Result of FASTA (omim) for
pFN21AB9724
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9724, 418 aa
1>>>pF1KB9724 418 - 418 aa - 418 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.9246+/-0.000516; mu= 5.5896+/- 0.032
mean_var=495.0126+/-98.776, 0's: 0 Z-trim(121.3): 94 B-trim: 0 in 0/55
Lambda= 0.057646
statistics sampled from 37528 (37649) to 37528 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.74), E-opt: 0.2 (0.441), width: 16
Scan time: 8.780
The best scores are: opt bits E(85289)
NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419) 2817 248.8 1.9e-65
NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 1028 100.0 1.2e-20
NP_002691 (OMIM: 602459,602460) POU domain, class ( 338) 996 97.2 6.8e-20
NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451) 631 67.0 1.1e-10
NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500) 524 58.2 5.4e-08
NP_000298 (OMIM: 300039,304400) POU domain, class ( 361) 518 57.5 6.5e-08
NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360) 514 57.1 8.2e-08
NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443) 514 57.3 9.1e-08
NP_001153014 (OMIM: 615739) putative POU domain, c ( 359) 488 55.0 3.7e-07
XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356) 481 54.4 5.4e-07
XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403) 481 54.5 5.8e-07
XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403) 481 54.5 5.8e-07
XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403) 481 54.5 5.8e-07
XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432) 481 54.5 6e-07
XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432) 481 54.5 6e-07
NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436) 481 54.5 6e-07
NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438) 481 54.5 6.1e-07
NP_000297 (OMIM: 173110,613038) pituitary-specific ( 291) 457 52.2 2e-06
NP_001116229 (OMIM: 173110,613038) pituitary-speci ( 317) 457 52.3 2e-06
XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671) 443 51.7 6.7e-06
NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703) 443 51.7 6.9e-06
XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743) 443 51.7 7.1e-06
NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755) 443 51.7 7.2e-06
NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766) 443 51.7 7.2e-06
XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769) 443 51.8 7.2e-06
NP_001272916 (OMIM: 164177) POU domain, class 5, t ( 265) 429 49.8 9.4e-06
NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655) 404 48.4 6.3e-05
NP_001167002 (OMIM: 164177) POU domain, class 5, t ( 190) 340 42.2 0.0013
NP_976034 (OMIM: 164177) POU domain, class 5, tran ( 190) 340 42.2 0.0013
NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400) 322 41.2 0.0055
NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463) 322 41.3 0.006
XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485) 322 41.4 0.0061
XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586) 322 41.5 0.0067
XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608) 322 41.5 0.0069
XP_016882380 (OMIM: 164176) PREDICTED: POU domain, ( 707) 322 41.6 0.0074
NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467) 315 40.8 0.009
NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479) 315 40.8 0.0091
XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501) 315 40.8 0.0093
XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537) 315 40.9 0.0096
>>NP_006228 (OMIM: 601632) POU domain, class 4, transcri (419 aa)
initn: 2170 init1: 2170 opt: 2817 Z-score: 1295.8 bits: 248.8 E(85289): 1.9e-65
Smith-Waterman score: 2817; 99.8% identity (99.8% similar) in 419 aa overlap (1-418:1-419)
10 20 30 40 50 60
pF1KB9 MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEA
10 20 30 40 50 60
70 80 90 100 110
pF1KB9 LAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHHHHHHH-QALEPGDLLDHI
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_006 LAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHHHHHHHHQALEPGDLLDHI
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB9 SSPSLALMAGAGGAGAAAGGGGAHDGPGGGGGPGGGGGPGGGPGGGGGGGPGGGGGGPGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SSPSLALMAGAGGAGAAAGGGGAHDGPGGGGGPGGGGGPGGGPGGGGGGGPGGGGGGPGG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB9 GLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAAAAAGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAAAAAGQV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB9 AAASAAAAVVGAAGLASICDSDTDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AAASAAAAVVGAAGLASICDSDTDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPG
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB9 VGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRT
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB9 SIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
370 380 390 400 410
>>NP_004566 (OMIM: 113725) POU domain, class 4, transcri (409 aa)
initn: 1166 init1: 964 opt: 1028 Z-score: 491.8 bits: 100.0 E(85289): 1.2e-20
Smith-Waterman score: 1292; 58.7% identity (67.6% similar) in 414 aa overlap (29-416:84-407)
10 20 30 40 50
pF1KB9 MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARA
:::.::::::::: ::.:..:::.:::::
NP_004 GGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP--SNIFGGLDESLLARA
60 70 80 90 100 110
60 70 80 90 100
pF1KB9 EALAAVDIAVSQGKSH--------PFKPDATYHTMNSVPCTS---TSTVPLAH-------
:::::::: :::.::: ::::::::::::..:::: .:.::..:
NP_004 EALAAVDI-VSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGT
120 130 140 150 160 170
110 120 130 140 150
pF1KB9 HHHHHHH--------QALEPGDLLDHISSPSLALMAGAGGAGAAAGGGGAHDGPGGGGGP
::::::: :::: :.::.:.: :.::: :: ::
NP_004 HHHHHHHHHHHHQPHQALE-GELLEHLS-PGLAL-------GAMAG--------------
180 190 200
160 170 180 190 200 210
pF1KB9 GGGGGPGGGPGGGGGGGPGGGGGGPGGGLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSG
: :.... :: ::: ... . . :: .: :
NP_004 ------------------------PDGAVVSTPAHA-PHMATMNPMHQ--AALSMAHAHG
210 220 230 240
220 230 240 250 260 270
pF1KB9 LPHPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAE
:: .: : . : :.:::.::::::
NP_004 LP--------SHMGC-----------------------------MSDVDADPRDLEAFAE
250 260
280 290 300 310 320 330
pF1KB9 RFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWL
270 280 290 300 310 320
340 350 360 370 380 390
pF1KB9 EEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLD
:::: ..:::..:::::::.::::::::::::::::::::::.:::::::::::::::::
NP_004 EEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLD
330 340 350 360 370 380
400 410
pF1KB9 LKKNVVRVWFCNQRQKQKRMKFSATY
:::::::::::::::::::::.::
NP_004 LKKNVVRVWFCNQRQKQKRMKYSAGI
390 400
>>NP_002691 (OMIM: 602459,602460) POU domain, class 4, t (338 aa)
initn: 1298 init1: 945 opt: 996 Z-score: 478.2 bits: 97.2 E(85289): 6.8e-20
Smith-Waterman score: 1447; 60.5% identity (71.8% similar) in 425 aa overlap (1-418:1-338)
10 20 30 40 50 60
pF1KB9 MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEA
::.:::::: :.:::.: : :. ::::.:::.::.:::.: ::.:.:.:.::.:::::::
NP_002 MMAMNSKQP-FGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEA
10 20 30 40 50
70 80 90 100 110
pF1KB9 LAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTS-TVPLAH------HHHHHHHQALEPG
:::::: ::.::.::::::::::::.:::::::: :::..: : :: ::.:: :
NP_002 LAAVDI-VSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLE-G
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 DLLDHISSPSLALMAGAGGAGAAAGGGGAHDGPGGGGGPGGGGGPGGGPGGGGGGGPGGG
:::.::: :.:.. .:
NP_002 DLLEHIS-PTLSV---------------------------------------------SG
120 130
180 190 200 210 220 230
pF1KB9 GGGPGGGLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAA
:.: ... .. ::: :. ..::: : : :. :: :: :.: :
NP_002 LGAPEHSVMPAQIHPH-HLGAMGHL-HQAM--------GMSHPHTVAP---HSAMPAC--
140 150 160 170
240 250 260 270 280 290
pF1KB9 AAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAERFKQRRIKLGVTQADVGSALA
. : ..:::::::::::::::::::::::::::.:::
NP_002 -----------------------LSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALA
180 190 200 210
300 310 320 330 340 350
pF1KB9 NLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGE
:::::::::::::::::::::::::::::::::.:::::::::.: ::: .:::::::.:
NP_002 NLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSE
220 230 240 250 260 270
360 370 380 390 400 410
pF1KB9 KKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMK
.::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
NP_002 RKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMK
280 290 300 310 320 330
pF1KB9 FSATY
.::..
NP_002 YSAVH
>>NP_002690 (OMIM: 602479) POU domain, class 3, transcri (451 aa)
initn: 598 init1: 369 opt: 631 Z-score: 313.0 bits: 67.0 E(85289): 1.1e-10
Smith-Waterman score: 673; 44.2% identity (68.5% similar) in 292 aa overlap (129-416:120-401)
100 110 120 130 140 150
pF1KB9 AHHHHHHHHQALEPGDLLDHISSPSLALMAGAGGAGAA-AGGGGAHD-GPGGGGGPGGGG
::. :::: : :. :: ::. . .::..:
NP_002 LEHGKAGGGGTGRADDGGGGGGFHARLVHQGAAHAGAAWAQGSTAHHLGPAMSPSPGASG
90 100 110 120 130 140
160 170 180 190 200 210
pF1KB9 GPGGGPGG--GGGGGPGGGGGGPGGGLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSGLP
: : : . .. ::::::: .: : .:.. : .: : : . :. :: :
NP_002 GHQPQPLGLYAQAAYPGGGGGGLAGMLAAGGGGAGPGLH---HALHEDGHEAQLEPSPPP
150 160 170 180 190 200
220 230 240 250 260 270
pF1KB9 HPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAERF
: : . : :. :.. :::: .:..... :: . . .:: .:: ::..:
NP_002 HLGAHGHAHGHAHAGGLHAAAAHLHPGAGGGGSSVGEHSDEDAPSSD----DLEQFAKQF
210 220 230 240 250 260
280 290 300 310 320 330
pF1KB9 KQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEE
:::::::: :::::: ::..: : . .::.::::::.: :: .:: :::.:. ::::
NP_002 KQRRIKLGFTQADVGLALGTLY--G-NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEE
270 280 290 300 310
340 350 360 370 380 390
pF1KB9 AEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLK
..... : .. :.:..::::: . : .::..: :.::...:...:..:.:.
NP_002 TDSSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLE
320 330 340 350 360 370
400 410
pF1KB9 KNVVRVWFCNQRQKQKRMKFSATY
:.::::::::.:::.::: .:
NP_002 KEVVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGGGASPPSAPPPPPPAALH
380 390 400 410 420 430
>>NP_006227 (OMIM: 602480) POU domain, class 3, transcri (500 aa)
initn: 957 init1: 369 opt: 524 Z-score: 264.5 bits: 58.2 E(85289): 5.4e-08
Smith-Waterman score: 612; 38.7% identity (59.5% similar) in 328 aa overlap (103-412:165-464)
80 90 100 110 120 130
pF1KB9 SHPFKPDATYHTMNSVPCTSTSTVPLAHHHHHHHHQALEPGDLLDHISSPSLALMAGAGG
::. : : : . :. :.:..
NP_006 QPPQPPPPPPQGPDVKGGAGRDDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAA
140 150 160 170 180 190
140 150 160 170 180
pF1KB9 AGAAAGGGGAH-DGPGGGGGPGGGGGPGGGPGG-------GGGGGPGGGGGGPGGG----
:.:::....:: . .:: : . . ::: .. :::::::: :::
NP_006 AAAAAAAAAAHLPSMAGGQQPPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSL
200 210 220 230 240 250
190 200 210 220 230
pF1KB9 -----LLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAAAA
. : . . : : : .:: : ::: . . :::.....:.
NP_006 VHPGLVRGDTPELAEHHHHHHHHAHP-------HP---PHPHHAQGPPHHGGGGGGAGP-
260 270 280 290 300
240 250 260 270 280 290
pF1KB9 AGQVAAASAAAAVVGAAGLASICDSDTDPRE-LEAFAERFKQRRIKLGVTQADVGSALAN
: . : :: . :: ::..::::::::: :::::: ::..
NP_006 --------------GLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGT
310 320 330 340
300 310 320 330 340 350
pF1KB9 LKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEK
: : . .::.::::::.: :: .:: :::.:. :::::... . .. :.:
NP_006 LY--G-NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRK
350 360 370 380 390 400
360 370 380 390 400 410
pF1KB9 KRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKF
..::::: . : .::..: :.::...:. .:..:.:.:.::::::::.:::.:::
NP_006 RKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFCNRRQKEKRMTP
410 420 430 440 450 460
pF1KB9 SATY
NP_006 PGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ
470 480 490 500
>>NP_000298 (OMIM: 300039,304400) POU domain, class 3, t (361 aa)
initn: 534 init1: 364 opt: 518 Z-score: 263.1 bits: 57.5 E(85289): 6.5e-08
Smith-Waterman score: 537; 42.6% identity (65.2% similar) in 244 aa overlap (187-412:96-336)
160 170 180 190 200 210
pF1KB9 GPGGGPGGGGGGGPGGGGGGPGGGLLGGSAHPHPHM-HSLGHLSHPAAAAAMNMP-----
: ::. : : .:: : .: :
NP_000 PWSSTLATSPLDQQDVKPGREDLQLGAIIHHRSPHVAHHSPHTNHPNAWGASPAPNPSIT
70 80 90 100 110 120
220 230 240 250
pF1KB9 -SGLP-----HPGL-VAAAAHHGAAAAAAAAAAGQ----VAAASAAAAVVGAAGLASICD
:: : .::. :.. .::. . :::..: : . .:. . :
NP_000 SSGQPLNVYSQPGFTVSGMLEHGGLTPPPAAASAQSLHPVLREPPDHGELGSHHCQDHSD
130 140 150 160 170 180
260 270 280 290 300 310
pF1KB9 SDTDPR-ELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSH
.: ::: ::..::::::::: :::::: ::..: : . .::.::::::.: ::
NP_000 EETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLY--G-NVFSQTTICRFEALQLSF
190 200 210 220 230 240
320 330 340 350 360 370
pF1KB9 NNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPR
.:: :::.:. :::::... . .. :.:..::::: . : ::..: :.
NP_000 KNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGVLETHFLKCPK
250 260 270 280 290 300
380 390 400 410
pF1KB9 PSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
:....:...:..:.:.:.::::::::.:::.:::
NP_000 PAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPHEVYSHTVKTDTSCHDL
310 320 330 340 350 360
>>NP_002692 (OMIM: 164177) POU domain, class 5, transcri (360 aa)
initn: 350 init1: 350 opt: 514 Z-score: 261.3 bits: 57.1 E(85289): 8.2e-08
Smith-Waterman score: 518; 38.8% identity (59.2% similar) in 289 aa overlap (138-411:16-287)
110 120 130 140 150
pF1KB9 QALEPGDLLDHISSPSLALMAGAGGAGAAAGGGGAHDGPGGGGGPG--------GGGGPG
:::: ::::: :: . ::
NP_002 MAGHLASDFAFSPPPGGGG--DGPGGPE-PGWVDPRTWLSFQGPP
10 20 30 40
160 170 180 190 200 210
pF1KB9 GGPGGGGGGGPGGGGGG-----PGGGLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSGLP
:::: : : :::. : : . :: :. :.. ..: . : .. ..: :
NP_002 GGPGIGPGVGPGSEVWGIPPCPPPYEFCGGMAYCGPQV-GVGLV--PQGGLETSQPEG--
50 60 70 80 90
220 230 240 250 260 270
pF1KB9 HPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAERF
. :. . . ::. ... : : . . : . .::: ::. .
NP_002 EAGVGVESNSDGASPEPCTVTPGAVKLEKEKLEQNPEESQ----DIKALQKELEQFAKLL
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB9 KQRRIKLGVTQADVGSALANLKIPGVGSL-SQSTICRFESLTLSHNNMIALKPILQAWLE
::.:: :: :::::: .:. : :.. ::.::::::.: :: .:: :.:.:: :.:
NP_002 KQKRITLGYTQADVGLTLGVL----FGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVE
160 170 180 190 200
340 350 360 370 380 390
pF1KB9 EAEGAQR-EKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLD
::.. . ... : : . . .::::::: . .:: : :.:. ..:. ::..:
NP_002 EADNNENLQEICKAETLVQA-RKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLG
210 220 230 240 250 260
400 410
pF1KB9 LKKNVVRVWFCNQRQKQKRMKFSATY
:.:.::::::::.::: ::
NP_002 LEKDVVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPLAPGPHFGTPGYGSP
270 280 290 300 310 320
>>NP_005595 (OMIM: 600494) POU domain, class 3, transcri (443 aa)
initn: 1020 init1: 372 opt: 514 Z-score: 260.4 bits: 57.3 E(85289): 9.1e-08
Smith-Waterman score: 550; 36.8% identity (54.9% similar) in 364 aa overlap (113-412:52-412)
90 100 110 120 130 140
pF1KB9 HTMNSVPCTSTSTVPLAHHHHHHHHQALEPGDLLDHISSPSLALMAGAGGAGAAAGGGGA
: :.: . :: :.::.:...::::.
NP_005 EPPGGMQQGAGGYREAQSLVQGDYGALQSNGHPLSHAHQWITALSHGGGGGGGGGGGGGG
30 40 50 60 70 80
150 160 170
pF1KB9 HDGPGGGGGPGGGGGPGGGPG---------GGGGG---GPGG------------------
: ::: : . .: : : :: : :::.
NP_005 GGGGGGGDGSPWSTSPLGQPDIKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQ
90 100 110 120 130 140
180 190 200
pF1KB9 -----------------GGGGPGGGLL---GGSAHPHPHMH-SLGHL--SHPAAAA----
.. :: : ...:: : : : : : :.:. ..
NP_005 QQQQQQQQRPPHLVHHAANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGML
150 160 170 180 190 200
210 220 230 240 250 260
pF1KB9 -AMNMPSGLPHPGLVAA--AAHHGAAAAAAAAAAGQVAAASAAA-AVVGAAGLASICDSD
: ..:.:: : :: : ::. . : . : : ::
NP_005 GAGGQPAGLHHHGLRDAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSD
210 220 230 240 250 260
270 280 290 300 310
pF1KB9 TD-PR--ELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSH
: : .:: ::..::::::::: :::::: ::..: : . .::.::::::.: ::
NP_005 EDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLY--G-NVFSQTTICRFEALQLSF
270 280 290 300 310
320 330 340 350 360 370
pF1KB9 NNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPR
.:: :::.:. :::::.... . .. :.:..::::: . : .::..: :.
NP_005 KNMCKLKPLLNKWLEEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPK
320 330 340 350 360 370
380 390 400 410
pF1KB9 PSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
::...:...:..:.:.:.::::::::.:::.:::
NP_005 PSAQEITSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGV
380 390 400 410 420 430
NP_005 QTPVQ
440
>>NP_001153014 (OMIM: 615739) putative POU domain, class (359 aa)
initn: 502 init1: 181 opt: 488 Z-score: 249.6 bits: 55.0 E(85289): 3.7e-07
Smith-Waterman score: 490; 38.4% identity (58.8% similar) in 289 aa overlap (138-411:16-286)
110 120 130 140 150
pF1KB9 QALEPGDLLDHISSPSLALMAGAGGAGAAAGGGGAHDGPGGGGGPG--------GGGGPG
:::: ::: :. :: . ::
NP_001 MAGHLASDFAFSPPPGGGG--DGPWGAE-PGWVDPLTWLSFQGPP
10 20 30 40
160 170 180 190 200 210
pF1KB9 GGPGGGGGGGPGGGGGG-----PGGGLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSGLP
:::: : : :::. : : : :: :. :.. ..: . : .. ..: .
NP_001 GGPGIGPGVGPGSEVWGIPPCPPPYELCGGMAYCGPQV-GVGLV--PQGGLETSQPES--
50 60 70 80 90
220 230 240 250 260 270
pF1KB9 HPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAERF
. :. . . .::. .. : : . . . : . .::: ::. .
NP_001 EAGVGVESNSNGASPEPCTVPPGAVKLEKEKLE----QNPEKSQDIKALQKELEQFAKLL
100 110 120 130 140 150
280 290 300 310 320 330
pF1KB9 KQRRIKLGVTQADVGSALANLKIPGVGSL-SQSTICRFESLTLSHNNMIALKPILQAWLE
::.:: :: :::::: :. : :.. ::.::::::.: :: .:: :.:.:: :.:
NP_001 KQKRITLGYTQADVGLILGVL----FGKVFSQKTICRFEALQLSFKNMCKLRPLLQKWVE
160 170 180 190 200
340 350 360 370 380 390
pF1KB9 EAEGAQR-EKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLD
::.. . ... : : . . .::::::: . .:: : :.:. . :. ::..:
NP_001 EADNNENLQEICKAETLMQA-RKRKRTSIENRVRGNLENLFLQCPKPTLQ-ISHIAQQLG
210 220 230 240 250 260
400 410
pF1KB9 LKKNVVRVWFCNQRQKQKRMKFSATY
:.:.::::::::.::: ::
NP_001 LEKDVVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPPAPGPHFGTPGYGSP
270 280 290 300 310 320
>>XP_016872976 (OMIM: 607394) PREDICTED: POU domain, cla (356 aa)
initn: 488 init1: 216 opt: 481 Z-score: 246.5 bits: 54.4 E(85289): 5.4e-07
Smith-Waterman score: 481; 40.3% identity (68.3% similar) in 221 aa overlap (198-412:127-339)
170 180 190 200 210 220
pF1KB9 GGPGGGGGGPGGGLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGA
: : ... .:. :::.. : : .
XP_016 LVLVPGHLQSVSQFLLSQTQPGQQGLQPNLLPFPQQQSGLLLPQ--TGPGLASQAFGHPG
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB9 AAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAERFKQRRIKLGVTQAD
... ... . . ..: : : .: .::: ::. ::::::::: ::.:
XP_016 LPGSSLEPHLEASQHLPVPKHLPSSGGA---DEPSDLEELEKFAKTFKQRRIKLGFTQGD
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB9 VGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQRE-KMNKP
:: :.. :. : ...::.:: :::.:.:: .:: :::.:. ::..::.. . ... :
XP_016 VGLAMG--KLYG-NDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTP
220 230 240 250 260
350 360 370 380 390 400
pF1KB9 ELFNG-----GEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVW
. . :.:..::::: . . .:: : .:.::::.:. :::.:...:.:::::
XP_016 SSYPSLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVW
270 280 290 300 310 320
410
pF1KB9 FCNQRQKQKRMKFSATY
:::.:::.::.
XP_016 FCNRRQKEKRINCPVATPIKPPVYNSRL
330 340 350
418 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 07:45:35 2016 done: Tue Nov 8 07:45:36 2016
Total Scan time: 8.780 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]