FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4024, 227 aa 1>>>pF1KE4024 227 - 227 aa - 227 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6632+/-0.000335; mu= 13.7782+/- 0.021 mean_var=125.4282+/-26.324, 0's: 0 Z-trim(119.0): 96 B-trim: 949 in 1/49 Lambda= 0.114519 statistics sampled from 32393 (32520) to 32393 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.381), width: 16 Scan time: 6.420 The best scores are: opt bits E(85289) NP_061935 (OMIM: 617163) RING finger protein 186 [ ( 227) 1569 269.7 2.8e-72 XP_005266709 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025 XP_005266707 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025 XP_011524181 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025 XP_016881102 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025 XP_011524180 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025 NP_775828 (OMIM: 616512) E3 ubiquitin-protein liga ( 203) 202 43.8 0.00025 XP_016881101 (OMIM: 616512) PREDICTED: E3 ubiquiti ( 203) 202 43.8 0.00025 XP_016872587 (OMIM: 605493) PREDICTED: tripartite ( 744) 179 40.7 0.0081 NP_001234935 (OMIM: 605493) tripartite motif-conta ( 744) 179 40.7 0.0081 NP_006449 (OMIM: 605493) tripartite motif-containi ( 744) 179 40.7 0.0081 NP_150594 (OMIM: 605493) tripartite motif-containi ( 744) 179 40.7 0.0081 XP_011518146 (OMIM: 605493) PREDICTED: tripartite ( 744) 179 40.7 0.0081 >>NP_061935 (OMIM: 617163) RING finger protein 186 [Homo (227 aa) initn: 1569 init1: 1569 opt: 1569 Z-score: 1418.7 bits: 269.7 E(85289): 2.8e-72 Smith-Waterman score: 1569; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227) 10 20 30 40 50 60 pF1KE4 MACTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MACTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 AFCAICLKLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 AFCAICLKLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 QGLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 QGLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRW 130 140 150 160 170 180 190 200 210 220 pF1KE4 VLTFIIALALLMSTLFCCLPSTRGSCWPSSRTLFCREQKHSHISSIA ::::::::::::::::::::::::::::::::::::::::::::::: NP_061 VLTFIIALALLMSTLFCCLPSTRGSCWPSSRTLFCREQKHSHISSIA 190 200 210 220 >>XP_005266709 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025 Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84) 10 20 30 40 50 60 pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF : . ::: .: . :: : :::: :.:. XP_005 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC 10 20 30 70 80 90 100 110 120 pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ :..::. . : . . :: :: :: .: :. . .: : :.. .: : : XP_005 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV XP_005 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV 100 110 120 130 140 150 >>XP_005266707 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025 Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84) 10 20 30 40 50 60 pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF : . ::: .: . :: : :::: :.:. XP_005 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC 10 20 30 70 80 90 100 110 120 pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ :..::. . : . . :: :: :: .: :. . .: : :.. .: : : XP_005 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV XP_005 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV 100 110 120 130 140 150 >>XP_011524181 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025 Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84) 10 20 30 40 50 60 pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF : . ::: .: . :: : :::: :.:. XP_011 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC 10 20 30 70 80 90 100 110 120 pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ :..::. . : . . :: :: :: .: :. . .: : :.. .: : : XP_011 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV XP_011 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV 100 110 120 130 140 150 >>XP_016881102 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025 Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84) 10 20 30 40 50 60 pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF : . ::: .: . :: : :::: :.:. XP_016 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC 10 20 30 70 80 90 100 110 120 pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ :..::. . : . . :: :: :: .: :. . .: : :.. .: : : XP_016 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV XP_016 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV 100 110 120 130 140 150 >>XP_011524180 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025 Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84) 10 20 30 40 50 60 pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF : . ::: .: . :: : :::: :.:. XP_011 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC 10 20 30 70 80 90 100 110 120 pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ :..::. . : . . :: :: :: .: :. . .: : :.. .: : : XP_011 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV XP_011 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV 100 110 120 130 140 150 >>NP_775828 (OMIM: 616512) E3 ubiquitin-protein ligase R (203 aa) initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025 Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84) 10 20 30 40 50 60 pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF : . ::: .: . :: : :::: :.:. NP_775 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC 10 20 30 70 80 90 100 110 120 pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ :..::. . : . . :: :: :: .: :. . .: : :.. .: : : NP_775 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV NP_775 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV 100 110 120 130 140 150 >>XP_016881101 (OMIM: 616512) PREDICTED: E3 ubiquitin-pr (203 aa) initn: 182 init1: 129 opt: 202 Z-score: 198.7 bits: 43.8 E(85289): 0.00025 Smith-Waterman score: 202; 38.6% identity (60.2% similar) in 83 aa overlap (33-114:5-84) 10 20 30 40 50 60 pF1KE4 CTKTLQQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAF : . ::: .: . :: : :::: :.:. XP_016 METLSQDSLLECQICFNYYSPRRRPKLLDCKHTC 10 20 30 70 80 90 100 110 120 pF1KE4 CAICLKLLLCVQDNTWSITCPLCRKVTAVPGGL-ICSLRDHEAVVGQLAQPCTEVSLCPQ :..::. . : . . :: :: :: .: :. . .: : :.. .: : : XP_016 CSVCLQQMRTSQKD---VRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 GLVDPADLAAGHPSLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWV XP_016 IKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAV 100 110 120 130 140 150 >>XP_016872587 (OMIM: 605493) PREDICTED: tripartite moti (744 aa) initn: 127 init1: 83 opt: 179 Z-score: 171.6 bits: 40.7 E(85289): 0.0081 Smith-Waterman score: 180; 30.1% identity (58.4% similar) in 113 aa overlap (38-149:20-118) 10 20 30 40 50 60 pF1KE4 QQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAFCAICL : : .: . :.:: :.: : :.:: :: XP_016 MAKREDSPGPEVQPMDKQFLVCSICLDRYQCP---KVLPCLHTFCERCL 10 20 30 40 70 80 90 100 110 120 pF1KE4 KLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCPQGLVDPA . . .: . ...::.::... .: . .:... ...: . .. :.: :: XP_016 QNYIPAQ--SLTLSCPVCRQTSILPEQGVSALQNNF-FISSLMEAMQQA---PDGAHDPE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 DLAAGHP-SLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWVLTFII : :: :.:. :. :: XP_016 D---PHPLSVVA--GRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVV 110 120 130 140 150 >>NP_001234935 (OMIM: 605493) tripartite motif-containin (744 aa) initn: 127 init1: 83 opt: 179 Z-score: 171.6 bits: 40.7 E(85289): 0.0081 Smith-Waterman score: 180; 30.1% identity (58.4% similar) in 113 aa overlap (38-149:20-118) 10 20 30 40 50 60 pF1KE4 QQSQPISAGATTTTTAVAPAGGHSGSTECDLECLVCREPYSCPRLPKLLACQHAFCAICL : : .: . :.:: :.: : :.:: :: NP_001 MAKREDSPGPEVQPMDKQFLVCSICLDRYQCP---KVLPCLHTFCERCL 10 20 30 40 70 80 90 100 110 120 pF1KE4 KLLLCVQDNTWSITCPLCRKVTAVPGGLICSLRDHEAVVGQLAQPCTEVSLCPQGLVDPA . . .: . ...::.::... .: . .:... ...: . .. :.: :: NP_001 QNYIPAQ--SLTLSCPVCRQTSILPEQGVSALQNNF-FISSLMEAMQQA---PDGAHDPE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE4 DLAAGHP-SLVGEDGQDEVSANHVAARRLAAHLLLLALLIILIGPFIYPGVLRWVLTFII : :: :.:. :. :: NP_001 D---PHPLSVVA--GRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVV 110 120 130 140 150 227 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 03:25:50 2016 done: Sun Nov 6 03:25:51 2016 Total Scan time: 6.420 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]