FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3488, 1826 aa 1>>>pF1KE3488 1826 - 1826 aa - 1826 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.5694+/-0.000353; mu= 15.0616+/- 0.022 mean_var=156.6137+/-31.390, 0's: 0 Z-trim(119.6): 300 B-trim: 57 in 1/57 Lambda= 0.102485 statistics sampled from 33507 (33846) to 33507 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.397), width: 16 Scan time: 19.080 The best scores are: opt bits E(85289) NP_722516 (OMIM: 607798) transcription initiation (1826) 12325 1835.5 0 XP_005262352 (OMIM: 300966,313650,314250) PREDICTE (1927) 11601 1728.5 0 XP_005262353 (OMIM: 300966,313650,314250) PREDICTE (1926) 11589 1726.7 0 NP_004597 (OMIM: 300966,313650,314250) transcripti (1893) 10977 1636.2 0 NP_001273003 (OMIM: 300966,313650,314250) transcri (1895) 10963 1634.1 0 XP_006724745 (OMIM: 300966,313650,314250) PREDICTE (1800) 10864 1619.5 0 XP_005262354 (OMIM: 300966,313650,314250) PREDICTE (1906) 10407 1551.9 0 NP_620278 (OMIM: 300966,313650,314250) transcripti (1872) 9783 1459.7 0 XP_005262357 (OMIM: 300966,313650,314250) PREDICTE ( 999) 6499 973.9 0 NP_001276975 (OMIM: 607576) cat eye syndrome criti (1300) 263 52.0 4.6e-05 XP_011544434 (OMIM: 607576) PREDICTED: cat eye syn (1409) 263 52.0 4.9e-05 XP_011544431 (OMIM: 607576) PREDICTED: cat eye syn (1436) 263 52.0 4.9e-05 XP_016884274 (OMIM: 607576) PREDICTED: cat eye syn (1463) 263 52.0 5e-05 NP_001276976 (OMIM: 607576) cat eye syndrome criti (1464) 263 52.0 5e-05 XP_011544430 (OMIM: 607576) PREDICTED: cat eye syn (1436) 249 49.9 0.00021 XP_016879937 (OMIM: 602301) PREDICTED: histone ace ( 476) 237 47.8 0.0003 XP_006721881 (OMIM: 602301) PREDICTED: histone ace ( 477) 237 47.8 0.0003 NP_066564 (OMIM: 602301) histone acetyltransferase ( 837) 237 48.0 0.00047 XP_006721880 (OMIM: 602301) PREDICTED: histone ace ( 838) 237 48.0 0.00047 XP_016870654 (OMIM: 601541) PREDICTED: bromodomain ( 725) 217 45.0 0.0032 NP_031397 (OMIM: 601541) bromodomain-containing pr ( 726) 217 45.0 0.0032 XP_006717354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 217 45.0 0.0032 XP_011517354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 217 45.0 0.0032 XP_016883269 (OMIM: 615713) PREDICTED: protein kin ( 909) 216 44.9 0.0043 XP_016883268 (OMIM: 615713) PREDICTED: protein kin ( 917) 216 44.9 0.0043 XP_016862912 (OMIM: 602303) PREDICTED: histone ace ( 735) 210 44.0 0.0067 XP_016862913 (OMIM: 602303) PREDICTED: histone ace ( 735) 210 44.0 0.0067 NP_003875 (OMIM: 602303) histone acetyltransferase ( 832) 210 44.0 0.0074 >>NP_722516 (OMIM: 607798) transcription initiation fact (1826 aa) initn: 12325 init1: 12325 opt: 12325 Z-score: 9848.3 bits: 1835.5 E(85289): 0 Smith-Waterman score: 12325; 100.0% identity (100.0% similar) in 1826 aa overlap (1-1826:1-1826) 10 20 30 40 50 60 pF1KE3 MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 CKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 CKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 QRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 QRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSES 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 GEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 GEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDAT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 KLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 KLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 VESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 VESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEW 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 RYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 RYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADEN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 FLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 FLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDD 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 KPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 KPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEAT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 SNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 SNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 GTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 GTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 HIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 HIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE3 NYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 NYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE3 FLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 FLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDR 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE3 PRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 PRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVS 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE3 PEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 PEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAA 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE3 MKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 MKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLK 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE3 NAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 NAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQER 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE3 YKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 YKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREW 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE3 EEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 EEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVR 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE3 CETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 CETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKE 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE3 KLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 KLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEE 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE3 ELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 ELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTT 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE3 VHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 VHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKII 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE3 TRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 TRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKL 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE3 KEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 KEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYY 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE3 KMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 KMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICY 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE3 QTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 QTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRD 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KE3 ASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 ASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGG 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KE3 DGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 DGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDV 1750 1760 1770 1780 1790 1800 1810 1820 pF1KE3 GYGGIRPKQPFMLQHASGEHKDGHGK :::::::::::::::::::::::::: NP_722 GYGGIRPKQPFMLQHASGEHKDGHGK 1810 1820 >>XP_005262352 (OMIM: 300966,313650,314250) PREDICTED: t (1927 aa) initn: 11673 init1: 9223 opt: 11601 Z-score: 9269.4 bits: 1728.5 E(85289): 0 Smith-Waterman score: 11601; 94.5% identity (98.0% similar) in 1824 aa overlap (1-1817:1-1824) 10 20 30 40 50 pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD : ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.::::::::::::: XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::: :::::::::.::::::::::::::::::: XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE :.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: ::: XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA .:: :::::::::: :::::::::: :::::::::::::::::::::::::::::::::: XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE :::::::::::::::::::::::.::::::::::::::::::::: :::::::::::::: XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA :::::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::: XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD :::::::::::::::: :::::::::::::::.:::::::::.::::::::.:::::::: XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD :::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: ::: XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG :::::::::::::::::::::::::::::.::::::::::::::::::::::::.::::: XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL ::::::::::::::::.:: ::::::::::::.::::::::::::::::::::::::::: XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE :::::::::::::::::::::::::::::::::::::::::::.::::::::.::::::: XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::: XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI :::::::::::::::.::::::::::::::::::::::::::::::::..:::::::::: XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY : ::::::::.::::.::::::::::::: :::.:::.:::::.:::::::::::::::: XP_005 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE ::::::::::::::::::::::::.::.:::::::.:::::::::::::::::::::::: XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::.:::.:::::::: XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::.::::::.. ::::::::::::::::::::::::: XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK ::::::::: :::::::::::::::::::::::::::::::::.:::::::::::::::: XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 1610 pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI :::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::. XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1570 1580 1590 1600 1610 1620 1620 1630 1640 1650 1660 1670 pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS ::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: : XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS 1630 1640 1650 1660 1670 1680 1680 1690 1700 1710 1720 1730 pF1KE3 RDASVFQDESNLSVLDISTATPEKQ---MCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPP :::::::::::.::::: .:::::: : ::.:::::::::::.::::::::::::: : XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP 1690 1700 1710 1720 1730 1740 1740 1750 1760 1770 1780 1790 pF1KE3 APEG--GDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSE :::: ::::::::::::::::.:::::::::.::::::::::::::::::::::::::: XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE 1750 1760 1770 1780 1790 1800 1800 1810 1820 pF1KE3 SGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK :::::::: :::::::: :::. . XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE 1810 1820 1830 1840 1850 1860 >>XP_005262353 (OMIM: 300966,313650,314250) PREDICTED: t (1926 aa) initn: 11242 init1: 5776 opt: 11589 Z-score: 9259.9 bits: 1726.7 E(85289): 0 Smith-Waterman score: 11589; 94.5% identity (97.9% similar) in 1824 aa overlap (1-1817:1-1823) 10 20 30 40 50 pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD : ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.::::::::::::: XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::: :::::::::.::::::::::::::::::: XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE :.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: ::: XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA .:: :::::::::: :::::::::: :::::::::::::::::::::::::::::::::: XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE :::::::::::::::::::::::.::::::::::::::::::::: :::::::::::::: XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA :::::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::: XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD :::::::::::::::: :::::::::::::::.:::::::::.::::::::.:::::::: XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD :::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: ::: XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG :::::::::::::::::::::::::::::.::::::::::::::::::::::::.::::: XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL ::::::::::::::::.:: ::::::::::::.::::::::::::::::::::::::::: XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE :::::::::::::::::::::::::::::::::::::::::::.::::::::.::::::: XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::: XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI :::::::::::::::.::::::::::::::::::::::::::::::::..:::::::::: XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY : ::::::::.:::: ::::::::::::: :::.:::.:::::.:::::::::::::::: XP_005 EREEQERKELQRMLL-AGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE ::::::::::::::::::::::::.::.:::::::.:::::::::::::::::::::::: XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1200 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::.:::.:::::::: XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1260 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::.::::::.. ::::::::::::::::::::::::: XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1320 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK ::::::::: :::::::::::::::::::::::::::::::::.:::::::::::::::: XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1380 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1440 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1500 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI :::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::. XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1560 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS ::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: : XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS 1620 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 pF1KE3 RDASVFQDESNLSVLDISTATPEKQ---MCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPP :::::::::::.::::: .:::::: : ::.:::::::::::.::::::::::::: : XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP 1680 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 pF1KE3 APEG--GDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSE :::: ::::::::::::::::.:::::::::.::::::::::::::::::::::::::: XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE 1740 1750 1760 1770 1780 1790 1800 1810 1820 pF1KE3 SGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK :::::::: :::::::: :::. . XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE 1800 1810 1820 1830 1840 1850 >>NP_004597 (OMIM: 300966,313650,314250) transcription i (1893 aa) initn: 11725 init1: 9223 opt: 10977 Z-score: 8770.9 bits: 1636.2 E(85289): 0 Smith-Waterman score: 11351; 93.2% identity (96.6% similar) in 1819 aa overlap (1-1817:1-1790) 10 20 30 40 50 pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD : ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.::::::::::::: NP_004 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::: :::::::::.::::::::::::::::::: NP_004 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE :.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: ::: NP_004 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA .:: :::::::::: :::::::::: :::::::::::::::::::::::::::::::::: NP_004 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE :::::::::::::::::::::::.::::::::::::::::::::: :::::::::::::: NP_004 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA :::::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::: NP_004 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD :::::::::::::::: :::::::::::::::.:::::::::.::::::::.:::::::: NP_004 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD :::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: ::: NP_004 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: NP_004 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG :::::::::::::::::::::::::::::.::::::::::::::::::::::::.::::: NP_004 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL ::::::::::::::::.:: ::::::::::::.::::::::::::::::::::::::::: NP_004 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: NP_004 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE :::::::::::::::::::::::::::::::::::::::::::.::::::::.::::::: NP_004 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::: NP_004 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI :::::::::::::::.::::::::::::::::::::::::::::::::..:::::::::: NP_004 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_004 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_004 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_004 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY : ::::::::.::::.::::::::::::: :::.:::.:::::.:::::::::::::::: NP_004 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE ::::::::::::::::::::::::.::.:::::::.:::::::::::::::::::::::: NP_004 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::.:::.:::::::: NP_004 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::.::::::.. ::::::::::::::::::::::::: NP_004 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK ::::::::: :::::::::::::::::::::::::::::::::.:::::::::::::::: NP_004 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: NP_004 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 1610 pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI :::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::. NP_004 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1570 1580 1590 1600 1610 1620 1620 1630 1640 1650 1660 1670 pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS ::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: : NP_004 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS 1630 1640 1650 1660 1670 1680 1680 1690 1700 1710 1720 1730 pF1KE3 RDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPE :::::::::::.::::: .::::::. : :: : NP_004 RDASVFQDESNMSVLDIPSATPEKQVTQ--------------EGED-------------- 1690 1700 1710 1740 1750 1760 1770 1780 1790 pF1KE3 GGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS ::::::::::::::::.:::::::::.:::::::::::::::::::::::::::::::: NP_004 -GDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS 1720 1730 1740 1750 1760 1770 1800 1810 1820 pF1KE3 DVGYGGIRPKQPFMLQHASGEHKDGHGK ::: :::::::: :::. . NP_004 DVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKS 1780 1790 1800 1810 1820 1830 >>NP_001273003 (OMIM: 300966,313650,314250) transcriptio (1895 aa) initn: 11659 init1: 8991 opt: 10963 Z-score: 8759.7 bits: 1634.1 E(85289): 0 Smith-Waterman score: 11337; 93.1% identity (96.5% similar) in 1821 aa overlap (1-1817:1-1792) 10 20 30 40 50 pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD : ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.::::::::::::: NP_001 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::: :::::::::.::::::::::::::::::: NP_001 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE :.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: ::: NP_001 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA .:: :::::::::: :::::::::: :::::::::::::::::::::::::::::::::: NP_001 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE :::::::::::::::::::::::.::::::::::::::::::::: :::::::::::::: NP_001 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA :::::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::: NP_001 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD :::::::::::::::: :::::::::::::::.:::::::::.::::::::.:::::::: NP_001 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD :::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: ::: NP_001 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: NP_001 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG :::::::::::::::::::::::::::::.::::::::::::::::::::::::.::::: NP_001 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL ::::::::::::::::.:: ::::::::::::.::::::::::::::::::::::::::: NP_001 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: NP_001 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE :::::::::::::::::::::::::::::::::::::::::::.::::::::.::::::: NP_001 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::: NP_001 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI :::::::::::::::.::::::::::::::::::::::::::::::::..:::::::::: NP_001 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_001 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_001 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 1130 pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_001 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1090 1100 1110 1120 1130 1140 1140 1150 1160 1170 1180 1190 pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY : ::::::::.::::.::::::::::::: :::.:::.:::::.:::::::::::::::: NP_001 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1150 1160 1170 1180 1190 1200 1200 1210 1220 1230 1240 1250 pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE ::::::::::::::::::::::::.::.:::::::.:::::::::::::::::::::::: NP_001 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1210 1220 1230 1240 1250 1260 1260 1270 1280 1290 1300 1310 pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::.:::.:::::::: NP_001 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1270 1280 1290 1300 1310 1320 1320 1330 1340 1350 1360 1370 pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::.::::::.. ::::::::::::::::::::::::: NP_001 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1330 1340 1350 1360 1370 1380 1380 1390 1400 1410 1420 1430 pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK ::::::::: :::::::::::::::::::::::::::::::::.:::::::::::::::: NP_001 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1390 1400 1410 1420 1430 1440 1440 1450 1460 1470 1480 1490 pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: NP_001 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1450 1460 1470 1480 1490 1500 1500 1510 1520 1530 1540 1550 pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1510 1520 1530 1540 1550 1560 1560 1570 1580 1590 1600 1610 pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI :::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::. NP_001 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1570 1580 1590 1600 1610 1620 1620 1630 1640 1650 1660 1670 pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQ--PPDMYDTNTSLS ::::.::::::::::::::::::::::::::::::::::::::: : :::.:::::::: NP_001 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQAKPPDLYDTNTSLS 1630 1640 1650 1660 1670 1680 1680 1690 1700 1710 1720 1730 pF1KE3 TSRDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPA ::::::::::::.::::: .::::::. : :: : NP_001 MSRDASVFQDESNMSVLDIPSATPEKQVTQ--------------EGED------------ 1690 1700 1710 1740 1750 1760 1770 1780 1790 pF1KE3 PEGGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGS ::::::::::::::::.:::::::::.:::::::::::::::::::::::::::::: NP_001 ---GDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGS 1720 1730 1740 1750 1760 1770 1800 1810 1820 pF1KE3 DSDVGYGGIRPKQPFMLQHASGEHKDGHGK ::::: :::::::: :::. . NP_001 DSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDP 1780 1790 1800 1810 1820 1830 >>XP_006724745 (OMIM: 300966,313650,314250) PREDICTED: t (1800 aa) initn: 11050 init1: 9223 opt: 10864 Z-score: 8680.9 bits: 1619.5 E(85289): 0 Smith-Waterman score: 10864; 94.9% identity (98.0% similar) in 1697 aa overlap (127-1817:1-1697) 100 110 120 130 140 150 pF1KE3 EGWIRSTEDAVDYSDINEVAEDESQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMP ::::::: :::::::::::::::::::::: XP_006 MGSLQPLCHSDYDEDDYDADCEDIDCKLMP 10 20 30 160 170 180 190 200 210 pF1KE3 PPPPPPGPMKKDKDQDAITCVSESGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQE ::::::::::::::::.:: :::.:: :::::::::: :::::::::: ::::::::::: XP_006 PPPPPPGPMKKDKDQDSITGVSENGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQE 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE3 ATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWR ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: XP_006 ATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWR 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE3 SARRKRKK-HRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVP :::::::: :::::::::::::::::::::::::::::::::::::::::.:::::::.: XP_006 SARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAP 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE3 VESKFSQSTGDVDKVTDTKPRVAEWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPV :::::::::::.::::::::::::::::::::::::::: :::::::::::::::.:::: XP_006 VESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPV 220 230 240 250 260 270 400 410 420 430 440 450 pF1KE3 IKSRMMEEFRKLEESNGTDLLADENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGW :::::.::::::::.:::::::::::::::::::::.:::::::.:::::::: :::::: XP_006 IKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGW 280 290 300 310 320 330 460 470 480 490 500 510 pF1KE3 LPSIKTRNVMAYNVQQGFAPTLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLE ::: :::.:::::::::: :::::::::::::::::::::::::::::::::::::::: XP_006 LPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLE 340 350 360 370 380 390 520 530 540 550 560 570 pF1KE3 PPVLALDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNM ::::.:::::::::::::::::::::::::::::::::::::::::::::::.::::::: XP_006 PPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNM 400 410 420 430 440 450 580 590 600 610 620 630 pF1KE3 SQPEVKDPWNLSNDEYYFPKQQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFH :::::::::::::::::.:::::::::::::::::::::.:: ::::::::::::.:::: XP_006 SQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFH 460 470 480 490 500 510 640 650 660 670 680 690 pF1KE3 RPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDG :::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::: XP_006 RPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDG 520 530 540 550 560 570 700 710 720 730 740 750 pF1KE3 DLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHP 580 590 600 610 620 630 760 770 780 790 800 810 pF1KE3 GQLLQALENNLFRAPVYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNS ::::::.::::::::.:::::::::::::::::::::::::::::::::::::::::::: XP_006 GQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNS 640 650 660 670 680 690 820 830 840 850 860 870 pF1KE3 RRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTG .::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTG 700 710 720 730 740 750 880 890 900 910 920 930 pF1KE3 MDSNWWVLKSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENE :::::::::::::::::::::: :::::::::::::::.::::::::::::::::::::: XP_006 MDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENE 760 770 780 790 800 810 940 950 960 970 980 990 pF1KE3 EDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQK :::::::::::..::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQK 820 830 840 850 860 870 1000 1010 1020 1030 1040 1050 pF1KE3 DDKEPQAVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ :::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ 880 890 900 910 920 930 1060 1070 1080 1090 1100 1110 pF1KE3 AHSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSD :.::::::::::::::::::::::::::::::::::::::::::::::::::: :::::: XP_006 ARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSD 940 950 960 970 980 990 1120 1130 1140 1150 1160 1170 pF1KE3 FEEMGKNIENMLQNKKTSSQLSREWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSL :::::::::::::::::::::::: ::::::::.::::.::::::::::::: :::.::: XP_006 FEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSL 1000 1010 1020 1030 1040 1050 1180 1190 1200 1210 1220 1230 pF1KE3 KSSATGHCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKH .:::::.::::::::::::::::::::::::::::::::::::::::.::.:::::::.: XP_006 NSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQH 1060 1070 1080 1090 1100 1110 1240 1250 1260 1270 1280 1290 pF1KE3 REEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTN 1120 1130 1140 1150 1160 1170 1300 1310 1320 1330 1340 1350 pF1KE3 KFCPLYYQTNVPPSKPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEV ::::::::::.:::.:::::::::::::::::::::::::::::::::.::::::.. :: XP_006 KFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEV 1180 1190 1200 1210 1220 1230 1360 1370 1380 1390 1400 1410 pF1KE3 RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDM :::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: XP_006 RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDM 1240 1250 1260 1270 1280 1290 1420 1430 1440 1450 1460 1470 pF1KE3 RDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNS ::::::.::::::::::::::::::::::::::::::::: ::::::::::::::::::: XP_006 RDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNS 1300 1310 1320 1330 1340 1350 1480 1490 1500 1510 1520 1530 pF1KE3 ATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVT 1360 1370 1380 1390 1400 1410 1540 1550 1560 1570 1580 1590 pF1KE3 QKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLIL ::::::::::::::::::::::::::.::::.:::::::::::::::::::::::::::: XP_006 QKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLIL 1420 1430 1440 1450 1460 1470 1600 1610 1620 1630 1640 1650 pF1KE3 ANSVKYNGPESQYTKTAQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDP ::::::::::::::::::::::.::::.:::::::::::::::::::::::::::::::: XP_006 ANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDP 1480 1490 1500 1510 1520 1530 1660 1670 1680 1690 1700 1710 pF1KE3 MTPGPYTSQPPDMYDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQ---MCQGQGRLG ::::::: ::::.:::::::: ::::::::::::.::::: .:::::: : ::.:::: XP_006 MTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLG 1540 1550 1560 1570 1580 1590 1720 1730 1740 1750 1760 1770 pF1KE3 EEDSDVDVEGYDDEEEDGKPKPPAPEG--GDGDLADEEEGTVQQPEASVLYEDLLISEGE :::::::.::::::::::::: ::::: ::::::::::::::::.:::::::::.:::: XP_006 EEDSDVDIEGYDDEEEDGKPKTPAPEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGE 1600 1610 1620 1630 1640 1650 1780 1790 1800 1810 1820 pF1KE3 DDEEDAGSDEEGDNPFSAIQLSESGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK ::::::::::::::::::::::::::::::: :::::::: :::. . XP_006 DDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSY 1660 1670 1680 1690 1700 1710 XP_006 EGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPS 1720 1730 1740 1750 1760 1770 >>XP_005262354 (OMIM: 300966,313650,314250) PREDICTED: t (1906 aa) initn: 11043 init1: 9207 opt: 10407 Z-score: 8315.4 bits: 1551.9 E(85289): 0 Smith-Waterman score: 11450; 93.5% identity (97.0% similar) in 1824 aa overlap (1-1817:1-1803) 10 20 30 40 50 pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD : ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.::::::::::::: XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::: :::::::::.::::::::::::::::::: XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE :.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSIT---- 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA .::::::: :::::::::::::::::::::::::::::::::: XP_005 -----------------GEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 180 190 200 210 240 250 260 270 280 290 pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE :::::::::::::::::::::::.::::::::::::::::::::: :::::::::::::: XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA :::::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::: XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD :::::::::::::::: :::::::::::::::.:::::::::.::::::::.:::::::: XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD :::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: ::: XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 460 470 480 490 500 510 540 550 560 570 580 590 pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG :::::::::::::::::::::::::::::.::::::::::::::::::::::::.::::: XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 520 530 540 550 560 570 600 610 620 630 640 650 pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL ::::::::::::::::.:: ::::::::::::.::::::::::::::::::::::::::: XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 580 590 600 610 620 630 660 670 680 690 700 710 pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 640 650 660 670 680 690 720 730 740 750 760 770 pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE :::::::::::::::::::::::::::::::::::::::::::.::::::::.::::::: XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 700 710 720 730 740 750 780 790 800 810 820 830 pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::: XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 760 770 780 790 800 810 840 850 860 870 880 890 pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 820 830 840 850 860 870 900 910 920 930 940 950 pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI :::::::::::::::.::::::::::::::::::::::::::::::::..:::::::::: XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 880 890 900 910 920 930 960 970 980 990 1000 1010 pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 940 950 960 970 980 990 1020 1030 1040 1050 1060 1070 pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1000 1010 1020 1030 1040 1050 1080 1090 1100 1110 1120 1130 pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1060 1070 1080 1090 1100 1110 1140 1150 1160 1170 1180 1190 pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY : ::::::::.::::.::::::::::::: :::.:::.:::::.:::::::::::::::: XP_005 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1120 1130 1140 1150 1160 1170 1200 1210 1220 1230 1240 1250 pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE ::::::::::::::::::::::::.::.:::::::.:::::::::::::::::::::::: XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1180 1190 1200 1210 1220 1230 1260 1270 1280 1290 1300 1310 pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::.:::.:::::::: XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1240 1250 1260 1270 1280 1290 1320 1330 1340 1350 1360 1370 pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::.::::::.. ::::::::::::::::::::::::: XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1300 1310 1320 1330 1340 1350 1380 1390 1400 1410 1420 1430 pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK ::::::::: :::::::::::::::::::::::::::::::::.:::::::::::::::: XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1360 1370 1380 1390 1400 1410 1440 1450 1460 1470 1480 1490 pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1420 1430 1440 1450 1460 1470 1500 1510 1520 1530 1540 1550 pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1480 1490 1500 1510 1520 1530 1560 1570 1580 1590 1600 1610 pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI :::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::. XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1540 1550 1560 1570 1580 1590 1620 1630 1640 1650 1660 1670 pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS ::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: : XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS 1600 1610 1620 1630 1640 1650 1680 1690 1700 1710 1720 1730 pF1KE3 RDASVFQDESNLSVLDISTATPEKQ---MCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPP :::::::::::.::::: .:::::: : ::.:::::::::::.::::::::::::: : XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP 1660 1670 1680 1690 1700 1710 1740 1750 1760 1770 1780 1790 pF1KE3 APEG--GDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSE :::: ::::::::::::::::.:::::::::.::::::::::::::::::::::::::: XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE 1720 1730 1740 1750 1760 1770 1800 1810 1820 pF1KE3 SGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK :::::::: :::::::: :::. . XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE 1780 1790 1800 1810 1820 1830 >>NP_620278 (OMIM: 300966,313650,314250) transcription i (1872 aa) initn: 11044 init1: 9207 opt: 9783 Z-score: 7816.9 bits: 1459.7 E(85289): 0 Smith-Waterman score: 11200; 92.2% identity (95.7% similar) in 1819 aa overlap (1-1817:1-1769) 10 20 30 40 50 pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD : ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.::::::::::::: NP_620 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::: :::::::::.::::::::::::::::::: NP_620 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE :.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: NP_620 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSIT---- 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA .::::::: :::::::::::::::::::::::::::::::::: NP_620 -----------------GEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 180 190 200 210 240 250 260 270 280 290 pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE :::::::::::::::::::::::.::::::::::::::::::::: :::::::::::::: NP_620 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA :::::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::: NP_620 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD :::::::::::::::: :::::::::::::::.:::::::::.::::::::.:::::::: NP_620 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD :::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: ::: NP_620 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 400 410 420 430 440 450 480 490 500 510 520 530 pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: NP_620 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 460 470 480 490 500 510 540 550 560 570 580 590 pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG :::::::::::::::::::::::::::::.::::::::::::::::::::::::.::::: NP_620 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 520 530 540 550 560 570 600 610 620 630 640 650 pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL ::::::::::::::::.:: ::::::::::::.::::::::::::::::::::::::::: NP_620 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 580 590 600 610 620 630 660 670 680 690 700 710 pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: NP_620 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 640 650 660 670 680 690 720 730 740 750 760 770 pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE :::::::::::::::::::::::::::::::::::::::::::.::::::::.::::::: NP_620 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 700 710 720 730 740 750 780 790 800 810 820 830 pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::: NP_620 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 760 770 780 790 800 810 840 850 860 870 880 890 pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 820 830 840 850 860 870 900 910 920 930 940 950 pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI :::::::::::::::.::::::::::::::::::::::::::::::::..:::::::::: NP_620 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 880 890 900 910 920 930 960 970 980 990 1000 1010 pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_620 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 940 950 960 970 980 990 1020 1030 1040 1050 1060 1070 pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_620 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1000 1010 1020 1030 1040 1050 1080 1090 1100 1110 1120 1130 pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_620 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1060 1070 1080 1090 1100 1110 1140 1150 1160 1170 1180 1190 pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY : ::::::::.::::.::::::::::::: :::.:::.:::::.:::::::::::::::: NP_620 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1120 1130 1140 1150 1160 1170 1200 1210 1220 1230 1240 1250 pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE ::::::::::::::::::::::::.::.:::::::.:::::::::::::::::::::::: NP_620 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1180 1190 1200 1210 1220 1230 1260 1270 1280 1290 1300 1310 pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::.:::.:::::::: NP_620 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1240 1250 1260 1270 1280 1290 1320 1330 1340 1350 1360 1370 pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::.::::::.. ::::::::::::::::::::::::: NP_620 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1300 1310 1320 1330 1340 1350 1380 1390 1400 1410 1420 1430 pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK ::::::::: :::::::::::::::::::::::::::::::::.:::::::::::::::: NP_620 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1360 1370 1380 1390 1400 1410 1440 1450 1460 1470 1480 1490 pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: NP_620 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1420 1430 1440 1450 1460 1470 1500 1510 1520 1530 1540 1550 pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1480 1490 1500 1510 1520 1530 1560 1570 1580 1590 1600 1610 pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI :::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::. NP_620 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1540 1550 1560 1570 1580 1590 1620 1630 1640 1650 1660 1670 pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS ::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: : NP_620 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS 1600 1610 1620 1630 1640 1650 1680 1690 1700 1710 1720 1730 pF1KE3 RDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPE :::::::::::.::::: .::::::. : :: : NP_620 RDASVFQDESNMSVLDIPSATPEKQVTQ--------------EGED-------------- 1660 1670 1680 1690 1740 1750 1760 1770 1780 1790 pF1KE3 GGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS ::::::::::::::::.:::::::::.:::::::::::::::::::::::::::::::: NP_620 -GDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS 1700 1710 1720 1730 1740 1750 1800 1810 1820 pF1KE3 DVGYGGIRPKQPFMLQHASGEHKDGHGK ::: :::::::: :::. . NP_620 DVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKS 1760 1770 1780 1790 1800 1810 >>XP_005262357 (OMIM: 300966,313650,314250) PREDICTED: t (999 aa) initn: 4953 init1: 4785 opt: 6499 Z-score: 5196.6 bits: 973.9 E(85289): 0 Smith-Waterman score: 6499; 94.8% identity (98.3% similar) in 997 aa overlap (1-995:1-997) 10 20 30 40 50 pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD : ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.::::::::::::: XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::: :::::::::.::::::::::::::::::: XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE :.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: ::: XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA .:: :::::::::: :::::::::: :::::::::::::::::::::::::::::::::: XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE :::::::::::::::::::::::.::::::::::::::::::::: :::::::::::::: XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA :::::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::: XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD :::::::::::::::: :::::::::::::::.:::::::::.::::::::.:::::::: XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD :::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: ::: XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG :::::::::::::::::::::::::::::.::::::::::::::::::::::::.::::: XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL ::::::::::::::::.:: ::::::::::::.::::::::::::::::::::::::::: XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE :::::::::::::::::::::::::::::::::::::::::::.::::::::.::::::: XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::: XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI :::::::::::::::.::::::::::::::::::::::::::::::::..:::::::::: XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS ::::::::::::::::::::::::::::::::::::: XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKVG 970 980 990 1020 1030 1040 1050 1060 1070 pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ >>NP_001276975 (OMIM: 607576) cat eye syndrome critical (1300 aa) initn: 217 init1: 217 opt: 263 Z-score: 212.0 bits: 52.0 E(85289): 4.6e-05 Smith-Waterman score: 276; 24.2% identity (55.6% similar) in 360 aa overlap (1373-1710:104-444) 1350 1360 1370 1380 1390 1400 pF1KE3 VFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSIHRRRTDPMV ..:.. . :.: . : .. :. NP_001 GPGQGTWWLLCQTEEEWRQVTESFRERTSLRERQLYKLLSEDFLPEICNMIAQKGKRPQR 80 90 100 110 120 130 1410 1420 1430 1440 1450 1460 pF1KE3 TLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIIT--RPMDLQTLRENVRKCLYPS : . . ..: .. .. .::: ... :. : : . : . ... .. : NP_001 TKAELHPRWMSDHLSIKPVKQEETPVLTRIEKQKRKEEEEERQILLAVQKKEQEQML--- 140 150 160 170 180 190 1470 1480 1490 1500 1510 pF1KE3 REEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKL-----ARLEKAIN .:: ...:: :: :. . :. . .. : ..: . ..: : :: . NP_001 KEERKRELEEKVK--AVEDRAKRRKLREERAWLLAQGKELPPELSHLDPNSPMREEKKTK 200 210 220 230 240 1520 1530 1540 1550 1560 1570 pF1KE3 PLLD-DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRK :.. ::: .:. .:: . ..: ::::: .::.....:.::..: :.:. ...: NP_001 DLFELDDDFTAMYKVLDVVKAHK-----DSWPFLEPVDESYAPNYYQIIKAPMDISSMEK 250 260 270 280 290 300 1580 1590 1600 1610 1620 pF1KE3 NISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEY-------- ... : ..: :..:.. .. : :::: :.::: .... .... .. NP_001 KLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKHFPGEDGDT 310 320 330 340 350 360 1630 1640 1650 1660 1670 1680 pF1KE3 DEHL-----TQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRDA ::.. . :: : ... .. .: :: : .: : : . . :: .: : NP_001 DEEFWIREDEKREKRRSRAGRSGGSHVWTRSRDP--EGSSRKQQP-MENGGKSLPPTRRA 370 380 390 400 410 420 1690 1700 1710 1720 1730 1740 pF1KE3 -SVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGG : .:.:. :.. : ... ..:: NP_001 PSSGDDQSS------SSTQPPREVGTSNGRGFSHPLHCGGTPSQAPFLNQMRPAVPGTFG 430 440 450 460 470 1826 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 07:16:12 2016 done: Tue Nov 8 07:16:15 2016 Total Scan time: 19.080 Total Display time: 1.330 Function used was FASTA [36.3.4 Apr, 2011]