FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1294, 475 aa 1>>>pF1KE1294 475 - 475 aa - 475 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.3272+/-0.000512; mu= 4.8349+/- 0.031 mean_var=242.2277+/-49.214, 0's: 0 Z-trim(116.1): 257 B-trim: 1220 in 1/53 Lambda= 0.082407 statistics sampled from 26719 (26999) to 26719 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.317), width: 16 Scan time: 9.990 The best scores are: opt bits E(85289) NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475) 3213 395.6 1.6e-109 XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555) 3183 392.1 2.1e-108 NP_001317412 (OMIM: 616755) E3 ubiquitin-protein l ( 354) 2256 281.7 2.3e-75 XP_016857119 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 544) 2049 257.3 7.9e-68 XP_016857120 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 291) 1160 151.3 3.4e-36 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 862 116.1 2.2e-25 NP_892030 (OMIM: 616017) E3 ubiquitin-protein liga ( 500) 835 112.9 2.1e-24 XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 781 106.5 1.8e-22 NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 781 106.5 1.8e-22 NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 779 106.2 2.1e-22 NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 779 106.2 2.1e-22 NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 743 101.9 4e-21 NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 663 92.4 3e-18 NP_542783 (OMIM: 616017) E3 ubiquitin-protein liga ( 341) 635 88.9 2.3e-17 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 613 86.5 1.8e-16 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 613 86.5 1.8e-16 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 613 86.5 1.8e-16 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 613 86.5 1.8e-16 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 613 86.5 1.8e-16 NP_001288073 (OMIM: 616017) E3 ubiquitin-protein l ( 296) 603 85.1 2.9e-16 NP_001008275 (OMIM: 613288) tripartite motif-conta ( 477) 573 81.7 4.8e-15 NP_001288075 (OMIM: 616017) E3 ubiquitin-protein l ( 263) 544 78.0 3.5e-14 NP_001288074 (OMIM: 616017) E3 ubiquitin-protein l ( 279) 544 78.0 3.7e-14 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 538 77.6 9.2e-14 NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 536 77.3 1e-13 NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 534 77.1 1.3e-13 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 529 76.5 1.8e-13 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 529 76.5 1.9e-13 XP_011538873 (OMIM: 111620,111750,609017) PREDICTE ( 468) 527 76.2 2.1e-13 XP_011538872 (OMIM: 111620,111750,609017) PREDICTE ( 475) 527 76.3 2.1e-13 XP_006710376 (OMIM: 111620,111750,609017) PREDICTE ( 475) 527 76.3 2.1e-13 NP_061008 (OMIM: 111620,111750,609017) erythroid m ( 475) 527 76.3 2.1e-13 NP_001017922 (OMIM: 111620,111750,609017) erythroi ( 475) 527 76.3 2.1e-13 XP_011514090 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 278) 494 72.1 2.2e-12 XP_011512523 (OMIM: 605701) PREDICTED: tripartite ( 499) 490 71.9 4.7e-12 XP_011512524 (OMIM: 605701) PREDICTED: tripartite ( 499) 490 71.9 4.7e-12 XP_011512525 (OMIM: 605701) PREDICTED: tripartite ( 499) 490 71.9 4.7e-12 XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 479 70.5 1.1e-11 XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 478 70.4 1.2e-11 NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 478 70.4 1.2e-11 NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 476 70.1 1.3e-11 NP_000234 (OMIM: 134610,249100,608107) pyrin isofo ( 781) 479 70.8 1.6e-11 NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 473 69.9 1.9e-11 NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 473 69.9 1.9e-11 NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 472 69.7 2e-11 XP_016878725 (OMIM: 134610,249100,608107) PREDICTE ( 780) 472 69.9 2.8e-11 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 468 69.3 2.9e-11 NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 466 69.0 3.3e-11 NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 466 69.0 3.3e-11 XP_016878743 (OMIM: 613288) PREDICTED: tripartite ( 333) 461 68.2 3.9e-11 >>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T (475 aa) initn: 3213 init1: 3213 opt: 3213 Z-score: 2087.3 bits: 395.6 E(85289): 1.6e-109 Smith-Waterman score: 3213; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475) 10 20 30 40 50 60 pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ALAPSLKLANIVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 EQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 AFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 AFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 RHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 RHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 PGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 TQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFL 370 380 390 400 410 420 430 440 450 460 470 pF1KE1 DYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI 430 440 450 460 470 >>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (555 aa) initn: 3183 init1: 3183 opt: 3183 Z-score: 2067.2 bits: 392.1 E(85289): 2.1e-108 Smith-Waterman score: 3183; 100.0% identity (100.0% similar) in 471 aa overlap (5-475:85-555) 10 20 30 pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRC :::::::::::::::::::::::::::::: XP_016 AAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFCRRC 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE1 ITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQ 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE1 AHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHT 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE1 EALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQK 240 250 260 270 280 290 220 230 240 250 260 270 pF1KE1 VQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKY 300 310 320 330 340 350 280 290 300 310 320 330 pF1KE1 TGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRF 360 370 380 390 400 410 340 350 360 370 380 390 pF1KE1 DVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDG 420 430 440 450 460 470 400 410 420 430 440 450 pF1KE1 NQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFS 480 490 500 510 520 530 460 470 pF1KE1 PGQSHANGKNVQPLRINTVRI ::::::::::::::::::::: XP_016 PGQSHANGKNVQPLRINTVRI 540 550 >>NP_001317412 (OMIM: 616755) E3 ubiquitin-protein ligas (354 aa) initn: 2256 init1: 2256 opt: 2256 Z-score: 1474.0 bits: 281.7 E(85289): 2.3e-75 Smith-Waterman score: 2256; 97.4% identity (98.9% similar) in 350 aa overlap (126-475:5-354) 100 110 120 130 140 150 pF1KE1 HDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTE :..:. . . ::::::::::::::::::: NP_001 MPEKTAVDQPWTQALRELKDQLQALQDSEREHTE 10 20 30 160 170 180 190 200 210 pF1KE1 ALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKV 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE1 QRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYT 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE1 GPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFD 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE1 VEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGN 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE1 QYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSP 280 290 300 310 320 330 460 470 pF1KE1 GQSHANGKNVQPLRINTVRI :::::::::::::::::::: NP_001 GQSHANGKNVQPLRINTVRI 340 350 >>XP_016857119 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (544 aa) initn: 2049 init1: 2049 opt: 2049 Z-score: 1338.7 bits: 257.3 E(85289): 7.9e-68 Smith-Waterman score: 2049; 99.7% identity (100.0% similar) in 308 aa overlap (168-475:237-544) 140 150 160 170 180 190 pF1KE1 ELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAML .::::::::::::::::::::::::::::: XP_016 RQRAGTHRSAAAAQATTGGDQAITPDDCPPQSSTKSLRTTIGEAFERLHRLLRERQKAML 210 220 230 240 250 260 200 210 220 230 240 250 pF1KE1 EELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKG 270 280 290 300 310 320 260 270 280 290 300 310 pF1KE1 KIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIV 330 340 350 360 370 380 320 330 340 350 360 370 pF1KE1 AYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGS 390 400 410 420 430 440 380 390 400 410 420 430 pF1KE1 IQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSW 450 460 470 480 490 500 440 450 460 470 pF1KE1 LYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI :::::::::::::::::::::::::::::::::::::: XP_016 LYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI 510 520 530 540 >>XP_016857120 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (291 aa) initn: 1184 init1: 1160 opt: 1160 Z-score: 770.8 bits: 151.3 E(85289): 3.4e-36 Smith-Waterman score: 1160; 96.0% identity (98.3% similar) in 175 aa overlap (5-179:85-259) 10 20 30 pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRC :::::::::::::::::::::::::::::: XP_016 AAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFCRRC 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE1 ITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQ 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE1 AHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHT 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE1 EALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQK :::::::::::::: .:::...: XP_016 EALQLLKRQLAETKELRQSLRNALGLWRSSWGLKTPLETQIYAPAWPPTHCGVSGRS 240 250 260 270 280 290 >>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T (488 aa) initn: 819 init1: 467 opt: 862 Z-score: 576.6 bits: 116.1 E(85289): 2.2e-25 Smith-Waterman score: 862; 33.5% identity (61.7% similar) in 472 aa overlap (4-470:22-481) 10 20 30 40 pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQ .:. : ::.:: ..:: . : : ::. :::. : NP_742 MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL 10 20 30 40 50 60 50 60 70 80 90 pF1KE1 EAQGARD--CPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPC-QAHDKV : :: :: ::.: .: :. .:...:: .. :.:. : : : :. . NP_742 E----RDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQ--LQAVKRKIRDESLCPQHHEAL 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 KLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQL .::: :. .:..: :. : :. .::: .: ...:. :. :... .: :. . NP_742 SLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSS 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 LKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYS ... .: : ..: : : . ::.::: : :.:...: .:: . : ..... . . NP_742 EEKKPGELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLG 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE1 QQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTG--P .. : . . : .. . .. .: : : :. . :.. ..: .. : . : NP_742 DKRRDLAHLAAEVEGKCLQSG-FEMLKDVKSTLEKCE-KVKTMEVTSVSIELEKNFSNFP 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE1 LQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVE :: ....... : .:::: ::: :.::.: : . . . . : :.:.:: NP_742 RQYFALRKILKQL---IADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFY 300 310 320 330 340 340 350 360 370 380 390 pF1KE1 VSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQY ::..:.:.:: ::::: :..::.:..:. ....:::: . : :.. . . .:..: NP_742 PCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKY 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE1 SACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQ .: : :.: :... : .::.::::. : : :::. : : .::: . : :: : :: NP_742 AATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGI 410 420 430 440 450 460 460 470 pF1KE1 SHANGKNVQPLRINTVRI .:. ::. :: : NP_742 -RAGRKNAAPLTIRPPTDWE 470 480 >>NP_892030 (OMIM: 616017) E3 ubiquitin-protein ligase T (500 aa) initn: 751 init1: 368 opt: 835 Z-score: 559.1 bits: 112.9 E(85289): 2.1e-24 Smith-Waterman score: 835; 32.2% identity (60.8% similar) in 469 aa overlap (8-470:38-496) 10 20 30 pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITE :: : .: . ..::. :.: : ::. :: . NP_892 SSNIDPGDYVEMNDSITHLPSKVVIQDITMELHCPLCNDWFRDPLMLSCGHNFCEACIQD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE1 HWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAH- : : .:. . ::::. . . : ..::. ...:: .. : : NP_892 FW-RLQAKETF-CPECKMLCQYNNCTFNPVLDKLVEKIKKLPL------LKGHPQCPEHG 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 DKVKLFCLTDRALLCFFCDEPALH--EQHQVTGIDDAFDELQRELKDQLQALQDSEREHT ...::: : :.:: : . : .... :.:: . .:: : :. . .: NP_892 ENLKLFSKPDGKLICFQCKDARLSVGQSKEFLQISDAVHFFTEELAIQQGQLETTLKELQ 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 EALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQK .. :. .: : . :. .. : .::..:. ..: .: ::. . ..: . NP_892 TLRNMQKEAIAAHKENKLHLQQHVSMEFLKLHQFLHSKEKDILTELREEGKALNEEMELN 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE1 VQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERL-KG-KIHET-NLTYEDFPT ... ..: ... .: . . . :: ...: . : .: :. : .: . . NP_892 LSQLQEQCLLAKDMLVSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVLATRELISRKLNL 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE1 SKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSP ..: ::.:: .:. . . . : . ::::: ::: :.:: . : : .:... . . :.: NP_892 GQYKGPIQYMVWREMQDTLCPGLSPLTLDPKTAHPNLVLSKSQTSVWHGDIK-KIMPDDP 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE1 KRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVM .::: :.::::..:.:: :::: ::.::.:..:...:. :::: . : .::. . . NP_892 ERFDSSVAVLGSRGFTSGKWYWEVEVAKKTKWTVGVVRESIIRKGSCPLTPEQGFWLLRL 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE1 HDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCS .. .. .: : :.. ..:::::..:::. : : :::: :. .::: . : :: NP_892 RNQTDLKALDLPSFSLTLTNNLDKVGIYLDYEGGQLSFYNAKTMTHIYTFSNTFMEKLYP 420 430 440 450 460 470 460 470 pF1KE1 YFSPGQSHANGKNVQPLRINTVRI :: : . . :.: .::.: NP_892 YFCPCLNDG-GENKEPLHILHPQ 480 490 500 >>XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquitin-pr (486 aa) initn: 653 init1: 286 opt: 781 Z-score: 524.6 bits: 106.5 E(85289): 1.8e-22 Smith-Waterman score: 781; 30.0% identity (60.9% similar) in 470 aa overlap (5-468:10-467) 10 20 30 40 50 pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRR :.:.: : ::: ....:. : : : .:. :.. . .:. :: ::. XP_011 MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAE--LRCPVCRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 TFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAH-DKVKLFCLTDRALLCFFC . . :...:: ..: .: : . : : . ..::: :. :.: .: XP_011 AVDGSSSLPNVSLARVIEALR-LPGDP------EPKVCVHHRNPLSLFCEKDQELICGLC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 DEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSL . :..: :: .. .......:: .. :.. ... : . : . .. . . . XP_011 GLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 RTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQE .: . :..::.:. :.. :: . . : .......... .: :. :. . : XP_011 SWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQ-AQGTRERLAQAECVLE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 RLAETDRHTFLA--GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHP .... :.: :. ..:: .: ... : .. .: . . . .. :.:: ::. . : XP_011 QFGNEDHHKFIRFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 VPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHY .: : :::.::: : :: :.: : : : ..:.::: . ::.:..:: : :: XP_011 APEPLKLDPATAHPLLELSKGNTVVQCG-LLAQRRASQPERFDYSTCVLASRGFSCGRHY 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 WEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDK :::::. :..: .:. . .:::::... .: .: . : ...: : : . : . : : . XP_011 WEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGH 350 360 370 380 390 400 420 430 440 450 460 pF1KE1 LDKVGVFLDYDQGLLIFYNAD---DMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLR ..:..: :.:: : :..:: :. ::::. : ::: .. : :.: :. XP_011 PHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCW-HERGSNSLPMV 410 420 430 440 450 460 470 pF1KE1 INTVRI XP_011 LPPPSGPGPLSPEQPTKL 470 480 >>NP_001268379 (OMIM: 612548) E3 ubiquitin-protein ligas (486 aa) initn: 653 init1: 286 opt: 781 Z-score: 524.6 bits: 106.5 E(85289): 1.8e-22 Smith-Waterman score: 781; 30.0% identity (60.9% similar) in 470 aa overlap (5-468:10-467) 10 20 30 40 50 pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRR :.:.: : ::: ....:. : : : .:. :.. . .:. :: ::. NP_001 MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAE--LRCPVCRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 TFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAH-DKVKLFCLTDRALLCFFC . . :...:: ..: .: : . : : . ..::: :. :.: .: NP_001 AVDGSSSLPNVSLARVIEALR-LPGDP------EPKVCVHHRNPLSLFCEKDQELICGLC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 DEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSL . :..: :: .. .......:: .. :.. ... : . : . .. . . . NP_001 GLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 RTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQE .: . :..::.:. :.. :: . . : .......... .: :. :. . : NP_001 SWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQ-AQGTRERLAQAECVLE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 RLAETDRHTFLA--GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHP .... :.: :. ..:: .: ... : .. .: . . . .. :.:: ::. . : NP_001 QFGNEDHHKFIRFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 VPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHY .: : :::.::: : :: :.: : : : ..:.::: . ::.:..:: : :: NP_001 APEPLKLDPATAHPLLELSKGNTVVQCG-LLAQRRASQPERFDYSTCVLASRGFSCGRHY 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 WEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDK :::::. :..: .:. . .:::::... .: .: . : ...: : : . : . : : . NP_001 WEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGH 350 360 370 380 390 400 420 430 440 450 460 pF1KE1 LDKVGVFLDYDQGLLIFYNAD---DMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLR ..:..: :.:: : :..:: :. ::::. : ::: .. : :.: :. NP_001 PHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCW-HERGSNSLPMV 410 420 430 440 450 460 470 pF1KE1 INTVRI NP_001 LPPPSGPGPLSPEQPTKL 470 480 >>NP_001268380 (OMIM: 612548) E3 ubiquitin-protein ligas (487 aa) initn: 653 init1: 286 opt: 779 Z-score: 523.3 bits: 106.2 E(85289): 2.1e-22 Smith-Waterman score: 779; 29.9% identity (60.7% similar) in 471 aa overlap (5-468:10-468) 10 20 30 40 50 pF1KE1 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRR :.:.: : ::: ....:. : : : .:. :.. . .:. :: ::. NP_001 MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAE--LRCPVCRQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 TFAEPALAPSLKLANIVERYSSFPLDAILNARRAARPCQAH-DKVKLFCLTDRALLCFFC . . :...:: ..: .: : . : : . ..::: :. :.: .: NP_001 AVDGSSSLPNVSLARVIEALR-LPGDP------EPKVCVHHRNPLSLFCEKDQELICGLC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 DEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLKRQLAETKSSTKSL . :..: :: .. .......:: .. :.. ... : . : . .. . . . NP_001 GLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 RTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQE .: . :..::.:. :.. :: . . : .......... .: :. :. . : NP_001 SWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQ-AQGTRERLAQAECVLE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 RLAETDRHTFLA---GVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIH .... :.: :. ..:: .: ... : .. .: . . . .. :.:: ::. . NP_001 QFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 PVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVH :.: : :::.::: : :: :.: : : : ..:.::: . ::.:..:: : : NP_001 PAPEPLKLDPATAHPLLELSKGNTVVQCG-LLAQRRASQPERFDYSTCVLASRGFSCGRH 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 YWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRD ::::::. :..: .:. . .:::::... .: .: . : ...: : : . : . : : NP_001 YWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAG 350 360 370 380 390 400 420 430 440 450 460 pF1KE1 KLDKVGVFLDYDQGLLIFYNAD---DMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPL . ..:..: :.:: : :..:: :. ::::. : ::: .. : :.: :. NP_001 HPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCW-HERGSNSLPM 410 420 430 440 450 460 470 pF1KE1 RINTVRI NP_001 VLPPPSGPGPLSPEQPTKL 470 480 475 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 19:23:29 2016 done: Sun Nov 6 19:23:30 2016 Total Scan time: 9.990 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]