FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9722, 410 aa 1>>>pF1KB9722 410 - 410 aa - 410 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6673+/-0.00042; mu= 5.6202+/- 0.027 mean_var=360.8089+/-74.688, 0's: 0 Z-trim(122.0): 63 B-trim: 138 in 1/55 Lambda= 0.067520 statistics sampled from 39348 (39430) to 39348 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.766), E-opt: 0.2 (0.462), width: 16 Scan time: 7.420 The best scores are: opt bits E(85289) NP_004566 (OMIM: 113725) POU domain, class 4, tran ( 409) 2750 281.6 2.5e-75 NP_002691 (OMIM: 602459,602460) POU domain, class ( 338) 1208 131.2 3.7e-30 NP_006228 (OMIM: 601632) POU domain, class 4, tran ( 419) 1028 113.8 7.9e-25 NP_005595 (OMIM: 600494) POU domain, class 3, tran ( 443) 657 77.7 6.2e-14 NP_001231611 (OMIM: 607394) POU domain, class 2, t ( 438) 544 66.7 1.3e-10 XP_016872976 (OMIM: 607394) PREDICTED: POU domain, ( 356) 542 66.4 1.3e-10 XP_011541041 (OMIM: 607394) PREDICTED: POU domain, ( 432) 542 66.5 1.4e-10 XP_011541042 (OMIM: 607394) PREDICTED: POU domain, ( 432) 542 66.5 1.4e-10 NP_055167 (OMIM: 607394) POU domain, class 2, tran ( 436) 542 66.5 1.4e-10 NP_002690 (OMIM: 602479) POU domain, class 3, tran ( 451) 526 65.0 4.4e-10 XP_011541045 (OMIM: 607394) PREDICTED: POU domain, ( 403) 524 64.7 4.7e-10 XP_011541044 (OMIM: 607394) PREDICTED: POU domain, ( 403) 524 64.7 4.7e-10 XP_011541043 (OMIM: 607394) PREDICTED: POU domain, ( 403) 524 64.7 4.7e-10 NP_006227 (OMIM: 602480) POU domain, class 3, tran ( 500) 521 64.5 6.5e-10 NP_000298 (OMIM: 300039,304400) POU domain, class ( 361) 518 64.1 6.6e-10 NP_001116229 (OMIM: 173110,613038) pituitary-speci ( 317) 460 58.3 3.1e-08 NP_000297 (OMIM: 173110,613038) pituitary-specific ( 291) 454 57.7 4.4e-08 XP_011507957 (OMIM: 164175) PREDICTED: POU domain, ( 671) 460 58.8 4.7e-08 NP_001185715 (OMIM: 164175) POU domain, class 2, t ( 703) 460 58.8 4.9e-08 XP_011507956 (OMIM: 164175) PREDICTED: POU domain, ( 743) 460 58.8 5e-08 NP_001185712 (OMIM: 164175) POU domain, class 2, t ( 755) 460 58.9 5.1e-08 NP_002688 (OMIM: 164175) POU domain, class 2, tran ( 766) 460 58.9 5.1e-08 XP_011507955 (OMIM: 164175) PREDICTED: POU domain, ( 769) 460 58.9 5.1e-08 NP_001272916 (OMIM: 164177) POU domain, class 5, t ( 265) 442 56.5 9.3e-08 NP_002692 (OMIM: 164177) POU domain, class 5, tran ( 360) 444 56.9 9.7e-08 NP_001153014 (OMIM: 615739) putative POU domain, c ( 359) 426 55.1 3.3e-07 NP_001159490 (OMIM: 601583,609062) POU domain, cla ( 655) 411 54.0 1.3e-06 NP_976034 (OMIM: 164177) POU domain, class 5, tran ( 190) 346 46.9 5e-05 NP_001167002 (OMIM: 164177) POU domain, class 5, t ( 190) 346 46.9 5e-05 XP_016882380 (OMIM: 164176) PREDICTED: POU domain, ( 707) 338 46.9 0.00018 XP_011525344 (OMIM: 164176) PREDICTED: POU domain, ( 485) 334 46.3 0.00019 XP_016882382 (OMIM: 164176) PREDICTED: POU domain, ( 608) 334 46.4 0.00022 XP_011525343 (OMIM: 164176) PREDICTED: POU domain, ( 501) 331 46.0 0.00024 XP_011525342 (OMIM: 164176) PREDICTED: POU domain, ( 624) 331 46.2 0.00028 NP_001234923 (OMIM: 164176) POU domain, class 2, t ( 400) 326 45.4 0.0003 NP_002689 (OMIM: 164176) POU domain, class 2, tran ( 463) 326 45.5 0.00032 XP_005259067 (OMIM: 164176) PREDICTED: POU domain, ( 586) 326 45.6 0.00037 XP_011525345 (OMIM: 164176) PREDICTED: POU domain, ( 537) 324 45.4 0.0004 XP_016882385 (OMIM: 164176) PREDICTED: POU domain, ( 600) 324 45.5 0.00043 NP_001193955 (OMIM: 164176) POU domain, class 2, t ( 467) 321 45.0 0.00046 NP_001193954 (OMIM: 164176) POU domain, class 2, t ( 479) 321 45.0 0.00046 XP_016882381 (OMIM: 164176) PREDICTED: POU domain, ( 701) 324 45.6 0.00047 XP_016882375 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048 XP_016882377 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048 XP_016882376 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048 XP_016882378 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048 XP_016882379 (OMIM: 164176) PREDICTED: POU domain, ( 711) 324 45.6 0.00048 XP_016882374 (OMIM: 164176) PREDICTED: POU domain, ( 723) 324 45.6 0.00048 XP_016882373 (OMIM: 164176) PREDICTED: POU domain, ( 723) 324 45.6 0.00048 XP_016882383 (OMIM: 164176) PREDICTED: POU domain, ( 602) 321 45.2 0.00053 >>NP_004566 (OMIM: 113725) POU domain, class 4, transcri (409 aa) initn: 2438 init1: 2438 opt: 2750 Z-score: 1473.4 bits: 281.6 E(85289): 2.5e-75 Smith-Waterman score: 2750; 99.8% identity (99.8% similar) in 410 aa overlap (1-410:1-409) 10 20 30 40 50 60 pF1KB9 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSSNAGGGGGGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 GGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDI :::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GGGGGGGG-RSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDI 70 80 90 100 110 130 140 150 160 170 180 pF1KB9 VSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB9 HHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATMNPMHQAALSMAHAH 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB9 GLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB9 CRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRS 300 310 320 330 340 350 370 380 390 400 410 pF1KB9 LEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI :::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI 360 370 380 390 400 >>NP_002691 (OMIM: 602459,602460) POU domain, class 4, t (338 aa) initn: 1377 init1: 979 opt: 1208 Z-score: 662.4 bits: 131.2 E(85289): 3.7e-30 Smith-Waterman score: 1506; 70.7% identity (86.3% similar) in 335 aa overlap (79-408:22-336) 50 60 70 80 90 100 pF1KB9 SSSNAGGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP--SNIFGGLDE :: .:::::::.:::.: .::::..:: NP_002 MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDE 10 20 30 40 50 110 120 130 140 150 160 pF1KB9 SLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPS ::::::::::::::::..:.: :::::::::::...:::: .::.::::::. NP_002 SLLARAEALAAVDIVSHGKNH--------PFKPDATYHTMSSVPCTS--TSSTVPISHPA 60 70 80 90 100 170 180 190 200 210 220 pF1KB9 ALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMATM ::.. : :: ::.:::.::::.:: :.......:. .:. . : :...: NP_002 ALTS---------HPHHAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAM 110 120 130 140 150 230 240 250 260 270 280 pF1KB9 NPMHQAALSMAHAHGLPSHMG---CMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSA . .::: ..:.: : . : . :.:::..:::.:::::::::::::::::::::::.: NP_002 GHLHQA-MGMSHPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAA 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB9 LANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNG :::::::::::::::::::::::::::::::::::.::::::::: ..::: .::::::: NP_002 LANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNG 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB9 AEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR .:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKR 280 290 300 310 320 330 410 pF1KB9 MKYSAGI ::::: NP_002 MKYSAVH >>NP_006228 (OMIM: 601632) POU domain, class 4, transcri (419 aa) initn: 1176 init1: 964 opt: 1028 Z-score: 566.7 bits: 113.8 E(85289): 7.9e-25 Smith-Waterman score: 1304; 58.9% identity (67.9% similar) in 414 aa overlap (85-408:29-417) 60 70 80 90 100 110 pF1KB9 GGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP--SNIFGGLDESLLARA :::.::::::::: ::.:..:::.::::: NP_006 MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARA 10 20 30 40 50 120 130 140 150 160 170 pF1KB9 EALAAVDI-VSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGT :::::::: :::.::: ::::::::::::..:::: .:.::..: NP_006 EALAAVDIAVSQGKSH--------PFKPDATYHTMNSVPCTS---TSTVPLAH------- 60 70 80 90 100 180 190 200 pF1KB9 HHHHHHHHHHHHQPHQALE-GELLEHLS-PGLAL-------GAMAG-------------- ::::::: ::::: :.::.:.: :.::: :: :: NP_006 -----HHHHHHH--HQALEPGDLLDHISSPSLALMAGAGGAGAAAGGGGAHDGPGGGGGP 110 120 130 140 150 210 220 230 240 pF1KB9 ------------------------PDGAVVSTPAHA-PHMATMNPMHQ--AALSMAHAHG : :.... :: ::: ... . . :: .: : NP_006 GGGGGPGGGPGGGGGGGPGGGGGGPGGGLLGGSAHPHPHMHSLGHLSHPAAAAAMNMPSG 160 170 180 190 200 210 250 260 pF1KB9 LP--------SHMGC-----------------------------MSDVDADPRDLEAFAE :: .: : . : :.:::.:::::: NP_006 LPHPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAE 220 230 240 250 260 270 270 280 290 300 310 320 pF1KB9 RFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWL 280 290 300 310 320 330 330 340 350 360 370 380 pF1KB9 EEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLD :::: ..:::..:::::::.::::::::::::::::::::::.::::::::::::::::: NP_006 EEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLD 340 350 360 370 380 390 390 400 410 pF1KB9 LKKNVVRVWFCNQRQKQKRMKYSAGI :::::::::::::::::::::.:: NP_006 LKKNVVRVWFCNQRQKQKRMKFSATY 400 410 >>NP_005595 (OMIM: 600494) POU domain, class 3, transcri (443 aa) initn: 621 init1: 368 opt: 657 Z-score: 371.1 bits: 77.7 E(85289): 6.2e-14 Smith-Waterman score: 663; 35.2% identity (59.6% similar) in 406 aa overlap (22-409:41-417) 10 20 30 40 50 pF1KB9 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSASSPSSSS :. :.::.: .. :.. . . .. : NP_005 LLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGDYGALQS----NGHPLSHAHQWITALS 20 30 40 50 60 60 70 80 90 100 pF1KB9 NAGGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIF--GGLDESL- ..:::::::::::::::: .....: :.. :. .. :: . :: . : NP_005 HGGGGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPDIK-------PSVVVQQGGRGDELH 70 80 90 100 110 110 120 130 140 150 160 pF1KB9 ----LARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISH : . . . .:....... .. : : ..:. : : .: :... NP_005 GPGALQQQHQQQQQQQQQQQQQQQQQQQQQRP--PHLVHHAANHHPGPGAWRSAAAAAHL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB9 PSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAVVSTPAHAPHMA : ...... . :: ...: : : : : :: . :: : NP_005 PPSMGASNGGLLYS-----QPSFTVNGML------G-AGGQPAGLHHHGLRDAHDEPHHA 180 190 200 210 220 230 240 250 260 270 pF1KB9 TMNPM-----HQAALSMAHAHGLPSHMGCMSDVDAD---PR--DLEAFAERFKQRRIKLG .: :: .: :.: : : .: : ::: ::..::::::::: NP_005 DHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFAKQFKQRRIKLG 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB9 VTQADVGSALANLKIPGVGSL-SQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE :::::: ::..: :.. ::.::::::.: :: .:: :::.:. :::::..: NP_005 FTQADVGLALGTL----YGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSSGS 290 300 310 320 330 340 340 350 360 370 380 390 pF1KB9 KLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVW . .. ..:..::::: . : .::..: :.::...:...:..:.:.:.::::: NP_005 PTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADSLQLEKEVVRVW 350 360 370 380 390 400 400 410 pF1KB9 FCNQRQKQKRMKYSAGI :::.:::.::: .: NP_005 FCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ 410 420 430 440 >>NP_001231611 (OMIM: 607394) POU domain, class 2, trans (438 aa) initn: 493 init1: 216 opt: 544 Z-score: 311.7 bits: 66.7 E(85289): 1.3e-10 Smith-Waterman score: 544; 35.9% identity (64.1% similar) in 351 aa overlap (68-404:9-341) 40 50 60 70 80 90 pF1KB9 APIAPSASSPSSSSNAGGGGGGGGGGGGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP :::. . :.. .. : : . . : NP_001 MESPRTAKGGRDIKMSGDVAD----STDARSTLSQVEP 10 20 30 100 110 120 130 140 150 pF1KB9 SNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHS--PFKPDATYHT-MNTIPCTSA .: .::: . ..: :. : ..:. ::. : : : : ... . .:. :: . NP_001 GNDRNGLDFNRQIKTEDLS--DSLQQTLSHR--PCHLSQGPAMMSGNQMSGLNASPCQDM 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB9 ASSSSVPISHPSALAGTHHHHHHHHHHHHQP-HQALEGELLE--HLSPGLALGAMAGPDG :: :... . : . . . :: .:.:. .:: . . :: : ..:: : NP_001 ASLH--PLQQLVLVPGHLQSVSQFLLSQTQPGQQGLQPNLLPFPQQQSGLLL-PQTGP-G 100 110 120 130 140 220 230 240 250 260 pF1KB9 AVVSTPAHAPHM--ATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQR . .. .: : . ....: .:. . . ::: : .: .: ..:: ::. :::: NP_001 LASQAFGH-PGLPGSSLEPHLEASQHLPVPKHLPSSGG--ADEPSDLEELEKFAKTFKQR 150 160 170 180 190 200 270 280 290 300 310 320 pF1KB9 RIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEK ::::: ::.::: :.. :. : ...::.:: :::.:.:: .:: :::.:. ::..::. NP_001 RIKLGFTQGDVGLAMG--KLYG-NDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAES 210 220 230 240 250 260 330 340 350 360 370 380 pF1KB9 SHRE-KLTKPELFNG-----AEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKL : . ... : . . ..:..::::: . . .:: : .:.::::.:. :::.: NP_001 SPSDPSVSTPSSYPSLSEVFGRKRKKRTSIETNIRLTLEKRFQDNPKPSSEEISMIAEQL 270 280 290 300 310 320 390 400 410 pF1KB9 DLKKNVVRVWFCNQRQKQKRMKYSAGI ...:.::::::::.:::.::. NP_001 SMEKEVVRVWFCNRRQKEKRINCPVATPIKPPVYNSRLVSPSGSLGPLSVPPVHSTMPGT 330 340 350 360 370 380 >>XP_016872976 (OMIM: 607394) PREDICTED: POU domain, cla (356 aa) initn: 515 init1: 216 opt: 542 Z-score: 311.6 bits: 66.4 E(85289): 1.3e-10 Smith-Waterman score: 542; 37.3% identity (65.5% similar) in 322 aa overlap (97-404:32-339) 70 80 90 100 110 120 pF1KB9 GGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKS :.: .::: . ..: :. : ..:. : XP_016 VNLESMHTDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLS--DSLQQTLS 10 20 30 40 50 130 140 150 160 170 180 pF1KB9 HHHHPPHHS--PFKPDATYHT-MNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHH : .: : : : ... . .:. :: . :: :... . : . . . XP_016 H--RPCHLSQGPAMMSGNQMSGLNASPCQDMASLH--PLQQLVLVPGHLQSVSQFLLSQT 60 70 80 90 100 110 190 200 210 220 230 pF1KB9 QP-HQALEGELLE--HLSPGLALGAMAGPDGAVVSTPAHAPHM--ATMNPMHQAALSMAH :: .:.:. .:: . . :: : ..:: : . .. .: : . ....: .:. . XP_016 QPGQQGLQPNLLPFPQQQSGLLL-PQTGP-GLASQAFGH-PGLPGSSLEPHLEASQHLPV 120 130 140 150 160 170 240 250 260 270 280 290 pF1KB9 AHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQS . ::: : .: .: ..:: ::. ::::::::: ::.::: :.. :. : ...::. XP_016 PKHLPSSGG--ADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQT 180 190 200 210 220 300 310 320 330 340 350 pF1KB9 TICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE-KLTKPELFNG-----AEKKRKRTS :: :::.:.:: .:: :::.:. ::..::.: . ... : . . ..:..:::: XP_016 TISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTS 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB9 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI : . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::. XP_016 IETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPI 290 300 310 320 330 340 XP_016 KPPVYNSRL 350 >>XP_011541041 (OMIM: 607394) PREDICTED: POU domain, cla (432 aa) initn: 493 init1: 216 opt: 542 Z-score: 310.7 bits: 66.5 E(85289): 1.4e-10 Smith-Waterman score: 542; 37.3% identity (65.5% similar) in 322 aa overlap (97-404:28-335) 70 80 90 100 110 120 pF1KB9 GGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKS :.: .::: . ..: :. : ..:. : XP_011 MNDAKDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLS--DSLQQTLS 10 20 30 40 50 130 140 150 160 170 180 pF1KB9 HHHHPPHHS--PFKPDATYHT-MNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHH : .: : : : ... . .:. :: . :: :... . : . . . XP_011 H--RPCHLSQGPAMMSGNQMSGLNASPCQDMASLH--PLQQLVLVPGHLQSVSQFLLSQT 60 70 80 90 100 110 190 200 210 220 230 pF1KB9 QP-HQALEGELLE--HLSPGLALGAMAGPDGAVVSTPAHAPHM--ATMNPMHQAALSMAH :: .:.:. .:: . . :: : ..:: : . .. .: : . ....: .:. . XP_011 QPGQQGLQPNLLPFPQQQSGLLL-PQTGP-GLASQAFGH-PGLPGSSLEPHLEASQHLPV 120 130 140 150 160 240 250 260 270 280 290 pF1KB9 AHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQS . ::: : .: .: ..:: ::. ::::::::: ::.::: :.. :. : ...::. XP_011 PKHLPSSGG--ADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQT 170 180 190 200 210 220 300 310 320 330 340 350 pF1KB9 TICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE-KLTKPELFNG-----AEKKRKRTS :: :::.:.:: .:: :::.:. ::..::.: . ... : . . ..:..:::: XP_011 TISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTS 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB9 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI : . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::. XP_011 IETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPI 290 300 310 320 330 340 XP_011 KPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQ 350 360 370 380 390 400 >>XP_011541042 (OMIM: 607394) PREDICTED: POU domain, cla (432 aa) initn: 493 init1: 216 opt: 542 Z-score: 310.7 bits: 66.5 E(85289): 1.4e-10 Smith-Waterman score: 542; 37.3% identity (65.5% similar) in 322 aa overlap (97-404:28-335) 70 80 90 100 110 120 pF1KB9 GGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKS :.: .::: . ..: :. : ..:. : XP_011 MNDAKDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLS--DSLQQTLS 10 20 30 40 50 130 140 150 160 170 180 pF1KB9 HHHHPPHHS--PFKPDATYHT-MNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHH : .: : : : ... . .:. :: . :: :... . : . . . XP_011 H--RPCHLSQGPAMMSGNQMSGLNASPCQDMASLH--PLQQLVLVPGHLQSVSQFLLSQT 60 70 80 90 100 110 190 200 210 220 230 pF1KB9 QP-HQALEGELLE--HLSPGLALGAMAGPDGAVVSTPAHAPHM--ATMNPMHQAALSMAH :: .:.:. .:: . . :: : ..:: : . .. .: : . ....: .:. . XP_011 QPGQQGLQPNLLPFPQQQSGLLL-PQTGP-GLASQAFGH-PGLPGSSLEPHLEASQHLPV 120 130 140 150 160 240 250 260 270 280 290 pF1KB9 AHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQS . ::: : .: .: ..:: ::. ::::::::: ::.::: :.. :. : ...::. XP_011 PKHLPSSGG--ADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQT 170 180 190 200 210 220 300 310 320 330 340 350 pF1KB9 TICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE-KLTKPELFNG-----AEKKRKRTS :: :::.:.:: .:: :::.:. ::..::.: . ... : . . ..:..:::: XP_011 TISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTS 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB9 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI : . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::. XP_011 IETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPI 290 300 310 320 330 340 XP_011 KPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQ 350 360 370 380 390 400 >>NP_055167 (OMIM: 607394) POU domain, class 2, transcri (436 aa) initn: 493 init1: 216 opt: 542 Z-score: 310.7 bits: 66.5 E(85289): 1.4e-10 Smith-Waterman score: 542; 37.3% identity (65.5% similar) in 322 aa overlap (97-404:32-339) 70 80 90 100 110 120 pF1KB9 GGGRSSSSSSSGSSGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKS :.: .::: . ..: :. : ..:. : NP_055 VNLESMHTDIKMSGDVADSTDARSTLSQVEPGNDRNGLDFNRQIKTEDLS--DSLQQTLS 10 20 30 40 50 130 140 150 160 170 180 pF1KB9 HHHHPPHHS--PFKPDATYHT-MNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHH : .: : : : ... . .:. :: . :: :... . : . . . NP_055 H--RPCHLSQGPAMMSGNQMSGLNASPCQDMASLH--PLQQLVLVPGHLQSVSQFLLSQT 60 70 80 90 100 110 190 200 210 220 230 pF1KB9 QP-HQALEGELLE--HLSPGLALGAMAGPDGAVVSTPAHAPHM--ATMNPMHQAALSMAH :: .:.:. .:: . . :: : ..:: : . .. .: : . ....: .:. . NP_055 QPGQQGLQPNLLPFPQQQSGLLL-PQTGP-GLASQAFGH-PGLPGSSLEPHLEASQHLPV 120 130 140 150 160 170 240 250 260 270 280 290 pF1KB9 AHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQS . ::: : .: .: ..:: ::. ::::::::: ::.::: :.. :. : ...::. NP_055 PKHLPSSGG--ADEPSDLEELEKFAKTFKQRRIKLGFTQGDVGLAMG--KLYG-NDFSQT 180 190 200 210 220 300 310 320 330 340 350 pF1KB9 TICRFESLTLSHNNMIALKPILQAWLEEAEKSHRE-KLTKPELFNG-----AEKKRKRTS :: :::.:.:: .:: :::.:. ::..::.: . ... : . . ..:..:::: NP_055 TISRFEALNLSFKNMCKLKPLLEKWLNDAESSPSDPSVSTPSSYPSLSEVFGRKRKKRTS 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB9 IAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI : . . .:: : .:.::::.:. :::.:...:.::::::::.:::.::. NP_055 IETNIRLTLEKRFQDNPKPSSEEISMIAEQLSMEKEVVRVWFCNRRQKEKRINCPVATPI 290 300 310 320 330 340 NP_055 KPPVYNSRLVSPSGSLGPLSVPPVHSTMPGTVTSSCSPGNNSRPSSPGSGLHASSPTASQ 350 360 370 380 390 400 >>NP_002690 (OMIM: 602479) POU domain, class 3, transcri (451 aa) initn: 566 init1: 367 opt: 526 Z-score: 302.1 bits: 65.0 E(85289): 4.4e-10 Smith-Waterman score: 604; 36.5% identity (57.4% similar) in 411 aa overlap (16-409:41-402) 10 20 30 40 pF1KB9 MMMMSLNSKQAFSMPHGGSLHVEPKYSALHSTSPGSSAPIAPSAS :.:. . : . . .: :..: . . NP_002 GPGGGAGGTGPLMHPDAAAAAAAAAAAERLHAGAAYREVQ-KLMHHEWLGAGAGHPVGLA 20 30 40 50 60 50 60 70 80 90 pF1KB9 SPSSSSNAGGGGGGGGGG--------GGGGGGRSSSSSSSGSSGGGGSEAMRRACLPTPP :. ..::::: .:: :::: ::... :::: NP_002 HPQWLPTGGGGGGDWAGGPHLEHGKAGGGGTGRADD-------GGGG------------- 70 80 90 100 100 110 120 130 140 150 pF1KB9 SNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATY-HTMNTIPCTSAAS ::. :. .. : :.. .:... :: : :: .: :. : . . . :. NP_002 ----GGFHARLVHQGAAHAGA-AWAQGSTAHHLGPAMSP-SPGASGGHQPQPLGLYAQAA 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB9 ---SSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGAV ... .. : .: :: :.. :.: :: :: ::: . : NP_002 YPGGGGGGLAGMLAAGGGGAGPGLHHALHEDGHEAQ----LEP-SPPPHLGAHGHAHGH- 170 180 190 200 210 220 230 240 250 260 pF1KB9 VSTPAHAPHMATMNPMHQAALSMAHAH----GLPSHMGCMSDVDADPRD-LEAFAERFKQ ::: . .: :: :: : : : .: :: :: : :: ::..::: NP_002 ----AHA------GGLHAAA---AHLHPGAGGGGSSVGEHSDEDAPSSDDLEQFAKQFKQ 220 230 240 250 260 270 280 290 300 310 320 pF1KB9 RRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAE :::::: :::::: ::..: : . .::.::::::.: :: .:: :::.:. ::::.. NP_002 RRIKLGFTQADVGLALGTLY--G-NVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETD 270 280 290 300 310 320 330 340 350 360 370 380 pF1KB9 KSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKN .: . .. ..:..::::: . : .::..: :.::...:...:..:.:.:. NP_002 SSSGSPTNLDKIAAQGRKRKKRTSIEVGVKGALESHFLKCPKPSAHEITGLADSLQLEKE 330 340 350 360 370 380 390 400 410 pF1KB9 VVRVWFCNQRQKQKRMKYSAGI ::::::::.:::.::: .:: NP_002 VVRVWFCNRRQKEKRMTPAAGAGHPPMDDVYAPGELGPGGGGASPPSAPPPPPPAALHHH 390 400 410 420 430 440 410 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 04:27:39 2016 done: Tue Nov 8 04:27:40 2016 Total Scan time: 7.420 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]