Result of FASTA (omim) for
pFN21AE3375
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3375, 1081 aa
1>>>pF1KE3375 1081 - 1081 aa - 1081 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.0000+/-0.000462; mu= -18.4730+/- 0.029
mean_var=750.5667+/-164.048, 0's: 0 Z-trim(122.7): 1164 B-trim: 0 in 0/59
Lambda= 0.046814
statistics sampled from 39615 (41139) to 39615 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.78), E-opt: 0.2 (0.482), width: 16
Scan time: 14.070
The best scores are: opt bits E(85289)
XP_005267740 (OMIM: 600136) PREDICTED: mitogen-act (1081) 7339 512.4 5.8e-144
NP_001271159 (OMIM: 600136) mitogen-activated prot (1104) 4204 300.6 3.2e-80
NP_149132 (OMIM: 600136) mitogen-activated protein (1118) 4171 298.4 1.5e-79
XP_011535090 (OMIM: 600136) PREDICTED: mitogen-act (1166) 3814 274.3 2.8e-72
XP_011535096 (OMIM: 600136) PREDICTED: mitogen-act ( 804) 2952 215.9 7.5e-55
XP_011535094 (OMIM: 600136) PREDICTED: mitogen-act ( 860) 2952 215.9 7.8e-55
NP_001271161 (OMIM: 600136) mitogen-activated prot ( 837) 2946 215.5 1e-54
NP_001271160 (OMIM: 600136) mitogen-activated prot ( 880) 2946 215.6 1.1e-54
NP_002437 (OMIM: 600137) mitogen-activated protein ( 954) 2444 181.7 1.8e-44
NP_115811 (OMIM: 614793) mitogen-activated protein (1036) 2363 176.3 8.3e-43
XP_011542607 (OMIM: 614793) PREDICTED: mitogen-act ( 905) 2343 174.8 1.9e-42
NP_002410 (OMIM: 600050) mitogen-activated protein ( 847) 2155 162.1 1.2e-38
XP_011525283 (OMIM: 600137) PREDICTED: mitogen-act ( 962) 2123 160.0 6e-38
XP_011525284 (OMIM: 600137) PREDICTED: mitogen-act ( 860) 2086 157.5 3.2e-37
XP_006723285 (OMIM: 600137) PREDICTED: mitogen-act ( 620) 1115 91.7 1.4e-17
XP_016859813 (OMIM: 609479,616890) PREDICTED: mito ( 455) 704 63.8 2.6e-09
NP_598407 (OMIM: 609479,616890) mitogen-activated ( 455) 704 63.8 2.6e-09
XP_016859812 (OMIM: 609479,616890) PREDICTED: mito ( 455) 704 63.8 2.6e-09
XP_005246697 (OMIM: 609479,616890) PREDICTED: mito ( 800) 704 64.1 3.8e-09
NP_057737 (OMIM: 609479,616890) mitogen-activated ( 800) 704 64.1 3.8e-09
XP_006723286 (OMIM: 600137) PREDICTED: mitogen-act ( 524) 684 62.5 7.3e-09
XP_016875445 (OMIM: 600447) PREDICTED: mitogen-act ( 859) 635 59.5 1e-07
NP_006292 (OMIM: 600447) mitogen-activated protein ( 859) 635 59.5 1e-07
NP_001180440 (OMIM: 600447) mitogen-activated prot ( 892) 635 59.5 1e-07
XP_005269195 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 635 59.5 1e-07
XP_006719651 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 635 59.5 1e-07
XP_011537027 (OMIM: 600447) PREDICTED: mitogen-act ( 892) 635 59.5 1e-07
XP_016862948 (OMIM: 604915) PREDICTED: mitogen-act ( 734) 596 56.7 5.6e-07
XP_016862947 (OMIM: 604915) PREDICTED: mitogen-act ( 734) 596 56.7 5.6e-07
NP_001229246 (OMIM: 604915) mitogen-activated prot ( 759) 596 56.8 5.7e-07
XP_016862946 (OMIM: 604915) PREDICTED: mitogen-act ( 817) 596 56.8 6e-07
NP_001229243 (OMIM: 604915) mitogen-activated prot ( 966) 596 56.9 6.7e-07
XP_016862945 (OMIM: 604915) PREDICTED: mitogen-act ( 966) 596 56.9 6.7e-07
XP_011511612 (OMIM: 604915) PREDICTED: mitogen-act ( 966) 596 56.9 6.7e-07
NP_004712 (OMIM: 604915) mitogen-activated protein ( 966) 596 56.9 6.7e-07
XP_005269197 (OMIM: 600447) PREDICTED: mitogen-act ( 453) 571 54.8 1.3e-06
XP_011533958 (OMIM: 606573) PREDICTED: tyrosine-pr ( 392) 532 52.1 7.4e-06
XP_011533957 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 532 52.2 8.8e-06
XP_011533955 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 532 52.2 8.8e-06
XP_016866134 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 532 52.2 8.8e-06
XP_005266938 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 532 52.2 8.8e-06
NP_002022 (OMIM: 606573) tyrosine-protein kinase F ( 505) 532 52.2 8.8e-06
XP_005266937 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 532 52.2 8.8e-06
XP_005266939 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 532 52.2 8.8e-06
XP_011533956 (OMIM: 606573) PREDICTED: tyrosine-pr ( 505) 532 52.2 8.8e-06
NP_005148 (OMIM: 189980) tyrosine-protein kinase A (1130) 510 51.2 4.2e-05
NP_009297 (OMIM: 189980) tyrosine-protein kinase A (1149) 510 51.2 4.2e-05
NP_001137257 (OMIM: 190030) tyrosine-protein kinas ( 694) 496 50.0 5.8e-05
XP_016877497 (OMIM: 190030) PREDICTED: tyrosine-pr ( 694) 496 50.0 5.8e-05
XP_016877496 (OMIM: 190030) PREDICTED: tyrosine-pr ( 752) 496 50.0 6.1e-05
>>XP_005267740 (OMIM: 600136) PREDICTED: mitogen-activat (1081 aa)
initn: 7339 init1: 7339 opt: 7339 Z-score: 2705.5 bits: 512.4 E(85289): 5.8e-144
Smith-Waterman score: 7339; 100.0% identity (100.0% similar) in 1081 aa overlap (1-1081:1-1081)
10 20 30 40 50 60
pF1KE3 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 PGTLGQKELASGDEGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGTLGQKELASGDEGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 GSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGG
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 AHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 PRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMP
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 VSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKP
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 ETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTL
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 ERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 EERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFW
1030 1040 1050 1060 1070 1080
pF1KE3 S
:
XP_005 S
>>NP_001271159 (OMIM: 600136) mitogen-activated protein (1104 aa)
initn: 4214 init1: 4152 opt: 4204 Z-score: 1561.1 bits: 300.6 E(85289): 3.2e-80
Smith-Waterman score: 7283; 97.9% identity (97.9% similar) in 1104 aa overlap (1-1081:1-1104)
10 20 30 40 50 60
pF1KE3 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
550 560 570 580 590 600
610 620 630
pF1KE3 PGTLGQKELASGDEG-----------------------LKSLVDGYKQWSSSAPNLVKGP
::::::::::::::: ::::::::::::::::::::::
NP_001 PGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGP
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE3 RSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEE
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE3 PTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPL
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE3 EEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSI
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE3 SECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTH
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE3 VTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPR
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE3 LPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSP
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE3 ANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDST
1030 1040 1050 1060 1070 1080
1060 1070 1080
pF1KE3 VPLCRAELNTHRPAPYEIQQEFWS
::::::::::::::::::::::::
NP_001 VPLCRAELNTHRPAPYEIQQEFWS
1090 1100
>>NP_149132 (OMIM: 600136) mitogen-activated protein kin (1118 aa)
initn: 7078 init1: 4152 opt: 4171 Z-score: 1549.0 bits: 298.4 E(85289): 1.5e-79
Smith-Waterman score: 7204; 96.7% identity (96.7% similar) in 1113 aa overlap (1-1076:1-1113)
10 20 30 40 50 60
pF1KE3 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 SLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWG
550 560 570 580 590 600
610 620 630
pF1KE3 PGTLGQKELASGDEG-----------------------LKSLVDGYKQWSSSAPNLVKGP
::::::::::::::: ::::::::::::::::::::::
NP_149 PGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGP
610 620 630 640 650 660
640 650 660 670 680
pF1KE3 RSSPALPGFTSLMEM--------------EDEDSEGPGSGESRLQHSPSQSYLCIPFPRG
::::::::::::::: :::::::::::::::::::::::::::::::
NP_149 RSSPALPGFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRG
670 680 690 700 710 720
690 700 710 720 730 740
pF1KE3 EDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 EDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLG
730 740 750 760 770 780
750 760 770 780 790 800
pF1KE3 FDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 FDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLG
790 800 810 820 830 840
810 820 830 840 850 860
pF1KE3 DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 DPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVE
850 860 870 880 890 900
870 880 890 900 910 920
pF1KE3 RFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 RFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGML
910 920 930 940 950 960
930 940 950 960 970 980
pF1KE3 KTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 KTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDP
970 980 990 1000 1010 1020
990 1000 1010 1020 1030 1040
pF1KE3 WWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 WWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERT
1030 1040 1050 1060 1070 1080
1050 1060 1070 1080
pF1KE3 LLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
:::::::::::::::::::::::::::::::::
NP_149 LLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
1090 1100 1110
>>XP_011535090 (OMIM: 600136) PREDICTED: mitogen-activat (1166 aa)
initn: 7064 init1: 3798 opt: 3814 Z-score: 1418.5 bits: 274.3 E(85289): 2.8e-72
Smith-Waterman score: 6769; 92.4% identity (92.4% similar) in 1113 aa overlap (1-1028:1-1113)
10 20 30 40 50 60
pF1KE3 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDED
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLARE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFH
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDIL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRK
490 500 510 520 530 540
550 560
pF1KE3 SLINSRSSPPASPTIIPRLRAIQ-------------------------------------
:::::::::::::::::::::::
XP_011 SLINSRSSPPASPTIIPRLRAIQCETVSQISWGQNTQGHLSPALSSHRLVQACSIHNFCH
550 560 570 580 590 600
570 580 590 600 610
pF1KE3 -----------LTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASG
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSSTMCIYMHILTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASG
610 620 630 640 650 660
620 630 640
pF1KE3 DEG-----------------------LKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSL
::: ::::::::::::::::::::::::::::::::::
XP_011 DEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSL
670 680 690 700 710 720
650 660 670 680 690
pF1KE3 MEM--------------EDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIH
::: :::::::::::::::::::::::::::::::::::::::::::
XP_011 MEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIH
730 740 750 760 770 780
700 710 720 730 740 750
pF1KE3 EEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLL
790 800 810 820 830 840
760 770 780 790 800 810
pF1KE3 PLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLS
850 860 870 880 890 900
820 830 840 850 860 870
pF1KE3 SISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTP
910 920 930 940 950 960
880 890 900 910 920 930
pF1KE3 THVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEF
970 980 990 1000 1010 1020
940 950 960 970 980 990
pF1KE3 PRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARST
1030 1040 1050 1060 1070 1080
1000 1010 1020 1030 1040 1050
pF1KE3 SPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQD
:::::::::::::::::::::::::::::::::
XP_011 SPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQD
1090 1100 1110 1120 1130 1140
1060 1070 1080
pF1KE3 STVPLCRAELNTHRPAPYEIQQEFWS
XP_011 STVPLCRAELNTHRPAPYEIQQEFWS
1150 1160
>>XP_011535096 (OMIM: 600136) PREDICTED: mitogen-activat (804 aa)
initn: 4626 init1: 2940 opt: 2952 Z-score: 1105.8 bits: 215.9 E(85289): 7.5e-55
Smith-Waterman score: 4701; 89.4% identity (89.4% similar) in 804 aa overlap (363-1081:1-804)
340 350 360 370 380 390
pF1KE3 WSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHS
::::::::::::::::::::::::::::::
XP_011 MNKLALPIPSTCPEPFAKLMEDCWNPDPHS
10 20 30
400 410 420 430 440 450
pF1KE3 RPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELT
40 50 60 70 80 90
460 470 480 490 500 510
pF1KE3 RAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKL
100 110 120 130 140 150
520 530 540 550 560
pF1KE3 KDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQ---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQCETVSQISW
160 170 180 190 200 210
570 580
pF1KE3 ---------------------------------------LTPGESSKTWGRSSVVPKEEG
:::::::::::::::::::::
XP_011 GQNTQGHLSPALSSHRLVQACSIHNFCHLSSTMCIYMHILTPGESSKTWGRSSVVPKEEG
220 230 240 250 260 270
590 600 610 620
pF1KE3 EEEEKRAPKKKGRTWGPGTLGQKELASGDEG-----------------------LKSLVD
::::::::::::::::::::::::::::::: ::::::
XP_011 EEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVD
280 290 300 310 320 330
630 640 650 660
pF1KE3 GYKQWSSSAPNLVKGPRSSPALPGFTSLMEM--------------EDEDSEGPGSGESRL
::::::::::::::::::::::::::::::: :::::::::::::::
XP_011 GYKQWSSSAPNLVKGPRSSPALPGFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRL
340 350 360 370 380 390
670 680 690 700 710 720
pF1KE3 QHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCE
400 410 420 430 440 450
730 740 750 760 770 780
pF1KE3 VALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSP
460 470 480 490 500 510
790 800 810 820 830 840
pF1KE3 PSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAP
520 530 540 550 560 570
850 860 870 880 890 900
pF1KE3 PLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASR
580 590 600 610 620 630
910 920 930 940 950 960
pF1KE3 SPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLE
640 650 660 670 680 690
970 980 990 1000 1010 1020
pF1KE3 FLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLP
700 710 720 730 740 750
1030 1040 1050 1060 1070 1080
pF1KE3 ALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
760 770 780 790 800
>>XP_011535094 (OMIM: 600136) PREDICTED: mitogen-activat (860 aa)
initn: 5002 init1: 2940 opt: 2952 Z-score: 1105.4 bits: 215.9 E(85289): 7.8e-55
Smith-Waterman score: 5077; 90.1% identity (90.1% similar) in 860 aa overlap (307-1081:1-860)
280 290 300 310 320 330
pF1KE3 LQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYG
::::::::::::::::::::::::::::::
XP_011 MSAAGTYAWMAPEVIRASMFSKGSDVWSYG
10 20 30
340 350 360 370 380 390
pF1KE3 VLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSF
40 50 60 70 80 90
400 410 420 430 440 450
pF1KE3 TNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAAL
100 110 120 130 140 150
460 470 480 490 500 510
pF1KE3 QQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGN
160 170 180 190 200 210
520 530 540 550 560
pF1KE3 RISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQ-------------
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQCETVSQISWGQNT
220 230 240 250 260 270
570 580
pF1KE3 -----------------------------------LTPGESSKTWGRSSVVPKEEGEEEE
:::::::::::::::::::::::::
XP_011 QGHLSPALSSHRLVQACSIHNFCHLSSTMCIYMHILTPGESSKTWGRSSVVPKEEGEEEE
280 290 300 310 320 330
590 600 610 620
pF1KE3 KRAPKKKGRTWGPGTLGQKELASGDEG-----------------------LKSLVDGYKQ
::::::::::::::::::::::::::: ::::::::::
XP_011 KRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQ
340 350 360 370 380 390
630 640 650 660 670
pF1KE3 WSSSAPNLVKGPRSSPALPGFTSLMEM--------------EDEDSEGPGSGESRLQHSP
::::::::::::::::::::::::::: :::::::::::::::::::
XP_011 WSSSAPNLVKGPRSSPALPGFTSLMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHSP
400 410 420 430 440 450
680 690 700 710 720 730
pF1KE3 SQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALL
460 470 480 490 500 510
740 750 760 770 780 790
pF1KE3 GCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRK
520 530 540 550 560 570
800 810 820 830 840 850
pF1KE3 LFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSP
580 590 600 610 620 630
860 870 880 890 900 910
pF1KE3 CTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSS
640 650 660 670 680 690
920 930 940 950 960 970
pF1KE3 NGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPR
700 710 720 730 740 750
980 990 1000 1010 1020 1030
pF1KE3 PRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLP
760 770 780 790 800 810
1040 1050 1060 1070 1080
pF1KE3 FQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
820 830 840 850 860
>>NP_001271161 (OMIM: 600136) mitogen-activated protein (837 aa)
initn: 5249 init1: 2940 opt: 2946 Z-score: 1103.4 bits: 215.5 E(85289): 1e-54
Smith-Waterman score: 5133; 92.6% identity (92.6% similar) in 837 aa overlap (307-1081:1-837)
280 290 300 310 320 330
pF1KE3 LQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYG
::::::::::::::::::::::::::::::
NP_001 MSAAGTYAWMAPEVIRASMFSKGSDVWSYG
10 20 30
340 350 360 370 380 390
pF1KE3 VLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSF
40 50 60 70 80 90
400 410 420 430 440 450
pF1KE3 TNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAAL
100 110 120 130 140 150
460 470 480 490 500 510
pF1KE3 QQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGN
160 170 180 190 200 210
520 530 540 550 560
pF1KE3 RISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQ-------------
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQCETVSQISWGQNT
220 230 240 250 260 270
570 580
pF1KE3 -----------------------------------LTPGESSKTWGRSSVVPKEEGEEEE
:::::::::::::::::::::::::
NP_001 QGHLSPALSSHRLVQACSIHNFCHLSSTMCIYMHILTPGESSKTWGRSSVVPKEEGEEEE
280 290 300 310 320 330
590 600 610 620 630 640
pF1KE3 KRAPKKKGRTWGPGTLGQKELASGDEGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRAPKKKGRTWGPGTLGQKELASGDEGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTS
340 350 360 370 380 390
650 660 670 680 690
pF1KE3 LMEM--------------EDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGI
:::: ::::::::::::::::::::::::::::::::::::::::::
NP_001 LMEMALLAASWVVPIDIEEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGI
400 410 420 430 440 450
700 710 720 730 740 750
pF1KE3 HEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQL
460 470 480 490 500 510
760 770 780 790 800 810
pF1KE3 LPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSL
520 530 540 550 560 570
820 830 840 850 860 870
pF1KE3 SSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLT
580 590 600 610 620 630
880 890 900 910 920 930
pF1KE3 PTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGE
640 650 660 670 680 690
940 950 960 970 980 990
pF1KE3 FPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARS
700 710 720 730 740 750
1000 1010 1020 1030 1040 1050
pF1KE3 TSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQ
760 770 780 790 800 810
1060 1070 1080
pF1KE3 DSTVPLCRAELNTHRPAPYEIQQEFWS
:::::::::::::::::::::::::::
NP_001 DSTVPLCRAELNTHRPAPYEIQQEFWS
820 830
>>NP_001271160 (OMIM: 600136) mitogen-activated protein (880 aa)
initn: 5459 init1: 2940 opt: 2946 Z-score: 1103.1 bits: 215.6 E(85289): 1.1e-54
Smith-Waterman score: 5344; 92.3% identity (92.7% similar) in 875 aa overlap (269-1081:6-880)
240 250 260 270 280 290
pF1KE3 PDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLA
:. . .::::::::::::::::::::::::
NP_001 MELTGLEVALVLILQKVENGDLSNKILKITDFGLA
10 20 30
300 310 320 330 340 350
pF1KE3 REWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVA
40 50 60 70 80 90
360 370 380 390 400 410
pF1KE3 YGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDS
100 110 120 130 140 150
420 430 440 450 460 470
pF1KE3 FHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREID
160 170 180 190 200 210
480 490 500 510 520 530
pF1KE3 ILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDK
220 230 240 250 260 270
540 550 560
pF1KE3 RKSLINSRSSPPASPTIIPRLRAIQ-----------------------------------
:::::::::::::::::::::::::
NP_001 RKSLINSRSSPPASPTIIPRLRAIQCETVSQISWGQNTQGHLSPALSSHRLVQACSIHNF
280 290 300 310 320 330
570 580 590 600 610
pF1KE3 -------------LTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELA
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHLSSTMCIYMHILTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELA
340 350 360 370 380 390
620 630 640 650
pF1KE3 SGDEGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEM--------------EDED
:::::::::::::::::::::::::::::::::::::::::: ::::
NP_001 SGDEGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMALLAASWVVPIDIEEDED
400 410 420 430 440 450
660 670 680 690 700 710
pF1KE3 SEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSL
460 470 480 490 500 510
720 730 740 750 760 770
pF1KE3 KRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQ
520 530 540 550 560 570
780 790 800 810 820 830
pF1KE3 RSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVV
580 590 600 610 620 630
840 850 860 870 880 890
pF1KE3 YEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDG
640 650 660 670 680 690
900 910 920 930 940 950
pF1KE3 ALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQ
700 710 720 730 740 750
960 970 980 990 1000 1010
pF1KE3 DSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASS
760 770 780 790 800 810
1020 1030 1040 1050 1060 1070
pF1KE3 SSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQ
820 830 840 850 860 870
1080
pF1KE3 QEFWS
:::::
NP_001 QEFWS
880
>>NP_002437 (OMIM: 600137) mitogen-activated protein kin (954 aa)
initn: 3055 init1: 1976 opt: 2444 Z-score: 919.5 bits: 181.7 E(85289): 1.8e-44
Smith-Waterman score: 3441; 56.6% identity (74.2% similar) in 1052 aa overlap (35-1063:2-950)
10 20 30 40 50 60
pF1KE3 RALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYE
::::.:.: : : : :::::.::
NP_002 MEEEEGAVA---KEWGTTPAGPVWTAVFDYE
10 20
70 80 90 100 110 120
pF1KE3 AAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQL-NQRVGIFPSNYVTPRSAFSSRCQP
:::..::::: :: :.:::.: :::::::::::: . :::.::::::.: .. :
NP_002 AAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAP----GAPAAP
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE3 GGEDPSCYPPIQL-LEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDIS
.: .:: :: : :: ::::::.:::::::::.: :.:::::::: ::..: .
NP_002 AG--------LQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPA
90 100 110 120 130
190 200 210 220 230 240
pF1KE3 QTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDIL
: :.: :::.::. :.:::::::::.::. :.::::::.:::: :.:::.:.:.:: .:
NP_002 VTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE3 VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH
::::::.::::::::..: :::::::::: :::::. .:: .:.. .:::::::::::::
NP_002 VNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWH
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE3 RTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVA
.::::::::::::::::::: :.:::.:::::.:::::::::::::.: ::.::::::::
NP_002 KTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVA
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE3 MNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCL
::::.::::::::::::.:.:.::.::::.::.: .:: .: .::.:..:.:: .::: :
NP_002 MNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSL
320 330 340 350 360 370
430 440 450 460 470 480
pF1KE3 QDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILER
:..:: :::.:::.::.::::::. :::: ::: .:. ::: ::::::::::::.::.::
NP_002 QEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVER
380 390 400 410 420 430
490 500 510 520 530 540
pF1KE3 ELNIIIHQLCQEKPRVKKRKGKFRKSRL-KLKDG-NRISLPSDFQHKFTVQASPTMDKRK
::.... :: ::::::.::::.:..::: ::..: ..::::: :.::.:::::::.::::
NP_002 ELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRK
440 450 460 470 480 490
550 560 570 580
pF1KE3 SLINSRSSPPASPTIIPRLRAIQLTP---GESSK--------TWGRSSVVPKEEGEEEEK
. .. .::::::.::::::::.::: : ::. ::.:.. ::.: :
NP_002 G--SDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGP-PKKE----EL
500 510 520 530 540
590 600 610 620 630 640
pF1KE3 RAPKKKGRTWGPGTLGQKELASGDEGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSL
. :::::::::.. ::: ..:.: ::.: .: :::::::::: :.:. .: :::.::
NP_002 VGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASL
550 560 570 580 590 600
650 660 670 680 690 700
pF1KE3 MEMEDEDSEGPGSGESRLQHSP--SQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATST
::: : .:. .: : . :: . ::: .:.: .: . : . :::: :.
NP_002 NEME-EFAEAEDGG-SSVPPSPYSTPSYLSVPLP-AEPSPGARAPW---EPTP-----SA
610 620 630 640 650
710 720 730 740 750 760
pF1KE3 PQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREE
: :. . : . .:::..:::::...:.:.::: :. :: . ..:.
NP_002 P---PA---RWGHGARRRCDLALLGCATLLGAVGLGADVAEARAAD----------GEEQ
660 670 680 690 700
770 780 790 800 810 820
pF1KE3 KKRREGLF-QRSSRPRRSTSPPSRKLFKKEE--PMLLLGDPSASLTLLSLSSISECNSTR
.. .::: :..: :. :::.: ..:. : : :. ::: ::.::::.:.:::::
NP_002 RRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLA-PSA--TLVSLSSVSDCNSTR
710 720 730 740 750
830 840 850 860 870 880
pF1KE3 SLLRSDSDEIVVYEM---PVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLT
::::::::: . : :. .: :: : ::::....: ::.:: ::::::::: .
NP_002 SLLRSDSDEAAPAAPSPPPSPPAPTPTPSPST-NPLVDLELESFKKDPRQSLTPTHVTAA
760 770 780 790 800 810
890 900 910 920 930 940
pF1KE3 TPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDP
. .:::::::::: ..:.: : : :: . :.: :: .:::::::
NP_002 C-AVSRGHRRTPSDGAL------GQRGP------PEP-AG--HGPGP-RDLLDFPRLPDP
820 830 840 850 860
950 960 970 980 990 1000
pF1KE3 NVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSS
...:: :: . . :: :: : :::::.:.: ::::: .:: ... . :: :
NP_002 QALFP--ARRRPPEFPG---RPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPP--S
870 880 890 900 910
1010 1020 1030 1040 1050 1060
pF1KE3 STETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLC
.:: : :: :.. : ::::.: :::.::::::::
NP_002 RPDTP---------------ESPGPPSVQP-----------TLLDMDMEGQNQDSTVPLC
920 930 940
1070 1080
pF1KE3 RAELNTHRPAPYEIQQEFWS
:
NP_002 GAHGSH
950
>>NP_115811 (OMIM: 614793) mitogen-activated protein kin (1036 aa)
initn: 2488 init1: 1893 opt: 2363 Z-score: 889.5 bits: 176.3 E(85289): 8.3e-43
Smith-Waterman score: 3192; 50.1% identity (70.9% similar) in 1124 aa overlap (6-1081:2-1036)
10 20 30 40 50
pF1KE3 MEPSRALLGCLASAAAAAP-PGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTA
:: : :..:. .: . :: .:. ..:..: : :.:
NP_115 MALRG--AAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAG---------LWAA
10 20 30 40
60 70 80 90 100 110
pF1KE3 VFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSS
...::: :::::.:: :..:::::.:. ::::::::.::...:.::::.:::.:
NP_115 LYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAP------
50 60 70 80 90
120 130 140 150 160 170
pF1KE3 RCQPGGEDPSCYP--PIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDP
:.:.. .:. : : . ... : .: :.:.:: ::::.:::: : :.::::::::.::
NP_115 -CRPAA-SPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDP
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE3 DEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSG---
..: . . :.::.::.:::::.::::: ::::::..:.::::.:::::: :::.:..
NP_115 EQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANA
160 170 180 190 200 210
240 250 260 270 280
pF1KE3 ------------KRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVEN
.:::: .:::::::::::: :::.::.:::.::::::::::.:.:.:.
NP_115 APDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEH
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE3 GDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWEL
:. :: :::::::::::::::::::.::::::::::::..:.::::::.::::::::::
NP_115 DDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWEL
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE3 LTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQ
::::::.:::::::::::::.:::.:::::::::::::::..::. ::: ::::. ::.:
NP_115 LTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQ
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE3 LTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQE
::.:: . . :::..::: .::.:: :::.:::.::.::::::. ::::::::::::.::
NP_115 LTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQE
400 410 420 430 440 450
470 480 490 500 510 520
pF1KE3 ELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPS
:::.::::.:::::::.:::::::.: :: ::::.::::::::..::::::::.::::::
NP_115 ELLKRREQQLAEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPS
460 470 480 490 500 510
530 540 550 560 570 580
pF1KE3 DFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKE
:::::.::::::..:::.:: .: ::::.:::..::::::::: ::.:::::..: .:
NP_115 DFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQE
520 530 540 550 560 570
590 600 610 620 630 640
pF1KE3 EGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGLKSLVDGYKQWSSSAPNLVKGPRSSPA
: :. :: :::: ::::... .:. .. : .. : :: . ::. :.:. .. :
NP_115 E-FEDVKRNFKKKGCTWGPNSIQMKDRTDCKERIRPLSDGNSPWSTI---LIKNQKTMPL
580 590 600 610 620 630
650 660 670 680 690
pF1KE3 LPGFTSLMEMEDEDSEGPGSGESRLQHS---PSQSYLCIPFPRGEDGDGPSSDGIHEEPT
:.. .: . .: . : : .. :::.:. .:. . . ..:. :: .
NP_115 ASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGKDAQRENPAEAESWEEAA
640 650 660 670 680 690
700 710 720 730 740 750
pF1KE3 PVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEE
.:.:: . ..::::::.:. .... : :: :: ..::...::.:: : : : ::
NP_115 SANAATVSIEMTPTNSLSRS-PQRKKTESALYGCTVLLASVALGLDLRELHKAQ--AAEE
700 710 720 730 740 750
760 770 780 790 800 810
pF1KE3 PEPPAREEKKRREGLFQRSSRPRRSTSPP----SRKLFKKEEPMLLLGDPSASLTLLSLS
: : .::::.:::.:::.:. :::.::: : . : : : :..: .::
NP_115 PLP--KEEKKKREGIFQRASKSRRSASPPTSLPSTCGEASSPPSLPL---SSALGILSTP
760 770 780 790 800
820 830 840 850 860
pF1KE3 SISECNSTRSLLRSDSDEIVVYEMPV---SPVEAP---PLSPCT-HNPLVNVRVER---F
:.: :. ::. ::.. .: :: : . .: : .: . ..: . :..
NP_115 SFS----TKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMPRLDTDCSV
810 820 830 840 850 860
870 880 890 900 910 920
pF1KE3 KRD-PNQSLTPT--HVTLTTPSQ--PSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGA
.:. :.. : : .: . :. :: :::: ::: .: .:.. . . ::
NP_115 SRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDG--NP-------TPTGATIISATGA
870 880 890 900 910
930 940 950 960 970
pF1KE3 GMLKT-PSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQ
. : :::. : .. ::. . .. ::.. ..:. ::.. :.
NP_115 SALPLCPSPA---------PHSHL-----PREVSPKKHSTVH------IVPQRRPASLRS
920 930 940 950
980 990 1000 1010 1020 1030
pF1KE3 RLD-PWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLP
: : : . :.. : .:... .: ::: : . :
NP_115 RSDLPQAY-------------------PQTAVSQLAQTACVVG-RPG-----PHPTQFLA
960 970 980
1040 1050 1060 1070 1080
pF1KE3 PTERT------LLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS
::: ::: :.::::.: :::::: . .: ::. ::...:: :
NP_115 AKERTKSHVPSLLDADVEGQSRDYTVPLCRMRSKTSRPSIYELEKEFLS
990 1000 1010 1020 1030
1081 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:51:38 2016 done: Mon Nov 7 20:51:40 2016
Total Scan time: 14.070 Total Display time: 0.360
Function used was FASTA [36.3.4 Apr, 2011]