..: :: :..: : ...: ::. XP_011 GYDLSPLTPLSELSVQCNRGEVKYPLCTRKESKGMCTSPPLIKHGVIISSTVDTYENGSS 490 500 510 520 530 540 480 490 500 510 520 530 pF1KE1 VTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKT : ::: . . :.:: . : . .:. :: ::.::..: .:.:::. ::: :.. . XP_011 VEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEMEKNNLLLKWDFDNRPHILH 550 560 570 580 590 600 540 550 560 pF1KE1 GDAVEFQCK---FPHKAMISSPPFRAICQEGKFEYPICE :. .:: :. .: . .:.. .: :..:...:: : XP_011 GEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRCIPRQSKQTTGSGNQFNRPSELS 610 620 630 640 650 660 XP_011 EVKATFAI 670 >>NP_005657 (OMIM: 600889) complement factor H-related p (270 aa) initn: 1476 init1: 857 opt: 929 Z-score: 994.0 bits: 192.7 E(85289): 1.3e-48 Smith-Waterman score: 929; 53.5% identity (72.5% similar) in 273 aa overlap (1-265:1-270) 10 20 30 40 50 60 pF1KE1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV : :: :::::: .:.::::. .::::::.::.::::: :.:::::::::::::::::::: NP_005 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL ::::::::::::.::::::::::::.: ::::.:::::::: ::::::::::::::: : NP_005 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 QNNEKNISCVERGWSTPPIC--SFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRK ::::.::::::::::::: : ... .: : : : : : :. ....: . NP_005 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQC-Q 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 NLIRV-GSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEE-YGHN-EVVE :: .. :.... : . :: : : . : ..: ... :... ..:: NP_005 NLYQLEGNNQITCRNGQWSEP-PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 YDCNPNFIINGPK--KIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVS . :. .. . . . .: .:. . :.: :. NP_005 FVCKSGYHPTKSHSFRAMCQNGK-LVYPSCEEK 240 250 260 270 300 310 320 330 340 350 pF1KE1 VEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHN >>XP_011507760 (OMIM: 600889) PREDICTED: complement fact (266 aa) initn: 1065 init1: 855 opt: 925 Z-score: 989.8 bits: 191.9 E(85289): 2.2e-48 Smith-Waterman score: 925; 53.9% identity (72.7% similar) in 271 aa overlap (1-265:1-266) 10 20 30 40 50 60 pF1KE1 MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV : :: :::::: .:.::::. .::::::.::.::::: :.:::::::::::::::::::: XP_011 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL ::::::::::::.::::::::::::.: ::::.:::::::: ::::::::::::::: : XP_011 SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 QNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRKNL ::::.::::::::::::: .:. .: : : : : : :. ....: .:: XP_011 QNNENNISCVERGWSTPP--KFSAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQC-QNL 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 IRV-GSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEE-YGHN-EVVEYD .. :.... : . :: : : . : ..: ... :... ..::. XP_011 YQLEGNNQITCRNGQWSEP-PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 CNPNFIINGPK--KIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVE :. .. . . . .: .:. . :.: :. XP_011 CKSGYHPTKSHSFRAMCQNGK-LVYPSCEEK 240 250 260 300 310 320 330 340 350 pF1KE1 VNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSR 569 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:44:54 2016 done: Sun Nov 6 18:44:56 2016 Total Scan time: 9.810 Total Display time: 0.130 Function used was FASTA [36.3.4 Apr, 2011]