FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8943, 301 aa 1>>>pF1KB8943 301 - 301 aa - 301 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.0860+/-0.000277; mu= 5.2780+/- 0.018 mean_var=182.8796+/-37.084, 0's: 0 Z-trim(124.7): 6 B-trim: 0 in 0/61 Lambda= 0.094840 statistics sampled from 46821 (46827) to 46821 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.823), E-opt: 0.2 (0.549), width: 16 Scan time: 7.970 The best scores are: opt bits E(85289) NP_116179 (OMIM: 610277,612782,615883) calcium rel ( 301) 2021 287.7 2e-77 NP_116220 (OMIM: 610929) protein orai-2 isoform a ( 254) 875 130.8 2.8e-30 NP_001119812 (OMIM: 610929) protein orai-2 isoform ( 254) 875 130.8 2.8e-30 NP_001258747 (OMIM: 610929) protein orai-2 isoform ( 254) 875 130.8 2.8e-30 NP_689501 (OMIM: 610930) protein orai-3 [Homo sapi ( 295) 832 125.0 1.8e-28 NP_001258748 (OMIM: 610929) protein orai-2 isoform ( 177) 585 91.0 1.8e-18 >>NP_116179 (OMIM: 610277,612782,615883) calcium release (301 aa) initn: 2021 init1: 2021 opt: 2021 Z-score: 1511.1 bits: 287.7 E(85289): 2e-77 Smith-Waterman score: 2021; 100.0% identity (100.0% similar) in 301 aa overlap (1-301:1-301) 10 20 30 40 50 60 pF1KB8 MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY 250 260 270 280 290 300 pF1KB8 A : NP_116 A >>NP_116220 (OMIM: 610929) protein orai-2 isoform a [Hom (254 aa) initn: 842 init1: 842 opt: 875 Z-score: 664.7 bits: 130.8 E(85289): 2.8e-30 Smith-Waterman score: 1032; 65.0% identity (81.9% similar) in 254 aa overlap (36-287:10-245) 10 20 30 40 50 60 pF1KB8 APPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMS : :. : : ... : ::. .:: :... NP_116 MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVT 10 20 30 70 80 90 100 110 120 pF1KB8 LNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSA :.::.::::::::::::::::::::::::::::::::::::::.....:: ::::::: NP_116 SNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 CTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTL :::::::::::::.::::::::.:::::.:::::..:::::::: .:::::.::::.: : NP_116 CTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGIL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 LFLAEVVLLCWVKFLPL--KKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIM :::::::::::.::::. ..::: : ::. :. . : ::..:: :: NP_116 LFLAEVVLLCWIKFLPVDARRQPG---P---PPGPGSHT---------GWQAALVSTIIM 160 170 180 190 200 250 260 270 280 290 300 pF1KB8 VPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA :: ::::.::..::::::: :::.:. .:..:: .:. ::: NP_116 VPVGLIFVVFTIHFYRSLVRHKTERHNREIEEL---HKLKVQLDGHERSLQVL 210 220 230 240 250 >>NP_001119812 (OMIM: 610929) protein orai-2 isoform a [ (254 aa) initn: 842 init1: 842 opt: 875 Z-score: 664.7 bits: 130.8 E(85289): 2.8e-30 Smith-Waterman score: 1032; 65.0% identity (81.9% similar) in 254 aa overlap (36-287:10-245) 10 20 30 40 50 60 pF1KB8 APPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMS : :. : : ... : ::. .:: :... NP_001 MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVT 10 20 30 70 80 90 100 110 120 pF1KB8 LNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSA :.::.::::::::::::::::::::::::::::::::::::::.....:: ::::::: NP_001 SNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 CTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTL :::::::::::::.::::::::.:::::.:::::..:::::::: .:::::.::::.: : NP_001 CTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGIL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 LFLAEVVLLCWVKFLPL--KKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIM :::::::::::.::::. ..::: : ::. :. . : ::..:: :: NP_001 LFLAEVVLLCWIKFLPVDARRQPG---P---PPGPGSHT---------GWQAALVSTIIM 160 170 180 190 200 250 260 270 280 290 300 pF1KB8 VPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA :: ::::.::..::::::: :::.:. .:..:: .:. ::: NP_001 VPVGLIFVVFTIHFYRSLVRHKTERHNREIEEL---HKLKVQLDGHERSLQVL 210 220 230 240 250 >>NP_001258747 (OMIM: 610929) protein orai-2 isoform a [ (254 aa) initn: 842 init1: 842 opt: 875 Z-score: 664.7 bits: 130.8 E(85289): 2.8e-30 Smith-Waterman score: 1032; 65.0% identity (81.9% similar) in 254 aa overlap (36-287:10-245) 10 20 30 40 50 60 pF1KB8 APPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMS : :. : : ... : ::. .:: :... NP_001 MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVT 10 20 30 70 80 90 100 110 120 pF1KB8 LNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSA :.::.::::::::::::::::::::::::::::::::::::::.....:: ::::::: NP_001 SNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 CTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTL :::::::::::::.::::::::.:::::.:::::..:::::::: .:::::.::::.: : NP_001 CTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGIL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB8 LFLAEVVLLCWVKFLPL--KKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIM :::::::::::.::::. ..::: : ::. :. . : ::..:: :: NP_001 LFLAEVVLLCWIKFLPVDARRQPG---P---PPGPGSHT---------GWQAALVSTIIM 160 170 180 190 200 250 260 270 280 290 300 pF1KB8 VPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA :: ::::.::..::::::: :::.:. .:..:: .:. ::: NP_001 VPVGLIFVVFTIHFYRSLVRHKTERHNREIEEL---HKLKVQLDGHERSLQVL 210 220 230 240 250 >>NP_689501 (OMIM: 610930) protein orai-3 [Homo sapiens] (295 aa) initn: 1023 init1: 789 opt: 832 Z-score: 632.0 bits: 125.0 E(85289): 1.8e-28 Smith-Waterman score: 984; 57.1% identity (75.4% similar) in 289 aa overlap (34-286:8-292) 10 20 30 40 50 60 pF1KB8 EPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEP--PGAPPPPPSAVTYPDWIGQSYS .:. : : . : :: :: ... ..: NP_689 MKGGEGDAGEQAPLNPEGESPAGSA-TYREFVHRGYL 10 20 30 70 80 90 100 110 120 pF1KB8 EVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLI ..:. ..::..:::::.:::::::::::::::::::::::::::::::..::.::::::. NP_689 DLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLV 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB8 AFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTV ::::::::::::::::::.:::.::.::::::.::::::..:::.:.::..::::.:::. NP_689 AFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTA 100 110 120 130 140 150 190 200 210 220 230 pF1KB8 IGTLLFLAEVVLLCWVKFLPLKKQPGQPRP---TSKPPASGA--------AANVSTSGIT .::.::::::::. ::::.:. : : ::. :.. : :.:. :. . NP_689 LGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSAS 160 170 180 190 200 210 240 250 260 pF1KB8 -----------------------PGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTD :: ::.:::.:::: ::.:..::.:::::::.:::: NP_689 AAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTD 220 230 240 250 260 270 270 280 290 300 pF1KB8 RQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA : :::.:: ::: .: NP_689 RYKQELEELN---RLQGELQAV 280 290 >>NP_001258748 (OMIM: 610929) protein orai-2 isoform b [ (177 aa) initn: 552 init1: 552 opt: 585 Z-score: 452.4 bits: 91.0 E(85289): 1.8e-18 Smith-Waterman score: 742; 64.5% identity (81.7% similar) in 186 aa overlap (104-287:1-168) 80 90 100 110 120 130 pF1KB8 LSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAV ::::::.....:: ::::::::::::::: NP_001 MVEVQLETQYQYPRPLLIAFSACTTVLVAV 10 20 30 140 150 160 170 180 190 pF1KB8 HLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVL :::::.::::::::.:::::.:::::..:::::::: .:::::.::::.: ::::::::: NP_001 HLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVL 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB8 LCWVKFLPL--KKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFI :::.::::. ..::: : ::. :. . : ::..:: :::: ::::. NP_001 LCWIKFLPVDARRQPG-P-----PPGPGSHT---------GWQAALVSTIIMVPVGLIFV 100 110 120 130 260 270 280 290 300 pF1KB8 VFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA ::..::::::: :::.:. .:..:: .:. ::: NP_001 VFTIHFYRSLVRHKTERHNREIEELH---KLKVQLDGHERSLQVL 140 150 160 170 301 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 04:22:46 2016 done: Tue Nov 8 04:22:47 2016 Total Scan time: 7.970 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]