FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9392, 1278 aa 1>>>pF1KE9392 1278 - 1278 aa - 1278 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.5695+/-0.000405; mu= -7.1469+/- 0.025 mean_var=283.3464+/-57.823, 0's: 0 Z-trim(120.8): 132 B-trim: 39 in 1/55 Lambda= 0.076193 statistics sampled from 36290 (36435) to 36290 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.729), E-opt: 0.2 (0.427), width: 16 Scan time: 12.940 The best scores are: opt bits E(85289) NP_001162593 (OMIM: 300806,309548) AF4/FMR2 family (1276) 8448 943.0 0 NP_001162596 (OMIM: 300806,309548) AF4/FMR2 family (1272) 8418 939.7 0 NP_001162595 (OMIM: 300806,309548) AF4/FMR2 family (1276) 8400 937.7 0 NP_001164099 (OMIM: 300806,309548) AF4/FMR2 family ( 952) 6150 690.4 1.6e-197 NP_002016 (OMIM: 300806,309548) AF4/FMR2 family me (1311) 6048 679.2 4.9e-194 NP_001162594 (OMIM: 300806,309548) AF4/FMR2 family (1301) 5992 673.1 3.5e-192 XP_011509473 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1235) 1083 133.4 9.2e-30 XP_005272021 (OMIM: 604417,616368) PREDICTED: AF4/ ( 785) 999 124.1 3.7e-27 XP_006714650 (OMIM: 604417,616368) PREDICTED: AF4/ (1134) 999 124.2 5.1e-27 XP_005272020 (OMIM: 604417,616368) PREDICTED: AF4/ (1163) 999 124.2 5.2e-27 NP_055238 (OMIM: 604417,616368) AF4/FMR2 family me (1163) 999 124.2 5.2e-27 XP_016859576 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 861) 771 99.1 1.4e-19 XP_016859575 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 862) 771 99.1 1.4e-19 XP_011509481 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 864) 771 99.1 1.4e-19 XP_011509480 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 865) 771 99.1 1.4e-19 XP_016859574 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 894) 771 99.1 1.5e-19 XP_005264002 (OMIM: 601464) PREDICTED: AF4/FMR2 fa ( 895) 771 99.1 1.5e-19 NP_002276 (OMIM: 601464) AF4/FMR2 family member 3 (1226) 771 99.1 1.9e-19 XP_011509478 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1226) 771 99.1 1.9e-19 XP_011509479 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1226) 771 99.1 1.9e-19 XP_011509477 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1226) 771 99.1 1.9e-19 XP_005264000 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1226) 771 99.1 1.9e-19 XP_011509474 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1235) 771 99.1 1.9e-19 XP_011509471 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1250) 771 99.1 2e-19 NP_001020279 (OMIM: 601464) AF4/FMR2 family member (1251) 771 99.1 2e-19 XP_011509476 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1251) 771 99.1 2e-19 XP_011509475 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1251) 771 99.1 2e-19 XP_011509472 (OMIM: 601464) PREDICTED: AF4/FMR2 fa (1303) 771 99.1 2e-19 NP_001300888 (OMIM: 159557) AF4/FMR2 family member (1211) 761 98.0 4.1e-19 XP_005263068 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1216) 761 98.0 4.1e-19 NP_001160165 (OMIM: 159557) AF4/FMR2 family member (1218) 761 98.0 4.1e-19 XP_011530275 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1218) 761 98.0 4.1e-19 XP_005263064 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1218) 761 98.0 4.1e-19 XP_005263066 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1217) 760 97.9 4.4e-19 NP_005926 (OMIM: 159557) AF4/FMR2 family member 1 (1210) 751 96.9 8.7e-19 XP_016863704 (OMIM: 159557) PREDICTED: AF4/FMR2 fa ( 849) 738 95.4 1.7e-18 NP_001300889 (OMIM: 159557) AF4/FMR2 family member ( 849) 738 95.4 1.7e-18 XP_016863705 (OMIM: 159557) PREDICTED: AF4/FMR2 fa ( 849) 738 95.4 1.7e-18 XP_005263070 (OMIM: 159557) PREDICTED: AF4/FMR2 fa (1057) 380 56.1 1.5e-06 NP_001121180 (OMIM: 208250,604283) proteoglycan 4 (1363) 295 46.8 0.0012 NP_005798 (OMIM: 208250,604283) proteoglycan 4 iso (1404) 295 46.8 0.0012 NP_001121182 (OMIM: 208250,604283) proteoglycan 4 (1270) 288 46.0 0.0019 XP_016855492 (OMIM: 208250,604283) PREDICTED: prot (1270) 288 46.0 0.0019 NP_001121181 (OMIM: 208250,604283) proteoglycan 4 (1311) 288 46.1 0.002 XP_016855491 (OMIM: 208250,604283) PREDICTED: prot (1311) 288 46.1 0.002 NP_001290161 (OMIM: 208250,604283) proteoglycan 4 (1361) 288 46.1 0.002 >>NP_001162593 (OMIM: 300806,309548) AF4/FMR2 family mem (1276 aa) initn: 6392 init1: 6392 opt: 8448 Z-score: 5030.5 bits: 943.0 E(85289): 0 Smith-Waterman score: 8448; 99.8% identity (99.8% similar) in 1278 aa overlap (1-1278:1-1276) 10 20 30 40 50 60 pF1KE9 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKTNKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKTNKG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 DALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 TQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 AVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 LKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILRES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILRES 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 QHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 AVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 RVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 TNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE9 VEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE9 KKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGAS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE9 LTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRV 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE9 PGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEE 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE9 ATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGN 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE9 NGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIAT :::::::::::::::::::::::::::::::::::: :::::::::::::::::::::: NP_001 NGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGIS--EGDTPKKASSATITVTNTAIAT 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KE9 ATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSS 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KE9 SSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAM 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KE9 ERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKL 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE9 KKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPV 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KE9 TIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNL 1200 1210 1220 1230 1240 1250 1270 pF1KE9 VRYVRQGLCWLRIDAHLL :::::::::::::::::: NP_001 VRYVRQGLCWLRIDAHLL 1260 1270 >>NP_001162596 (OMIM: 300806,309548) AF4/FMR2 family mem (1272 aa) initn: 5848 init1: 5848 opt: 8418 Z-score: 5012.7 bits: 939.7 E(85289): 0 Smith-Waterman score: 8418; 99.5% identity (99.5% similar) in 1278 aa overlap (1-1278:1-1272) 10 20 30 40 50 60 pF1KE9 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKTNKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKTNKG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 DALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 TQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 AVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 LKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILRES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILRES 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 QHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQ :::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_001 QHLTPGFTLQKWNDPTTRASTK------MLEDDLKLSSDEDDLEPVKTLTTQCTATELYQ 370 380 390 400 410 430 440 450 460 470 480 pF1KE9 AVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAP 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE9 RVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVK 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE9 TNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKK 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE9 VEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPE 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE9 KKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGAS 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE9 LTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRV 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE9 PGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEE 780 790 800 810 820 830 850 860 870 880 890 900 pF1KE9 ATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGN 840 850 860 870 880 890 910 920 930 940 950 960 pF1KE9 NGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIAT 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KE9 ATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSS 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KE9 SSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAM 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 1130 1140 pF1KE9 ERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKL 1080 1090 1100 1110 1120 1130 1150 1160 1170 1180 1190 1200 pF1KE9 KKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPV 1140 1150 1160 1170 1180 1190 1210 1220 1230 1240 1250 1260 pF1KE9 TIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNL 1200 1210 1220 1230 1240 1250 1270 pF1KE9 VRYVRQGLCWLRIDAHLL :::::::::::::::::: NP_001 VRYVRQGLCWLRIDAHLL 1260 1270 >>NP_001162595 (OMIM: 300806,309548) AF4/FMR2 family mem (1276 aa) initn: 6246 init1: 5848 opt: 8400 Z-score: 5002.0 bits: 937.7 E(85289): 0 Smith-Waterman score: 8400; 99.2% identity (99.2% similar) in 1282 aa overlap (1-1278:1-1276) 10 20 30 40 50 pF1KE9 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYK---- :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 TNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE9 RIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE9 MQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE9 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE9 ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE9 LRESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTAT :::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_001 LRESQHLTPGFTLQKWNDPTTRASTK------MLEDDLKLSSDEDDLEPVKTLTTQCTAT 370 380 390 400 410 420 430 440 450 460 470 pF1KE9 ELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSES 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE9 NEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQ 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE9 MKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKK 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE9 QPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIP 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE9 LAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEI 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE9 CGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDL 720 730 740 750 760 770 780 790 800 810 820 830 pF1KE9 LSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQ 780 790 800 810 820 830 840 850 860 870 880 890 pF1KE9 RLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRN 840 850 860 870 880 890 900 910 920 930 940 950 pF1KE9 VSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNT 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KE9 AIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALP 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KE9 LLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTEC 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 pF1KE9 GNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLR 1080 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 pF1KE9 MFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCN 1140 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KE9 NGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSS 1200 1210 1220 1230 1240 1250 1260 1270 pF1KE9 MTNLVRYVRQGLCWLRIDAHLL :::::::::::::::::::::: NP_001 MTNLVRYVRQGLCWLRIDAHLL 1260 1270 >>NP_001164099 (OMIM: 300806,309548) AF4/FMR2 family mem (952 aa) initn: 6148 init1: 6148 opt: 6150 Z-score: 3667.3 bits: 690.4 E(85289): 1.6e-197 Smith-Waterman score: 6150; 99.0% identity (99.5% similar) in 946 aa overlap (333-1278:10-952) 310 320 330 340 350 360 pF1KE9 PSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILRESQH .:.: .. ::::::::::::::::::: NP_001 MKFKRRHQAFPSFFKMK---VSLPSDPSCVEEILRESQH 10 20 30 370 380 390 400 410 420 pF1KE9 LTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAV 40 50 60 70 80 90 430 440 450 460 470 480 pF1KE9 EKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKAKPRNNPVNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRV 100 110 120 130 140 150 490 500 510 520 530 540 pF1KE9 ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVKTN 160 170 180 190 200 210 550 560 570 580 590 600 pF1KE9 ASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVE 220 230 240 250 260 270 610 620 630 640 650 660 pF1KE9 KNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKK 280 290 300 310 320 330 670 680 690 700 710 720 pF1KE9 KYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLT 340 350 360 370 380 390 730 740 750 760 770 780 pF1KE9 LSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPG 400 410 420 430 440 450 790 800 810 820 830 840 pF1KE9 HSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEAT 460 470 480 490 500 510 850 860 870 880 890 900 pF1KE9 TICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNG 520 530 540 550 560 570 910 920 930 940 950 960 pF1KE9 PFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATAT 580 590 600 610 620 630 970 980 990 1000 1010 1020 pF1KE9 VTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSS 640 650 660 670 680 690 1030 1040 1050 1060 1070 1080 pF1KE9 TNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAMER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAMER 700 710 720 730 740 750 1090 1100 1110 1120 1130 1140 pF1KE9 DPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKK 760 770 780 790 800 810 1150 1160 1170 1180 1190 1200 pF1KE9 DHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPVTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPVTI 820 830 840 850 860 870 1210 1220 1230 1240 1250 1260 pF1KE9 PQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVR 880 890 900 910 920 930 1270 pF1KE9 YVRQGLCWLRIDAHLL :::::::::::::::: NP_001 YVRQGLCWLRIDAHLL 940 950 >>NP_002016 (OMIM: 300806,309548) AF4/FMR2 family member (1311 aa) initn: 6446 init1: 6048 opt: 6048 Z-score: 3604.5 bits: 679.2 E(85289): 4.9e-194 Smith-Waterman score: 8381; 97.5% identity (97.5% similar) in 1310 aa overlap (2-1278:2-1311) 10 20 30 40 50 pF1KE9 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYK---- ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 TNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE9 RIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE9 MQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE9 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE9 ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEI 310 320 330 340 350 360 360 370 380 pF1KE9 LRE-----------------------------SQHLTPGFTLQKWNDPTTRASTKSVSFK ::: :::::::::::::::::::::::::::: NP_002 LREMTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFK 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE9 SMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQA 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE9 SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQ 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE9 NKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NKSFICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRP 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE9 TQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TQKIPETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKES 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE9 VELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VELHDPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDS 670 680 690 700 710 720 690 700 710 720 730 740 pF1KE9 NTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSP 730 740 750 760 770 780 750 760 770 780 790 800 pF1KE9 IPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTA 790 800 810 820 830 840 810 820 830 840 850 860 pF1KE9 VTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNS 850 860 870 880 890 900 870 880 890 900 910 920 pF1KE9 SRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGK 910 920 930 940 950 960 930 940 950 960 970 980 pF1KE9 FCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTT 970 980 990 1000 1010 1020 990 1000 1010 1020 1030 1040 pF1KE9 TTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAK 1030 1040 1050 1060 1070 1080 1050 1060 1070 1080 1090 1100 pF1KE9 KLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRL 1090 1100 1110 1120 1130 1140 1110 1120 1130 1140 1150 1160 pF1KE9 KNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIP 1150 1160 1170 1180 1190 1200 1170 1180 1190 1200 1210 1220 pF1KE9 SPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SPWVSNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHW 1210 1220 1230 1240 1250 1260 1230 1240 1250 1260 1270 pF1KE9 DMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL 1270 1280 1290 1300 1310 >>NP_001162594 (OMIM: 300806,309548) AF4/FMR2 family mem (1301 aa) initn: 8278 init1: 5848 opt: 5992 Z-score: 3571.3 bits: 673.1 E(85289): 3.5e-192 Smith-Waterman score: 8350; 97.3% identity (97.3% similar) in 1307 aa overlap (1-1278:1-1301) 10 20 30 40 50 60 pF1KE9 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKTNKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKTNKG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 DALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 PHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 TQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFKEIFQSNSPEESEF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 AVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPT 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 LKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILRE- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILREM 310 320 330 340 350 360 360 370 380 390 pF1KE9 ----------------------------SQHLTPGFTLQKWNDPTTRASTKSVSFKSMLE ::::::::::::::::::::::: ::: NP_001 THSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTK------MLE 370 380 390 400 410 400 410 420 430 440 450 pF1KE9 DDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATPQPPPAVQASGGS 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE9 GSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSF 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE9 ICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ICGQNETPMETISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSLIREKARPRPTQKI 540 550 560 570 580 590 580 590 600 610 620 630 pF1KE9 PETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PETKALKHKLSTTSETVSQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELH 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE9 DPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPPRGRNKATAHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQ 660 670 680 690 700 710 700 710 720 730 740 750 pF1KE9 EETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVM 720 730 740 750 760 770 760 770 780 790 800 810 pF1KE9 QTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAV 780 790 800 810 820 830 820 830 840 850 860 870 pF1KE9 EKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRA 840 850 860 870 880 890 880 890 900 910 920 930 pF1KE9 NRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCAT 900 910 920 930 940 950 940 950 960 970 980 990 pF1KE9 FKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTIS 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 1050 pF1KE9 TITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKH 1020 1030 1040 1050 1060 1070 1060 1070 1080 1090 1100 1110 pF1KE9 KADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFA 1080 1090 1100 1110 1120 1130 1120 1130 1140 1150 1160 1170 pF1KE9 SPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWV 1140 1150 1160 1170 1180 1190 1180 1190 1200 1210 1220 1230 pF1KE9 SNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNGKNTPSPVSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMAD 1200 1210 1220 1230 1240 1250 1240 1250 1260 1270 pF1KE9 KLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLTRENKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL 1260 1270 1280 1290 1300 >>XP_011509473 (OMIM: 601464) PREDICTED: AF4/FMR2 family (1235 aa) initn: 2266 init1: 660 opt: 1083 Z-score: 655.3 bits: 133.4 E(85289): 9.2e-30 Smith-Waterman score: 2413; 37.5% identity (60.4% similar) in 1327 aa overlap (18-1277:45-1234) 10 20 30 40 pF1KE9 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSG :: ::.::...: ::::::.::.: :.:. XP_011 ESLWGEDILNQRNDSLVVEFQSSASRCRSVYEPDRNALRRKERERRNQETQQDDGTFNSS 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE9 FDLFGEPYKTNKGDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNE ..::.::::::::: :.::.:::::::::::..::..:::.::::.:: .:::.: :: . XP_011 YSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKID 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE9 PSFFPEQKNRIIPPHQDNTHPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLA : ... . : .: :.: : ....... :.. .: :: . XP_011 EHFVADSRAQNQPSSICSTTTSTPAAVP---------VQQSKRGTMGWQKAGHPPSD--G 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 SQASGQPNKMQTLTQDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGEDAFK .: . : ....:: : .:. ..: ::. : XP_011 QQRATQQGSLRTLLGDG-----------------VGR---QQPRAKQVCN---------- 190 200 210 230 240 250 260 270 280 pF1KE9 EIFQSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRP : ..:. : : . ::: ::::::.: : :. :::::::::: XP_011 ----------VEVGLQTQERP-PAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRP 220 230 240 250 260 290 300 310 320 330 340 pF1KE9 MDGQDQAPDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLP ::::::::: :: :: : :.: :. . .:: : .:.:: ::.: . .: : XP_011 MDGQDQAPDESPKLKSSS--ETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRS 270 280 290 300 310 320 350 360 370 pF1KE9 SDP-SCVEEILRE---------------------------SQHLTPGFTLQKWNDPTTRA .. ::::::.:: :: .. : . : .: .. XP_011 GETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPES 330 340 350 360 370 380 380 390 400 410 420 430 pF1KE9 STKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPPLATP ...: :::::::::::::.. : . : : .:.. . :.. . . XP_011 PDNGTSNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTS-----VPSS 390 400 410 420 430 440 450 460 470 480 490 pF1KE9 QPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDK . . ..::.:.:::.::::: :::.::::...::... :. ..:: :: :.::::::: XP_011 KGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDK 440 450 460 470 480 490 500 510 520 530 540 550 pF1KE9 WLNKVTSQNKSFICGQNETP-METISLPPPIIQPMEVQMKVKTNASQVPAEPKERPLLSL ::::: . .: : :::. :. . :. . .. :: .. : :. .:. . : XP_011 WLNKV-NPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVP-DVCQ-PSL-REKEIKST 500 510 520 530 540 550 560 570 580 590 pF1KE9 IREKARPRPTQKIPETKALKHKLSTTSETVS----------------------QRTIGKK .:. ::: ..: : .:..:.: .. .:. .:. ::: XP_011 CKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKK 560 570 580 590 600 610 600 610 620 630 640 650 pF1KE9 QPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKPAPRKEPRPNIP ...:.... : . .:. ... :: . : .. . ::: : .. XP_011 PTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVT 620 630 640 650 660 670 660 670 680 690 700 pF1KE9 LAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTD------QEE-TLQIKVLPPCIISGGN ::.. :: ..:::::.:::::.::.:.:..: ::: :. :.:: XP_011 C--EKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGN 680 690 700 710 720 710 720 730 740 750 760 pF1KE9 TAKSKEIC--GASLTLSTLMS-SSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLK . :: :.: . . : .. ...... :: .. .: ..:.::::.: .... XP_011 DQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIR 730 740 750 760 770 780 770 780 790 800 810 820 pF1KE9 NLWVKIDLDLLSRVPGHSSLHAAP---AKPDHKETATKPKRQTAVTAVEKPAPKGKRKHK .::::::: ::::.: : : : . : :.. . : .:. : .:: ::.:::.: XP_011 SLWVKIDLTLLSRIPEH--LPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRK 790 800 810 820 830 840 830 840 850 860 870 880 pF1KE9 PIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPP . . : :. : . : : . . : :. . : :.::.. : XP_011 -CDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPIN--KNEKMLRSP 850 860 870 880 890 900 890 900 910 920 930 940 pF1KE9 LSPLPEDPPRR---RNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEG .::: . .. ....... : : : .:. .: ::: . .. . : XP_011 ISPLSDASKHKYTSEDLTSSSRPNG---NSLFTSASSSKKPKAD--------SQLQPHGG 910 920 930 940 950 950 960 970 980 990 1000 pF1KE9 DTPKKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTG : : : . . .. XP_011 DLTKAAHNNSENIP---------------------------------------------- 960 1010 1020 1030 1040 1050 1060 pF1KE9 LMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKF . .:. . :. : :.. . .: ::.::: ..:::.:::::..::::::. ::: XP_011 -LHKSRPQTKPWS--PG-SNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKF 970 980 990 1000 1010 1020 1070 1080 1090 1100 1110 1120 pF1KE9 GKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDK :::.:::.::::: :::::::. :.:.:::::::::::::.:::::::. ..: :. :: XP_011 GKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDK 1030 1040 1050 1060 1070 1080 1130 1140 1150 1160 1170 1180 pF1KE9 KLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSP .::.::::::.::: :::.::.:::.:::..:..::: :.::.:: :::: ..:... : XP_011 QLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFK-NSSKAAQAPSPWGASGNSVGSQ 1090 1100 1110 1120 1130 1140 1190 1200 1210 1220 1230 1240 pF1KE9 VSLNNVSPINAMGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEF ::.:.: .. . :.::::::.:::.::.::...:..:..:.:::.:..::.:: XP_011 GSLSNASALSP-----STIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREF 1150 1160 1170 1180 1190 1250 1260 1270 pF1KE9 FGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL :.::: ::::.: :::: .::.: .::: ::: .::: XP_011 FNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS 1200 1210 1220 1230 >>XP_005272021 (OMIM: 604417,616368) PREDICTED: AF4/FMR2 (785 aa) initn: 1336 init1: 586 opt: 999 Z-score: 608.5 bits: 124.1 E(85289): 3.7e-27 Smith-Waterman score: 1555; 37.3% identity (61.8% similar) in 908 aa overlap (389-1278:1-784) 360 370 380 390 400 410 pF1KE9 ESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATEL ::.:::::::.:: .. XP_005 MLKDDLKLSSSED--------------SDG 10 420 430 440 450 460 470 pF1KE9 YQAVEKAKPRNNP-VNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESSTTDSESN : .:. ::..: : . . : .. :.: : ::::: :::..:::..:::.: XP_005 EQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEAN 20 30 40 50 60 70 480 490 500 510 520 530 pF1KE9 EAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQPMEVQM : . :.:::::: :::::::.:::::. .. : : ... : : .. . XP_005 EPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVS--------PASSVDSNIPSSQGYKKEG 80 90 100 110 120 540 550 560 570 580 590 pF1KE9 KVK-TNASQVPAE-PKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQR-TIG . . :. : . . ::: . :.. . :: :. ..: . :....:: :.: XP_005 REQGTGNSYTDTSGPKETSSATPGRDS---KTIQKGSESGRGRQKSPAQSDSTTQRRTVG 130 140 150 160 170 180 600 610 620 630 640 650 pF1KE9 KKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKAT---AHKPAPRKEP ::::::.:: .. . : : : :: . : . : .:.::. ..:: .:: XP_005 KKQPKKAEKAAAEEPRGGLK--IESETPVDLAS----SMPSSRHKAATKGSRKPNIKKES 190 200 210 220 230 660 670 680 690 700 710 pF1KE9 RPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTA . . . :::::.. .: ::::.::::.:.::: :. :.: :: ...: XP_005 KSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDS--DESESL-----PP----SSQTP 240 250 260 270 280 720 730 740 750 760 770 pF1KE9 KSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVK : : . : .. :. ... :. .. :::. . :.:::: . .. : :: XP_005 KYPE------SNRTPVKPSSVEEEDSFFRQR-MFSPME--EKELLSPLSEPDDRYPLIVK 290 300 310 320 330 780 790 800 810 820 830 pF1KE9 IDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKI :::.::.:.::. .. : : ..:.. : :.. : :: . ::::::: . . XP_005 IDLNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRAS 340 350 360 370 380 390 840 850 860 870 880 890 pF1KE9 PEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDP :: . :. .. ::: ..::.... : ::. :.: : .:.: XP_005 ESKKPKTEDKNSA-----------GHKPSSNRESSKQSAA---KEKDLLPSPAGPVPSKD 400 410 420 430 440 900 910 920 930 940 950 pF1KE9 PRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATI :. .. : . ..:...... :.. . : . : : : ..: :. .. XP_005 PKTEHGS-------RKRTISQSSSLKSSSNSNKETS------GSSKNSSSTSKQKKTE-- 450 460 470 480 490 960 970 980 990 1000 1010 pF1KE9 TVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMDSSHLEMTS . :.... .. . . ... :. XP_005 -----------------------------GKTSSSSKEVKEKAPSSSSNCPPSA------ 500 510 1020 1030 1040 1050 1060 1070 pF1KE9 WAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAAL : :.::. :: ::.::: ..::.:.::::::::.:::: ..: ::: : ::.. XP_005 ----PTLDSSKP--RRTKLVFDDRNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVV 520 530 540 550 560 1080 1090 1100 1110 1120 1130 pF1KE9 SFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLS :: :::::.:.. :.:::. ::::::.:..:.:.:::. .: :. .::.:.::: :: : XP_005 SFIECGNALEKNAQESKSPFPMYSETVDLIKYTMKLKNYLAPDATAADKRLTVLCLRCES 570 580 590 600 610 620 1140 1150 1160 1170 1180 1190 pF1KE9 LLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWV-SNGKNTPSPVSLNNVSPIN :::::.:::::..:.:::..: :..: :. . .: ::: . :.. . ::::: ..:: : XP_005 LLYLRLFKLKKENALKYSKTLTEHLK-NSYNNSQAPSPGLGSKAVGMPSPVS-PKLSPGN 630 640 650 660 670 680 1200 1210 1220 1230 1240 pF1KE9 AMGNCNNGP---------VTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFF . :: ..: :::::.::.::::.:..::: : . : ::.:..:..:.:::: XP_005 S-GNYSSGASSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFF 690 700 710 720 730 740 1250 1260 1270 pF1KE9 GDLDTLMGPLTQHSS-MTNLVRYVRQGLCWLRIDAHLL ..:: .:::: ..: ::.::::.:::: ::: ::.:. XP_005 AELDKVMGPLIFNASIMTDLVRYTRQGLHWLRQDAKLIS 750 760 770 780 >>XP_006714650 (OMIM: 604417,616368) PREDICTED: AF4/FMR2 (1134 aa) initn: 1629 init1: 586 opt: 999 Z-score: 606.0 bits: 124.2 E(85289): 5.1e-27 Smith-Waterman score: 2114; 36.8% identity (62.1% similar) in 1287 aa overlap (20-1278:4-1133) 10 20 30 40 50 pF1KE9 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYK-TNK .::..:. .: ::::::.:: .: : . ::.:::: :.: XP_006 MNREDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSK 10 20 30 40 60 70 80 90 100 110 pF1KE9 GDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRII : :..:.:. ::::::::... ..: . ::.::: .:: . ..:..:.:: ::.. XP_006 EDKLSSRIQSMLGNYDEMKDFIGDRSIPK-LVAIPKPTVPPSADEKSNPNFF-EQRHG-- 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE9 PPHQDNT-HPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQ ::.. : .: : : :. ..:...:. : : . :. ....::: . . XP_006 GSHQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQ----RTSAGSSS--GTNSSGQRHDRE 110 120 130 140 150 180 190 200 210 220 230 pF1KE9 TLTQDQSQAKLEDFFVYPAEQPQIGEVEESNP---SAKEDSNPNSSGEDAF-KEIFQSNS . ... :... . . .:. . ..: :. ..:. : :.: :: .:.: XP_006 SYNNSGSSSRKKG--QHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKS 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE9 PEESEFAVQAPGSPLVASSLLAPSSGL-SVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQ :.. . ..: : . ::: :.:.:::.:. :.. :::::::::::::.. XP_006 PRDPDANWDSP-------SRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQES 220 230 240 250 260 300 310 320 330 340 350 pF1KE9 APDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTI-LQTSEVSLPSDPSC . : :. .: :: .. . ::: ::..: :. : : ..: .: :: XP_006 ---MEPKLSSEHYSSQSHGN----SMTELKPS---SKAHLTKLKIPSQPLDASASGDVSC 270 280 290 300 310 360 370 380 390 400 410 pF1KE9 VEEILRESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLKLSSDEDDLEPVKTLTTQ :.:::.:::. . : :: .:. ..:. : ::::.:::::::.:: XP_006 VDEILKESQQSNFGTGEQKRYNPS-KTSNGHQS-KSMLKDDLKLSSSED----------- 320 330 340 350 360 420 430 440 450 460 470 pF1KE9 CTATELYQAVEKAKPRNNP-VNPPLATPQPPPAVQASGGSGSSSESESSSESDSDTESST .. : .:. ::..: : . . : .. :.: : ::::: :::..:::. XP_006 ---SDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSS 370 380 390 400 410 480 490 500 510 520 530 pF1KE9 TDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETISLPPPIIQ .:::.:: . :.:::::: :::::::.:::::. .. : : ... : : XP_006 SDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVS--------PASSVDSNIPSSQ 420 430 440 450 460 470 540 550 560 570 580 pF1KE9 PMEVQMKVK-TNASQVPAE-PKERPLLSLIREKARPRPTQKIPETKALKHKLSTTSETVS .. . . . :. : . . ::: . :.. . :: :. ..: . :.... XP_006 GYKKEGREQGTGNSYTDTSGPKETSSATPGRDS---KTIQKGSESGRGRQKSPAQSDSTT 480 490 500 510 520 590 600 610 620 630 640 pF1KE9 QR-TIGKKQPKKVEKNTSTDEFTWPKPN--ITSSTPKEKESVELHDPPRGRNKAT---AH :: :.:::::::.:: .. . :. . : : :: . : . : .:.::. .. XP_006 QRRTVGKKQPKKAEKAAAEE----PRGGLKIESETPVDLAS----SMPSSRHKAATKGSR 530 540 550 560 570 580 650 660 670 680 690 700 pF1KE9 KPAPRKEPRPNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPC :: .:: . . . :::::.. .: ::::.::::.:.::: :. :.: :: XP_006 KPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDS--DESESL-----PP- 590 600 610 620 630 710 720 730 740 750 760 pF1KE9 IISGGNTAKSKEICGASLTLSTLMSSSGSNNNLSISNEEPTFSPIPVMQTEILSPLRDHE ...: : : . : .. :. ... :. .. :::. . :.:::: . . XP_006 ---SSQTPKYPE------SNRTPVKPSSVEEEDSFFRQR-MFSPME--EKELLSPLSEPD 640 650 660 670 680 770 780 790 800 810 820 pF1KE9 NLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAVEKPAPKGKRKHK . : :::::.::.:.::. .. : : ..:.. : :.. : :: . ::::::: XP_006 DRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHK 690 700 710 720 730 740 830 840 850 860 870 880 pF1KE9 PIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPP . . :: . :. .. ::: ..::.... : ::. :.: : XP_006 NEDDNRASESKKPKTEDKNSA-----------GHKPSSNRESSKQSAA---KEKDLLPSP 750 760 770 780 890 900 910 920 930 940 pF1KE9 LSPLPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTP .:.: :. .. : . ..:...... :.. . : .: : : ..: XP_006 AGPVPSKDPKTEHGS-------RKRTISQSSSLKSSSNSNKET------SGSSKNSSSTS 790 800 810 820 830 950 960 970 980 990 1000 pF1KE9 KKASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTITTGLMD :. .. : ... : : ..... .. XP_006 KQKKTEGKTSSSSK--------------EVKEKAPSSSSNCPPSA--------------- 840 850 860 1010 1020 1030 1040 1050 1060 pF1KE9 SSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKA : :.::. :: ::.::: ..::.:.::::::::.:::: ..: :: XP_006 ------------PTLDSSKP--RRTKLVFDDRNYSADHYLQEAKKLKHNADALSDRFEKA 870 880 890 900 910 1070 1080 1090 1100 1110 1120 pF1KE9 VNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLA : : ::..:: :::::.:.. :.:::. ::::::.:..:.:.:::. .: :. .::.:. XP_006 VYYLDAVVSFIECGNALEKNAQESKSPFPMYSETVDLIKYTMKLKNYLAPDATAADKRLT 920 930 940 950 960 970 1130 1140 1150 1160 1170 1180 pF1KE9 VLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWV-SNGKNTPSPVS ::: :: ::::::.:::::..:.:::..: :..: :. . .: ::: . :.. . ::::: XP_006 VLCLRCESLLYLRLFKLKKENALKYSKTLTEHLK-NSYNNSQAPSPGLGSKAVGMPSPVS 980 990 1000 1010 1020 1190 1200 1210 1220 1230 pF1KE9 LNNVSPINAMGNCNNGP---------VTIPQRIHHMAASHVNITSNVLRGYEHWDMADKL ..:: :. :: ..: :::::.::.::::.:..::: : . : ::.:..: XP_006 -PKLSPGNS-GNYSSGASSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQL 1030 1040 1050 1060 1070 1080 1240 1250 1260 1270 pF1KE9 TRENKEFFGDLDTLMGPLTQHSS-MTNLVRYVRQGLCWLRIDAHLL ..:.::::..:: .:::: ..: ::.::::.:::: ::: ::.:. XP_006 SKEQKEFFAELDKVMGPLIFNASIMTDLVRYTRQGLHWLRQDAKLIS 1090 1100 1110 1120 1130 >>XP_005272020 (OMIM: 604417,616368) PREDICTED: AF4/FMR2 (1163 aa) initn: 1642 init1: 586 opt: 999 Z-score: 605.8 bits: 124.2 E(85289): 5.2e-27 Smith-Waterman score: 2051; 36.0% identity (60.6% similar) in 1316 aa overlap (20-1278:4-1162) 10 20 30 40 50 pF1KE9 MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYK-TNK .::..:. .: ::::::.:: .: : . ::.:::: :.: XP_005 MNREDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSK 10 20 30 40 60 70 80 90 100 110 pF1KE9 GDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRII : :..:.:. ::::::::... ..: . ::.::: .:: . ..:..:.:: ::.. XP_005 EDKLSSRIQSMLGNYDEMKDFIGDRSIPK-LVAIPKPTVPPSADEKSNPNFF-EQRHG-- 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE9 PPHQDNT-HPSAPMPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQ ::.. : .: : : :. ..:...:. : : . :. ....::: . . XP_005 GSHQSSKWTPVGPAPSTSQSQKRSSGLQSGHSSQ----RTSAGSSS--GTNSSGQRHDRE 110 120 130 140 150 180 190 200 210 220 230 pF1KE9 TLTQDQSQAKLEDFFVYPAEQPQIGEVEESNP---SAKEDSNPNSSGEDAF-KEIFQSNS . ... :... . . .:. . ..: :. ..:. : :.: :: .:.: XP_005 SYNNSGSSSRKKG--QHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKS 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE9 PEESEFAVQAPGSPLVASSLLAPSSGL-SVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQ :.. . ..: : . ::: :.:.:::.:. :.. :::::::::::::.. XP_005 PRDPDANWDSP-------SRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQES 220 230 240 250 260 300 310 320 330 340 350 pF1KE9 APDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTI-LQTSEVSLPSDPSC . : :. .: :: .. . ::: ::..: :. : : ..: .: :: XP_005 ---MEPKLSSEHYSSQSHGN----SMTELKPS---SKAHLTKLKIPSQPLDASASGDVSC 270 280 290 300 310 360 370 380 pF1KE9 VEEILRESQHLTP-----------------------------GFTLQKWNDPTTRASTKS :.:::.: : : : :: .:. ..:. XP_005 VDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPS-KTSNGH 320 330 340 350 360 370 390 400 410 420 430 440 pF1KE9 VSFKSMLEDDLKLSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNP-VNPPLATPQPP : ::::.:::::::.:: .. : .:. ::..: : . . XP_005 QS-KSMLKDDLKLSSSED--------------SDGEQDCDKTMPRSTPGSNSEPSHHNSE 380 390 400 410 450 460 470 480 490 500 pF1KE9 PAVQASGGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLN : .. :.: : ::::: :::..:::..:::.:: . :.:::::: :::::::.::: XP_005 GADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLN 420 430 440 450 460 470 510 520 530 540 550 560 pF1KE9 KVTSQNKSFICGQNETPMETISLPPPIIQPMEVQMKVK-TNASQVPAE-PKERPLLSLIR ::. .. : : ... : : .. . . . :. : . . ::: . : XP_005 KVNPHKVS--------PASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGR 480 490 500 510 520 530 570 580 590 600 610 pF1KE9 EKARPRPTQKIPETKALKHKLSTTSETVSQR-TIGKKQPKKVEKNTSTDEFTWPKPN--I .. . :: :. ..: . :....:: :.:::::::.:: .. . :. . : XP_005 DS---KTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEE----PRGGLKI 540 550 560 570 580 620 630 640 650 660 670 pF1KE9 TSSTPKEKESVELHDPPRGRNKAT---AHKPAPRKEPRPNIPLAPEKKKYRGPGKIVPKS : :: . : . : .:.::. ..:: .:: . . . :::::.. .: :: XP_005 ESETPVDLAS----SMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKS 590 600 610 620 630 640 680 690 700 710 720 730 pF1KE9 REFIETDSSTSDSNTDQEETLQIKVLPPCIISGGNTAKSKEICGASLTLSTLMSSSGSNN ::.::::.:.::: :. :.: :: ...: : : . : .. :. .. XP_005 REIIETDTSSSDS--DESESL-----PP----SSQTPKYPE------SNRTPVKPSSVEE 650 660 670 680 740 750 760 770 780 790 pF1KE9 NLSISNEEPTFSPIPVMQTEILSPLRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPD . :. .. :::. . :.:::: . .. : :::::.::.:.::. .. : : . XP_005 EDSFFRQR-MFSPME--EKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGE 690 700 710 720 730 740 800 810 820 830 840 850 pF1KE9 HKETATKPKRQTAVTAVEKPAPKGKRKHKPIEVAEKIPEKKQRLEEATTICLLPPCISPA .:.. : :.. : :: . ::::::: . . :: . :. .. XP_005 KKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSA---------- 750 760 770 780 790 860 870 880 890 900 910 pF1KE9 PPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPPRRRNVSGNNGPFGQDKNIAMTG ::: ..::.... : ::. :.: : .:.: :. .. : . ..:.... XP_005 -GHKPSSNRESSKQSAA---KEKDLLPSPAGPVPSKDPKTEHGS-------RKRTISQSS 800 810 820 830 920 930 940 950 960 970 pF1KE9 QITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATITVTNTAIATATVTATAIVTTTVT .. :.. . : .: : : ..: :. .. : ... : XP_005 SLKSSSNSNKET------SGSSKNSSSTSKQKKTEGKTSSSSK--------------EVK 840 850 860 870 980 990 1000 1010 1020 1030 pF1KE9 ATATATATTTTTTTTISTITSTITTGLMDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDD : ..... .. : :.::. :: ::.::: XP_005 EKAPSSSSNCPPSA---------------------------PTLDSSKP--RRTKLVFDD 880 890 900 910 1040 1050 1060 1070 1080 1090 pF1KE9 SVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMY ..::.:.::::::::.:::: ..: ::: : ::..:: :::::.:.. :.:::. :: XP_005 RNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMY 920 930 940 950 960 970 1100 1110 1120 1130 1140 1150 pF1KE9 SETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLME ::::.:..:.:.:::. .: :. .::.:.::: :: ::::::.:::::..:.:::..: : XP_005 SETVDLIKYTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTE 980 990 1000 1010 1020 1030 1160 1170 1180 1190 1200 pF1KE9 YFKQNASKVAQIPSPWV-SNGKNTPSPVSLNNVSPINAMGNCNNGP---------VTIPQ ..: :. . .: ::: . :.. . ::::: ..:: :. :: ..: ::::: XP_005 HLK-NSYNNSQAPSPGLGSKAVGMPSPVS-PKLSPGNS-GNYSSGASSASASGSSVTIPQ 1040 1050 1060 1070 1080 1210 1220 1230 1240 1250 1260 pF1KE9 RIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSS-MTNLVRY .::.::::.:..::: : . : ::.:..:..:.::::..:: .:::: ..: ::.:::: XP_005 KIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLVRY 1090 1100 1110 1120 1130 1140 1270 pF1KE9 VRQGLCWLRIDAHLL .:::: ::: ::.:. XP_005 TRQGLHWLRQDAKLIS 1150 1160 1278 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 10:23:48 2016 done: Tue Nov 8 10:23:50 2016 Total Scan time: 12.940 Total Display time: 0.470 Function used was FASTA [36.3.4 Apr, 2011]