Result of FASTA (omim) for
pFN21AE3041
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3041, 178 aa
1>>>pF1KE3041 178 - 178 aa - 178 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0285+/-0.000272; mu= 15.2141+/- 0.017
mean_var=74.4008+/-14.827, 0's: 0 Z-trim(119.8): 19 B-trim: 94 in 2/53
Lambda= 0.148691
statistics sampled from 34233 (34253) to 34233 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.773), E-opt: 0.2 (0.402), width: 16
Scan time: 6.090
The best scores are: opt bits E(85289)
NP_001947 (OMIM: 131241) endothelin-2 isoform 1 pr ( 178) 1242 274.7 5.6e-74
NP_001289198 (OMIM: 131241) endothelin-2 isoform 2 ( 145) 836 187.5 7.9e-48
XP_016856001 (OMIM: 131241) PREDICTED: endothelin- ( 132) 518 119.3 2.5e-27
NP_001161791 (OMIM: 131240,612798,615706) endothel ( 211) 276 67.5 1.5e-11
XP_011512634 (OMIM: 131240,612798,615706) PREDICTE ( 211) 276 67.5 1.5e-11
XP_016865820 (OMIM: 131240,612798,615706) PREDICTE ( 212) 276 67.5 1.5e-11
XP_011512632 (OMIM: 131240,612798,615706) PREDICTE ( 212) 276 67.5 1.5e-11
NP_001946 (OMIM: 131240,612798,615706) endothelin- ( 212) 276 67.5 1.5e-11
XP_011512633 (OMIM: 131240,612798,615706) PREDICTE ( 212) 276 67.5 1.5e-11
NP_001289385 (OMIM: 131242,209880,613265,613712) e ( 192) 268 65.8 4.6e-11
NP_001289384 (OMIM: 131242,209880,613265,613712) e ( 198) 268 65.8 4.8e-11
XP_006723797 (OMIM: 131242,209880,613265,613712) P ( 208) 268 65.8 4.9e-11
XP_005260370 (OMIM: 131242,209880,613265,613712) P ( 212) 268 65.8 5e-11
NP_996915 (OMIM: 131242,209880,613265,613712) endo ( 219) 268 65.8 5.1e-11
NP_996916 (OMIM: 131242,209880,613265,613712) endo ( 224) 268 65.8 5.2e-11
NP_996917 (OMIM: 131242,209880,613265,613712) endo ( 238) 268 65.8 5.5e-11
XP_011526957 (OMIM: 131242,209880,613265,613712) P ( 244) 268 65.9 5.6e-11
XP_005260369 (OMIM: 131242,209880,613265,613712) P ( 251) 268 65.9 5.7e-11
>>NP_001947 (OMIM: 131241) endothelin-2 isoform 1 prepro (178 aa)
initn: 1242 init1: 1242 opt: 1242 Z-score: 1449.2 bits: 274.7 E(85289): 5.6e-74
Smith-Waterman score: 1242; 100.0% identity (100.0% similar) in 178 aa overlap (1-178:1-178)
10 20 30 40 50 60
pF1KE3 MVSVPTTWCSVALALLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVSVPTTWCSVALALLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 YFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGA
70 80 90 100 110 120
130 140 150 160 170
pF1KE3 VPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR
130 140 150 160 170
>>NP_001289198 (OMIM: 131241) endothelin-2 isoform 2 pre (145 aa)
initn: 1021 init1: 836 opt: 836 Z-score: 979.7 bits: 187.5 E(85289): 7.9e-48
Smith-Waterman score: 959; 81.5% identity (81.5% similar) in 178 aa overlap (1-178:1-145)
10 20 30 40 50 60
pF1KE3 MVSVPTTWCSVALALLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVSVPTTWCSVALALLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 YFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPWTEAGA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPACATFCLRRPW-----
70 80 90 100 110
130 140 150 160 170
pF1KE3 VPSRKSPADVFQTGKTGATTGELLQRLRDISTVKSLFAKRQQEAMREPRSTHSRWRKR
::::::::::::::::::::::::::::::
NP_001 ----------------------------DISTVKSLFAKRQQEAMREPRSTHSRWRKR
120 130 140
>>XP_016856001 (OMIM: 131241) PREDICTED: endothelin-2 is (132 aa)
initn: 703 init1: 518 opt: 518 Z-score: 611.5 bits: 119.3 E(85289): 2.5e-27
Smith-Waterman score: 559; 58.4% identity (58.4% similar) in 178 aa overlap (1-178:29-132)
10 20 30
pF1KE3 MVSVPTTWCSVALALLVALHEGKGQAAATLEQ
::::::::::::::::::::::::::::::::
XP_016 MSYLLSLIAGRWQQALPAPVQPARSTAAMVSVPTTWCSVALALLVALHEGKGQAAATLEQ
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 PASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPEQTAPYGLGNPPRRRRRSL
::::::::::::::::::::::::::::::::::::::::::
XP_016 PASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPE------------------
70 80 90 100
100 110 120 130 140 150
pF1KE3 PRRCQCSSARDPACATFCLRRPWTEAGAVPSRKSPADVFQTGKTGATTGELLQRLRDIST
::::
XP_016 --------------------------------------------------------DIST
160 170
pF1KE3 VKSLFAKRQQEAMREPRSTHSRWRKR
::::::::::::::::::::::::::
XP_016 VKSLFAKRQQEAMREPRSTHSRWRKR
110 120 130
>>NP_001161791 (OMIM: 131240,612798,615706) endothelin-1 (211 aa)
initn: 341 init1: 254 opt: 276 Z-score: 328.3 bits: 67.5 E(85289): 1.5e-11
Smith-Waterman score: 323; 38.4% identity (56.7% similar) in 164 aa overlap (45-175:48-211)
20 30 40 50 60 70
pF1KE3 LLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPE
: .:::::: .:::::::::::::::::::
NP_001 APETVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPE
20 30 40 50 60 70
80 90 100 110
pF1KE3 QTAPYGLGNPPRRR--RRSLPR-------RCQCSSARDPACATFC-----------LRRP
...:::::.: .: . :: ::::.: .: : .:: ...
NP_001 HVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKD
80 90 100 110 120 130
120 130 140 150 160
pF1KE3 WT--EAGAVPSRKSPADVFQTGKTGA----TTGELLQRLRDIS---TVKSLF--AKRQQE
:. . : :. . ..: : .. : :.. :. . .::: : : . .
NP_001 WNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGK
140 150 160 170 180 190
170
pF1KE3 AMREPRSTHSR--WRKR
:: ::.: :
NP_001 PSRERYVTHNRAHW
200 210
>>XP_011512634 (OMIM: 131240,612798,615706) PREDICTED: e (211 aa)
initn: 341 init1: 254 opt: 276 Z-score: 328.3 bits: 67.5 E(85289): 1.5e-11
Smith-Waterman score: 323; 38.4% identity (56.7% similar) in 164 aa overlap (45-175:48-211)
20 30 40 50 60 70
pF1KE3 LLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPE
: .:::::: .:::::::::::::::::::
XP_011 APETVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPE
20 30 40 50 60 70
80 90 100 110
pF1KE3 QTAPYGLGNPPRRR--RRSLPR-------RCQCSSARDPACATFC-----------LRRP
...:::::.: .: . :: ::::.: .: : .:: ...
XP_011 HVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKD
80 90 100 110 120 130
120 130 140 150 160
pF1KE3 WT--EAGAVPSRKSPADVFQTGKTGA----TTGELLQRLRDIS---TVKSLF--AKRQQE
:. . : :. . ..: : .. : :.. :. . .::: : : . .
XP_011 WNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGK
140 150 160 170 180 190
170
pF1KE3 AMREPRSTHSR--WRKR
:: ::.: :
XP_011 PSRERYVTHNRAHW
200 210
>>XP_016865820 (OMIM: 131240,612798,615706) PREDICTED: e (212 aa)
initn: 341 init1: 254 opt: 276 Z-score: 328.2 bits: 67.5 E(85289): 1.5e-11
Smith-Waterman score: 323; 38.4% identity (56.7% similar) in 164 aa overlap (45-175:49-212)
20 30 40 50 60 70
pF1KE3 LLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPE
: .:::::: .:::::::::::::::::::
XP_016 PETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPE
20 30 40 50 60 70
80 90 100 110
pF1KE3 QTAPYGLGNPPRRR--RRSLPR-------RCQCSSARDPACATFC-----------LRRP
...:::::.: .: . :: ::::.: .: : .:: ...
XP_016 HVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKD
80 90 100 110 120 130
120 130 140 150 160
pF1KE3 WT--EAGAVPSRKSPADVFQTGKTGA----TTGELLQRLRDIS---TVKSLF--AKRQQE
:. . : :. . ..: : .. : :.. :. . .::: : : . .
XP_016 WNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGK
140 150 160 170 180 190
170
pF1KE3 AMREPRSTHSR--WRKR
:: ::.: :
XP_016 PSRERYVTHNRAHW
200 210
>>XP_011512632 (OMIM: 131240,612798,615706) PREDICTED: e (212 aa)
initn: 341 init1: 254 opt: 276 Z-score: 328.2 bits: 67.5 E(85289): 1.5e-11
Smith-Waterman score: 323; 38.4% identity (56.7% similar) in 164 aa overlap (45-175:49-212)
20 30 40 50 60 70
pF1KE3 LLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPE
: .:::::: .:::::::::::::::::::
XP_011 PETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPE
20 30 40 50 60 70
80 90 100 110
pF1KE3 QTAPYGLGNPPRRR--RRSLPR-------RCQCSSARDPACATFC-----------LRRP
...:::::.: .: . :: ::::.: .: : .:: ...
XP_011 HVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKD
80 90 100 110 120 130
120 130 140 150 160
pF1KE3 WT--EAGAVPSRKSPADVFQTGKTGA----TTGELLQRLRDIS---TVKSLF--AKRQQE
:. . : :. . ..: : .. : :.. :. . .::: : : . .
XP_011 WNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGK
140 150 160 170 180 190
170
pF1KE3 AMREPRSTHSR--WRKR
:: ::.: :
XP_011 PSRERYVTHNRAHW
200 210
>>NP_001946 (OMIM: 131240,612798,615706) endothelin-1 is (212 aa)
initn: 341 init1: 254 opt: 276 Z-score: 328.2 bits: 67.5 E(85289): 1.5e-11
Smith-Waterman score: 323; 38.4% identity (56.7% similar) in 164 aa overlap (45-175:49-212)
20 30 40 50 60 70
pF1KE3 LLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPE
: .:::::: .:::::::::::::::::::
NP_001 PETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPE
20 30 40 50 60 70
80 90 100 110
pF1KE3 QTAPYGLGNPPRRR--RRSLPR-------RCQCSSARDPACATFC-----------LRRP
...:::::.: .: . :: ::::.: .: : .:: ...
NP_001 HVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKD
80 90 100 110 120 130
120 130 140 150 160
pF1KE3 WT--EAGAVPSRKSPADVFQTGKTGA----TTGELLQRLRDIS---TVKSLF--AKRQQE
:. . : :. . ..: : .. : :.. :. . .::: : : . .
NP_001 WNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGK
140 150 160 170 180 190
170
pF1KE3 AMREPRSTHSR--WRKR
:: ::.: :
NP_001 PSRERYVTHNRAHW
200 210
>>XP_011512633 (OMIM: 131240,612798,615706) PREDICTED: e (212 aa)
initn: 341 init1: 254 opt: 276 Z-score: 328.2 bits: 67.5 E(85289): 1.5e-11
Smith-Waterman score: 323; 38.4% identity (56.7% similar) in 164 aa overlap (45-175:49-212)
20 30 40 50 60 70
pF1KE3 LLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPE
: .:::::: .:::::::::::::::::::
XP_011 PETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPE
20 30 40 50 60 70
80 90 100 110
pF1KE3 QTAPYGLGNPPRRR--RRSLPR-------RCQCSSARDPACATFC-----------LRRP
...:::::.: .: . :: ::::.: .: : .:: ...
XP_011 HVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKD
80 90 100 110 120 130
120 130 140 150 160
pF1KE3 WT--EAGAVPSRKSPADVFQTGKTGA----TTGELLQRLRDIS---TVKSLF--AKRQQE
:. . : :. . ..: : .. : :.. :. . .::: : : . .
XP_011 WNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGK
140 150 160 170 180 190
170
pF1KE3 AMREPRSTHSR--WRKR
:: ::.: :
XP_011 PSRERYVTHNRAHW
200 210
>>NP_001289385 (OMIM: 131242,209880,613265,613712) endot (192 aa)
initn: 288 init1: 233 opt: 268 Z-score: 319.5 bits: 65.8 E(85289): 4.6e-11
Smith-Waterman score: 291; 45.5% identity (59.8% similar) in 112 aa overlap (22-110:62-173)
10 20 30 40
pF1KE3 MVSVPTTWCSVALALLVALHEGKGQAAATLEQ------PASSSHAQGT--H
:.: .: : : :.. . :.:. :
NP_001 GVSQAPTAARSEGDCEETVAGPGEETVAGPGEGTVAPTALQGPSPGSPGQEQAAEGAPEH
40 50 60 70 80 90
50 60 70 80 90
pF1KE3 LRLRRCSCSSWLDKECVYFCHLDIIWVNTPEQTAPYGLGN--PPRRRRRS---LPR----
: :::.: .. ::::::.:::::::.::::::.::::.: : .:: ::
NP_001 HRSRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNYRGSFRGKRSAGPLPGNLQL
100 110 120 130 140 150
100 110 120 130 140
pF1KE3 ------RCQCSSARDPACATFCLRRPWTEAGAVPSRKSPADVFQTGKTGATTGELLQRLR
:: : . : :: ::
NP_001 SHRPHLRCACVGRYDKACLHFCTQTLDVSRLKSRTNKASRL
160 170 180 190
178 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:55:44 2016 done: Sun Nov 6 04:55:45 2016
Total Scan time: 6.090 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]