FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4175, 635 aa 1>>>pF1KE4175 635 - 635 aa - 635 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4242+/-0.000366; mu= 14.7788+/- 0.023 mean_var=128.2605+/-24.556, 0's: 0 Z-trim(117.6): 211 B-trim: 245 in 1/50 Lambda= 0.113247 statistics sampled from 29483 (29745) to 29483 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.349), width: 16 Scan time: 12.290 The best scores are: opt bits E(85289) NP_004969 (OMIM: 176265) potassium voltage-gated c ( 635) 4316 716.9 5.2e-206 XP_011539703 (OMIM: 176265) PREDICTED: potassium v ( 609) 4116 684.2 3.5e-196 NP_001034663 (OMIM: 176265) potassium voltage-gate ( 626) 4110 683.3 7e-196 XP_006710690 (OMIM: 176265) PREDICTED: potassium v ( 624) 4109 683.1 7.8e-196 XP_006710688 (OMIM: 176265) PREDICTED: potassium v ( 618) 4108 682.9 8.7e-196 NP_001106212 (OMIM: 176258,616187) potassium volta ( 585) 2648 444.4 5.3e-124 NP_004967 (OMIM: 176258,616187) potassium voltage- ( 511) 2503 420.6 6.5e-117 XP_011518382 (OMIM: 176258,616187) PREDICTED: pota ( 535) 2499 420.0 1.1e-116 NP_001247428 (OMIM: 176256) potassium voltage-gate ( 583) 2359 397.2 8.7e-110 NP_715624 (OMIM: 176256) potassium voltage-gated c ( 558) 2346 395.0 3.7e-109 XP_006719445 (OMIM: 176256) PREDICTED: potassium v ( 613) 2340 394.1 7.8e-109 NP_631874 (OMIM: 176256) potassium voltage-gated c ( 613) 2340 394.1 7.8e-109 NP_001247426 (OMIM: 176256) potassium voltage-gate ( 618) 2340 394.1 7.8e-109 NP_001247427 (OMIM: 176256) potassium voltage-gate ( 629) 2340 394.1 7.9e-109 NP_631875 (OMIM: 176256) potassium voltage-gated c ( 638) 2340 394.1 8e-109 XP_005268912 (OMIM: 176256) PREDICTED: potassium v ( 574) 2337 393.6 1e-108 XP_006719447 (OMIM: 176256) PREDICTED: potassium v ( 612) 2337 393.6 1.1e-108 XP_006719446 (OMIM: 176256) PREDICTED: potassium v ( 612) 2337 393.6 1.1e-108 XP_006719448 (OMIM: 176256) PREDICTED: potassium v ( 612) 2337 393.6 1.1e-108 XP_016874771 (OMIM: 176256) PREDICTED: potassium v ( 612) 2337 393.6 1.1e-108 XP_011525230 (OMIM: 176264,605259) PREDICTED: pota ( 728) 1732 294.8 7e-79 XP_006723266 (OMIM: 176264,605259) PREDICTED: pota ( 757) 1732 294.8 7.2e-79 NP_004968 (OMIM: 176264,605259) potassium voltage- ( 757) 1732 294.8 7.2e-79 XP_011525228 (OMIM: 176264,605259) PREDICTED: pota ( 757) 1732 294.8 7.2e-79 XP_011525227 (OMIM: 176264,605259) PREDICTED: pota ( 768) 1732 294.8 7.3e-79 XP_011539706 (OMIM: 176265) PREDICTED: potassium v ( 319) 1625 277.0 7.1e-74 XP_011539705 (OMIM: 176265) PREDICTED: potassium v ( 403) 1625 277.1 8.4e-74 XP_011539704 (OMIM: 176265) PREDICTED: potassium v ( 403) 1625 277.1 8.4e-74 XP_006719453 (OMIM: 176256) PREDICTED: potassium v ( 255) 741 132.5 1.8e-30 NP_000208 (OMIM: 160120,176260) potassium voltage- ( 495) 650 117.9 8.7e-26 NP_002224 (OMIM: 176266) potassium voltage-gated c ( 653) 642 116.7 2.6e-25 NP_005540 (OMIM: 602420) potassium voltage-gated c ( 511) 640 116.3 2.8e-25 XP_011539701 (OMIM: 176262,616366) PREDICTED: pota ( 499) 620 113.0 2.6e-24 XP_011539702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 620 113.0 2.6e-24 XP_011539699 (OMIM: 176262,616366) PREDICTED: pota ( 499) 620 113.0 2.6e-24 NP_004965 (OMIM: 176262,616366) potassium voltage- ( 499) 620 113.0 2.6e-24 XP_011539700 (OMIM: 176262,616366) PREDICTED: pota ( 499) 620 113.0 2.6e-24 XP_011539698 (OMIM: 176262,616366) PREDICTED: pota ( 499) 620 113.0 2.6e-24 XP_016856702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 620 113.0 2.6e-24 NP_114092 (OMIM: 176268) potassium voltage-gated c ( 456) 611 111.5 6.8e-24 NP_002223 (OMIM: 176263) potassium voltage-gated c ( 575) 606 110.8 1.4e-23 NP_579875 (OMIM: 606767) potassium voltage-gated c ( 436) 583 106.9 1.6e-22 XP_011527101 (OMIM: 600397,616056) PREDICTED: pota ( 858) 537 99.6 4.7e-20 XP_006723847 (OMIM: 600397,616056) PREDICTED: pota ( 858) 537 99.6 4.7e-20 NP_004966 (OMIM: 600397,616056) potassium voltage- ( 858) 537 99.6 4.7e-20 NP_004761 (OMIM: 607738) potassium voltage-gated c ( 911) 530 98.5 1.1e-19 NP_036415 (OMIM: 605696) potassium voltage-gated c ( 466) 506 94.3 1e-18 XP_016881194 (OMIM: 605696) PREDICTED: potassium v ( 466) 506 94.3 1e-18 XP_011524222 (OMIM: 605696) PREDICTED: potassium v ( 466) 506 94.3 1e-18 XP_011524220 (OMIM: 605696) PREDICTED: potassium v ( 466) 506 94.3 1e-18 >>NP_004969 (OMIM: 176265) potassium voltage-gated chann (635 aa) initn: 4316 init1: 4316 opt: 4316 Z-score: 3819.5 bits: 716.9 E(85289): 5.2e-206 Smith-Waterman score: 4316; 99.8% identity (99.8% similar) in 635 aa overlap (1-635:1-635) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTYSDTSPPAREEGMIERKRADS ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_004 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA 550 560 570 580 590 600 610 620 630 pF1KE4 DGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH ::::::::::::::::::::::::::::::::::: NP_004 DGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH 610 620 630 >>XP_011539703 (OMIM: 176265) PREDICTED: potassium volta (609 aa) initn: 4116 init1: 4116 opt: 4116 Z-score: 3643.2 bits: 684.2 E(85289): 3.5e-196 Smith-Waterman score: 4116; 99.8% identity (99.8% similar) in 607 aa overlap (1-607:1-607) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTYSDTSPPAREEGMIERKRADS ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_011 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA 550 560 570 580 590 600 610 620 630 pF1KE4 DGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH ::::::: XP_011 DGSVRKGKI >>NP_001034663 (OMIM: 176265) potassium voltage-gated ch (626 aa) initn: 4204 init1: 4110 opt: 4110 Z-score: 3637.7 bits: 683.3 E(85289): 7e-196 Smith-Waterman score: 4110; 99.7% identity (99.7% similar) in 608 aa overlap (1-608:1-608) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTYSDTSPPAREEGMIERKRADS ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_001 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA 550 560 570 580 590 600 610 620 630 pF1KE4 DGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH :::::: : NP_001 DGSVRKETCQDALSSNYAQAEVLTLS 610 620 >>XP_006710690 (OMIM: 176265) PREDICTED: potassium volta (624 aa) initn: 4108 init1: 4108 opt: 4109 Z-score: 3636.8 bits: 683.1 E(85289): 7.8e-196 Smith-Waterman score: 4109; 97.9% identity (98.9% similar) in 621 aa overlap (1-619:1-621) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTYSDTSPPAREEGMIERKRADS ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_006 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA 550 560 570 580 590 600 610 620 630 pF1KE4 DGSVRK-GTFVLRD-LPLQHSPEAACPPTAGTLFLPH :::::: :. . .:..:. XP_006 DGSVRKEGNVEPKACVPVSHTCAL 610 620 >>XP_006710688 (OMIM: 176265) PREDICTED: potassium volta (618 aa) initn: 4108 init1: 4108 opt: 4108 Z-score: 3636.0 bits: 682.9 E(85289): 8.7e-196 Smith-Waterman score: 4108; 99.8% identity (99.8% similar) in 606 aa overlap (1-606:1-606) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTYSDTSPPAREEGMIERKRADS ::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_006 LAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACA 550 560 570 580 590 600 610 620 630 pF1KE4 DGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH :::::: XP_006 DGSVRKALSSAEEALCSH 610 >>NP_001106212 (OMIM: 176258,616187) potassium voltage-g (585 aa) initn: 2654 init1: 1787 opt: 2648 Z-score: 2347.2 bits: 444.4 E(85289): 5.3e-124 Smith-Waterman score: 2648; 71.3% identity (84.0% similar) in 586 aa overlap (29-606:1-564) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :..:. ::.:.::::::::.:::::::::::: NP_001 MGQGDESERIVINVGGTRHQTYRSTLRTLPGT 10 20 30 70 80 90 100 110 120 pF1KE4 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD ::::::.::. .. . : . ::::::::::::..:::::::::::::: NP_001 RLAWLAEPDAHSHFDYDPRAD-----------EFFFDRHPGVFAHILNYYRTGKLHCPAD 40 50 60 70 80 130 140 150 160 170 pF1KE4 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFE-SP-DGGGSGA---GPSD :::::.::::.:::::::::::::::::::::::::::: : .: :.... : ::.: NP_001 VCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGD 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE4 EAGDDERELAL-QRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLF .:: : :: . .::. .. :. .: : ::::.::::::::::: :: ::::::: NP_001 -SGDGEDELEMTKRLALSDSPDGRPGGFW--RRWQPRIWALFEDPYSSRYARYVAFASLF 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 FILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTL ::::::::::::::: :: : ::: : : :.:.. ::.::: .:::::::::.:::. NP_001 FILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTF 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 EFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRI :::.:.. ::. ..:.:: ::::::::::::::::::::::::::.:::::::::::::: NP_001 EFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRI 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE4 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRG :::::::::::::::::::::::::::::::::::::::::::::::::::::.:.:: . NP_001 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSA 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE4 NDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNN ..:: :::::::::::::::::::::::::.::::::::::::::::::::::::::::: NP_001 SEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNN 380 390 400 410 420 430 480 490 500 510 520 530 pF1KE4 FGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTYSDTSPPAREEGMIE :::::::::::::::::.:::.::: :: :: :::: .::. :: ::: : :.:: ..: NP_001 FGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILE 440 450 460 470 480 490 540 550 560 570 580 590 pF1KE4 RKRADSKQNGD-ANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLS .::::: ::. :.:.:..:. . : : ::.: . :: ::.: . ::::: NP_001 INRADSKLNGEVAKAALANEDCPHIDQAL----TPDEGLPFTRSGTRERY---GPCFLLS 500 510 520 530 540 550 600 610 620 630 pF1KE4 TGDYACADGS-VRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH ::.::: :. .:: NP_001 TGEYACPPGGGMRKDLCKESPVIAKYMPTEAVRVT 560 570 580 >>NP_004967 (OMIM: 176258,616187) potassium voltage-gate (511 aa) initn: 2490 init1: 1787 opt: 2503 Z-score: 2219.9 bits: 420.6 E(85289): 6.5e-117 Smith-Waterman score: 2503; 74.6% identity (86.1% similar) in 519 aa overlap (29-541:1-504) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :..:. ::.:.::::::::.:::::::::::: NP_004 MGQGDESERIVINVGGTRHQTYRSTLRTLPGT 10 20 30 70 80 90 100 110 120 pF1KE4 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD ::::::.::. .. . : . ::::::::::::..:::::::::::::: NP_004 RLAWLAEPDAHSHFDYDPRAD-----------EFFFDRHPGVFAHILNYYRTGKLHCPAD 40 50 60 70 80 130 140 150 160 170 pF1KE4 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFE-SP-DGGGSGA---GPSD :::::.::::.:::::::::::::::::::::::::::: : .: :.... : ::.: NP_004 VCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGD 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE4 EAGDDERELAL-QRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLF .:: : :: . .::. .. :. .: : ::::.::::::::::: :: ::::::: NP_004 -SGDGEDELEMTKRLALSDSPDGRPGGFW--RRWQPRIWALFEDPYSSRYARYVAFASLF 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 FILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTL ::::::::::::::: :: : ::: : : :.:.. ::.::: .:::::::::.:::. NP_004 FILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTF 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 EFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRI :::.:.. ::. ..:.:: ::::::::::::::::::::::::::.:::::::::::::: NP_004 EFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRI 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE4 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRG :::::::::::::::::::::::::::::::::::::::::::::::::::::.:.:: . NP_004 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSA 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE4 NDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNN ..:: :::::::::::::::::::::::::.::::::::::::::::::::::::::::: NP_004 SEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNN 380 390 400 410 420 430 480 490 500 510 520 530 pF1KE4 FGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTYSDTSPPAREEGMIE :::::::::::::::::.:::.::: :: :: :::: .::. :: ::: : :.:: ..: NP_004 FGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILE 440 450 460 470 480 490 540 550 560 570 580 590 pF1KE4 RKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLST .:: : NP_004 INRAGRKPLRGMSI 500 510 >>XP_011518382 (OMIM: 176258,616187) PREDICTED: potassiu (535 aa) initn: 2490 init1: 1787 opt: 2499 Z-score: 2216.1 bits: 420.0 E(85289): 1.1e-116 Smith-Waterman score: 2499; 74.8% identity (86.4% similar) in 516 aa overlap (29-538:1-501) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :..:. ::.:.::::::::.:::::::::::: XP_011 MGQGDESERIVINVGGTRHQTYRSTLRTLPGT 10 20 30 70 80 90 100 110 120 pF1KE4 RLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPAD ::::::.::. .. . : . ::::::::::::..:::::::::::::: XP_011 RLAWLAEPDAHSHFDYDPRA-----------DEFFFDRHPGVFAHILNYYRTGKLHCPAD 40 50 60 70 80 130 140 150 160 170 pF1KE4 VCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFE-SP-DGGGSGA---GPSD :::::.::::.:::::::::::::::::::::::::::: : .: :.... : ::.: XP_011 VCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGD 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE4 EAGDDERELAL-QRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLF .:: : :: . .::. .. :. .: : ::::.::::::::::: :: ::::::: XP_011 -SGDGEDELEMTKRLALSDSPDGRPGGFW--RRWQPRIWALFEDPYSSRYARYVAFASLF 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 FILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTL ::::::::::::::: :: : ::: : : :.:.. ::.::: .:::::::::.:::. XP_011 FILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTF 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 EFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRI :::.:.. ::. ..:.:: ::::::::::::::::::::::::::.:::::::::::::: XP_011 EFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRI 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE4 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRG :::::::::::::::::::::::::::::::::::::::::::::::::::::.:.:: . XP_011 LRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSA 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE4 NDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNN ..:: :::::::::::::::::::::::::.::::::::::::::::::::::::::::: XP_011 SEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNN 380 390 400 410 420 430 480 490 500 510 520 530 pF1KE4 FGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTYSDTSPPAREEGMIE :::::::::::::::::.:::.::: :: :: :::: .::. :: ::: : :.:: ..: XP_011 FGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEE-ILE 440 450 460 470 480 490 540 550 560 570 580 590 pF1KE4 RKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLST .:: XP_011 INRAGISKEQMTQRRMTALSKKECQMLISAHFKPGNHL 500 510 520 530 >>NP_001247428 (OMIM: 176256) potassium voltage-gated ch (583 aa) initn: 2175 init1: 1435 opt: 2359 Z-score: 2092.0 bits: 397.2 E(85289): 8.7e-110 Smith-Waterman score: 2486; 68.1% identity (79.6% similar) in 593 aa overlap (29-579:1-577) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :.: : .:..:.::::::::::::::.::::: NP_001 MGKIENNERVILNVGGTRHETYRSTLKTLPGT 10 20 30 70 80 pF1KE4 RLAWLA--DPDG------GGR---------------PETDG------GGVGSSGSSGG-- ::: :: .: : : . : . : ::.:. .: :: NP_001 RLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRA 40 50 60 70 80 90 90 100 110 120 130 140 pF1KE4 -----GGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCC :: ::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_001 SDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCC 100 110 120 130 140 150 150 160 170 180 190 200 pF1KE4 WMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGG ::::::::::::::::::.:: :. . :::: .:: .::: : .:: :. .: NP_001 WMTYRQHRDAEEALDIFETPDLIGG------DPGDDE-DLAAKRLGI-EDAAGLGGPDGK 160 170 180 190 200 210 220 230 240 250 260 pF1KE4 CRGW---QPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIL : :::::::::::::::::: .::::::::::::::::::::::::: .: :: NP_001 SGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTE-- 210 220 230 240 250 260 270 280 290 300 310 320 pF1KE4 RVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVA : : ::: .. :.::.: :::.:::::.:::.::::::: :. :.:.::::::::::: NP_001 PVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVA 270 280 290 300 310 320 330 340 350 360 370 380 pF1KE4 ILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: NP_001 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 330 340 350 360 370 380 390 400 410 420 430 440 pF1KE4 LLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGD :::::::::::::::::::::::.::.:.:: ...::.:::::::::::::::::::::: NP_001 LLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGD 390 400 410 420 430 440 450 460 470 480 490 500 pF1KE4 MYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQ :::.::::::::::::::::::::::::::::::::::::::::::::.:::::.: : NP_001 MYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQ 450 460 470 480 490 500 510 520 530 540 550 560 pF1KE4 LESPMYCKSEETSPRDSTYSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQP :: .::.: . .:: ::: .... ..:..:. ... . : . . .: .: NP_001 ASSPTFCKTELNMACNSTQSDTCL-GKDNRLLEHNRSGYEKSRSLNNIAGLAGNALRLSP 510 520 530 540 550 560 570 580 590 600 610 pF1KE4 LAS---SPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACADGSVRKGTFVLRDLPLQH ..: :: : :::: . NP_001 VTSPYNSPCP-----LRRSRSPIPSIL 570 580 >>NP_715624 (OMIM: 176256) potassium voltage-gated chann (558 aa) initn: 2175 init1: 1435 opt: 2346 Z-score: 2080.8 bits: 395.0 E(85289): 3.7e-109 Smith-Waterman score: 2473; 71.5% identity (82.0% similar) in 551 aa overlap (29-540:1-540) 10 20 30 40 50 60 pF1KE4 MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGT :.: : .:..:.::::::::::::::.::::: NP_715 MGKIENNERVILNVGGTRHETYRSTLKTLPGT 10 20 30 70 80 pF1KE4 RLAWLA--DPDG------GGR---------------PETDG------GGVGSSGSSGG-- ::: :: .: : : . : . : ::.:. .: :: NP_715 RLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPPLSPGPGGCFEGGAGNCSSRGGRA 40 50 60 70 80 90 90 100 110 120 130 140 pF1KE4 -----GGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCC :: ::::::::::::::::::::::::::::::::::::::.::::::::::::: NP_715 SDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCC 100 110 120 130 140 150 150 160 170 180 190 200 pF1KE4 WMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGG ::::::::::::::::::.:: :. . :::: .:: .::: : .:: :. .: NP_715 WMTYRQHRDAEEALDIFETPDLIGG------DPGDDE-DLAAKRLGI-EDAAGLGGPDGK 160 170 180 190 200 210 220 230 240 250 260 pF1KE4 CRGW---QPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEIL : :::::::::::::::::: .::::::::::::::::::::::::: .: :: NP_715 SGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEP- 210 220 230 240 250 260 270 280 290 300 310 320 pF1KE4 RVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVA : : ::: .. :.::.: :::.:::::.:::.::::::: :. :.:.::::::::::: NP_715 -VINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVA 270 280 290 300 310 320 330 340 350 360 370 380 pF1KE4 ILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF ::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::: NP_715 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEF 330 340 350 360 370 380 390 400 410 420 430 440 pF1KE4 LLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGD :::::::::::::::::::::::.::.:.:: ...::.:::::::::::::::::::::: NP_715 LLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGD 390 400 410 420 430 440 450 460 470 480 490 500 pF1KE4 MYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQ :::.::::::::::::::::::::::::::::::::::::::::::::.:::::.: : NP_715 MYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQ 450 460 470 480 490 500 510 520 530 540 550 560 pF1KE4 LESPMYCKSEETSPRDSTYSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQP :: .::.: . .:: ::: .... ..:..:.:. NP_715 ASSPTFCKTELNMACNSTQSDTCL-GKDNRLLEHNRSDNCKEVVITGYTQAEARSLT 510 520 530 540 550 570 580 590 600 610 620 pF1KE4 LASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACADGSVRKGTFVLRDLPLQHSPE 635 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 03:36:56 2016 done: Sun Nov 6 03:36:58 2016 Total Scan time: 12.290 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]