Result of FASTA (omim) for
pFN21AE5747
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5747, 638 aa
1>>>pF1KE5747 638 - 638 aa - 638 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5134+/-0.000289; mu= 11.3864+/- 0.018
mean_var=150.2313+/-30.052, 0's: 0 Z-trim(122.7): 45 B-trim: 52 in 1/60
Lambda= 0.104639
statistics sampled from 41332 (41377) to 41332 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.485), width: 16
Scan time: 13.120
The best scores are: opt bits E(85289)
XP_011540235 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 4455 684.0 4.3e-196
XP_011540234 (OMIM: 601328) PREDICTED: amiloride-s ( 638) 4455 684.0 4.3e-196
XP_016857529 (OMIM: 601328) PREDICTED: amiloride-s ( 764) 4455 684.1 5e-196
XP_011540208 (OMIM: 601328) PREDICTED: amiloride-s ( 816) 4455 684.1 5.2e-196
XP_011540231 (OMIM: 601328) PREDICTED: amiloride-s ( 696) 4319 663.5 7e-190
XP_011540227 (OMIM: 601328) PREDICTED: amiloride-s ( 704) 4319 663.5 7.1e-190
XP_016857533 (OMIM: 601328) PREDICTED: amiloride-s ( 732) 4319 663.5 7.3e-190
XP_011540222 (OMIM: 601328) PREDICTED: amiloride-s ( 736) 4319 663.5 7.3e-190
XP_016857532 (OMIM: 601328) PREDICTED: amiloride-s ( 749) 4319 663.5 7.4e-190
XP_016857531 (OMIM: 601328) PREDICTED: amiloride-s ( 757) 4319 663.5 7.5e-190
XP_016857530 (OMIM: 601328) PREDICTED: amiloride-s ( 760) 4319 663.5 7.5e-190
XP_011540210 (OMIM: 601328) PREDICTED: amiloride-s ( 795) 4319 663.5 7.8e-190
NP_001123885 (OMIM: 601328) amiloride-sensitive so ( 802) 4319 663.5 7.8e-190
XP_016857528 (OMIM: 601328) PREDICTED: amiloride-s ( 810) 4319 663.5 7.9e-190
XP_011540207 (OMIM: 601328) PREDICTED: amiloride-s ( 827) 4319 663.6 8e-190
XP_016857527 (OMIM: 601328) PREDICTED: amiloride-s ( 846) 4319 663.6 8.2e-190
XP_011540204 (OMIM: 601328) PREDICTED: amiloride-s ( 851) 4319 663.6 8.2e-190
XP_011540203 (OMIM: 601328) PREDICTED: amiloride-s ( 859) 4319 663.6 8.3e-190
XP_016857526 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 4319 663.6 8.5e-190
XP_011540201 (OMIM: 601328) PREDICTED: amiloride-s ( 895) 4319 663.6 8.5e-190
NP_001029 (OMIM: 264350,600228,613021) amiloride-s ( 669) 1196 192.0 5.7e-48
NP_001153047 (OMIM: 264350,600228,613021) amilorid ( 692) 1196 192.0 5.8e-48
NP_001153048 (OMIM: 264350,600228,613021) amilorid ( 728) 1196 192.1 6.1e-48
NP_001030 (OMIM: 177200,264350,600761,613071) amil ( 649) 928 151.6 8.4e-36
NP_000327 (OMIM: 177200,211400,264350,600760) amil ( 640) 858 141.0 1.3e-32
XP_011544216 (OMIM: 177200,211400,264350,600760) P ( 646) 858 141.0 1.3e-32
XP_011544215 (OMIM: 177200,211400,264350,600760) P ( 651) 858 141.0 1.3e-32
XP_016879014 (OMIM: 177200,211400,264350,600760) P ( 659) 858 141.0 1.3e-32
XP_016879015 (OMIM: 177200,211400,264350,600760) P ( 623) 570 97.5 1.5e-19
NP_061144 (OMIM: 606715) acid-sensing ion channel ( 666) 278 53.4 3e-06
XP_016859928 (OMIM: 606715) PREDICTED: acid-sensin ( 320) 266 51.4 5.8e-06
NP_004760 (OMIM: 611741) acid-sensing ion channel ( 531) 264 51.3 1.1e-05
NP_064718 (OMIM: 611741) acid-sensing ion channel ( 543) 264 51.3 1.1e-05
NP_064717 (OMIM: 611741) acid-sensing ion channel ( 549) 264 51.3 1.1e-05
NP_059115 (OMIM: 616693) acid-sensing ion channel ( 505) 259 50.5 1.7e-05
NP_064423 (OMIM: 602866) acid-sensing ion channel ( 574) 257 50.2 2.4e-05
NP_878267 (OMIM: 606715) acid-sensing ion channel ( 647) 249 49.1 6e-05
NP_001085 (OMIM: 601784) acid-sensing ion channel ( 512) 247 48.7 6.1e-05
NP_899233 (OMIM: 601784) acid-sensing ion channel ( 563) 247 48.7 6.6e-05
XP_016863780 (OMIM: 616693) PREDICTED: acid-sensin ( 463) 240 47.6 0.00012
>>XP_011540235 (OMIM: 601328) PREDICTED: amiloride-sensi (638 aa)
initn: 4455 init1: 4455 opt: 4455 Z-score: 3641.5 bits: 684.0 E(85289): 4.3e-196
Smith-Waterman score: 4455; 100.0% identity (100.0% similar) in 638 aa overlap (1-638:1-638)
10 20 30 40 50 60
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 LALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 THGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEY
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 CSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 TLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 LSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSD
550 560 570 580 590 600
610 620 630
pF1KE5 DPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
::::::::::::::::::::::::::::::::::::::
XP_011 DPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
610 620 630
>>XP_011540234 (OMIM: 601328) PREDICTED: amiloride-sensi (638 aa)
initn: 4455 init1: 4455 opt: 4455 Z-score: 3641.5 bits: 684.0 E(85289): 4.3e-196
Smith-Waterman score: 4455; 100.0% identity (100.0% similar) in 638 aa overlap (1-638:1-638)
10 20 30 40 50 60
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPGPPSAPPPPPKEGHQEGLVELPASFRELL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFERHWHRPVLMAVS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLSKGRAALSATVPR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHFHYVDI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 LALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LALLPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 THGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THGVGLVLRVEQQPHLPLLSTLAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEY
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 CSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 TLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 LSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSLLELLELLLDASALTLVLGGRRLRRAWFSWPRASPASGASSIKPEASQMPPPAGGTSD
550 560 570 580 590 600
610 620 630
pF1KE5 DPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
::::::::::::::::::::::::::::::::::::::
XP_011 DPEPSGPHLPRVMLPGVLAGVSAEESWAGPQPLETLDT
610 620 630
>>XP_016857529 (OMIM: 601328) PREDICTED: amiloride-sensi (764 aa)
initn: 4455 init1: 4455 opt: 4455 Z-score: 3640.3 bits: 684.1 E(85289): 5e-196
Smith-Waterman score: 4455; 100.0% identity (100.0% similar) in 638 aa overlap (1-638:127-764)
10 20 30
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPR
::::::::::::::::::::::::::::::
XP_016 EDVTGGSCFLPEPAGGQRLHPASELPAAPAMAEHRSMDGRMEAATRGGSHLQAAAQTPPR
100 110 120 130 140 150
40 50 60 70 80 90
pF1KE5 PGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL
160 170 180 190 200 210
100 110 120 130 140 150
pF1KE5 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL
220 230 240 250 260 270
160 170 180 190 200 210
pF1KE5 LDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLC
280 290 300 310 320 330
220 230 240 250 260 270
pF1KE5 NSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDC
340 350 360 370 380 390
280 290 300 310 320 330
pF1KE5 QARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVH
400 410 420 430 440 450
340 350 360 370 380 390
pF1KE5 GRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQ
460 470 480 490 500 510
400 410 420 430 440 450
pF1KE5 ACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSR
520 530 540 550 560 570
460 470 480 490 500 510
pF1KE5 CPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNY
580 590 600 610 620 630
520 530 540 550 560 570
pF1KE5 RSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWF
640 650 660 670 680 690
580 590 600 610 620 630
pF1KE5 SWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGP
700 710 720 730 740 750
pF1KE5 QPLETLDT
::::::::
XP_016 QPLETLDT
760
>>XP_011540208 (OMIM: 601328) PREDICTED: amiloride-sensi (816 aa)
initn: 4455 init1: 4455 opt: 4455 Z-score: 3639.9 bits: 684.1 E(85289): 5.2e-196
Smith-Waterman score: 4455; 100.0% identity (100.0% similar) in 638 aa overlap (1-638:179-816)
10 20 30
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPR
::::::::::::::::::::::::::::::
XP_011 TSPVAAASFQSRQAGGQRLHPASELPAAPAMAEHRSMDGRMEAATRGGSHLQAAAQTPPR
150 160 170 180 190 200
40 50 60 70 80 90
pF1KE5 PGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGPPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGL
210 220 230 240 250 260
100 110 120 130 140 150
pF1KE5 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSLGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLEL
270 280 290 300 310 320
160 170 180 190 200 210
pF1KE5 LDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDEFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLC
330 340 350 360 370 380
220 230 240 250 260 270
pF1KE5 NSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSTGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDC
390 400 410 420 430 440
280 290 300 310 320 330
pF1KE5 QARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVH
450 460 470 480 490 500
340 350 360 370 380 390
pF1KE5 GRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQ
510 520 530 540 550 560
400 410 420 430 440 450
pF1KE5 ACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSR
570 580 590 600 610 620
460 470 480 490 500 510
pF1KE5 CPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNY
630 640 650 660 670 680
520 530 540 550 560 570
pF1KE5 RSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWF
690 700 710 720 730 740
580 590 600 610 620 630
pF1KE5 SWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGP
750 760 770 780 790 800
pF1KE5 QPLETLDT
::::::::
XP_011 QPLETLDT
810
>>XP_011540231 (OMIM: 601328) PREDICTED: amiloride-sensi (696 aa)
initn: 4314 init1: 4314 opt: 4319 Z-score: 3530.0 bits: 663.5 E(85289): 7e-190
Smith-Waterman score: 4319; 97.8% identity (98.4% similar) in 636 aa overlap (3-638:66-696)
10 20 30
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPG
.:: . .:: . : :::::::::::
XP_011 AGRMDTLPYLPLGRSPGPVAPQRPCHLKGWQHRPT--QHNAACKQG---QAAAQTPPRPG
40 50 60 70 80 90
40 50 60 70 80 90
pF1KE5 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE5 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE5 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE5 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE5 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE5 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE5 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE5 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE5 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE5 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
640 650 660 670 680 690
pF1KE5 LETLDT
::::::
XP_011 LETLDT
>>XP_011540227 (OMIM: 601328) PREDICTED: amiloride-sensi (704 aa)
initn: 4314 init1: 4314 opt: 4319 Z-score: 3529.9 bits: 663.5 E(85289): 7.1e-190
Smith-Waterman score: 4319; 97.8% identity (98.4% similar) in 636 aa overlap (3-638:74-704)
10 20 30
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPG
.:: . .:: . : :::::::::::
XP_011 GEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPT--QHNAACKQG---QAAAQTPPRPG
50 60 70 80 90
40 50 60 70 80 90
pF1KE5 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
100 110 120 130 140 150
100 110 120 130 140 150
pF1KE5 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
160 170 180 190 200 210
160 170 180 190 200 210
pF1KE5 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
220 230 240 250 260 270
220 230 240 250 260 270
pF1KE5 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
280 290 300 310 320 330
280 290 300 310 320 330
pF1KE5 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
340 350 360 370 380 390
340 350 360 370 380 390
pF1KE5 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE5 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
460 470 480 490 500 510
460 470 480 490 500 510
pF1KE5 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
520 530 540 550 560 570
520 530 540 550 560 570
pF1KE5 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
580 590 600 610 620 630
580 590 600 610 620 630
pF1KE5 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
640 650 660 670 680 690
pF1KE5 LETLDT
::::::
XP_011 LETLDT
700
>>XP_016857533 (OMIM: 601328) PREDICTED: amiloride-sensi (732 aa)
initn: 4314 init1: 4314 opt: 4319 Z-score: 3529.7 bits: 663.5 E(85289): 7.3e-190
Smith-Waterman score: 4319; 97.8% identity (98.4% similar) in 636 aa overlap (3-638:102-732)
10 20 30
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPG
.:: . .:: . : :::::::::::
XP_016 GEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPT--QHNAACKQG---QAAAQTPPRPG
80 90 100 110 120
40 50 60 70 80 90
pF1KE5 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
130 140 150 160 170 180
100 110 120 130 140 150
pF1KE5 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE5 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
250 260 270 280 290 300
220 230 240 250 260 270
pF1KE5 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
310 320 330 340 350 360
280 290 300 310 320 330
pF1KE5 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
370 380 390 400 410 420
340 350 360 370 380 390
pF1KE5 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
430 440 450 460 470 480
400 410 420 430 440 450
pF1KE5 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
490 500 510 520 530 540
460 470 480 490 500 510
pF1KE5 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
550 560 570 580 590 600
520 530 540 550 560 570
pF1KE5 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
610 620 630 640 650 660
580 590 600 610 620 630
pF1KE5 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
670 680 690 700 710 720
pF1KE5 LETLDT
::::::
XP_016 LETLDT
730
>>XP_011540222 (OMIM: 601328) PREDICTED: amiloride-sensi (736 aa)
initn: 4314 init1: 4314 opt: 4319 Z-score: 3529.6 bits: 663.5 E(85289): 7.3e-190
Smith-Waterman score: 4319; 97.8% identity (98.4% similar) in 636 aa overlap (3-638:106-736)
10 20 30
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPG
.:: . .:: . : :::::::::::
XP_011 GEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPT--QHNAACKQG---QAAAQTPPRPG
80 90 100 110 120 130
40 50 60 70 80 90
pF1KE5 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
140 150 160 170 180 190
100 110 120 130 140 150
pF1KE5 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
200 210 220 230 240 250
160 170 180 190 200 210
pF1KE5 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE5 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
320 330 340 350 360 370
280 290 300 310 320 330
pF1KE5 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
380 390 400 410 420 430
340 350 360 370 380 390
pF1KE5 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
440 450 460 470 480 490
400 410 420 430 440 450
pF1KE5 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
500 510 520 530 540 550
460 470 480 490 500 510
pF1KE5 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
560 570 580 590 600 610
520 530 540 550 560 570
pF1KE5 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
620 630 640 650 660 670
580 590 600 610 620 630
pF1KE5 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
680 690 700 710 720 730
pF1KE5 LETLDT
::::::
XP_011 LETLDT
>>XP_016857532 (OMIM: 601328) PREDICTED: amiloride-sensi (749 aa)
initn: 4314 init1: 4314 opt: 4319 Z-score: 3529.5 bits: 663.5 E(85289): 7.4e-190
Smith-Waterman score: 4319; 97.8% identity (98.4% similar) in 636 aa overlap (3-638:119-749)
10 20 30
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPG
.:: . .:: . : :::::::::::
XP_016 GEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPT--QHNAACKQG---QAAAQTPPRPG
90 100 110 120 130 140
40 50 60 70 80 90
pF1KE5 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
150 160 170 180 190 200
100 110 120 130 140 150
pF1KE5 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
210 220 230 240 250 260
160 170 180 190 200 210
pF1KE5 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
270 280 290 300 310 320
220 230 240 250 260 270
pF1KE5 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
330 340 350 360 370 380
280 290 300 310 320 330
pF1KE5 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
390 400 410 420 430 440
340 350 360 370 380 390
pF1KE5 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
450 460 470 480 490 500
400 410 420 430 440 450
pF1KE5 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
510 520 530 540 550 560
460 470 480 490 500 510
pF1KE5 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
570 580 590 600 610 620
520 530 540 550 560 570
pF1KE5 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
630 640 650 660 670 680
580 590 600 610 620 630
pF1KE5 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
690 700 710 720 730 740
pF1KE5 LETLDT
::::::
XP_016 LETLDT
>>XP_016857531 (OMIM: 601328) PREDICTED: amiloride-sensi (757 aa)
initn: 4314 init1: 4314 opt: 4319 Z-score: 3529.4 bits: 663.5 E(85289): 7.5e-190
Smith-Waterman score: 4319; 97.8% identity (98.4% similar) in 636 aa overlap (3-638:127-757)
10 20 30
pF1KE5 MAEHRSMDGRMEAATRGGSHLQAAAQTPPRPG
.:: . .:: . : :::::::::::
XP_016 GEWKQPHGGALTSRSPGPVAPQRPCHLKGWQHRPT--QHNAACKQG---QAAAQTPPRPG
100 110 120 130 140 150
40 50 60 70 80 90
pF1KE5 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPSAPPPPPKEGHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLS
160 170 180 190 200 210
100 110 120 130 140 150
pF1KE5 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLD
220 230 240 250 260 270
160 170 180 190 200 210
pF1KE5 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFARENIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNS
280 290 300 310 320 330
220 230 240 250 260 270
pF1KE5 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGGDCFYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSYDGLDCQA
340 350 360 370 380 390
280 290 300 310 320 330
pF1KE5 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVHGR
400 410 420 430 440 450
340 350 360 370 380 390
pF1KE5 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGVEVELLHNTSYTRQAC
460 470 480 490 500 510
400 410 420 430 440 450
pF1KE5 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCP
520 530 540 550 560 570
460 470 480 490 500 510
pF1KE5 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPCRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRS
580 590 600 610 620 630
520 530 540 550 560 570
pF1KE5 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRRAWFSW
640 650 660 670 680 690
580 590 600 610 620 630
pF1KE5 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEESWAGPQP
700 710 720 730 740 750
pF1KE5 LETLDT
::::::
XP_016 LETLDT
638 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:19:45 2016 done: Tue Nov 8 06:19:46 2016
Total Scan time: 13.120 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]