FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7761, 448 aa 1>>>pF1KB7761 448 - 448 aa - 448 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2437+/-0.000379; mu= 5.4605+/- 0.024 mean_var=193.7824+/-40.528, 0's: 0 Z-trim(119.8): 78 B-trim: 883 in 2/56 Lambda= 0.092133 statistics sampled from 34213 (34294) to 34213 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.402), width: 16 Scan time: 10.390 The best scores are: opt bits E(85289) NP_005140 (OMIM: 201400,604614) T-box transcriptio ( 448) 3093 423.5 5.7e-118 XP_011534382 (OMIM: 182940,601397,615709) PREDICTE ( 436) 1601 225.1 2.8e-58 NP_003172 (OMIM: 182940,601397,615709) brachyury p ( 435) 1582 222.6 1.6e-57 NP_001257413 (OMIM: 182940,601397,615709) brachyur ( 377) 1247 178.0 3.7e-44 XP_011544228 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 671 101.5 4.6e-21 NP_004599 (OMIM: 122600,602427) T-box transcriptio ( 436) 671 101.5 4.6e-21 XP_016879103 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 671 101.5 4.6e-21 XP_005255580 (OMIM: 122600,602427) PREDICTED: T-bo ( 436) 671 101.5 4.6e-21 NP_060958 (OMIM: 147891,601719) T-box transcriptio ( 545) 653 99.2 2.8e-20 XP_011523793 (OMIM: 147891,601719) PREDICTED: T-bo ( 608) 653 99.2 3.1e-20 NP_001308049 (OMIM: 147891,601719) T-box transcrip ( 546) 648 98.5 4.5e-20 XP_011523792 (OMIM: 147891,601719) PREDICTED: T-bo ( 609) 648 98.6 4.9e-20 XP_011523797 (OMIM: 147891,601719) PREDICTED: T-bo ( 417) 634 96.6 1.3e-19 NP_542448 (OMIM: 142900,601620) T-box transcriptio ( 468) 632 96.4 1.7e-19 NP_000183 (OMIM: 142900,601620) T-box transcriptio ( 518) 632 96.4 1.9e-19 NP_852259 (OMIM: 142900,601620) T-box transcriptio ( 518) 632 96.4 1.9e-19 XP_016875401 (OMIM: 142900,601620) PREDICTED: T-bo ( 534) 632 96.4 1.9e-19 NP_005985 (OMIM: 600747) T-box transcription facto ( 712) 597 91.9 6.1e-18 NP_005987 (OMIM: 181450,601621) T-box transcriptio ( 723) 567 87.9 9.7e-17 XP_016877522 (OMIM: 616061) PREDICTED: MAX gene-as (1439) 558 86.9 3.8e-16 XP_011519703 (OMIM: 616061) PREDICTED: MAX gene-as (1549) 558 86.9 4e-16 XP_016877519 (OMIM: 616061) PREDICTED: MAX gene-as (2207) 558 87.1 5.2e-16 NP_001074010 (OMIM: 616061) MAX gene-associated pr (2856) 558 87.2 6.3e-16 XP_005254310 (OMIM: 616061) PREDICTED: MAX gene-as (2906) 558 87.2 6.4e-16 XP_005254309 (OMIM: 616061) PREDICTED: MAX gene-as (2956) 558 87.2 6.5e-16 XP_011519700 (OMIM: 616061) PREDICTED: MAX gene-as (3004) 558 87.2 6.6e-16 XP_011519699 (OMIM: 616061) PREDICTED: MAX gene-as (3005) 558 87.2 6.6e-16 NP_001157745 (OMIM: 616061) MAX gene-associated pr (3065) 558 87.2 6.7e-16 XP_005254306 (OMIM: 616061) PREDICTED: MAX gene-as (3066) 558 87.2 6.7e-16 XP_005254305 (OMIM: 616061) PREDICTED: MAX gene-as (3114) 558 87.2 6.7e-16 XP_005254300 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16 XP_005254304 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16 XP_005254301 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16 XP_005254303 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16 XP_005254302 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16 XP_006720506 (OMIM: 616061) PREDICTED: MAX gene-as (3115) 558 87.2 6.7e-16 NP_037483 (OMIM: 208550,604895) T-box transcriptio ( 535) 537 83.8 1.2e-15 XP_006724720 (OMIM: 300307,302905,303400) PREDICTE ( 350) 487 77.0 8.9e-14 NP_058650 (OMIM: 300307,302905,303400) T-box trans ( 520) 487 77.1 1.2e-13 NP_001103348 (OMIM: 300307,302905,303400) T-box tr ( 520) 487 77.1 1.2e-13 XP_005262193 (OMIM: 300307,302905,303400) PREDICTE ( 521) 487 77.1 1.2e-13 NP_006584 (OMIM: 604616) T-box brain protein 1 [Ho ( 682) 489 77.5 1.2e-13 XP_006715665 (OMIM: 143100,143400,604613) PREDICTE ( 364) 480 76.1 1.7e-13 XP_011534551 (OMIM: 143100,143400,604613) PREDICTE ( 372) 480 76.1 1.8e-13 XP_016866962 (OMIM: 143100,143400,604613) PREDICTE ( 376) 480 76.1 1.8e-13 XP_011534550 (OMIM: 143100,143400,604613) PREDICTE ( 377) 480 76.1 1.8e-13 XP_011534549 (OMIM: 143100,143400,604613) PREDICTE ( 379) 480 76.1 1.8e-13 NP_001073977 (OMIM: 143100,143400,604613) T-box tr ( 607) 480 76.3 2.6e-13 NP_005986 (OMIM: 604648) T-box transcription facto ( 385) 470 74.8 4.6e-13 XP_011543294 (OMIM: 604648) PREDICTED: T-box trans ( 430) 470 74.8 5e-13 >>NP_005140 (OMIM: 201400,604614) T-box transcription fa (448 aa) initn: 3093 init1: 3093 opt: 3093 Z-score: 2238.9 bits: 423.5 E(85289): 5.7e-118 Smith-Waterman score: 3093; 100.0% identity (100.0% similar) in 448 aa overlap (1-448:1-448) 10 20 30 40 50 60 pF1KB7 MAMSELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAMSELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 MIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 CVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSAHRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSAHRM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 VTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQHVTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQHVTY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAYMHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAYMHR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLWTIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLWTIS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 NGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLTSIAVST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLTSIAVST 370 380 390 400 410 420 430 440 pF1KB7 WTAVASHPFAGWGGPGAGGHHSPSSLDG :::::::::::::::::::::::::::: NP_005 WTAVASHPFAGWGGPGAGGHHSPSSLDG 430 440 >>XP_011534382 (OMIM: 182940,601397,615709) PREDICTED: b (436 aa) initn: 1479 init1: 1294 opt: 1601 Z-score: 1167.3 bits: 225.1 E(85289): 2.8e-58 Smith-Waterman score: 1601; 56.6% identity (78.6% similar) in 435 aa overlap (3-432:1-428) 10 20 30 40 50 pF1KB7 MAMSELGTR---KPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEV :: ::. : . :.:::..::.::::: :::::::..:.. ::.. :: ::::. XP_011 MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKEL 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 TNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVS ::::::::::::::::::..:.:::::::::.::::: .:.::::::::::::.:::: . XP_011 TNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 SHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSA . ::::::::::::::::::::.:::::::::::::::::::::::::::..::::::. XP_011 APSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH .::.:. :::::::::::::::::::::::::::::::::::::. ... : ..::. XP_011 QRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAY ::. :::.. . . .: .: . :... : ::. :. :..: ::.::..:::: : XP_011 PGYSQSGGWLLPGTSTLCPPANPHPQFGGALSLPSTHS---CDRYPTLRSHRSSPYPSPY 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 MHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLW :::.::. . ..: :..... :.:.::. : :.: : :. .: . . : :: :: XP_011 AHRNNSPTYS--DNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSS-SQYPSLW 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 TISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVL-GEPSLTSI ..:::: :.. . : . . :. :.:: .: . ..::.:.: . : . :.: XP_011 SVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLT-HPVSAPSSSGSPLYEGAAAATDI 360 370 380 390 400 410 420 430 440 pF1KB7 AVSTWTAVASHPF-AGWGGPGAGGHHSPSSLDG . : . :.:. . :.: XP_011 VDSQYDAAAQGRLIASWTPVSPPSM 420 430 >>NP_003172 (OMIM: 182940,601397,615709) brachyury prote (435 aa) initn: 1401 init1: 1216 opt: 1582 Z-score: 1153.7 bits: 222.6 E(85289): 1.6e-57 Smith-Waterman score: 1582; 56.3% identity (78.4% similar) in 435 aa overlap (3-432:1-427) 10 20 30 40 50 pF1KB7 MAMSELGTR---KPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEV :: ::. : . :.:::..::.::::: :::::::..:.. ::.. :: ::::. NP_003 MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKEL 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 TNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVS ::::::::::::::::::..:.:::::::::.::::: .:.::::::::::::.:::: . NP_003 TNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 SHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSA . ::::::::::::::::::::.:::::::::::::::::::::::::::..::::::. NP_003 APSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH .::.:. :::::::::::::::::::::::::::::::::::::. ... : ..::. NP_003 QRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAY ::. : :.. . . .: .: . :... : ::. :. :..: ::.::..:::: : NP_003 PGYSQWG-WLLPGTSTLCPPANPHPQFGGALSLPSTHS---CDRYPTLRSHRSSPYPSPY 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 MHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLW :::.::. . ..: :..... :.:.::. : :.: : :. .: . . : :: :: NP_003 AHRNNSPTYS--DNSPACLSMLQSHDNWSSLGMPAHPSMLPVSHNASPPTSS-SQYPSLW 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 TISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVL-GEPSLTSI ..:::: :.. . : . . :. :.:: .: . ..::.:.: . : . :.: NP_003 SVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLT-HPVSAPSSSGSPLYEGAAAATDI 360 370 380 390 400 410 420 430 440 pF1KB7 AVSTWTAVASHPF-AGWGGPGAGGHHSPSSLDG . : . :.:. . :.: NP_003 VDSQYDAAAQGRLIASWTPVSPPSM 420 430 >>NP_001257413 (OMIM: 182940,601397,615709) brachyury pr (377 aa) initn: 1293 init1: 1205 opt: 1247 Z-score: 913.8 bits: 178.0 E(85289): 3.7e-44 Smith-Waterman score: 1286; 52.4% identity (68.7% similar) in 435 aa overlap (3-432:1-369) 10 20 30 40 50 pF1KB7 MAMSELGTR---KPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEV :: ::. : . :.:::..::.::::: :::::::..:.. ::.. :: ::::. NP_001 MSSPGTESAGKSLQYRVDHLLSAVENELQAGSEKGDPTERELRVGLEESELWLRFKEL 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 TNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVS ::::::::::::::::::..:.:::::::::.::::: .:.::::::::::::.:::: . NP_001 TNEMIVTKNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQ 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 SHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSLHKYEPQVHIVRVGSA . ::::::::::::::::::::.:::::::::::::::::::::::::::..::::::. NP_001 APSCVYIHPDSPNFGAHWMKAPVSFSKVKLTNKLNGGGQIMLNSLHKYEPRIHIVRVGGP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH .::.:. :::::::::::::::::::::::::::::::::::::. ... : ..::. NP_001 QRMITSHCFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERSDHKEMMEEPGDSQQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPYPSAY ::. : : :: :: : : :..: NP_001 PGYSQ------SYSD------NS----------PA------C--LSMLQSH--------- 240 250 300 310 320 330 340 350 pF1KB7 MHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPINPGPSPYPCLW :.:.::. : :.: : :. .: . . : :: :: NP_001 -------------------------DNWSSLGMPAHPSMLPVSHNASPPTSS-SQYPSLW 260 270 280 290 360 370 380 390 400 410 pF1KB7 TISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVL-GEPSLTSI ..:::: :.. . : . . :. :.:: .: . ..::.:.: . : . :.: NP_001 SVSNGAVTPGSQAAAVSNGLGAQFFRGSPAHYTPLT-HPVSAPSSSGSPLYEGAAAATDI 300 310 320 330 340 350 420 430 440 pF1KB7 AVSTWTAVASHPF-AGWGGPGAGGHHSPSSLDG . : . :.:. . :.: NP_001 VDSQYDAAAQGRLIASWTPVSPPSM 360 370 >>XP_011544228 (OMIM: 122600,602427) PREDICTED: T-box tr (436 aa) initn: 574 init1: 417 opt: 671 Z-score: 499.2 bits: 101.5 E(85289): 4.6e-21 Smith-Waterman score: 672; 38.3% identity (60.6% similar) in 358 aa overlap (45-382:95-428) 20 30 40 50 60 70 pF1KB7 TVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVL ::. ::..:. : .:::.:: ::::::. XP_011 PLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB7 KISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAH ..:::::::.: : .::: .:.:. :... . .: :.:: : . :::::::: ::: XP_011 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAH 130 140 150 160 170 180 140 150 160 170 180 pF1KB7 WMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRVG---SAHRM-VTNCSFPET ::. :.:: .:::::. :. :...:.:.:::.:..:.::.. : : ... :::: XP_011 WMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPET 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB7 QFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH-----VTYSHLG ::.:::::: .:: ::: :::::.: . :: :. .... . .: .. . XP_011 TFISVTAYQNPQITQLKIAANPFAKGFRENG-RNCKRERDARVKRKLRGPEPAATEAYGS 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB7 GWIFSNPDGVCTAG-NSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPY---PSAYMHR : ..: : : . ... . . : ::: : :: ::: . XP_011 G---DTPGGPCDSTLGGDIRESDPEQAPAP----------GEATAAPAPLCGGPSAEAYL 310 320 330 340 350 310 320 330 340 350 pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPH-ASILSVPHTNG----PINPGPSPY-P : :.. : . : :.. : :.:. :..: .:: .: : : :. : XP_011 LH-PAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAP 360 370 380 390 400 360 370 380 390 400 410 pF1KB7 CLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLT . ::: : : ..::..: XP_011 HFLQ-----GGPF-PLPY---TAPGGYLDVGSKPMY 410 420 430 >>NP_004599 (OMIM: 122600,602427) T-box transcription fa (436 aa) initn: 574 init1: 417 opt: 671 Z-score: 499.2 bits: 101.5 E(85289): 4.6e-21 Smith-Waterman score: 672; 38.3% identity (60.6% similar) in 358 aa overlap (45-382:95-428) 20 30 40 50 60 70 pF1KB7 TVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVL ::. ::..:. : .:::.:: ::::::. NP_004 PLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB7 KISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAH ..:::::::.: : .::: .:.:. :... . .: :.:: : . :::::::: ::: NP_004 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAH 130 140 150 160 170 180 140 150 160 170 180 pF1KB7 WMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRVG---SAHRM-VTNCSFPET ::. :.:: .:::::. :. :...:.:.:::.:..:.::.. : : ... :::: NP_004 WMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPET 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB7 QFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH-----VTYSHLG ::.:::::: .:: ::: :::::.: . :: :. .... . .: .. . NP_004 TFISVTAYQNPQITQLKIAANPFAKGFRENG-RNCKRERDARVKRKLRGPEPAATEAYGS 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB7 GWIFSNPDGVCTAG-NSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPY---PSAYMHR : ..: : : . ... . . : ::: : :: ::: . NP_004 G---DTPGGPCDSTLGGDIRESDPEQAPAP----------GEATAAPAPLCGGPSAEAYL 310 320 330 340 350 310 320 330 340 350 pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPH-ASILSVPHTNG----PINPGPSPY-P : :.. : . : :.. : :.:. :..: .:: .: : : :. : NP_004 LH-PAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAP 360 370 380 390 400 360 370 380 390 400 410 pF1KB7 CLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLT . ::: : : ..::..: NP_004 HFLQ-----GGPF-PLPY---TAPGGYLDVGSKPMY 410 420 430 >>XP_016879103 (OMIM: 122600,602427) PREDICTED: T-box tr (436 aa) initn: 574 init1: 417 opt: 671 Z-score: 499.2 bits: 101.5 E(85289): 4.6e-21 Smith-Waterman score: 672; 38.3% identity (60.6% similar) in 358 aa overlap (45-382:95-428) 20 30 40 50 60 70 pF1KB7 TVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVL ::. ::..:. : .:::.:: ::::::. XP_016 PLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB7 KISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAH ..:::::::.: : .::: .:.:. :... . .: :.:: : . :::::::: ::: XP_016 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAH 130 140 150 160 170 180 140 150 160 170 180 pF1KB7 WMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRVG---SAHRM-VTNCSFPET ::. :.:: .:::::. :. :...:.:.:::.:..:.::.. : : ... :::: XP_016 WMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPET 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB7 QFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH-----VTYSHLG ::.:::::: .:: ::: :::::.: . :: :. .... . .: .. . XP_016 TFISVTAYQNPQITQLKIAANPFAKGFRENG-RNCKRERDARVKRKLRGPEPAATEAYGS 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB7 GWIFSNPDGVCTAG-NSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPY---PSAYMHR : ..: : : . ... . . : ::: : :: ::: . XP_016 G---DTPGGPCDSTLGGDIRESDPEQAPAP----------GEATAAPAPLCGGPSAEAYL 310 320 330 340 350 310 320 330 340 350 pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPH-ASILSVPHTNG----PINPGPSPY-P : :.. : . : :.. : :.:. :..: .:: .: : : :. : XP_016 LH-PAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAP 360 370 380 390 400 360 370 380 390 400 410 pF1KB7 CLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLT . ::: : : ..::..: XP_016 HFLQ-----GGPF-PLPY---TAPGGYLDVGSKPMY 410 420 430 >>XP_005255580 (OMIM: 122600,602427) PREDICTED: T-box tr (436 aa) initn: 574 init1: 417 opt: 671 Z-score: 499.2 bits: 101.5 E(85289): 4.6e-21 Smith-Waterman score: 672; 38.3% identity (60.6% similar) in 358 aa overlap (45-382:95-428) 20 30 40 50 60 70 pF1KB7 TVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVTKNGRRMFPVL ::. ::..:. : .:::.:: ::::::. XP_005 PLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPAC 70 80 90 100 110 120 80 90 100 110 120 130 pF1KB7 KISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYIHPDSPNFGAH ..:::::::.: : .::: .:.:. :... . .: :.:: : . :::::::: ::: XP_005 RVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAH 130 140 150 160 170 180 140 150 160 170 180 pF1KB7 WMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRVG---SAHRM-VTNCSFPET ::. :.:: .:::::. :. :...:.:.:::.:..:.::.. : : ... :::: XP_005 WMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPET 190 200 210 220 230 240 190 200 210 220 230 240 pF1KB7 QFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH-----VTYSHLG ::.:::::: .:: ::: :::::.: . :: :. .... . .: .. . XP_005 TFISVTAYQNPQITQLKIAANPFAKGFRENG-RNCKRERDARVKRKLRGPEPAATEAYGS 250 260 270 280 290 300 250 260 270 280 290 300 pF1KB7 GWIFSNPDGVCTAG-NSNYQYAAPLPLPAPHTHHGCEHYSGLRGHRQAPY---PSAYMHR : ..: : : . ... . . : ::: : :: ::: . XP_005 G---DTPGGPCDSTLGGDIRESDPEQAPAP----------GEATAAPAPLCGGPSAEAYL 310 320 330 340 350 310 320 330 340 350 pF1KB7 NHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPH-ASILSVPHTNG----PINPGPSPY-P : :.. : . : :.. : :.:. :..: .:: .: : : :. : XP_005 LH-PAAFHGAPSHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAP 360 370 380 390 400 360 370 380 390 400 410 pF1KB7 CLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVEVLGEPSLT . ::: : : ..::..: XP_005 HFLQ-----GGPF-PLPY---TAPGGYLDVGSKPMY 410 420 430 >>NP_060958 (OMIM: 147891,601719) T-box transcription fa (545 aa) initn: 666 init1: 415 opt: 653 Z-score: 485.0 bits: 99.2 E(85289): 2.8e-20 Smith-Waterman score: 662; 35.4% identity (59.3% similar) in 413 aa overlap (35-429:61-442) 10 20 30 40 50 60 pF1KB7 ELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVT . : ..... :.. ::..:.:. .:::.: NP_060 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT 40 50 60 70 80 90 70 80 90 100 110 120 pF1KB7 KNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYI : :::::: :..:::..:.. : ::.:.::.:.::.:. ...:. ::: : . . .:. NP_060 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV 100 110 120 130 140 150 130 140 150 160 170 pF1KB7 HPDSPNFGAHWMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRV------GSA ::::: :::::. .::.:.::::. :. :.:.:::.:::.:..:::.. :: NP_060 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK 160 170 180 190 200 210 180 190 200 210 220 230 pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH . . ::::.::.::.:::..:: :::. :::::.: . . . :: : . :. NP_060 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSD-LR-VARLQSKEYP 220 230 240 250 260 240 250 260 270 280 290 pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRG-HRQAPYPSA : . . . .:. :.: : ::.. .::. : : : :. NP_060 VISKSIMRQRLISPQ----------LSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQD 270 280 290 300 310 300 310 320 330 340 350 pF1KB7 YMHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPIN----PGP-- . . :. ..:: . .. :. :. . : : .: . : . : : NP_060 -LPLSTFPT---QRDSSLFYHCLKRRDGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYD 320 330 340 350 360 370 360 370 380 390 400 pF1KB7 ----SPYPCLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVE :: : . : :: :::. :.. :. : :: :: . ::.. NP_060 QQMLSPSYCSEVTPREACMYSGSGPEI-AGVSGVDDL-------PPPPLSCNMWTSVS-- 380 390 400 410 420 410 420 430 440 pF1KB7 VLGEPSLTSIAVSTWTAVASHPFAGWGGPGAGGHHSPSSLDG : :: .:.: .: .:: NP_060 ----P-YTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQ 430 440 450 460 470 >>XP_011523793 (OMIM: 147891,601719) PREDICTED: T-box tr (608 aa) initn: 666 init1: 415 opt: 653 Z-score: 484.3 bits: 99.2 E(85289): 3.1e-20 Smith-Waterman score: 662; 35.4% identity (59.3% similar) in 413 aa overlap (35-429:124-505) 10 20 30 40 50 60 pF1KB7 ELGTRKPSDGTVSHLLNVVESELQAGREKGDPTEKQLQIILEDAPLWQRFKEVTNEMIVT . : ..... :.. ::..:.:. .:::.: XP_011 EPALAAPGLSGAALGSPPGPGADVVAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIIT 100 110 120 130 140 150 70 80 90 100 110 120 pF1KB7 KNGRRMFPVLKISVTGLDPNAMYSLLLDFVPTDSHRWKYVNGEWVPAGKPEVSSHSCVYI : :::::: :..:::..:.. : ::.:.::.:.::.:. ...:. ::: : . . .:. XP_011 KAGRRMFPSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYV 160 170 180 190 200 210 130 140 150 160 170 pF1KB7 HPDSPNFGAHWMKAPISFSKVKLTNK-LNGGGQIMLNSLHKYEPQVHIVRV------GSA ::::: :::::. .::.:.::::. :. :.:.:::.:::.:..:::.. :: XP_011 HPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSK 220 230 240 250 260 270 180 190 200 210 220 230 pF1KB7 HRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAKERNHLRDVPEAISESQH . . ::::.::.::.:::..:: :::. :::::.: . . . :: : . :. XP_011 NTAFCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSD-LR-VARLQSKEYP 280 290 300 310 320 330 240 250 260 270 280 290 pF1KB7 VTYSHLGGWIFSNPDGVCTAGNSNYQYAAPLPLPAPHTHHGCEHYSGLRG-HRQAPYPSA : . . . .:. :.: : ::.. .::. : : : :. XP_011 VISKSIMRQRLISPQ----------LSATPDVGPLLGTHQALQHYQHENGAHSQLAEPQD 340 350 360 370 380 300 310 320 330 340 350 pF1KB7 YMHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASILSVPHTNGPIN----PGP-- . . :. ..:: . .. :. :. . : : .: . : . : : XP_011 -LPLSTFPT---QRDSSLFYHCLKRRDGTRHLDLPCKRSYLEAPSSVGEDHYFRSPPPYD 390 400 410 420 430 360 370 380 390 400 pF1KB7 ----SPYPCLWTISNGAGGPSGPGPEVHASTPGAFLLGNPAVTSPPSVLSTQAPTSAGVE :: : . : :: :::. :.. :. : :: :: . ::.. XP_011 QQMLSPSYCSEVTPREACMYSGSGPEI-AGVSGVDDL-------PPPPLSCNMWTSVS-- 440 450 460 470 480 410 420 430 440 pF1KB7 VLGEPSLTSIAVSTWTAVASHPFAGWGGPGAGGHHSPSSLDG : :: .:.: .: .:: XP_011 ----P-YTSYSVQTMETVPYQPFPTHFTATTMMPRLPTLSAQSSQPPGNAHFSVYNQLSQ 490 500 510 520 530 540 448 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:48:24 2016 done: Sun Nov 6 18:48:26 2016 Total Scan time: 10.390 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]