Result of FASTA (omim) for
pFN21AE4232
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4232, 825 aa
1>>>pF1KE4232 825 - 825 aa - 825 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.9019+/-0.000397; mu= 8.9212+/- 0.025
mean_var=166.1191+/-34.316, 0's: 0 Z-trim(117.4): 157 B-trim: 0 in 0/55
Lambda= 0.099509
statistics sampled from 29115 (29312) to 29115 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.344), width: 16
Scan time: 12.530
The best scores are: opt bits E(85289)
NP_001248338 (OMIM: 604704) breast cancer anti-est ( 825) 5569 812.3 0
NP_001248337 (OMIM: 604704) breast cancer anti-est ( 825) 5569 812.3 0
XP_016857969 (OMIM: 604704) PREDICTED: breast canc ( 825) 5569 812.3 0
NP_003558 (OMIM: 604704) breast cancer anti-estrog ( 825) 5569 812.3 0
NP_001248339 (OMIM: 604704) breast cancer anti-est ( 734) 4739 693.2 1.1e-198
XP_011540553 (OMIM: 604704) PREDICTED: breast canc ( 605) 4054 594.8 3.9e-169
NP_001295180 (OMIM: 604704) breast cancer anti-est ( 501) 3346 493.1 1.3e-138
NP_001136004 (OMIM: 604722) SH2 domain-containing ( 506) 1140 176.4 2.9e-43
XP_016869663 (OMIM: 604722) PREDICTED: SH2 domain- ( 506) 1140 176.4 2.9e-43
XP_005251696 (OMIM: 604722) PREDICTED: SH2 domain- ( 506) 1140 176.4 2.9e-43
NP_001136003 (OMIM: 604722) SH2 domain-containing ( 506) 1140 176.4 2.9e-43
XP_011516419 (OMIM: 604722) PREDICTED: SH2 domain- ( 506) 1140 176.4 2.9e-43
NP_005481 (OMIM: 604721) SH2 domain-containing pro ( 576) 849 134.6 1.2e-30
XP_011516417 (OMIM: 604722) PREDICTED: SH2 domain- ( 804) 792 126.5 4.6e-28
XP_011516416 (OMIM: 604722) PREDICTED: SH2 domain- ( 804) 792 126.5 4.6e-28
NP_733745 (OMIM: 604722) SH2 domain-containing pro ( 860) 792 126.6 4.8e-28
NP_005480 (OMIM: 604722) SH2 domain-containing pro ( 703) 780 124.8 1.4e-27
NP_001239263 (OMIM: 604722) SH2 domain-containing ( 792) 780 124.8 1.5e-27
NP_001136006 (OMIM: 604722) SH2 domain-containing ( 700) 770 123.3 3.7e-27
NP_001136005 (OMIM: 604722) SH2 domain-containing ( 702) 766 122.8 5.4e-27
XP_005259529 (OMIM: 604721) PREDICTED: SH2 domain- ( 483) 469 80.0 2.8e-14
XP_011525911 (OMIM: 604721) PREDICTED: SH2 domain- ( 510) 469 80.0 2.9e-14
XP_011525910 (OMIM: 604721) PREDICTED: SH2 domain- ( 510) 469 80.0 2.9e-14
XP_005259524 (OMIM: 604721) PREDICTED: SH2 domain- ( 605) 469 80.1 3.3e-14
XP_016881612 (OMIM: 604721) PREDICTED: SH2 domain- ( 399) 361 64.5 1.1e-09
XP_016881613 (OMIM: 604721) PREDICTED: SH2 domain- ( 327) 359 64.1 1.2e-09
XP_006722665 (OMIM: 604721) PREDICTED: SH2 domain- ( 485) 359 64.2 1.6e-09
>>NP_001248338 (OMIM: 604704) breast cancer anti-estroge (825 aa)
initn: 5569 init1: 5569 opt: 5569 Z-score: 4331.1 bits: 812.3 E(85289): 0
Smith-Waterman score: 5569; 99.9% identity (99.9% similar) in 825 aa overlap (1-825:1-825)
10 20 30 40 50 60
pF1KE4 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 KELFTNNDPKVIAQHVLSMDGRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_001 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
730 740 750 760 770 780
790 800 810 820
pF1KE4 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
790 800 810 820
>>NP_001248337 (OMIM: 604704) breast cancer anti-estroge (825 aa)
initn: 5569 init1: 5569 opt: 5569 Z-score: 4331.1 bits: 812.3 E(85289): 0
Smith-Waterman score: 5569; 99.9% identity (99.9% similar) in 825 aa overlap (1-825:1-825)
10 20 30 40 50 60
pF1KE4 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 KELFTNNDPKVIAQHVLSMDGRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_001 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
730 740 750 760 770 780
790 800 810 820
pF1KE4 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
790 800 810 820
>>XP_016857969 (OMIM: 604704) PREDICTED: breast cancer a (825 aa)
initn: 5569 init1: 5569 opt: 5569 Z-score: 4331.1 bits: 812.3 E(85289): 0
Smith-Waterman score: 5569; 99.9% identity (99.9% similar) in 825 aa overlap (1-825:1-825)
10 20 30 40 50 60
pF1KE4 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 KELFTNNDPKVIAQHVLSMDGRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_016 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
730 740 750 760 770 780
790 800 810 820
pF1KE4 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
790 800 810 820
>>NP_003558 (OMIM: 604704) breast cancer anti-estrogen r (825 aa)
initn: 5569 init1: 5569 opt: 5569 Z-score: 4331.1 bits: 812.3 E(85289): 0
Smith-Waterman score: 5569; 99.9% identity (99.9% similar) in 825 aa overlap (1-825:1-825)
10 20 30 40 50 60
pF1KE4 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 KELFTNNDPKVIAQHVLSMDGRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_003 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
730 740 750 760 770 780
790 800 810 820
pF1KE4 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
:::::::::::::::::::::::::::::::::::::::::::::
NP_003 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
790 800 810 820
>>NP_001248339 (OMIM: 604704) breast cancer anti-estroge (734 aa)
initn: 4739 init1: 4739 opt: 4739 Z-score: 3687.8 bits: 693.2 E(85289): 1.1e-198
Smith-Waterman score: 4739; 99.9% identity (99.9% similar) in 708 aa overlap (118-825:27-734)
90 100 110 120 130 140
pF1KE4 DGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSE
::::::::::::::::::::::::::::::
NP_001 MPKECSAFHALSAALCCFYHRKSFIGVKFSKERHIMDRTPEKLKKELEEELLLSSE
10 20 30 40 50
150 160 170 180 190 200
pF1KE4 DLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLR
60 70 80 90 100 110
210 220 230 240 250 260
pF1KE4 LSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYG
120 130 140 150 160 170
270 280 290 300 310 320
pF1KE4 TSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQD
180 190 200 210 220 230
330 340 350 360 370 380
pF1KE4 RRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDAR
240 250 260 270 280 290
390 400 410 420 430 440
pF1KE4 AGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLP
300 310 320 330 340 350
450 460 470 480 490 500
pF1KE4 SCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTP
360 370 380 390 400 410
510 520 530 540 550 560
pF1KE4 LLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDGRVARIL
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_001 LLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARIL
420 430 440 450 460 470
570 580 590 600 610 620
pF1KE4 GVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATL
480 490 500 510 520 530
630 640 650 660 670 680
pF1KE4 SKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPF
540 550 560 570 580 590
690 700 710 720 730 740
pF1KE4 SKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATA
600 610 620 630 640 650
750 760 770 780 790 800
pF1KE4 RFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQI
660 670 680 690 700 710
810 820
pF1KE4 LTALSRKLEPPPVKQAEL
::::::::::::::::::
NP_001 LTALSRKLEPPPVKQAEL
720 730
>>XP_011540553 (OMIM: 604704) PREDICTED: breast cancer a (605 aa)
initn: 4054 init1: 4054 opt: 4054 Z-score: 3157.5 bits: 594.8 E(85289): 3.9e-169
Smith-Waterman score: 4054; 99.8% identity (99.8% similar) in 605 aa overlap (221-825:1-605)
200 210 220 230 240 250
pF1KE4 QWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIF
::::::::::::::::::::::::::::::
XP_011 MESFDSIPGLVRCYVGNRRPISQQSGAIIF
10 20 30
260 270 280 290 300 310
pF1KE4 QPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLR
40 50 60 70 80 90
320 330 340 350 360 370
pF1KE4 NKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGS
100 110 120 130 140 150
380 390 400 410 420 430
pF1KE4 EPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYC
160 170 180 190 200 210
440 450 460 470 480 490
pF1KE4 ELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPA
220 230 240 250 260 270
500 510 520 530 540 550
pF1KE4 AAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPK
280 290 300 310 320 330
560 570 580 590 600 610
pF1KE4 VIAQHVLSMDGRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIA
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIA
340 350 360 370 380 390
620 630 640 650 660 670
pF1KE4 VDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALR
400 410 420 430 440 450
680 690 700 710 720 730
pF1KE4 HQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMW
460 470 480 490 500 510
740 750 760 770 780 790
pF1KE4 EKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGS
520 530 540 550 560 570
800 810 820
pF1KE4 KGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
:::::::::::::::::::::::::::::::::::
XP_011 KGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
580 590 600
>>NP_001295180 (OMIM: 604704) breast cancer anti-estroge (501 aa)
initn: 3346 init1: 3346 opt: 3346 Z-score: 2609.4 bits: 493.1 E(85289): 1.3e-138
Smith-Waterman score: 3346; 99.8% identity (99.8% similar) in 501 aa overlap (325-825:1-501)
300 310 320 330 340 350
pF1KE4 GVQAREQNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSG
::::::::::::::::::::::::::::::
NP_001 MQDRRALSLKAHQSESYLPIGCKLPPQSSG
10 20 30
360 370 380 390 400 410
pF1KE4 VDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLK
40 50 60 70 80 90
420 430 440 450 460 470
pF1KE4 VPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVN
100 110 120 130 140 150
480 490 500 510 520 530
pF1KE4 YLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLET
160 170 180 190 200 210
540 550 560 570 580 590
pF1KE4 AMLKRAKELFTNNDPKVIAQHVLSMDGRVARILGVSEEMRRNMGVSSGLELITLPHGHQL
:::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::
NP_001 AMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQL
220 230 240 250 260 270
600 610 620 630 640 650
pF1KE4 RLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKAL
280 290 300 310 320 330
660 670 680 690 700 710
pF1KE4 EMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLV
340 350 360 370 380 390
720 730 740 750 760 770
pF1KE4 TLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEM
400 410 420 430 440 450
780 790 800 810 820
pF1KE4 NEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
460 470 480 490 500
>>NP_001136004 (OMIM: 604722) SH2 domain-containing prot (506 aa)
initn: 1110 init1: 704 opt: 1140 Z-score: 897.7 bits: 176.4 E(85289): 2.9e-43
Smith-Waterman score: 1171; 42.2% identity (69.3% similar) in 502 aa overlap (343-825:24-506)
320 330 340 350 360
pF1KE4 EKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLP-PQSS------GVDTSP---CPN
: . .:: :..: ..: : :
NP_001 MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPM
10 20 30 40 50
370 380 390 400 410
pF1KE4 SPVFRTGSEPALSPAVVRRVSSDARAGEAL-------RGSDSQLCPKPPPKPCKVPFLKV
::. .. : :: : .. ... : .. :: :.:. :::: :: . :
NP_001 SPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKT-HGESDKG
60 70 80 90 100 110
420 430 440 450 460 470
pF1KE4 P-SSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVN
: .::: :.. . :. :. .: ..::. .: .. . :. :
NP_001 PHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSRE--WAATETSSQQARSYG--
120 130 140 150 160
480 490 500 510 520 530
pF1KE4 YLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLET
:: : . .:.: : :..:..:..::: : :.: ..: .:.:::.
NP_001 ---------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEV
170 180 190 200 210
540 550 560 570 580 590
pF1KE4 AMLKRAKELFTNNDPKVIAQHVLSMDGRVARILGVSEEMRRNMGVSSGLELITLPHGHQL
..:...:::... : ...:.:: ..: :::::::..::. ::: :.::.:::::.::
NP_001 GLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQL
220 230 240 250 260 270
600 610 620 630 640 650
pF1KE4 RLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKAL
:::..:: .::.: .:::::::::. :.::: : : ::.:.::. .::...::.:.: ::
NP_001 RLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGAL
280 290 300 310 320 330
660 670 680 690 700 710
pF1KE4 EMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPP-NNVSVPLLMPL
.: ::.:::.::..::...:. ::::::.:::: : :.::.:. :: .:.. : ..::
NP_001 DMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEG---PPLSNTTFPHVLPL
340 350 360 370 380 390
720 730 740 750 760 770
pF1KE4 VTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEE
.::.: ... :: . : ..... :..: :: .:: .:. . :. ::: : ::: :
NP_001 ITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPE
400 410 420 430 440 450
780 790 800 810 820
pF1KE4 MNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
. :. .:::::::::::.::. .:..:::::...:::::.:::: :...::
NP_001 LLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPA-VRSSEL
460 470 480 490 500
>>XP_016869663 (OMIM: 604722) PREDICTED: SH2 domain-cont (506 aa)
initn: 1110 init1: 704 opt: 1140 Z-score: 897.7 bits: 176.4 E(85289): 2.9e-43
Smith-Waterman score: 1171; 42.2% identity (69.3% similar) in 502 aa overlap (343-825:24-506)
320 330 340 350 360
pF1KE4 EKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLP-PQSS------GVDTSP---CPN
: . .:: :..: ..: : :
XP_016 MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPM
10 20 30 40 50
370 380 390 400 410
pF1KE4 SPVFRTGSEPALSPAVVRRVSSDARAGEAL-------RGSDSQLCPKPPPKPCKVPFLKV
::. .. : :: : .. ... : .. :: :.:. :::: :: . :
XP_016 SPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKT-HGESDKG
60 70 80 90 100 110
420 430 440 450 460 470
pF1KE4 P-SSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVN
: .::: :.. . :. :. .: ..::. .: .. . :. :
XP_016 PHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSRE--WAATETSSQQARSYG--
120 130 140 150 160
480 490 500 510 520 530
pF1KE4 YLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLET
:: : . .:.: : :..:..:..::: : :.: ..: .:.:::.
XP_016 ---------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEV
170 180 190 200 210
540 550 560 570 580 590
pF1KE4 AMLKRAKELFTNNDPKVIAQHVLSMDGRVARILGVSEEMRRNMGVSSGLELITLPHGHQL
..:...:::... : ...:.:: ..: :::::::..::. ::: :.::.:::::.::
XP_016 GLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQL
220 230 240 250 260 270
600 610 620 630 640 650
pF1KE4 RLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKAL
:::..:: .::.: .:::::::::. :.::: : : ::.:.::. .::...::.:.: ::
XP_016 RLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGAL
280 290 300 310 320 330
660 670 680 690 700 710
pF1KE4 EMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPP-NNVSVPLLMPL
.: ::.:::.::..::...:. ::::::.:::: : :.::.:. :: .:.. : ..::
XP_016 DMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEG---PPLSNTTFPHVLPL
340 350 360 370 380 390
720 730 740 750 760 770
pF1KE4 VTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEE
.::.: ... :: . : ..... :..: :: .:: .:. . :. ::: : ::: :
XP_016 ITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPE
400 410 420 430 440 450
780 790 800 810 820
pF1KE4 MNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
. :. .:::::::::::.::. .:..:::::...:::::.:::: :...::
XP_016 LLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPA-VRSSEL
460 470 480 490 500
>>XP_005251696 (OMIM: 604722) PREDICTED: SH2 domain-cont (506 aa)
initn: 1110 init1: 704 opt: 1140 Z-score: 897.7 bits: 176.4 E(85289): 2.9e-43
Smith-Waterman score: 1171; 42.2% identity (69.3% similar) in 502 aa overlap (343-825:24-506)
320 330 340 350 360
pF1KE4 EKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLP-PQSS------GVDTSP---CPN
: . .:: :..: ..: : :
XP_005 MKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPM
10 20 30 40 50
370 380 390 400 410
pF1KE4 SPVFRTGSEPALSPAVVRRVSSDARAGEAL-------RGSDSQLCPKPPPKPCKVPFLKV
::. .. : :: : .. ... : .. :: :.:. :::: :: . :
XP_005 SPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKT-HGESDKG
60 70 80 90 100 110
420 430 440 450 460 470
pF1KE4 P-SSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVN
: .::: :.. . :. :. .: ..::. .: .. . :. :
XP_005 PHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSRE--WAATETSSQQARSYG--
120 130 140 150 160
480 490 500 510 520 530
pF1KE4 YLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLET
:: : . .:.: : :..:..:..::: : :.: ..: .:.:::.
XP_005 ---------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEV
170 180 190 200 210
540 550 560 570 580 590
pF1KE4 AMLKRAKELFTNNDPKVIAQHVLSMDGRVARILGVSEEMRRNMGVSSGLELITLPHGHQL
..:...:::... : ...:.:: ..: :::::::..::. ::: :.::.:::::.::
XP_005 GLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQL
220 230 240 250 260 270
600 610 620 630 640 650
pF1KE4 RLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKAL
:::..:: .::.: .:::::::::. :.::: : : ::.:.::. .::...::.:.: ::
XP_005 RLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGAL
280 290 300 310 320 330
660 670 680 690 700 710
pF1KE4 EMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPP-NNVSVPLLMPL
.: ::.:::.::..::...:. ::::::.:::: : :.::.:. :: .:.. : ..::
XP_005 DMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEG---PPLSNTTFPHVLPL
340 350 360 370 380 390
720 730 740 750 760 770
pF1KE4 VTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEE
.::.: ... :: . : ..... :..: :: .:: .:. . :. ::: : ::: :
XP_005 ITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPE
400 410 420 430 440 450
780 790 800 810 820
pF1KE4 MNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
. :. .:::::::::::.::. .:..:::::...:::::.:::: :...::
XP_005 LLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPA-VRSSEL
460 470 480 490 500
825 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:25:32 2016 done: Sun Nov 6 01:25:34 2016
Total Scan time: 12.530 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]