FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3679, 304 aa 1>>>pF1KE3679 304 - 304 aa - 304 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7105+/-0.000305; mu= 15.3125+/- 0.019 mean_var=123.1085+/-26.004, 0's: 0 Z-trim(120.3): 185 B-trim: 496 in 2/49 Lambda= 0.115593 statistics sampled from 35063 (35329) to 35063 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.774), E-opt: 0.2 (0.414), width: 16 Scan time: 7.990 The best scores are: opt bits E(85289) NP_919442 (OMIM: 615177) E3 ubiquitin-protein liga ( 311) 720 130.7 3.7e-30 XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquiti ( 284) 654 119.6 7.1e-27 NP_057578 (OMIM: 612490) E3 ubiquitin-protein liga ( 153) 276 56.3 4.5e-08 NP_071763 (OMIM: 300420) E3 ubiquitin-protein liga ( 455) 253 53.0 1.3e-06 XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 588) 253 53.1 1.6e-06 NP_001027568 (OMIM: 300420) E3 ubiquitin-protein l ( 588) 253 53.1 1.6e-06 XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 643) 253 53.2 1.7e-06 NP_660095 (OMIM: 300420) E3 ubiquitin-protein liga ( 643) 253 53.2 1.7e-06 NP_078815 (OMIM: 300439) E3 ubiquitin-protein liga ( 402) 220 47.4 5.5e-05 NP_919445 (OMIM: 300439) E3 ubiquitin-protein liga ( 428) 220 47.5 5.7e-05 XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 217 46.9 7.8e-05 XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 217 46.9 7.8e-05 NP_919309 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 217 47.0 8.2e-05 XP_005251425 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05 XP_011516014 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05 XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05 XP_016869784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05 NP_919311 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 217 47.0 8.2e-05 XP_005251423 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05 XP_011516015 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05 XP_005251424 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 217 47.0 8.2e-05 NP_919313 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 217 47.0 8.2e-05 XP_016869783 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 444) 217 47.0 8.3e-05 NP_919310 (OMIM: 612488) E3 ubiquitin-protein liga ( 465) 217 47.0 8.6e-05 NP_073618 (OMIM: 612488) E3 ubiquitin-protein liga ( 515) 217 47.0 9.2e-05 XP_016868491 (OMIM: 144700,603046) PREDICTED: E3 u ( 537) 209 45.7 0.00024 NP_009149 (OMIM: 144700,603046) E3 ubiquitin-prote ( 664) 209 45.8 0.00027 NP_898864 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 209 45.9 0.00028 NP_898865 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 209 45.9 0.00028 XP_011533479 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 209 45.9 0.00028 XP_005266542 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 209 45.9 0.00028 XP_005266543 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 209 45.9 0.00028 NP_005968 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 209 45.9 0.00028 NP_001307291 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 198 43.6 0.0006 NP_001307292 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 198 43.6 0.0006 NP_001307294 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 198 43.6 0.0006 NP_001307293 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 198 43.6 0.0006 NP_001307289 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064 NP_056343 (OMIM: 610431) E3 ubiquitin-protein liga ( 350) 198 43.7 0.00064 NP_001307285 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064 NP_001307286 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064 NP_001307290 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064 NP_001307288 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064 XP_016879916 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 350) 198 43.7 0.00064 NP_001307287 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 198 43.7 0.00064 NP_115549 (OMIM: 612062) E3 ubiquitin-protein liga ( 836) 197 44.0 0.0013 XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 197 44.0 0.0013 XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 197 44.0 0.0013 XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 197 44.0 0.0013 XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 197 44.0 0.0013 >>NP_919442 (OMIM: 615177) E3 ubiquitin-protein ligase R (311 aa) initn: 832 init1: 605 opt: 720 Z-score: 662.4 bits: 130.7 E(85289): 3.7e-30 Smith-Waterman score: 875; 47.1% identity (69.0% similar) in 306 aa overlap (19-296:10-306) 10 20 30 40 50 60 pF1KE3 MAEASAAGADSGAAVAAHRFFCHFCKGEVSPKLPEYICPRCESGFIEEVTDDSSFLGGGG :.::: :. :. :.::.:::::::::::::. ... .:. NP_919 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGS 10 20 30 40 50 70 80 90 100 pF1KE3 SRIDNTTTTHFAELWGHLDHTMF-------------FQD-FR-PFLSSSPLDQDNRA--- . : : :.:. .: :.: :. : . . .:.: NP_919 APSTAPTDQSRPPLE-HVDQHLFTLPQGYGQFAFGIFDDSFEIPTFPPGAQADDGRDPES 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE3 -NERGHQTHTDFWGARPPRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGS :: : .. . ::: :: : : :...: . :..:::.:.. :... ..:: : NP_919 RRERDHPSRHRY-GARQPRARLTTR---RATGRHEGVPTLEGIIQQLVNGIITPATIP-S 120 130 140 150 160 170 180 190 200 210 220 pF1KE3 PHPFSWSGMLHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQ : : :.::::: ::::: .:::::.::::.:.::::::::::::: .:::: ::.:. NP_919 LGP--W-GVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEH 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE3 VDMGLECPVCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQ- : ::::::::.::.. :.::::::::.::..::::::: ::.::::::::.:.... . NP_919 VGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNP 230 240 250 260 270 280 290 300 pF1KE3 --------SQSTEASASNRFSNDSQLHDRWTF :.:. .:.:. ::.. NP_919 PGLTGVSFSSSSSSSSSSSPSNENATSNS 290 300 310 >>XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquitin-pr (284 aa) initn: 808 init1: 605 opt: 654 Z-score: 603.4 bits: 119.6 E(85289): 7.1e-27 Smith-Waterman score: 809; 46.0% identity (69.2% similar) in 289 aa overlap (19-296:10-279) 10 20 30 40 50 60 pF1KE3 MAEASAAGADSGAAVAAHRFFCHFCKGEVSPKLPEYICPRCESGFIEEVTDDSSFLGGGG :.::: :. :. :.::.:::::::::::::. ... .:. XP_005 MAEASPHPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRSTENGS 10 20 30 40 50 70 80 90 100 110 pF1KE3 SRIDNTTTTHFAELWGHLDHTMFF--QDFRPFLSSSPLDQDNRANERGHQTHTDFWGARP . : : :.:. .: : . : . . .:.. . ...: XP_005 APSTAPTDQSRPPLE-HVDQHLFTLPQGYGQF-AFGIFDDSFEIPTFPPGAQAD-----D 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 PRLPLGRRYRSRGSSRPDRSPAIEGILQHIFAGFFANSAIPGSPHPFSWSGMLHSNPGDY : : .:: :.. :. . :.:.. :... ..:: : : : :.::::: :: XP_005 GRDPESRRERDH--------PSRHRIIQQLVNGIITPATIP-SLGP--W-GVLHSNPMDY 110 120 130 140 150 180 190 200 210 220 230 pF1KE3 AWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPVCKEDYTVE ::: .:::::.::::.:.::::::::::::: .:::: ::.:.: ::::::::.::.. XP_005 AWGANGLDAIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKDDYALG 160 170 180 190 200 210 240 250 260 270 280 pF1KE3 EEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQ---------SQSTEASAS :.::::::::.::..::::::: ::.::::::::.:.... . :.:. .:.: XP_005 ERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVSFSSSSSSSSS 220 230 240 250 260 270 290 300 pF1KE3 NRFSNDSQLHDRWTF . ::.. XP_005 SSPSNENATSNS 280 >>NP_057578 (OMIM: 612490) E3 ubiquitin-protein ligase R (153 aa) initn: 295 init1: 217 opt: 276 Z-score: 265.9 bits: 56.3 E(85289): 4.5e-08 Smith-Waterman score: 276; 37.8% identity (68.4% similar) in 98 aa overlap (201-294:51-146) 180 190 200 210 220 230 pF1KE3 LHSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLECPV :::: : . .:: ... :.. :.::: NP_057 TNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAE--LKCPV 30 40 50 60 70 240 250 260 270 280 pF1KE3 CKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDST----RQSQSTEA : .. :: . ..::.:.::::::.::: ..::.:: : .:.: :.... . NP_057 CLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQ 80 90 100 110 120 130 290 300 pF1KE3 SASNRFSNDSQLHDRWTF . ..:. : NP_057 QQQHRLENLHGAMYT 140 150 >>NP_071763 (OMIM: 300420) E3 ubiquitin-protein ligase P (455 aa) initn: 190 init1: 190 opt: 253 Z-score: 239.6 bits: 53.0 E(85289): 1.3e-06 Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:379-448) 180 190 200 210 220 pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP :::.::.: .:: . ::... .: : :: NP_071 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 350 360 370 380 390 400 230 240 250 260 270 280 pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS .: .:. : . .:::.:.::. :. ::. :::::: NP_071 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 410 420 430 440 450 290 300 pF1KE3 NRFSNDSQLHDRWTF >>XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (588 aa) initn: 225 init1: 190 opt: 253 Z-score: 238.3 bits: 53.1 E(85289): 1.6e-06 Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:512-581) 180 190 200 210 220 pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP :::.::.: .:: . ::... .: : :: XP_005 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 490 500 510 520 530 540 230 240 250 260 270 280 pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS .: .:. : . .:::.:.::. :. ::. :::::: XP_005 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 550 560 570 580 290 300 pF1KE3 NRFSNDSQLHDRWTF >>NP_001027568 (OMIM: 300420) E3 ubiquitin-protein ligas (588 aa) initn: 225 init1: 190 opt: 253 Z-score: 238.3 bits: 53.1 E(85289): 1.6e-06 Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:512-581) 180 190 200 210 220 pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP :::.::.: .:: . ::... .: : :: NP_001 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 490 500 510 520 530 540 230 240 250 260 270 280 pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS .: .:. : . .:::.:.::. :. ::. :::::: NP_001 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 550 560 570 580 290 300 pF1KE3 NRFSNDSQLHDRWTF >>XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (643 aa) initn: 225 init1: 190 opt: 253 Z-score: 237.8 bits: 53.2 E(85289): 1.7e-06 Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:567-636) 180 190 200 210 220 pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP :::.::.: .:: . ::... .: : :: XP_011 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 540 550 560 570 580 590 230 240 250 260 270 280 pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS .: .:. : . .:::.:.::. :. ::. :::::: XP_011 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 600 610 620 630 640 290 300 pF1KE3 NRFSNDSQLHDRWTF >>NP_660095 (OMIM: 300420) E3 ubiquitin-protein ligase P (643 aa) initn: 225 init1: 190 opt: 253 Z-score: 237.8 bits: 53.2 E(85289): 1.7e-06 Smith-Waterman score: 253; 45.7% identity (71.4% similar) in 70 aa overlap (202-269:567-636) 180 190 200 210 220 pF1KE3 HSNPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEKITSLPTVTVTQEQVDMGLE--CP :::.::.: .:: . ::... .: : :: NP_660 YMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCP 540 550 560 570 580 590 230 240 250 260 270 280 pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCRKSLNGEDSTRQSQSTEASAS .: .:. : . .:::.:.::. :. ::. :::::: NP_660 ICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL 600 610 620 630 640 290 300 pF1KE3 NRFSNDSQLHDRWTF >>NP_078815 (OMIM: 300439) E3 ubiquitin-protein ligase R (402 aa) initn: 173 init1: 173 opt: 220 Z-score: 210.5 bits: 47.4 E(85289): 5.5e-05 Smith-Waterman score: 220; 38.7% identity (62.3% similar) in 106 aa overlap (204-300:223-328) 180 190 200 210 220 pF1KE3 NPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEK-ITSLPTVTVTQEQVDMGLE---CP :: .: : : :. : . ..: . : NP_078 TAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCA 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCR----KSLNGE-DSTRQSQST :: : : .. :: : :::.::..:. ::: : :::.:. :.:. : : : : NP_078 VCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSL 260 270 280 290 300 310 290 300 pF1KE3 EASASNRFSNDSQLHDRWTF .. .::..::... :. NP_078 QVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSV 320 330 340 350 360 370 >>NP_919445 (OMIM: 300439) E3 ubiquitin-protein ligase R (428 aa) initn: 197 init1: 173 opt: 220 Z-score: 210.2 bits: 47.5 E(85289): 5.7e-05 Smith-Waterman score: 220; 38.7% identity (62.3% similar) in 106 aa overlap (204-300:249-354) 180 190 200 210 220 pF1KE3 NPGDYAWGQTGLDAIVTQLLGQLENTGPPPADKEK-ITSLPTVTVTQEQVDMGLE---CP :: .: : : :. : . ..: . : NP_919 TAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCA 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE3 VCKEDYTVEEEVRQLPCNHFFHSSCIVPWLELHDTCPVCR----KSLNGE-DSTRQSQST :: : : .. :: : :::.::..:. ::: : :::.:. :.:. : : : : NP_919 VCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSL 280 290 300 310 320 330 290 300 pF1KE3 EASASNRFSNDSQLHDRWTF .. .::..::... :. NP_919 QVPVSNEISNSASSHEEDNRSETASSGYASVQGTDEPPLEEHVQSTNESLQLVNHEANSV 340 350 360 370 380 390 304 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:57:09 2016 done: Sun Nov 6 18:57:11 2016 Total Scan time: 7.990 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]