Result of FASTA (omim) for
pFN21AE5343
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5343, 270 aa
1>>>pF1KE5343 270 - 270 aa - 270 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8647+/-0.000285; mu= 17.5153+/- 0.018
mean_var=67.7611+/-13.426, 0's: 0 Z-trim(118.6): 305 B-trim: 0 in 0/56
Lambda= 0.155806
statistics sampled from 31433 (31753) to 31433 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.747), E-opt: 0.2 (0.372), width: 16
Scan time: 5.920
The best scores are: opt bits E(85289)
NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 1067 248.2 1.2e-65
NP_056933 (OMIM: 609444) chymotrypsin-like elastas ( 269) 1024 238.5 9.7e-63
NP_009203 (OMIM: 167800,601405) chymotrypsin-C pre ( 268) 1014 236.3 4.6e-62
NP_001962 (OMIM: 130120) chymotrypsin-like elastas ( 258) 936 218.7 8.5e-57
NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 710 167.9 1.7e-41
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 577 138.1 1.9e-32
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 577 138.1 1.9e-32
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 542 130.3 5.6e-30
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 542 130.3 5.6e-30
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 542 130.3 5.6e-30
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 542 130.3 5.6e-30
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 542 130.3 5.6e-30
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 536 129.0 1.5e-29
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 531 127.8 3e-29
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 524 126.2 7.7e-29
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 524 126.3 9.8e-29
XP_011538852 (OMIM: 167800,601405) PREDICTED: chym ( 280) 516 124.4 2.4e-28
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 513 123.8 5.3e-28
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 513 123.8 5.3e-28
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 512 123.6 5.9e-28
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 512 123.6 6.3e-28
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 512 123.6 6.4e-28
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 513 124.0 7.1e-28
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 513 124.0 7.2e-28
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 513 124.0 7.2e-28
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 505 122.0 1.7e-27
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 505 122.0 1.9e-27
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 505 122.1 2e-27
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 505 122.1 2e-27
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 505 122.1 2.1e-27
NP_001897 (OMIM: 118890) chymotrypsinogen B isofor ( 263) 496 119.8 5.1e-27
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 496 119.9 5.9e-27
NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 500 121.2 7.6e-27
XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 500 121.2 7.7e-27
XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 500 121.2 7.7e-27
XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 500 121.2 7.8e-27
XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 500 121.2 7.9e-27
XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 500 121.2 7.9e-27
XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 500 121.2 7.9e-27
NP_001265514 (OMIM: 605236,614595) atrial natriure ( 938) 496 120.3 1.3e-26
NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 496 120.3 1.5e-26
XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 490 118.7 2.2e-26
XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 490 118.8 2.5e-26
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 490 118.8 2.5e-26
XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 490 118.8 2.5e-26
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 487 117.9 2.6e-26
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 487 117.9 2.6e-26
NP_001182058 (OMIM: 613517,613858) serine protease ( 603) 478 116.1 1.6e-25
NP_059979 (OMIM: 610601) kallikrein-15 isoform 4 p ( 256) 467 113.3 4.6e-25
XP_006723328 (OMIM: 610601) PREDICTED: kallikrein- ( 256) 467 113.3 4.6e-25
>>NP_254275 (OMIM: 609443) chymotrypsin-like elastase fa (269 aa)
initn: 1064 init1: 454 opt: 1067 Z-score: 1299.6 bits: 248.2 E(85289): 1.2e-65
Smith-Waterman score: 1067; 57.6% identity (76.8% similar) in 271 aa overlap (2-270:1-269)
10 20 30 40 50
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRPS-SRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCG
:.: : ::: : . : :. : .:::.::.: : :::::::::: ..:..:::::
NP_254 MIRTLLLSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCG
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 GSLIAPDWVVTAGHCISSSWTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVA
::::: .::.::.:::::: ::.: ::... : :. .. ... . :: :: . ..
NP_254 GSLIANSWVLTAAHCISSSRTYRVGLGRHNLYVAESGSLAVSVSK--IVVHKDWNSNQIS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 CGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEAL
::::::.::. ..: : .::: ::::: ::::. :::.:::::: ::: .:: ::..
NP_254 KGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGR
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 LPVVDYEHCSRWNWWGSSVKKTMVCAGGD-IRSGCNGDSGGPLNCPTEDGGWQVHGVTSF
: :::: :: ::::::: .:.::::: . :.::::::::::: . :: :::::..::
NP_254 LLVVDYATCSSSAWWGSSVKTSMICAGGDGVISSCNGDSGGPLNCQASDGRWQVHGIVSF
180 190 200 210 220 230
240 250 260 270
pF1KE5 VSAFGCNTRRKPTVFTRVSAFIDWIEETIASH
: .::: .::.:::::: .::::. .::..
NP_254 GSRLGCNYYHKPSVFTRVSNYIDWINSVIANN
240 250 260
>>NP_056933 (OMIM: 609444) chymotrypsin-like elastase fa (269 aa)
initn: 1055 init1: 451 opt: 1024 Z-score: 1247.3 bits: 238.5 E(85289): 9.7e-63
Smith-Waterman score: 1024; 54.6% identity (76.0% similar) in 271 aa overlap (2-270:1-269)
10 20 30 40 50
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRPS-SRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCG
:.: : ::: : . : . :. ::...::.: : :::::::::: ..:..:::::
NP_056 MIRTLLLSTLVAGALSCGVSTYAPDMSRMLGGEEARPNSWPWQVSLQYSSNGQWYHTCG
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 GSLIAPDWVVTAGHCISSSWTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVA
::::: .::.::.:::::: :.:.::... : :. .. ... . :: :: . :.
NP_056 GSLIANSWVLTAAHCISSSGIYRVMLGQHNLYVAESGSLAVSVSK--IVVHKDWNSDQVS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 CGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEAL
::::::.::. ..: : .::: ::::: ::::. :::.:::::: ::: ::: :...
NP_056 KGNDIALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGALPDDLKQGR
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 LPVVDYEHCSRWNWWGSSVKKTMVCAGGD-IRSGCNGDSGGPLNCPTEDGGWQVHGVTSF
: :::: :: .::::.:: .:.::::: . ::::::::::: . :: :.:::. :.
NP_056 LLVVDYATCSSSGWWGSTVKTNMICAGGDGVICTCNGDSGGPLNCQASDGRWEVHGIGSL
180 190 200 210 220 230
240 250 260 270
pF1KE5 VSAFGCNTRRKPTVFTRVSAFIDWIEETIASH
.:..::: ::..::::: . :::. .::..
NP_056 TSVLGCNYYYKPSIFTRVSNYNDWINSVIANN
240 250 260
>>NP_009203 (OMIM: 167800,601405) chymotrypsin-C preprop (268 aa)
initn: 1030 init1: 414 opt: 1014 Z-score: 1235.2 bits: 236.3 E(85289): 4.6e-62
Smith-Waterman score: 1014; 55.0% identity (77.0% similar) in 269 aa overlap (2-267:1-266)
10 20 30 40 50
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRP--SSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTC
:: . :.: ::. : :: : :.:::.:::: :.:::::.:::: :. .. :::
NP_009 MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTC
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 GGSLIAPDWVVTAGHCISSSWTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCV
::.::: ..:.::.::::.. ::.:..:. . : : : . .. . :: :: .
NP_009 GGTLIASNFVLTAAHCISNTRTYRVAVGKNNLEV-EDEEGSLFVGVDTIHVHKRWN--AL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 ACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEA
::::::::.. ..:.:..:.: :: ..::.. :::.::::::.::::. ::::..
NP_009 LLRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 LLPVVDYEHCSRWNWWGSSVKKTMVCAGGD-IRSGCNGDSGGPLNCPTEDGGWQVHGVTS
: ::::. ::: .::: ::::::::::: . :.::::::::::: :.:.:.: :..:
NP_009 LQPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVS
180 190 200 210 220 230
240 250 260 270
pF1KE5 FVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH
: : :::::.::.:.:::::.::::.: .
NP_009 FGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL
240 250 260
>>NP_001962 (OMIM: 130120) chymotrypsin-like elastase fa (258 aa)
initn: 959 init1: 578 opt: 936 Z-score: 1140.7 bits: 218.7 E(85289): 8.5e-57
Smith-Waterman score: 936; 55.3% identity (80.5% similar) in 246 aa overlap (26-270:16-258)
10 20 30 40 50 60
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSFYHTCGG
..:::.: .: ::: :.::::...:: ::::::
NP_001 MLVLYGHSTQDLPETNARVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGG
10 20 30 40 50
70 80 90 100 110 120
pF1KE5 SLIAPDWVVTAGHCISSSWTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNRSCVAC
.:: .::.::.::.. . :..:: :... . ..: :: . ... . ::: :: . ::
NP_001 TLIRQNWVMTAAHCVDYQKTFRVVAGDHNLSQNDGTEQYVSVQK--IVVHPYWNSDNVAA
60 70 80 90 100
130 140 150 160 170 180
pF1KE5 GNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPLPDKLQEALL
: ::::..:..:. :.. :::. :: : :: :..::::::::. ::: : . ::.: :
NP_001 GYDIALLRLAQSVTLNSYVQLGVLPQEGAILANNSPCYITGWGKTKTNGQLAQTLQQAYL
110 120 130 140 150 160
190 200 210 220 230
pF1KE5 PVVDYEHCSRWNWWGSSVKKTMVCAGGD-IRSGCNGDSGGPLNCPTEDGGWQVHGVTSFV
: ::: :: ..:::.::.:::::::: .::::.:::::::.: . .: ..::::::::
NP_001 PSVDYAICSSSSYWGSTVKNTMVCAGGDGVRSGCQGDSGGPLHCLV-NGKYSVHGVTSFV
170 180 190 200 210 220
240 250 260 270
pF1KE5 SAFGCNTRRKPTVFTRVSAFIDWIEETIASH
:. :::. :::::::.:::.:.::...:::.
NP_001 SSRGCNVSRKPTVFTQVSAYISWINNVIASN
230 240 250
>>NP_001898 (OMIM: 118888) chymotrypsin-like protease CT (264 aa)
initn: 506 init1: 182 opt: 710 Z-score: 866.0 bits: 167.9 E(85289): 1.7e-41
Smith-Waterman score: 710; 43.2% identity (68.1% similar) in 273 aa overlap (1-268:2-262)
10 20 30 40 50
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRP----SSRVVNGEDAVPYSWPWQVSLQYEKSGSFY
..: : ::.:.. . : : :. .: :.:.::::.:: ::::::::: ..:: .
NP_001 MLLLSLTLSLVLLGSSWGCGIPAIKPALSFSQRIVNGENAVLGSWPWQVSLQ-DSSG--F
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 HTCGGSLIAPDWVVTAGHCISSSWTYQVVLGEYDRAVKEGPEQVIPINSGDLFVHPLWNR
: ::::::. .:::::.:: : . ::::::::. . : ::. .. . ..:: ::
NP_001 HFCGGSLISQSWVVTAAHCNVSPGRHFVVLGEYDRSSNAEPLQVLSVSRA--ITHPSWNS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 SCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRLYTNGPL-PDK
. . .::..:.::. :: .. . : ... : . : :::::: : . : .
NP_001 TTM--NNDVTLLKLASPAQYTTRISPVCLASSNEALTEGLTCVTTGWGRLSGVGNVTPAH
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE5 LQEALLPVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSGGPLNCPTEDGGWQVHG
::.. ::.: ..: . .::::. .:.:::: :.:.::::::: : . . : . :
NP_001 LQQVALPLVTVNQCRQ--YWGSSITDSMICAGGAGASSCQGDSGGPLVCQ-KGNTWVLIG
180 190 200 210 220 230
240 250 260 270
pF1KE5 VTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH
..:. . .::.: :.:.:::: : ::...::
NP_001 IVSWGTK-NCNVR-APAVYTRVSKFSTWINQVIAYN
240 250 260
>>NP_071402 (OMIM: 609343) brain-specific serine proteas (317 aa)
initn: 340 init1: 150 opt: 577 Z-score: 703.3 bits: 138.1 E(85289): 1.9e-32
Smith-Waterman score: 579; 36.7% identity (61.9% similar) in 286 aa overlap (2-267:21-289)
10 20 30
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRPS--SRVVNGEDAVPYS
.: : :. .: :. : ..:. .:::.:::..
NP_071 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
10 20 30 40 50 60
40 50 60 70 80
pF1KE5 WPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHC----ISSSWTYQVVLGEYD------
::: ::.: :.:. : :.:::.. ::.::.:: ... . ..:.:: ..
NP_071 WPWIVSIQ--KNGT--HHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGS
70 80 90 100 110
90 100 110 120 130 140
pF1KE5 RAVKEGPEQVIPINSGDLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGD
:. : : : : ::... . ::. ::::..: :: :... : :: :.
NP_071 RSQKVGVAWVEP--------HPVYSWKEGACA-DIALVRLERSIQFSERVLPICLPDASI
120 130 140 150 160
150 160 170 180 190 200
pF1KE5 ILPNETPCYITGWGRLYTNGPLP--DKLQEALLPVVDYEHCSRWNWWGSS---VKKTMVC
:: .: :.:.::: . . ::: . ::. .:..: : ::. : :.. . . :.:
NP_071 HLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLC
170 180 190 200 210 220
210 220 230 240 250 260
pF1KE5 AG---GDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFID
:: :. :..: ::::::: : . ::.: . :. :. . :: : .: :. .:: .
NP_071 AGYLEGE-RDACLGDSGGPLMCQV-DGAWLLAGIISW--GEGCAERNRPGVYISLSAHRS
230 240 250 260 270 280
270
pF1KE5 WIEETIASH
:.:. .
NP_071 WVEKIVQGVQLRGRAQGGGALRAPSQGSGAAARS
290 300 310
>>XP_005255530 (OMIM: 609343) PREDICTED: brain-specific (317 aa)
initn: 340 init1: 150 opt: 577 Z-score: 703.3 bits: 138.1 E(85289): 1.9e-32
Smith-Waterman score: 579; 36.7% identity (61.9% similar) in 286 aa overlap (2-267:21-289)
10 20 30
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRPS--SRVVNGEDAVPYS
.: : :. .: :. : ..:. .:::.:::..
XP_005 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
10 20 30 40 50 60
40 50 60 70 80
pF1KE5 WPWQVSLQYEKSGSFYHTCGGSLIAPDWVVTAGHC----ISSSWTYQVVLGEYD------
::: ::.: :.:. : :.:::.. ::.::.:: ... . ..:.:: ..
XP_005 WPWIVSIQ--KNGT--HHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGS
70 80 90 100 110
90 100 110 120 130 140
pF1KE5 RAVKEGPEQVIPINSGDLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGD
:. : : : : ::... . ::. ::::..: :: :... : :: :.
XP_005 RSQKVGVAWVEP--------HPVYSWKEGACA-DIALVRLERSIQFSERVLPICLPDASI
120 130 140 150 160
150 160 170 180 190 200
pF1KE5 ILPNETPCYITGWGRLYTNGPLP--DKLQEALLPVVDYEHCSRWNWWGSS---VKKTMVC
:: .: :.:.::: . . ::: . ::. .:..: : ::. : :.. . . :.:
XP_005 HLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLC
170 180 190 200 210 220
210 220 230 240 250 260
pF1KE5 AG---GDIRSGCNGDSGGPLNCPTEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFID
:: :. :..: ::::::: : . ::.: . :. :. . :: : .: :. .:: .
XP_005 AGYLEGE-RDACLGDSGGPLMCQV-DGAWLLAGIISW--GEGCAERNRPGVYISLSAHRS
230 240 250 260 270 280
270
pF1KE5 WIEETIASH
:.:. .
XP_005 WVEKIVQGVQLRGRAQGGGALRAPSQGSGAAARS
290 300 310
>>NP_892028 (OMIM: 142440) serine protease hepsin precur (417 aa)
initn: 360 init1: 219 opt: 542 Z-score: 659.2 bits: 130.3 E(85289): 5.6e-30
Smith-Waterman score: 542; 36.0% identity (60.5% similar) in 261 aa overlap (25-270:159-407)
10 20 30 40 50
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSF
: .:.:.:.:. :::::::.:. .
NP_892 QRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGA---
130 140 150 160 170 180
60 70 80 90 100
pF1KE5 YHTCGGSLIAPDWVVTAGHC------ISSSWTYQVVLGEYDRAVKEGPE---QVIPINSG
: :::::.. :::.::.:: . : : .: : .: .: . :.. ..:
NP_892 -HLCGGSLLSGDWVLTAAHCFPERNRVLSRW--RVFAGAVAQASPHGLQLGVQAVVYHGG
190 200 210 220 230 240
110 120 130 140 150 160
pF1KE5 DLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRL
: :. . . .:::::..:: : . .: . :: ::. : . : .::::
NP_892 YL---PFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNT
250 260 270 280 290
170 180 190 200 210 220
pF1KE5 YTNGPLPDKLQEALLPVVDYEHCSRWNWWGSSVKKTMVCAG---GDIRSGCNGDSGGPLN
: :::: .:... . :. ...:...: : ::: : : ..:.::::::.
NP_892 QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGI-DACQGDSGGPFV
300 310 320 330 340 350
230 240 250 260 270
pF1KE5 CP---TEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH
: .. :.. :..:. . :: .:: :.:.:: : .:: ..: .:
NP_892 CEDSISRTPRWRLCGIVSWGT--GCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQ
360 370 380 390 400 410
NP_892 L
>>NP_002142 (OMIM: 142440) serine protease hepsin precur (417 aa)
initn: 360 init1: 219 opt: 542 Z-score: 659.2 bits: 130.3 E(85289): 5.6e-30
Smith-Waterman score: 542; 36.0% identity (60.5% similar) in 261 aa overlap (25-270:159-407)
10 20 30 40 50
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSF
: .:.:.:.:. :::::::.:. .
NP_002 QRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGA---
130 140 150 160 170 180
60 70 80 90 100
pF1KE5 YHTCGGSLIAPDWVVTAGHC------ISSSWTYQVVLGEYDRAVKEGPE---QVIPINSG
: :::::.. :::.::.:: . : : .: : .: .: . :.. ..:
NP_002 -HLCGGSLLSGDWVLTAAHCFPERNRVLSRW--RVFAGAVAQASPHGLQLGVQAVVYHGG
190 200 210 220 230 240
110 120 130 140 150 160
pF1KE5 DLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRL
: :. . . .:::::..:: : . .: . :: ::. : . : .::::
NP_002 YL---PFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNT
250 260 270 280 290
170 180 190 200 210 220
pF1KE5 YTNGPLPDKLQEALLPVVDYEHCSRWNWWGSSVKKTMVCAG---GDIRSGCNGDSGGPLN
: :::: .:... . :. ...:...: : ::: : : ..:.::::::.
NP_002 QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGI-DACQGDSGGPFV
300 310 320 330 340 350
230 240 250 260 270
pF1KE5 CP---TEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH
: .. :.. :..:. . :: .:: :.:.:: : .:: ..: .:
NP_002 CEDSISRTPRWRLCGIVSWGT--GCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQ
360 370 380 390 400 410
NP_002 L
>>XP_016882220 (OMIM: 142440) PREDICTED: serine protease (417 aa)
initn: 360 init1: 219 opt: 542 Z-score: 659.2 bits: 130.3 E(85289): 5.6e-30
Smith-Waterman score: 542; 36.0% identity (60.5% similar) in 261 aa overlap (25-270:159-407)
10 20 30 40 50
pF1KE5 MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQVSLQYEKSGSF
: .:.:.:.:. :::::::.:. .
XP_016 QRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGA---
130 140 150 160 170 180
60 70 80 90 100
pF1KE5 YHTCGGSLIAPDWVVTAGHC------ISSSWTYQVVLGEYDRAVKEGPE---QVIPINSG
: :::::.. :::.::.:: . : : .: : .: .: . :.. ..:
XP_016 -HLCGGSLLSGDWVLTAAHCFPERNRVLSRW--RVFAGAVAQASPHGLQLGVQAVVYHGG
190 200 210 220 230 240
110 120 130 140 150 160
pF1KE5 DLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYITGWGRL
: :. . . .:::::..:: : . .: . :: ::. : . : .::::
XP_016 YL---PFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNT
250 260 270 280 290
170 180 190 200 210 220
pF1KE5 YTNGPLPDKLQEALLPVVDYEHCSRWNWWGSSVKKTMVCAG---GDIRSGCNGDSGGPLN
: :::: .:... . :. ...:...: : ::: : : ..:.::::::.
XP_016 QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGI-DACQGDSGGPFV
300 310 320 330 340 350
230 240 250 260 270
pF1KE5 CP---TEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH
: .. :.. :..:. . :: .:: :.:.:: : .:: ..: .:
XP_016 CEDSISRTPRWRLCGIVSWGT--GCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQ
360 370 380 390 400 410
XP_016 L
270 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 23:57:20 2016 done: Mon Nov 7 23:57:21 2016
Total Scan time: 5.920 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]