FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3314, 855 aa 1>>>pF1KE3314 855 - 855 aa - 855 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.6317+/-0.000706; mu= -9.4212+/- 0.042 mean_var=776.3587+/-185.153, 0's: 0 Z-trim(113.0): 772 B-trim: 0 in 0/53 Lambda= 0.046030 statistics sampled from 21302 (22084) to 21302 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.598), E-opt: 0.2 (0.259), width: 16 Scan time: 9.840 The best scores are: opt bits E(85289) NP_006173 (OMIM: 191311,271665) discoidin domain-c ( 855) 5822 404.3 1.2e-111 XP_006711407 (OMIM: 191311,271665) PREDICTED: disc ( 855) 5822 404.3 1.2e-111 XP_011507888 (OMIM: 191311,271665) PREDICTED: disc ( 855) 5822 404.3 1.2e-111 XP_011507889 (OMIM: 191311,271665) PREDICTED: disc ( 855) 5822 404.3 1.2e-111 NP_001014796 (OMIM: 191311,271665) discoidin domai ( 855) 5822 404.3 1.2e-111 XP_011507890 (OMIM: 191311,271665) PREDICTED: disc ( 559) 3455 246.8 2e-64 NP_001189450 (OMIM: 600408) epithelial discoidin d ( 508) 1369 108.2 9.7e-23 NP_001284581 (OMIM: 600408) epithelial discoidin d ( 876) 1250 100.7 3.1e-20 NP_001945 (OMIM: 600408) epithelial discoidin doma ( 876) 1250 100.7 3.1e-20 NP_001284582 (OMIM: 600408) epithelial discoidin d ( 876) 1250 100.7 3.1e-20 NP_001189452 (OMIM: 600408) epithelial discoidin d ( 894) 1250 100.7 3.1e-20 XP_016866758 (OMIM: 600408) PREDICTED: epithelial ( 882) 1084 89.7 6.5e-17 XP_011513190 (OMIM: 600408) PREDICTED: epithelial ( 900) 1084 89.7 6.6e-17 NP_054699 (OMIM: 600408) epithelial discoidin doma ( 913) 1026 85.9 9.5e-16 NP_001284583 (OMIM: 600408) epithelial discoidin d ( 913) 1026 85.9 9.5e-16 XP_006715248 (OMIM: 600408) PREDICTED: epithelial ( 931) 1026 85.9 9.6e-16 NP_001189451 (OMIM: 600408) epithelial discoidin d ( 767) 908 77.9 2e-13 XP_011513187 (OMIM: 600408) PREDICTED: epithelial ( 919) 908 78.0 2.2e-13 XP_011513185 (OMIM: 600408) PREDICTED: epithelial ( 919) 908 78.0 2.2e-13 XP_011513188 (OMIM: 600408) PREDICTED: epithelial ( 919) 908 78.0 2.2e-13 XP_011513189 (OMIM: 600408) PREDICTED: epithelial ( 919) 908 78.0 2.2e-13 XP_011513186 (OMIM: 600408) PREDICTED: epithelial ( 919) 908 78.0 2.2e-13 XP_016866757 (OMIM: 600408) PREDICTED: epithelial ( 919) 908 78.0 2.2e-13 NP_054700 (OMIM: 600408) epithelial discoidin doma ( 919) 908 78.0 2.2e-13 XP_011513184 (OMIM: 600408) PREDICTED: epithelial ( 937) 908 78.0 2.2e-13 XP_016877741 (OMIM: 191316) PREDICTED: NT-3 growth ( 448) 847 73.5 2.5e-12 XP_016877740 (OMIM: 191316) PREDICTED: NT-3 growth ( 456) 847 73.5 2.5e-12 XP_016877734 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 847 73.8 3.2e-12 XP_016877732 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 847 73.8 3.2e-12 XP_016877735 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 847 73.8 3.2e-12 XP_016877733 (OMIM: 191316) PREDICTED: NT-3 growth ( 727) 847 73.8 3.2e-12 XP_016877730 (OMIM: 191316) PREDICTED: NT-3 growth ( 763) 847 73.8 3.3e-12 XP_006720607 (OMIM: 191316) PREDICTED: NT-3 growth ( 817) 847 73.9 3.4e-12 NP_001230030 (OMIM: 191316) NT-3 growth factor rec ( 817) 847 73.9 3.4e-12 XP_016877729 (OMIM: 191316) PREDICTED: NT-3 growth ( 825) 847 73.9 3.4e-12 XP_006720606 (OMIM: 191316) PREDICTED: NT-3 growth ( 825) 847 73.9 3.4e-12 NP_002521 (OMIM: 191316) NT-3 growth factor recept ( 825) 847 73.9 3.4e-12 NP_001007793 (OMIM: 155240,191315,256800) high aff ( 760) 832 72.8 6.5e-12 NP_001012331 (OMIM: 155240,191315,256800) high aff ( 790) 832 72.9 6.7e-12 NP_002520 (OMIM: 155240,191315,256800) high affini ( 796) 832 72.9 6.7e-12 XP_016870241 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 808 71.3 2.1e-11 XP_016870243 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 808 71.3 2.1e-11 NP_001018074 (OMIM: 600456,613886) BDNF/NT-3 growt ( 822) 808 71.3 2.1e-11 XP_011517020 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 808 71.3 2.1e-11 XP_016870242 (OMIM: 600456,613886) PREDICTED: BDNF ( 822) 808 71.3 2.1e-11 NP_006171 (OMIM: 600456,613886) BDNF/NT-3 growth f ( 838) 808 71.3 2.1e-11 XP_005252060 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 808 71.3 2.1e-11 XP_005252058 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 808 71.3 2.1e-11 XP_016870240 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 808 71.3 2.1e-11 XP_005252061 (OMIM: 600456,613886) PREDICTED: BDNF ( 838) 808 71.3 2.1e-11 >>NP_006173 (OMIM: 191311,271665) discoidin domain-conta (855 aa) initn: 5822 init1: 5822 opt: 5822 Z-score: 2125.2 bits: 404.3 E(85289): 1.2e-111 Smith-Waterman score: 5822; 100.0% identity (100.0% similar) in 855 aa overlap (1-855:1-855) 10 20 30 40 50 60 pF1KE3 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 790 800 810 820 830 840 850 pF1KE3 SFQEIHLLLLQQGDE ::::::::::::::: NP_006 SFQEIHLLLLQQGDE 850 >>XP_006711407 (OMIM: 191311,271665) PREDICTED: discoidi (855 aa) initn: 5822 init1: 5822 opt: 5822 Z-score: 2125.2 bits: 404.3 E(85289): 1.2e-111 Smith-Waterman score: 5822; 100.0% identity (100.0% similar) in 855 aa overlap (1-855:1-855) 10 20 30 40 50 60 pF1KE3 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 790 800 810 820 830 840 850 pF1KE3 SFQEIHLLLLQQGDE ::::::::::::::: XP_006 SFQEIHLLLLQQGDE 850 >>XP_011507888 (OMIM: 191311,271665) PREDICTED: discoidi (855 aa) initn: 5822 init1: 5822 opt: 5822 Z-score: 2125.2 bits: 404.3 E(85289): 1.2e-111 Smith-Waterman score: 5822; 100.0% identity (100.0% similar) in 855 aa overlap (1-855:1-855) 10 20 30 40 50 60 pF1KE3 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 790 800 810 820 830 840 850 pF1KE3 SFQEIHLLLLQQGDE ::::::::::::::: XP_011 SFQEIHLLLLQQGDE 850 >>XP_011507889 (OMIM: 191311,271665) PREDICTED: discoidi (855 aa) initn: 5822 init1: 5822 opt: 5822 Z-score: 2125.2 bits: 404.3 E(85289): 1.2e-111 Smith-Waterman score: 5822; 100.0% identity (100.0% similar) in 855 aa overlap (1-855:1-855) 10 20 30 40 50 60 pF1KE3 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 790 800 810 820 830 840 850 pF1KE3 SFQEIHLLLLQQGDE ::::::::::::::: XP_011 SFQEIHLLLLQQGDE 850 >>NP_001014796 (OMIM: 191311,271665) discoidin domain-co (855 aa) initn: 5822 init1: 5822 opt: 5822 Z-score: 2125.2 bits: 404.3 E(85289): 1.2e-111 Smith-Waterman score: 5822; 100.0% identity (100.0% similar) in 855 aa overlap (1-855:1-855) 10 20 30 40 50 60 pF1KE3 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP 790 800 810 820 830 840 850 pF1KE3 SFQEIHLLLLQQGDE ::::::::::::::: NP_001 SFQEIHLLLLQQGDE 850 >>XP_011507890 (OMIM: 191311,271665) PREDICTED: discoidi (559 aa) initn: 3449 init1: 3449 opt: 3455 Z-score: 1277.5 bits: 246.8 E(85289): 2e-64 Smith-Waterman score: 3455; 98.1% identity (98.6% similar) in 516 aa overlap (1-516:1-516) 10 20 30 40 50 60 pF1KE3 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV :::::::::::::::::::::: . :: :. :. XP_011 YQEPSRLIRKLPEFAPGEEESGEDDVVGRVSREKPQQASDLVCRCSWPNLSNSPLLLNIR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN XP_011 CVEGPTYQKRKKKIIKHVN 550 >>NP_001189450 (OMIM: 600408) epithelial discoidin domai (508 aa) initn: 1475 init1: 543 opt: 1369 Z-score: 529.2 bits: 108.2 E(85289): 9.7e-23 Smith-Waterman score: 1588; 48.6% identity (70.7% similar) in 516 aa overlap (5-496:3-498) 10 20 30 40 50 pF1KE3 MILIPRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTA :. : :.::: . :. :.. .:: ::: :::. ::: ::.:::.::.::: NP_001 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTA 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 AKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPM :...::.: .::::::: : : . .:.::.::. ::...::::::::::: : ::. NP_001 ARHSRLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 YKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVC :.. ::::: ::..:..: :..:..:: .: . :::: ::.:::.::: : .:. :.:: NP_001 YRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 MRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGV .:::::::.: :::.::.::.:: . : . .:::::.::: .:: . :::::.::: NP_001 LRVELYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 SGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGV ::::: ...: .:::::::::: :.: ..::.:. :::::.: : .:.:::::: . :. NP_001 VGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 KIFKEVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADT .. :.: :: . : :: . . : . .: :: :.::: :.: ..:.. :: NP_001 RLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGP 300 310 320 330 340 350 360 370 380 390 pF1KE3 WMMFSEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDS :..::::.: ::. . :.: :: : .: . : .:. :.. : NP_001 WLLFSEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGS 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 NTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNN : ::::::::::..:: ::...::: :...: :: ::.:..:.:: ::.:.:. ..:: NP_001 PTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINN 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE3 NRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPE .: : : : :::: : . :. :: NP_001 --RPGPRE-----------P--PPYQEP-RPRGNPPHSAPCVPNGSGAPV 480 490 500 520 530 540 550 560 570 pF1KE3 GVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGE >>NP_001284581 (OMIM: 600408) epithelial discoidin domai (876 aa) initn: 3015 init1: 887 opt: 1250 Z-score: 484.3 bits: 100.7 E(85289): 3.1e-20 Smith-Waterman score: 3152; 54.8% identity (75.8% similar) in 887 aa overlap (5-849:3-868) 10 20 30 40 50 pF1KE3 MILIPRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTA :. : :.::: . :. :.. .:: ::: :::. ::: ::.:::.::.::: NP_001 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTA 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 AKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPM :...::.: .::::::: : : . .:.::.::. ::...::::::::::: : ::. NP_001 ARHSRLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 YKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVC :.. ::::: ::..:..: :..:..:: .: . :::: ::.:::.::: : .:. :.:: NP_001 YRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 MRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGV .:::::::.: :::.::.::.:: . : . .:::::.::: .:: . :::::.::: NP_001 LRVELYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 SGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGV ::::: ...: .:::::::::: :.: ..::.:. :::::.: : .:.:::::: . :. NP_001 VGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 KIFKEVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADT .. :.: :: . : :: . . : . .: :: :.::: :.: ..:.. :: NP_001 RLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGP 300 310 320 330 340 350 360 370 380 390 pF1KE3 WMMFSEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDS :..::::.: ::. . :.: :: : .: . : .:. :.. : NP_001 WLLFSEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGS 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 NTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNN : ::::::::::..:: ::...::: :...: :: ::.:..:.:: ::.:.:. ..:: NP_001 PTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINN 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE3 NRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEE-SGCSG-VVKPVQPSG .: : : : :::: : . :. :: . :. :: ..: .:.. NP_001 --RPGPRE-----------P--PPYQEP-RPRGNPPHSAPCVPNGSAYSGDYMEPEKPGA 480 490 500 510 520 530 540 550 560 pF1KE3 P-------EGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKE : ..::::::::::.::::::::::.:::. . : .:::. : ::: NP_001 PLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAV-GDGPPRVDFPRSRLRFKE 520 530 540 550 560 570 570 580 590 600 610 620 pF1KE3 KLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIK :::::::::::::::.. . . . :: :.: ..:.:::::.:: ::.::::::::::.: NP_001 KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVK 580 590 600 610 620 630 630 640 650 660 670 pF1KE3 IMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE---------PPNSSSSD :::::::::::.::.::. ::::::::.:::::::::::: :. : ...... NP_001 IMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQ 640 650 660 670 680 690 680 690 700 710 720 730 pF1KE3 VRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG :.:: : .:.::::::.::..::::::::::::::::.:.::::::::::::::.: NP_001 GPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG 700 710 720 730 740 750 740 750 760 770 780 790 pF1KE3 DYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVI ::::.:::::::::::.:: ::.::::::::::::::::::.. .:. ::..::.::::: NP_001 DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVI 760 770 780 790 800 810 800 810 820 830 840 850 pF1KE3 ENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE ::.::::::::::.:: .: ::...:.::: :: :....:: :...: .: NP_001 ENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 820 830 840 850 860 870 >>NP_001945 (OMIM: 600408) epithelial discoidin domain-c (876 aa) initn: 3015 init1: 887 opt: 1250 Z-score: 484.3 bits: 100.7 E(85289): 3.1e-20 Smith-Waterman score: 3152; 54.8% identity (75.8% similar) in 887 aa overlap (5-849:3-868) 10 20 30 40 50 pF1KE3 MILIPRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTA :. : :.::: . :. :.. .:: ::: :::. ::: ::.:::.::.::: NP_001 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTA 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 AKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPM :...::.: .::::::: : : . .:.::.::. ::...::::::::::: : ::. NP_001 ARHSRLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 YKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVC :.. ::::: ::..:..: :..:..:: .: . :::: ::.:::.::: : .:. :.:: NP_001 YRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 MRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGV .:::::::.: :::.::.::.:: . : . .:::::.::: .:: . :::::.::: NP_001 LRVELYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 SGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGV ::::: ...: .:::::::::: :.: ..::.:. :::::.: : .:.:::::: . :. NP_001 VGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 KIFKEVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADT .. :.: :: . : :: . . : . .: :: :.::: :.: ..:.. :: NP_001 RLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGP 300 310 320 330 340 350 360 370 380 390 pF1KE3 WMMFSEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDS :..::::.: ::. . :.: :: : .: . : .:. :.. : NP_001 WLLFSEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGS 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 NTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNN : ::::::::::..:: ::...::: :...: :: ::.:..:.:: ::.:.:. ..:: NP_001 PTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINN 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE3 NRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEE-SGCSG-VVKPVQPSG .: : : : :::: : . :. :: . :. :: ..: .:.. NP_001 --RPGPRE-----------P--PPYQEP-RPRGNPPHSAPCVPNGSAYSGDYMEPEKPGA 480 490 500 510 520 530 540 550 560 pF1KE3 P-------EGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKE : ..::::::::::.::::::::::.:::. . : .:::. : ::: NP_001 PLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAV-GDGPPRVDFPRSRLRFKE 520 530 540 550 560 570 570 580 590 600 610 620 pF1KE3 KLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIK :::::::::::::::.. . . . :: :.: ..:.:::::.:: ::.::::::::::.: NP_001 KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVK 580 590 600 610 620 630 630 640 650 660 670 pF1KE3 IMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE---------PPNSSSSD :::::::::::.::.::. ::::::::.:::::::::::: :. : ...... NP_001 IMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQ 640 650 660 670 680 690 680 690 700 710 720 730 pF1KE3 VRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG :.:: : .:.::::::.::..::::::::::::::::.:.::::::::::::::.: NP_001 GPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG 700 710 720 730 740 750 740 750 760 770 780 790 pF1KE3 DYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVI ::::.:::::::::::.:: ::.::::::::::::::::::.. .:. ::..::.::::: NP_001 DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVI 760 770 780 790 800 810 800 810 820 830 840 850 pF1KE3 ENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE ::.::::::::::.:: .: ::...:.::: :: :....:: :...: .: NP_001 ENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 820 830 840 850 860 870 >>NP_001284582 (OMIM: 600408) epithelial discoidin domai (876 aa) initn: 3015 init1: 887 opt: 1250 Z-score: 484.3 bits: 100.7 E(85289): 3.1e-20 Smith-Waterman score: 3152; 54.8% identity (75.8% similar) in 887 aa overlap (5-849:3-868) 10 20 30 40 50 pF1KE3 MILIPRMLLVLFLLLPILSS---AKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTA :. : :.::: . :. :.. .:: ::: :::. ::: ::.:::.::.::: NP_001 MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTA 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 AKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPM :...::.: .::::::: : : . .:.::.::. ::...::::::::::: : ::. NP_001 ARHSRLESSDGDGAWCPAGSVFPKE-EEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 YKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVC :.. ::::: ::..:..: :..:..:: .: . :::: ::.:::.::: : .:. :.:: NP_001 YRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 MRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDG-AVGYSMTEGLGQLTDGV .:::::::.: :::.::.::.:: . : . .:::::.::: .:: . :::::.::: NP_001 LRVELYGCLWRDGLLSYTAPVGQTMYL--SEAVYLNDSTYDGHTVGGLQYGGLGQLADGV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 SGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGV ::::: ...: .:::::::::: :.: ..::.:. :::::.: : .:.:::::: . :. NP_001 VGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 KIFKEVQCYFR-SEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADT .. :.: :: . : :: . . : . .: :: :.::: :.: ..:.. :: NP_001 RLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGP 300 310 320 330 340 350 360 370 380 390 pF1KE3 WMMFSEITFQSDAAMYNNSEAL----PTSP---------------MAPTTYDPMLKVDDS :..::::.: ::. . :.: :: : .: . : .:. :.. : NP_001 WLLFSEISFISDV-VNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGS 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE3 NTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNN : ::::::::::..:: ::...::: :...: :: ::.:..:.:: ::.:.:. ..:: NP_001 PTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINN 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE3 NRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEE-SGCSG-VVKPVQPSG .: : : : :::: : . :. :: . :. :: ..: .:.. NP_001 --RPGPRE-----------P--PPYQEP-RPRGNPPHSAPCVPNGSAYSGDYMEPEKPGA 480 490 500 510 520 530 540 550 560 pF1KE3 P-------EGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKE : ..::::::::::.::::::::::.:::. . : .:::. : ::: NP_001 PLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAV-GDGPPRVDFPRSRLRFKE 520 530 540 550 560 570 570 580 590 600 610 620 pF1KE3 KLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIK :::::::::::::::.. . . . :: :.: ..:.:::::.:: ::.::::::::::.: NP_001 KLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVK 580 590 600 610 620 630 630 640 650 660 670 pF1KE3 IMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE---------PPNSSSSD :::::::::::.::.::. ::::::::.:::::::::::: :. : ...... NP_001 IMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQ 640 650 660 670 680 690 680 690 700 710 720 730 pF1KE3 VRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSG :.:: : .:.::::::.::..::::::::::::::::.:.::::::::::::::.: NP_001 GPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAG 700 710 720 730 740 750 740 750 760 770 780 790 pF1KE3 DYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVI ::::.:::::::::::.:: ::.::::::::::::::::::.. .:. ::..::.::::: NP_001 DYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVI 760 770 780 790 800 810 800 810 820 830 840 850 pF1KE3 ENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE ::.::::::::::.:: .: ::...:.::: :: :....:: :...: .: NP_001 ENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV 820 830 840 850 860 870 855 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 02:13:33 2016 done: Tue Nov 8 02:13:35 2016 Total Scan time: 9.840 Total Display time: 0.250 Function used was FASTA [36.3.4 Apr, 2011]