FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9521, 317 aa 1>>>pF1KE9521 317 - 317 aa - 317 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1308+/-0.000471; mu= 17.1781+/- 0.029 mean_var=119.6575+/-31.572, 0's: 0 Z-trim(110.4): 335 B-trim: 2191 in 2/48 Lambda= 0.117248 statistics sampled from 18217 (18729) to 18217 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.572), E-opt: 0.2 (0.22), width: 16 Scan time: 4.640 The best scores are: opt bits E(85289) NP_002377 (OMIM: 155555,203200,266300,613098,61309 ( 317) 2064 360.9 2e-99 NP_005903 (OMIM: 155541,601665) melanocortin recep ( 332) 982 177.9 2.6e-44 NP_063941 (OMIM: 155540,602025,607948) melanocorti ( 323) 958 173.8 4.2e-43 NP_005904 (OMIM: 600042) melanocortin receptor 5 [ ( 325) 921 167.5 3.2e-41 NP_000520 (OMIM: 202200,607397) adrenocorticotropi ( 297) 750 138.6 1.6e-32 XP_016881270 (OMIM: 202200,607397) PREDICTED: adre ( 297) 750 138.6 1.6e-32 NP_001278840 (OMIM: 202200,607397) adrenocorticotr ( 297) 750 138.6 1.6e-32 NP_001307659 (OMIM: 601974) sphingosine 1-phosphat ( 382) 341 69.5 1.2e-11 NP_001391 (OMIM: 601974) sphingosine 1-phosphate r ( 382) 341 69.5 1.2e-11 NP_004221 (OMIM: 605111,610419,610419) sphingosine ( 353) 326 66.9 6.7e-11 XP_016882957 (OMIM: 605110) PREDICTED: lysophospha ( 351) 292 61.2 3.6e-09 NP_004711 (OMIM: 605110) lysophosphatidic acid rec ( 351) 292 61.2 3.6e-09 XP_016882958 (OMIM: 605110) PREDICTED: lysophospha ( 351) 292 61.2 3.6e-09 XP_011526723 (OMIM: 605110) PREDICTED: lysophospha ( 351) 292 61.2 3.6e-09 NP_005272 (OMIM: 600241) G-protein coupled recepto ( 330) 273 57.9 3.2e-08 NP_005217 (OMIM: 601965) sphingosine 1-phosphate r ( 378) 273 58.0 3.5e-08 NP_036284 (OMIM: 605106) lysophosphatidic acid rec ( 353) 272 57.8 3.8e-08 NP_005275 (OMIM: 600553) G-protein coupled recepto ( 362) 262 56.1 1.2e-07 NP_001273028 (OMIM: 600553) G-protein coupled rece ( 377) 262 56.2 1.3e-07 NP_005279 (OMIM: 600752) G-protein coupled recepto ( 334) 259 55.6 1.7e-07 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 253 54.5 3.4e-07 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 253 54.6 3.4e-07 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 253 54.6 3.6e-07 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 253 54.6 3.7e-07 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 253 54.7 3.8e-07 XP_016869888 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869892 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869885 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869877 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869894 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_005251838 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869893 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869887 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869878 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869883 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869872 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869876 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869889 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 NP_001392 (OMIM: 602282) lysophosphatidic acid rec ( 364) 252 54.4 4e-07 XP_016869879 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869886 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869880 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_005251839 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869884 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869895 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869874 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869896 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 XP_016869891 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 NP_476500 (OMIM: 602282) lysophosphatidic acid rec ( 364) 252 54.4 4e-07 XP_016869875 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07 >>NP_002377 (OMIM: 155555,203200,266300,613098,613099) m (317 aa) initn: 2064 init1: 2064 opt: 2064 Z-score: 1906.0 bits: 360.9 E(85289): 2e-99 Smith-Waterman score: 2064; 100.0% identity (100.0% similar) in 317 aa overlap (1-317:1-317) 10 20 30 40 50 60 pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF 250 260 270 280 290 300 310 pF1KE9 HSQELRRTLKEVLTCSW ::::::::::::::::: NP_002 HSQELRRTLKEVLTCSW 310 >>NP_005903 (OMIM: 155541,601665) melanocortin receptor (332 aa) initn: 982 init1: 398 opt: 982 Z-score: 916.6 bits: 177.9 E(85289): 2.6e-44 Smith-Waterman score: 982; 51.2% identity (78.1% similar) in 297 aa overlap (20-315:27-319) 10 20 30 40 50 pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLE-VSISDGLFLSLGLVS : .:: . .. : : : . .: .:..::..: NP_005 MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGG--CYEQLFVSPEVFVTLGVIS 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 LVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAV :.:: ::...::::.::::::: ::: ::..:.::: :: :: :: ::.. :.. . NP_005 LLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 LQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVAS .. .::::: . :::.:.:.: : .::::::..:::::.::.:.:. :. .. ::.: NP_005 VN-IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAAC 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 VVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVH .: . ::: : : ::..::...:..::.::: :::::. : : . :: : .. NP_005 TVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTG-AIR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 QGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAI :: ..:::.:::::.:.: .::.:::::: . . ::..: : :....:::.: ::.::.: NP_005 QGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSI 240 250 260 270 280 290 300 310 pF1KE9 IDPLIYAFHSQELRRTLKEVLTCSW :::::::..:::::.:.::.. : NP_005 IDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY 300 310 320 330 >>NP_063941 (OMIM: 155540,602025,607948) melanocortin re (323 aa) initn: 940 init1: 584 opt: 958 Z-score: 894.8 bits: 173.8 E(85289): 4.2e-43 Smith-Waterman score: 958; 49.5% identity (77.6% similar) in 295 aa overlap (23-315:22-315) 10 20 30 40 50 pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTG-ARCLEVSISDGLFLSLGLVSLVENALV : . .::.. : : .: :. .:::::.:::.:: :: NP_063 MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILV 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 VATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNV . ....: ::::::: :.: ::..:.::: ::.::: .: .... :. . .:..::. NP_063 ILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 IDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLF .: . : :...:.: : :::::::..::::::::::.:. .: ..:::: : ...: NP_063 FDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 IAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFG-LK :.: . :..::...:.::..::..:::::. : :.. :: : . . : . .: NP_063 IVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 GAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIY ::::.:::::.:..::.::::::.::. :: .: : : .:: .:.::.::..:::::: NP_063 GAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIY 240 250 260 270 280 290 300 310 pF1KE9 AFHSQELRRTLKEVLTCSW ::.: ::: :..:.: : NP_063 AFRSLELRNTFREIL-CGCNGMNLG 300 310 320 >>NP_005904 (OMIM: 600042) melanocortin receptor 5 [Homo (325 aa) initn: 904 init1: 563 opt: 921 Z-score: 860.9 bits: 167.5 E(85289): 3.2e-41 Smith-Waterman score: 921; 45.9% identity (76.9% similar) in 303 aa overlap (13-315:13-312) 10 20 30 40 50 60 pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV .::.: . : ... .. : ...:. .::.::..::.:: ::. NP_005 MNSSFHLHFLDLNLNATEGNLS--GPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVI 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI ..:.::.::::::: :.: ::..:.::: :.. :: .: ::. :: : ....:::. NP_005 GAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI : . : :...:.: : :::::::..:::::::: :.: :. .:.::. . . .:: NP_005 DSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA : . . :.:::. .:.::: :.. ::.::. : :.. :: : . ..: ...:: NP_005 LYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASS-ARQRTSMQGA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF ::.:.:::.: .::.::::::::.. ::.. :. ....::..: ::.::...::::::: NP_005 VTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAF 240 250 260 270 280 290 310 pF1KE9 HSQELRRTLKEVLTCSW .:::.:.:.::.. : NP_005 RSQEMRKTFKEIICCRGFRIACSFPRRD 300 310 320 >>NP_000520 (OMIM: 202200,607397) adrenocorticotropic ho (297 aa) initn: 773 init1: 390 opt: 750 Z-score: 705.0 bits: 138.6 E(85289): 1.6e-32 Smith-Waterman score: 750; 40.7% identity (73.0% similar) in 285 aa overlap (35-317:21-297) 10 20 30 40 50 60 pF1KE9 GSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIA : .: . . .:.....:...:: .:. .. NP_000 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 KNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVIT ::.::..::: ::: ::.::.: : ..::. .:.: . : : :.. :..:: . NP_000 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 CSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD :.:.:. :..::.::::.::.:::::::::. :. ....::. . . .. . NP_000 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 HVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLT :: ... .. .: :::.. :::::. : .:.. :. : . . .:::.::: NP_000 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN--------MKGAITLT 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 ILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQE ::::.:..::.:: ::. :...:: .: :.: .. :.. ::.:::.:::.::::.: : NP_000 ILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE 230 240 250 260 270 280 310 pF1KE9 LRRTLKEVLTCS--W :: ..:... :: : NP_000 LRDAFKKMIFCSRYW 290 >>XP_016881270 (OMIM: 202200,607397) PREDICTED: adrenoco (297 aa) initn: 773 init1: 390 opt: 750 Z-score: 705.0 bits: 138.6 E(85289): 1.6e-32 Smith-Waterman score: 750; 40.7% identity (73.0% similar) in 285 aa overlap (35-317:21-297) 10 20 30 40 50 60 pF1KE9 GSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIA : .: . . .:.....:...:: .:. .. XP_016 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 KNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVIT ::.::..::: ::: ::.::.: : ..::. .:.: . : : :.. :..:: . XP_016 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 CSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD :.:.:. :..::.::::.::.:::::::::. :. ....::. . . .. . XP_016 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 HVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLT :: ... .. .: :::.. :::::. : .:.. :. : . . .:::.::: XP_016 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN--------MKGAITLT 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 ILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQE ::::.:..::.:: ::. :...:: .: :.: .. :.. ::.:::.:::.::::.: : XP_016 ILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE 230 240 250 260 270 280 310 pF1KE9 LRRTLKEVLTCS--W :: ..:... :: : XP_016 LRDAFKKMIFCSRYW 290 >>NP_001278840 (OMIM: 202200,607397) adrenocorticotropic (297 aa) initn: 773 init1: 390 opt: 750 Z-score: 705.0 bits: 138.6 E(85289): 1.6e-32 Smith-Waterman score: 750; 40.7% identity (73.0% similar) in 285 aa overlap (35-317:21-297) 10 20 30 40 50 60 pF1KE9 GSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIA : .: . . .:.....:...:: .:. .. NP_001 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 KNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVIT ::.::..::: ::: ::.::.: : ..::. .:.: . : : :.. :..:: . NP_001 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 CSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD :.:.:. :..::.::::.::.:::::::::. :. ....::. . . .. . NP_001 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 HVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLT :: ... .. .: :::.. :::::. : .:.. :. : . . .:::.::: NP_001 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN--------MKGAITLT 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 ILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQE ::::.:..::.:: ::. :...:: .: :.: .. :.. ::.:::.:::.::::.: : NP_001 ILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE 230 240 250 260 270 280 310 pF1KE9 LRRTLKEVLTCS--W :: ..:... :: : NP_001 LRDAFKKMIFCSRYW 290 >>NP_001307659 (OMIM: 601974) sphingosine 1-phosphate re (382 aa) initn: 277 init1: 114 opt: 341 Z-score: 330.0 bits: 69.5 E(85289): 1.2e-11 Smith-Waterman score: 359; 28.3% identity (61.9% similar) in 315 aa overlap (23-315:34-328) 10 20 30 40 50 pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVS .:...:.. .. ..... .:. . NP_001 TSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENS----IKLTSVVFILICCFI 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 LVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAV ..:: .:. :: :....: ::: :: ::::::: ..: :: .:: .:: . . . NP_001 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL---AGVAYTANLLL--SGATTYKLTP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 LQQL--DNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWV : . .. . : .:..: : :::..:::... .. :. . : ..: :: NP_001 AQWFLREGSMFVALSASVFSLL----AIAIERYITML-KMKLHNGSNNFRLFLLISACWV 120 130 140 150 160 180 190 200 210 pF1KE9 ASVVF-----------------STLFIAYYDHVAVLLCLVVFFLAMLVLMAVLY--VHML :... ::.. :. : .:.: .:: : .:. ...:: .. : NP_001 ISLILGGLPIMGWNCISALSSCSTVLPLYHKHY-ILFCTTVFTL-LLLSIVILYCRIYSL 170 180 190 200 210 220 220 230 240 250 260 270 pF1KE9 ARACQHAQGIAR-LHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEH .:. .. . . . : .: .....: :. :.:..:. ::.:.:. : : : : . NP_001 VRTRSRRLTFRKNISKASRSSEKSLALLK--TVIIVLSVFIACWAPLFILLLLDVGC-KV 230 240 250 260 270 280 280 290 300 310 pF1KE9 PTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW :: .:. . ::.: . :. .:.::.. ..:.::.. ....: NP_001 KTCDILFRA-EYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRP 290 300 310 320 330 340 NP_001 IIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS 350 360 370 380 >>NP_001391 (OMIM: 601974) sphingosine 1-phosphate recep (382 aa) initn: 277 init1: 114 opt: 341 Z-score: 330.0 bits: 69.5 E(85289): 1.2e-11 Smith-Waterman score: 359; 28.3% identity (61.9% similar) in 315 aa overlap (23-315:34-328) 10 20 30 40 50 pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVS .:...:.. .. ..... .:. . NP_001 TSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENS----IKLTSVVFILICCFI 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 LVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAV ..:: .:. :: :....: ::: :: ::::::: ..: :: .:: .:: . . . NP_001 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL---AGVAYTANLLL--SGATTYKLTP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 LQQL--DNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWV : . .. . : .:..: : :::..:::... .. :. . : ..: :: NP_001 AQWFLREGSMFVALSASVFSLL----AIAIERYITML-KMKLHNGSNNFRLFLLISACWV 120 130 140 150 160 180 190 200 210 pF1KE9 ASVVF-----------------STLFIAYYDHVAVLLCLVVFFLAMLVLMAVLY--VHML :... ::.. :. : .:.: .:: : .:. ...:: .. : NP_001 ISLILGGLPIMGWNCISALSSCSTVLPLYHKHY-ILFCTTVFTL-LLLSIVILYCRIYSL 170 180 190 200 210 220 220 230 240 250 260 270 pF1KE9 ARACQHAQGIAR-LHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEH .:. .. . . . : .: .....: :. :.:..:. ::.:.:. : : : : . NP_001 VRTRSRRLTFRKNISKASRSSEKSLALLK--TVIIVLSVFIACWAPLFILLLLDVGC-KV 230 240 250 260 270 280 280 290 300 310 pF1KE9 PTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW :: .:. . ::.: . :. .:.::.. ..:.::.. ....: NP_001 KTCDILFRA-EYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRP 290 300 310 320 330 340 NP_001 IIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS 350 360 370 380 >>NP_004221 (OMIM: 605111,610419,610419) sphingosine 1-p (353 aa) initn: 339 init1: 109 opt: 326 Z-score: 316.6 bits: 66.9 E(85289): 6.7e-11 Smith-Waterman score: 326; 29.6% identity (59.9% similar) in 294 aa overlap (40-317:35-306) 10 20 30 40 50 60 pF1KE9 LLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNL ....... : . .::: ::. ..:.: .. NP_004 YSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 HSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDV-ITCSSM :: :: :. :: ::::.. . : .: : .:... : . .: . .. :: :. NP_004 HSAMYLFLGNLAASDLLAGVAFVANT-----LLSGSVTLRLTPVQWFAREGSAFITLSAS 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 LSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD---H . :: :::..:...: . : : . : ..: :. :.:.. : : .. : NP_004 VFSLL---AIAIERHVAIAKVKLYGSDKSC-RMLLLIGASWLISLVLGGLPILGWNCLGH 120 130 140 150 160 170 190 200 210 220 230 pF1KE9 VAV------------LLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQ . . .::.:..: .:. ...:::.. : ..: . . . : NP_004 LEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIY---C-----VVRSSHADMAAPQ 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 GFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAII ..: :.::.::.:..:: : : : : :: : .: ..: . :.:. :... NP_004 TLALLK--TVTIVLGVFIVCWLPAFSILLLDYACPVH-SCPILYKA-HYFFAVSTLNSLL 230 240 250 260 270 280 300 310 pF1KE9 DPLIYAFHSQELRRTLKEVLTCSW .:.::...:..::: . . : : : NP_004 NPVIYTWRSRDLRREVLRPLQC-WRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPT 290 300 310 320 330 340 317 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 02:17:50 2016 done: Tue Nov 8 02:17:51 2016 Total Scan time: 4.640 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]