FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6463, 500 aa 1>>>pF1KE6463 500 - 500 aa - 500 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9259+/-0.000418; mu= 20.1799+/- 0.026 mean_var=61.3032+/-12.697, 0's: 0 Z-trim(110.6): 97 B-trim: 549 in 2/48 Lambda= 0.163807 statistics sampled from 18820 (18975) to 18820 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.583), E-opt: 0.2 (0.222), width: 16 Scan time: 7.490 The best scores are: opt bits E(85289) NP_995322 (OMIM: 113750,609802) sodium/potassium/c ( 500) 3315 792.3 0 XP_016877568 (OMIM: 113750,609802) PREDICTED: sodi ( 314) 1789 431.6 1.6e-120 XP_016877569 (OMIM: 113750,609802) PREDICTED: sodi ( 314) 1789 431.6 1.6e-120 XP_011534743 (OMIM: 210750,609840,615887) PREDICTE ( 316) 684 170.4 6.6e-42 XP_011534744 (OMIM: 210750,609840,615887) PREDICTE ( 316) 684 170.4 6.6e-42 XP_011534742 (OMIM: 210750,609840,615887) PREDICTE ( 372) 684 170.5 7.5e-42 NP_065740 (OMIM: 609839) sodium/potassium/calcium ( 644) 631 158.1 6.9e-38 NP_705934 (OMIM: 210750,609840,615887) sodium/pota ( 558) 616 154.5 7.2e-37 NP_705932 (OMIM: 210750,609840,615887) sodium/pota ( 622) 616 154.6 7.8e-37 XP_011534740 (OMIM: 210750,609840,615887) PREDICTE ( 645) 616 154.6 8.1e-37 XP_011534738 (OMIM: 210750,609840,615887) PREDICTE ( 669) 616 154.6 8.3e-37 NP_705933 (OMIM: 210750,609840,615887) sodium/pota ( 603) 609 152.9 2.4e-36 XP_011534741 (OMIM: 210750,609840,615887) PREDICTE ( 626) 609 152.9 2.5e-36 XP_011534739 (OMIM: 210750,609840,615887) PREDICTE ( 650) 609 152.9 2.6e-36 NP_001180217 (OMIM: 609838) sodium/potassium/calci ( 644) 593 149.1 3.5e-35 XP_016870082 (OMIM: 609838) PREDICTED: sodium/pota ( 644) 593 149.1 3.5e-35 XP_006716813 (OMIM: 609838) PREDICTED: sodium/pota ( 644) 593 149.1 3.5e-35 XP_005251482 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 593 149.1 3.6e-35 XP_005251483 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 593 149.1 3.6e-35 NP_065077 (OMIM: 609838) sodium/potassium/calcium ( 661) 593 149.1 3.6e-35 XP_016870081 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 593 149.1 3.6e-35 XP_006720831 (OMIM: 603617,613830) PREDICTED: sodi ( 985) 568 143.3 3e-33 XP_011520528 (OMIM: 603617,613830) PREDICTED: sodi ( 688) 564 142.3 4.3e-33 XP_005254838 (OMIM: 603617,613830) PREDICTED: sodi ( 717) 564 142.3 4.4e-33 NP_001287962 (OMIM: 603617,613830) sodium/potassiu (1012) 565 142.6 4.9e-33 XP_011520522 (OMIM: 603617,613830) PREDICTED: sodi (1081) 565 142.7 5.2e-33 NP_001287961 (OMIM: 603617,613830) sodium/potassiu (1081) 565 142.7 5.2e-33 XP_016878214 (OMIM: 603617,613830) PREDICTED: sodi ( 966) 564 142.4 5.6e-33 XP_011520524 (OMIM: 603617,613830) PREDICTED: sodi (1030) 564 142.4 5.9e-33 XP_016878213 (OMIM: 603617,613830) PREDICTED: sodi (1049) 564 142.4 6e-33 NP_001287960 (OMIM: 603617,613830) sodium/potassiu (1069) 564 142.4 6.1e-33 XP_011520523 (OMIM: 603617,613830) PREDICTED: sodi (1069) 564 142.4 6.1e-33 XP_011520521 (OMIM: 603617,613830) PREDICTED: sodi (1099) 564 142.4 6.2e-33 XP_005254835 (OMIM: 603617,613830) PREDICTED: sodi (1099) 564 142.4 6.2e-33 NP_004718 (OMIM: 603617,613830) sodium/potassium/c (1099) 564 142.4 6.2e-33 NP_001241669 (OMIM: 603617,613830) sodium/potassiu ( 426) 533 134.8 4.6e-31 NP_001317395 (OMIM: 609841) sodium/potassium/calci ( 528) 309 82.0 4.8e-15 XP_005267399 (OMIM: 210750,609840,615887) PREDICTE ( 352) 285 76.2 1.7e-13 XP_006719670 (OMIM: 609841) PREDICTED: sodium/pota ( 389) 251 68.2 5e-11 XP_011537054 (OMIM: 609841) PREDICTED: sodium/pota ( 389) 251 68.2 5e-11 NP_079235 (OMIM: 609841) sodium/potassium/calcium ( 584) 251 68.3 6.9e-11 XP_011537051 (OMIM: 609841) PREDICTED: sodium/pota ( 584) 251 68.3 6.9e-11 XP_016875467 (OMIM: 609841) PREDICTED: sodium/pota ( 422) 218 60.4 1.2e-08 XP_005264571 (OMIM: 182305) PREDICTED: sodium/calc ( 937) 177 50.9 1.9e-05 NP_001106273 (OMIM: 182305) sodium/calcium exchang ( 937) 177 50.9 1.9e-05 XP_016860252 (OMIM: 182305) PREDICTED: sodium/calc ( 938) 177 50.9 1.9e-05 XP_016860251 (OMIM: 182305) PREDICTED: sodium/calc ( 938) 177 50.9 1.9e-05 XP_016860249 (OMIM: 182305) PREDICTED: sodium/calc ( 945) 177 50.9 1.9e-05 XP_016860250 (OMIM: 182305) PREDICTED: sodium/calc ( 945) 177 50.9 1.9e-05 XP_016860248 (OMIM: 182305) PREDICTED: sodium/calc ( 945) 177 50.9 1.9e-05 >>NP_995322 (OMIM: 113750,609802) sodium/potassium/calci (500 aa) initn: 3315 init1: 3315 opt: 3315 Z-score: 4230.8 bits: 792.3 E(85289): 0 Smith-Waterman score: 3315; 100.0% identity (100.0% similar) in 500 aa overlap (1-500:1-500) 10 20 30 40 50 60 pF1KE6 MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 RQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 PELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 PELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAME 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 RSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 RSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 ADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 ADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 KTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_995 KTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLAT 430 440 450 460 470 480 490 500 pF1KE6 LSVLYELGIIGNNKIRGCGG :::::::::::::::::::: NP_995 LSVLYELGIIGNNKIRGCGG 490 500 >>XP_016877568 (OMIM: 113750,609802) PREDICTED: sodium/p (314 aa) initn: 1789 init1: 1789 opt: 1789 Z-score: 2284.7 bits: 431.6 E(85289): 1.6e-120 Smith-Waterman score: 1804; 90.1% identity (90.1% similar) in 313 aa overlap (114-395:1-313) 90 100 110 120 pF1KE6 SIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG-------------- :::::::::::::::: XP_016 MAAGSSAPELVTAFLGKYCSLYFLLTQCDF 10 20 30 130 140 150 160 170 pF1KE6 -----------------VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPL ::::::::::::::::::::::::::::::::::::::::::: XP_016 YFLQVNTNLAGTILHIGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPL 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE6 FRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCC 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE6 ACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDP 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE6 PSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYIL 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE6 VWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDML ::::::::::::::::::::::::::::::::::::::::::: XP_016 VWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKN 280 290 300 310 420 430 440 450 460 470 pF1KE6 CLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCL >>XP_016877569 (OMIM: 113750,609802) PREDICTED: sodium/p (314 aa) initn: 1789 init1: 1789 opt: 1789 Z-score: 2284.7 bits: 431.6 E(85289): 1.6e-120 Smith-Waterman score: 1804; 90.1% identity (90.1% similar) in 313 aa overlap (114-395:1-313) 90 100 110 120 pF1KE6 SIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG-------------- :::::::::::::::: XP_016 MAAGSSAPELVTAFLGKYCSLYFLLTQCDF 10 20 30 130 140 150 160 170 pF1KE6 -----------------VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPL ::::::::::::::::::::::::::::::::::::::::::: XP_016 YFLQVNTNLAGTILHIGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPL 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE6 FRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCC 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE6 ACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDP 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE6 PSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYIL 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE6 VWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDML ::::::::::::::::::::::::::::::::::::::::::: XP_016 VWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKN 280 290 300 310 420 430 440 450 460 470 pF1KE6 CLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCL >>XP_011534743 (OMIM: 210750,609840,615887) PREDICTED: s (316 aa) initn: 653 init1: 472 opt: 684 Z-score: 873.3 bits: 170.4 E(85289): 6.6e-42 Smith-Waterman score: 684; 46.8% identity (77.3% similar) in 203 aa overlap (288-489:101-303) 260 270 280 290 300 310 pF1KE6 IRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITL : : : :..::: .. ::.. :.: : XP_011 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFL 80 90 100 110 120 130 320 330 340 350 360 370 pF1KE6 LFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA : .: :.: : :...:..::. ...::..:.::.::.::: : :: :::..::.:.::: XP_011 LCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAA 140 150 160 170 180 190 380 390 400 410 420 430 pF1KE6 GTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSR :::.:: .::..:::.: ::::.:: .::::::.: ::.:: ..: .: .. ...::: XP_011 GTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSR 200 210 220 230 240 250 440 450 460 470 480 490 pF1KE6 GLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIR ::.: .. : :. . :..:.: :.::::::. :. : . .:.. :... XP_011 GLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLP 260 270 280 290 300 310 500 pF1KE6 GCGG XP_011 MCREDD >>XP_011534744 (OMIM: 210750,609840,615887) PREDICTED: s (316 aa) initn: 653 init1: 472 opt: 684 Z-score: 873.3 bits: 170.4 E(85289): 6.6e-42 Smith-Waterman score: 684; 46.8% identity (77.3% similar) in 203 aa overlap (288-489:101-303) 260 270 280 290 300 310 pF1KE6 IRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITL : : : :..::: .. ::.. :.: : XP_011 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFL 80 90 100 110 120 130 320 330 340 350 360 370 pF1KE6 LFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA : .: :.: : :...:..::. ...::..:.::.::.::: : :: :::..::.:.::: XP_011 LCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAA 140 150 160 170 180 190 380 390 400 410 420 430 pF1KE6 GTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSR :::.:: .::..:::.: ::::.:: .::::::.: ::.:: ..: .: .. ...::: XP_011 GTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSR 200 210 220 230 240 250 440 450 460 470 480 490 pF1KE6 GLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIR ::.: .. : :. . :..:.: :.::::::. :. : . .:.. :... XP_011 GLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLP 260 270 280 290 300 310 500 pF1KE6 GCGG XP_011 MCREDD >>XP_011534742 (OMIM: 210750,609840,615887) PREDICTED: s (372 aa) initn: 653 init1: 472 opt: 684 Z-score: 872.3 bits: 170.5 E(85289): 7.5e-42 Smith-Waterman score: 684; 46.8% identity (77.3% similar) in 203 aa overlap (288-489:157-359) 260 270 280 290 300 310 pF1KE6 IRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITL : : : :..::: .. ::.. :.: : XP_011 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFL 130 140 150 160 170 180 320 330 340 350 360 370 pF1KE6 LFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA : .: :.: : :...:..::. ...::..:.::.::.::: : :: :::..::.:.::: XP_011 LCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAA 190 200 210 220 230 240 380 390 400 410 420 430 pF1KE6 GTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSR :::.:: .::..:::.: ::::.:: .::::::.: ::.:: ..: .: .. ...::: XP_011 GTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSR 250 260 270 280 290 300 440 450 460 470 480 490 pF1KE6 GLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIR ::.: .. : :. . :..:.: :.::::::. :. : . .:.. :... XP_011 GLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLP 310 320 330 340 350 360 500 pF1KE6 GCGG XP_011 MCREDD 370 >>NP_065740 (OMIM: 609839) sodium/potassium/calcium exch (644 aa) initn: 1150 init1: 631 opt: 631 Z-score: 801.2 bits: 158.1 E(85289): 6.9e-38 Smith-Waterman score: 958; 36.7% identity (60.8% similar) in 490 aa overlap (42-428:83-572) 20 30 40 50 60 70 pF1KE6 RALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGIII :: .:. :::. .:: ..::.:.... NP_065 DLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVL 60 70 80 90 100 110 80 90 100 110 120 130 pF1KE6 YFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVF . : .:::.:..::::..:.:::: : : : ::.::::.:::::::::::: :. .::: NP_065 HVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVF 120 130 140 150 160 170 140 150 160 170 180 190 pF1KE6 ITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIY :::::.:..::.:::..:.: : ..:::... : .:: : :.:: ::.:. :.. .:: NP_065 ITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIY 180 190 200 210 220 230 200 210 220 230 pF1KE6 DNQVYWYEGALLLLIYGLYVLVL--------CFDIKI-----------NQYIIKKCSPCC :..: :.:. .:.:.: .:.... ::. . :. : : : NP_065 DEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCD 240 250 260 270 280 290 240 250 260 pF1KE6 AC---LAKAMERSEQQPLM------------GWEDEGQ--------PFIRRQSRTDSGIF : : :: . . . .: .. . : : : : .. .. NP_065 ATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLI 300 310 320 330 340 350 270 280 pF1KE6 YE----------DSGYSQLSISL-------HGLSQVS----------------------- : .: :...:.. .: . : NP_065 NERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETE 360 370 380 390 400 410 290 300 310 320 330 pF1KE6 -------------------EDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFW : : . :. : . :. . :... :. .:..:.:.: : : NP_065 NENEDNENDEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRW 420 430 440 450 460 470 340 350 360 370 380 390 pF1KE6 KNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLV ...:..:: :..::.::.:..:::::: : :: :::..::.:.::::::.:: .::..: NP_065 EKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIV 480 490 500 510 520 530 400 410 420 430 440 pF1KE6 ARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFIN-GSAPAEVNSRGLTYITISLNIS ::.: ::::.:: .::::::.: ::.:: ..: .. :: NP_065 ARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASV 540 550 560 570 580 590 450 460 470 480 490 500 pF1KE6 IIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG NP_065 FVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH 600 610 620 630 640 >>NP_705934 (OMIM: 210750,609840,615887) sodium/potassiu (558 aa) initn: 1237 init1: 598 opt: 616 Z-score: 782.9 bits: 154.5 E(85289): 7.2e-37 Smith-Waterman score: 1025; 36.5% identity (64.1% similar) in 493 aa overlap (40-443:7-499) 10 20 30 40 50 60 pF1KE6 ARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGI : .. .:. ::: .:. .::. :.. NP_705 MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAV 10 20 30 70 80 90 100 110 120 pF1KE6 IIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG ....: .:::.:..::::..:.:::: : : : ::.::::.::::::::.::: .. .: NP_705 LLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGI ::::.::.:..::.:::..:.: : ..:::... : :. : . :: . ::::. ... . NP_705 VFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVF 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE6 IYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYI-IKKCS-----PCCACLAKAMERSE :::.:. :.:: .:...: .:.:.. ...:.. .. .:. : : . : . . . NP_705 IYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYD 160 170 180 190 200 210 250 260 270 pF1KE6 QQ------PLMGWEDE----GQ-PFI---RRQSRTDSGIFYEDSGY-------------- . ::.: : :. : . . .: . . . ..: NP_705 GSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRL 220 230 240 250 260 270 280 290 pF1KE6 ---SQLSI--------SLHGLS----------------------------QVSEDPP--- :.. : : .:.: : .. :: NP_705 RMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP 280 290 300 310 320 330 300 310 320 330 340 pF1KE6 ------------SVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMS : :..::: .. ::.. :.: :: .: :.: : :...:..::. . NP_705 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 340 350 360 370 380 390 350 360 370 380 390 400 pF1KE6 AIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMS ..::..:.::.::.::: : :: :::..::.:.::::::.:: .::..:::.: ::::.: NP_705 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 400 410 420 430 440 450 410 420 430 440 450 460 pF1KE6 NIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNG : .::::::.: ::.:: ..: .: .. ...:::::.: .. NP_705 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNK 460 470 480 490 500 510 470 480 490 500 pF1KE6 WKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG NP_705 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD 520 530 540 550 >>NP_705932 (OMIM: 210750,609840,615887) sodium/potassiu (622 aa) initn: 1237 init1: 598 opt: 616 Z-score: 782.2 bits: 154.6 E(85289): 7.8e-37 Smith-Waterman score: 1025; 36.5% identity (64.1% similar) in 493 aa overlap (40-443:71-563) 10 20 30 40 50 60 pF1KE6 ARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGI : .. .:. ::: .:. .::. :.. NP_705 GSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAV 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE6 IIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG ....: .:::.:..::::..:.:::: : : : ::.::::.::::::::.::: .. .: NP_705 LLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIG 110 120 130 140 150 160 130 140 150 160 170 180 pF1KE6 VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGI ::::.::.:..::.:::..:.: : ..:::... : :. : . :: . ::::. ... . NP_705 VFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVF 170 180 190 200 210 220 190 200 210 220 230 240 pF1KE6 IYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYI-IKKCS-----PCCACLAKAMERSE :::.:. :.:: .:...: .:.:.. ...:.. .. .:. : : . : . . . NP_705 IYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYD 230 240 250 260 270 280 250 260 270 pF1KE6 QQ------PLMGWEDE----GQ-PFI---RRQSRTDSGIFYEDSGY-------------- . ::.: : :. : . . .: . . . ..: NP_705 GSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRL 290 300 310 320 330 340 280 290 pF1KE6 ---SQLSI--------SLHGLS----------------------------QVSEDPP--- :.. : : .:.: : .. :: NP_705 RMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP 350 360 370 380 390 400 300 310 320 330 340 pF1KE6 ------------SVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMS : :..::: .. ::.. :.: :: .: :.: : :...:..::. . NP_705 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 410 420 430 440 450 460 350 360 370 380 390 400 pF1KE6 AIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMS ..::..:.::.::.::: : :: :::..::.:.::::::.:: .::..:::.: ::::.: NP_705 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 470 480 490 500 510 520 410 420 430 440 450 460 pF1KE6 NIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNG : .::::::.: ::.:: ..: .: .. ...:::::.: .. NP_705 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNK 530 540 550 560 570 580 470 480 490 500 pF1KE6 WKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG NP_705 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD 590 600 610 620 >>XP_011534740 (OMIM: 210750,609840,615887) PREDICTED: s (645 aa) initn: 1177 init1: 598 opt: 616 Z-score: 782.0 bits: 154.6 E(85289): 8.1e-37 Smith-Waterman score: 1025; 36.5% identity (64.1% similar) in 493 aa overlap (40-443:118-610) 10 20 30 40 50 60 pF1KE6 ARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGI : .. .:. ::: .:. .::. :.. XP_011 AAAGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAV 90 100 110 120 130 140 70 80 90 100 110 120 pF1KE6 IIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG ....: .:::.:..::::..:.:::: : : : ::.::::.::::::::.::: .. .: XP_011 LLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIG 150 160 170 180 190 200 130 140 150 160 170 180 pF1KE6 VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGI ::::.::.:..::.:::..:.: : ..:::... : :. : . :: . ::::. ... . XP_011 VFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVF 210 220 230 240 250 260 190 200 210 220 230 240 pF1KE6 IYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYI-IKKCS-----PCCACLAKAMERSE :::.:. :.:: .:...: .:.:.. ...:.. .. .:. : : . : . . . XP_011 IYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYD 270 280 290 300 310 320 250 260 270 pF1KE6 QQ------PLMGWEDE----GQ-PFI---RRQSRTDSGIFYEDSGY-------------- . ::.: : :. : . . .: . . . ..: XP_011 GSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRL 330 340 350 360 370 380 280 290 pF1KE6 ---SQLSI--------SLHGLS----------------------------QVSEDPP--- :.. : : .:.: : .. :: XP_011 RMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP 390 400 410 420 430 440 300 310 320 330 340 pF1KE6 ------------SVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMS : :..::: .. ::.. :.: :: .: :.: : :...:..::. . XP_011 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA 450 460 470 480 490 500 350 360 370 380 390 400 pF1KE6 AIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMS ..::..:.::.::.::: : :: :::..::.:.::::::.:: .::..:::.: ::::.: XP_011 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS 510 520 530 540 550 560 410 420 430 440 450 460 pF1KE6 NIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNG : .::::::.: ::.:: ..: .: .. ...:::::.: .. XP_011 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTCSSEVPGI 570 580 590 600 610 620 470 480 490 500 pF1KE6 WKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG XP_011 QPQEALIEGQGGRQWKER 630 640 500 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:32:27 2016 done: Tue Nov 8 13:32:29 2016 Total Scan time: 7.490 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]