FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9284, 327 aa 1>>>pF1KE9284 327 - 327 aa - 327 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9459+/-0.000391; mu= 18.2527+/- 0.024 mean_var=68.4498+/-14.218, 0's: 0 Z-trim(112.1): 34 B-trim: 942 in 1/54 Lambda= 0.155020 statistics sampled from 20927 (20953) to 20927 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.611), E-opt: 0.2 (0.246), width: 16 Scan time: 6.110 The best scores are: opt bits E(85289) NP_006824 (OMIM: 614729) COP9 signalosome complex ( 327) 2135 486.6 3.1e-137 NP_002802 (OMIM: 157970) 26S proteasome non-ATPase ( 324) 366 90.9 3.8e-18 NP_003745 (OMIM: 603914) eukaryotic translation in ( 357) 354 88.3 2.7e-17 >>NP_006824 (OMIM: 614729) COP9 signalosome complex subu (327 aa) initn: 2135 init1: 2135 opt: 2135 Z-score: 2584.8 bits: 486.6 E(85289): 3.1e-137 Smith-Waterman score: 2135; 100.0% identity (100.0% similar) in 327 aa overlap (1-327:1-327) 10 20 30 40 50 60 pF1KE9 MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 QEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 FLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEAT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 MLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 YVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 YVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCN 250 260 270 280 290 300 310 320 pF1KE9 TMNQFVNKFNVLYDRQGIGRRMRGLFF ::::::::::::::::::::::::::: NP_006 TMNQFVNKFNVLYDRQGIGRRMRGLFF 310 320 >>NP_002802 (OMIM: 157970) 26S proteasome non-ATPase reg (324 aa) initn: 299 init1: 182 opt: 366 Z-score: 446.7 bits: 90.9 E(85289): 3.8e-18 Smith-Waterman score: 366; 26.4% identity (63.7% similar) in 273 aa overlap (41-307:9-277) 20 30 40 50 60 70 pF1KE9 TNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIG :..::::.:.. ::. :. .. : .:.: NP_002 MPELAVQKVVVHPLVLLSVVDHFNRI-GKVGNQKRVVG 10 20 30 80 90 100 110 120 pF1KE9 ALIGKQEGRNIEVMNSFEL-LSHTVEEKII--IDKEYYYTKEEQFKQVFKELEFLGWYTT .:.:. . . ..: ::: . ... .. . .:..: . .::.: . ...::: : NP_002 VLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHT 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE9 GGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIIN-GEATM-LFAE : .:: ... . . . ... .. : ::. .. :: .. . : : : . NP_002 GPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEH 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE9 LTYTLATEEAERIGVDHVAR-MTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKA .: ...::::..::.:. : . : : :..... : ..: :.:.. : :.. NP_002 VTSEIGAEEAEEVGVEHLLRDIKDTTVG---TLSQRITNQVHGLKGLNSKLLDIRSYLEK 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE9 SEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQ .:..:.::.:. . . . :: .: ..: :: . :: ...::... .. .... NP_002 VATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHN 220 230 240 250 260 270 310 320 pF1KE9 FVNKFNVLYDRQGIGRRMRGLFF ..: NP_002 LINNKIANRDAEKKEGQEKEESKKDRKEDKEKDKDKEKSDVKKEEKKEKK 280 290 300 310 320 >>NP_003745 (OMIM: 603914) eukaryotic translation initia (357 aa) initn: 296 init1: 131 opt: 354 Z-score: 431.6 bits: 88.3 E(85289): 2.7e-17 Smith-Waterman score: 354; 25.7% identity (59.8% similar) in 311 aa overlap (2-307:50-356) 10 20 pF1KE9 MAAAAAAAAATNGTGGSSGM--EVDAAVVPS ::::::.:: . : .:. .. : ..:. NP_003 AAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPGQTPASAQAPAQTPAPALPG 20 30 40 50 60 70 30 40 50 60 70 80 pF1KE9 VMACG-VTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFE : :. : :::... .: : . : .:: ..:::.:.: . ...:: : : NP_003 PALPGPFPGGRVVRLHPVILASIVDSY--ERRNEG-AARVIGTLLGTVDKHSVEVTNCFS 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE9 LLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIES . . :... .: :. . : :.: . .::::.:: .. .:. . . NP_003 VPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPN 140 150 160 170 180 190 150 160 170 180 190 200 pF1KE9 PLFLKLNPMTKHTDLPVSVFESVIDIINGEAT-MLFAELTYTLATEEAERIGVDHVARMT :. : .. .. . .... :.. . :.. ..:. :: : ..:::::: . . : NP_003 PIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMK-T 200 210 220 230 240 250 210 220 230 240 250 260 pF1KE9 ATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCL . .. .. : .: ... .. .:.:.. .:.: .. . : ..: . . NP_003 CFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQV 260 270 280 290 300 310 270 280 290 300 310 320 pF1KE9 PVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQ-FVNKFNVLYDRQGIGRRMRGLF : . : :.: . .. ::. ...::...:.. ..:. .:: NP_003 PKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL 320 330 340 350 pF1KE9 F 327 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 10:25:18 2016 done: Tue Nov 8 10:25:19 2016 Total Scan time: 6.110 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]