FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6505, 200 aa 1>>>pF1KE6505 200 - 200 aa - 200 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6447+/-0.000292; mu= 16.9234+/- 0.018 mean_var=58.8986+/-11.798, 0's: 0 Z-trim(117.7): 21 B-trim: 886 in 1/56 Lambda= 0.167117 statistics sampled from 29908 (29929) to 29908 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.74), E-opt: 0.2 (0.351), width: 16 Scan time: 4.770 The best scores are: opt bits E(85289) NP_973733 (OMIM: 602390,608374) hemojuvelin isofor ( 200) 1323 326.6 1.7e-89 NP_998817 (OMIM: 602390,608374) hemojuvelin isofor ( 200) 1323 326.6 1.7e-89 NP_001303696 (OMIM: 602390,608374) hemojuvelin iso ( 200) 1323 326.6 1.7e-89 NP_660320 (OMIM: 602390,608374) hemojuvelin isofor ( 313) 1323 326.7 2.3e-89 XP_005272989 (OMIM: 602390,608374) PREDICTED: hemo ( 426) 1323 326.8 3e-89 NP_998818 (OMIM: 602390,608374) hemojuvelin isofor ( 426) 1323 326.8 3e-89 NP_001159758 (OMIM: 607362) repulsive guidance mol ( 434) 366 96.1 8.7e-20 NP_001159760 (OMIM: 607362) repulsive guidance mol ( 434) 366 96.1 8.7e-20 NP_001159759 (OMIM: 607362) repulsive guidance mol ( 434) 366 96.1 8.7e-20 NP_001159761 (OMIM: 607362) repulsive guidance mol ( 434) 366 96.1 8.7e-20 NP_064596 (OMIM: 607362) repulsive guidance molecu ( 450) 366 96.1 8.9e-20 NP_001159755 (OMIM: 607362) repulsive guidance mol ( 458) 366 96.1 9e-20 XP_011541648 (OMIM: 612687) PREDICTED: RGM domain ( 396) 256 69.6 7.8e-12 XP_005272023 (OMIM: 612687) PREDICTED: RGM domain ( 477) 256 69.6 9e-12 XP_016864879 (OMIM: 612687) PREDICTED: RGM domain ( 478) 256 69.6 9e-12 XP_011541647 (OMIM: 612687) PREDICTED: RGM domain ( 478) 256 69.6 9e-12 NP_001012779 (OMIM: 612687) RGM domain family memb ( 478) 256 69.6 9e-12 XP_016864880 (OMIM: 612687) PREDICTED: RGM domain ( 478) 256 69.6 9e-12 >>NP_973733 (OMIM: 602390,608374) hemojuvelin isoform c (200 aa) initn: 1323 init1: 1323 opt: 1323 Z-score: 1727.9 bits: 326.6 E(85289): 1.7e-89 Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:1-200) 10 20 30 40 50 60 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_973 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_973 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_973 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 130 140 150 160 170 180 190 200 pF1KE6 SATLLAPLLSGLFVLWLCIQ :::::::::::::::::::: NP_973 SATLLAPLLSGLFVLWLCIQ 190 200 >>NP_998817 (OMIM: 602390,608374) hemojuvelin isoform c (200 aa) initn: 1323 init1: 1323 opt: 1323 Z-score: 1727.9 bits: 326.6 E(85289): 1.7e-89 Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:1-200) 10 20 30 40 50 60 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 130 140 150 160 170 180 190 200 pF1KE6 SATLLAPLLSGLFVLWLCIQ :::::::::::::::::::: NP_998 SATLLAPLLSGLFVLWLCIQ 190 200 >>NP_001303696 (OMIM: 602390,608374) hemojuvelin isoform (200 aa) initn: 1323 init1: 1323 opt: 1323 Z-score: 1727.9 bits: 326.6 E(85289): 1.7e-89 Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:1-200) 10 20 30 40 50 60 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQECIDQKVYQAEVDNLPVAFEDGSINGGDRPGGSSLSIQTANPGNHVEIQAAYIGTTII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRQTAGQLSFSIKVAEDVAMAFSAEQDLQLCVGGCPPSQRLSRSERNRRGAITIDTARRL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKEGLPVEDAYFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLFPSDAGVPLS 130 140 150 160 170 180 190 200 pF1KE6 SATLLAPLLSGLFVLWLCIQ :::::::::::::::::::: NP_001 SATLLAPLLSGLFVLWLCIQ 190 200 >>NP_660320 (OMIM: 602390,608374) hemojuvelin isoform b (313 aa) initn: 1323 init1: 1323 opt: 1323 Z-score: 1725.2 bits: 326.7 E(85289): 2.3e-89 Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:114-313) 10 20 30 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGD :::::::::::::::::::::::::::::: NP_660 DFLFVQATSSPMALGANATATRKLTIIFKNMQECIDQKVYQAEVDNLPVAFEDGSINGGD 90 100 110 120 130 140 40 50 60 70 80 90 pF1KE6 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL 150 160 170 180 190 200 100 110 120 130 140 150 pF1KE6 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA 210 220 230 240 250 260 160 170 180 190 200 pF1KE6 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ :::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ 270 280 290 300 310 >>XP_005272989 (OMIM: 602390,608374) PREDICTED: hemojuve (426 aa) initn: 1323 init1: 1323 opt: 1323 Z-score: 1723.4 bits: 326.8 E(85289): 3e-89 Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:227-426) 10 20 30 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGD :::::::::::::::::::::::::::::: XP_005 DFLFVQATSSPMALGANATATRKLTIIFKNMQECIDQKVYQAEVDNLPVAFEDGSINGGD 200 210 220 230 240 250 40 50 60 70 80 90 pF1KE6 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL 260 270 280 290 300 310 100 110 120 130 140 150 pF1KE6 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA 320 330 340 350 360 370 160 170 180 190 200 pF1KE6 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ 380 390 400 410 420 >>NP_998818 (OMIM: 602390,608374) hemojuvelin isoform a (426 aa) initn: 1323 init1: 1323 opt: 1323 Z-score: 1723.4 bits: 326.8 E(85289): 3e-89 Smith-Waterman score: 1323; 100.0% identity (100.0% similar) in 200 aa overlap (1-200:227-426) 10 20 30 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGD :::::::::::::::::::::::::::::: NP_998 DFLFVQATSSPMALGANATATRKLTIIFKNMQECIDQKVYQAEVDNLPVAFEDGSINGGD 200 210 220 230 240 250 40 50 60 70 80 90 pF1KE6 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 RPGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSAEQDLQL 260 270 280 290 300 310 100 110 120 130 140 150 pF1KE6 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 CVGGCPPSQRLSRSERNRRGAITIDTARRLCKEGLPVEDAYFHSCVFDVLISGDPNFTVA 320 330 340 350 360 370 160 170 180 190 200 pF1KE6 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ :::::::::::::::::::::::::::::::::::::::::::::::::: NP_998 AQAALEDARAFLPDLEKLHLFPSDAGVPLSSATLLAPLLSGLFVLWLCIQ 380 390 400 410 420 >>NP_001159758 (OMIM: 607362) repulsive guidance molecul (434 aa) initn: 591 init1: 321 opt: 366 Z-score: 476.3 bits: 96.1 E(85289): 8.7e-20 Smith-Waterman score: 543; 44.4% identity (65.5% similar) in 223 aa overlap (2-195:208-430) 10 20 30 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDR :::.::::::::.:.::.:: ::: ::::. NP_001 YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDK 180 190 200 210 220 230 40 50 60 70 80 pF1KE6 PGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSA--EQDLQ :..::.: :.:::::: ::::::..::.. :.:.... :.:. : : : NP_001 HGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLY 240 250 260 270 280 290 90 100 110 120 130 pF1KE6 LCVGGCPPSQRL--------SRSERNRRGAIT-----------IDTARRLCKEGLPVEDA ::. ::: .:.. ... :: : . .:: ::: ::::: NP_001 LCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL 300 310 320 330 340 350 140 150 160 170 180 pF1KE6 YFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLF------P--SDAGVPLSSA :...::::.: .:: :::.:: ::::.. . . .::::. : . ::.::. NP_001 YYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPR 360 370 380 390 400 410 190 200 pF1KE6 TLLAPLLSGLFVLWLCIQ ::. :. : .: NP_001 PLLGALVPLLALLPVFC 420 430 >>NP_001159760 (OMIM: 607362) repulsive guidance molecul (434 aa) initn: 591 init1: 321 opt: 366 Z-score: 476.3 bits: 96.1 E(85289): 8.7e-20 Smith-Waterman score: 543; 44.4% identity (65.5% similar) in 223 aa overlap (2-195:208-430) 10 20 30 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDR :::.::::::::.:.::.:: ::: ::::. NP_001 YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDK 180 190 200 210 220 230 40 50 60 70 80 pF1KE6 PGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSA--EQDLQ :..::.: :.:::::: ::::::..::.. :.:.... :.:. : : : NP_001 HGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLY 240 250 260 270 280 290 90 100 110 120 130 pF1KE6 LCVGGCPPSQRL--------SRSERNRRGAIT-----------IDTARRLCKEGLPVEDA ::. ::: .:.. ... :: : . .:: ::: ::::: NP_001 LCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL 300 310 320 330 340 350 140 150 160 170 180 pF1KE6 YFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLF------P--SDAGVPLSSA :...::::.: .:: :::.:: ::::.. . . .::::. : . ::.::. NP_001 YYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPR 360 370 380 390 400 410 190 200 pF1KE6 TLLAPLLSGLFVLWLCIQ ::. :. : .: NP_001 PLLGALVPLLALLPVFC 420 430 >>NP_001159759 (OMIM: 607362) repulsive guidance molecul (434 aa) initn: 591 init1: 321 opt: 366 Z-score: 476.3 bits: 96.1 E(85289): 8.7e-20 Smith-Waterman score: 543; 44.4% identity (65.5% similar) in 223 aa overlap (2-195:208-430) 10 20 30 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDR :::.::::::::.:.::.:: ::: ::::. NP_001 YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDK 180 190 200 210 220 230 40 50 60 70 80 pF1KE6 PGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSA--EQDLQ :..::.: :.:::::: ::::::..::.. :.:.... :.:. : : : NP_001 HGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLY 240 250 260 270 280 290 90 100 110 120 130 pF1KE6 LCVGGCPPSQRL--------SRSERNRRGAIT-----------IDTARRLCKEGLPVEDA ::. ::: .:.. ... :: : . .:: ::: ::::: NP_001 LCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL 300 310 320 330 340 350 140 150 160 170 180 pF1KE6 YFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLF------P--SDAGVPLSSA :...::::.: .:: :::.:: ::::.. . . .::::. : . ::.::. NP_001 YYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPR 360 370 380 390 400 410 190 200 pF1KE6 TLLAPLLSGLFVLWLCIQ ::. :. : .: NP_001 PLLGALVPLLALLPVFC 420 430 >>NP_001159761 (OMIM: 607362) repulsive guidance molecul (434 aa) initn: 591 init1: 321 opt: 366 Z-score: 476.3 bits: 96.1 E(85289): 8.7e-20 Smith-Waterman score: 543; 44.4% identity (65.5% similar) in 223 aa overlap (2-195:208-430) 10 20 30 pF1KE6 MQECIDQKVYQAEVDNLPVAFEDGSINGGDR :::.::::::::.:.::.:: ::: ::::. NP_001 YLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDK 180 190 200 210 220 230 40 50 60 70 80 pF1KE6 PGGSSLSIQTANPGNHVEIQAAYIGTTIIIRQTAGQLSFSIKVAEDVAMAFSA--EQDLQ :..::.: :.:::::: ::::::..::.. :.:.... :.:. : : : NP_001 HGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLY 240 250 260 270 280 290 90 100 110 120 130 pF1KE6 LCVGGCPPSQRL--------SRSERNRRGAIT-----------IDTARRLCKEGLPVEDA ::. ::: .:.. ... :: : . .:: ::: ::::: NP_001 LCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDL 300 310 320 330 340 350 140 150 160 170 180 pF1KE6 YFHSCVFDVLISGDPNFTVAAQAALEDARAFLPDLEKLHLF------P--SDAGVPLSSA :...::::.: .:: :::.:: ::::.. . . .::::. : . ::.::. NP_001 YYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPR 360 370 380 390 400 410 190 200 pF1KE6 TLLAPLLSGLFVLWLCIQ ::. :. : .: NP_001 PLLGALVPLLALLPVFC 420 430 200 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:55:30 2016 done: Tue Nov 8 13:55:31 2016 Total Scan time: 4.770 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]