FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5762, 751 aa 1>>>pF1KB5762 751 - 751 aa - 751 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7406+/-0.000385; mu= 18.2729+/- 0.024 mean_var=78.3204+/-15.248, 0's: 0 Z-trim(114.5): 25 B-trim: 33 in 1/54 Lambda= 0.144923 statistics sampled from 24412 (24436) to 24412 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.287), width: 16 Scan time: 9.270 The best scores are: opt bits E(85289) XP_016867436 (OMIM: 104610) PREDICTED: amiloride-s ( 751) 5253 1108.3 0 NP_001082 (OMIM: 104610) amiloride-sensitive amine ( 751) 5253 1108.3 0 XP_016867434 (OMIM: 104610) PREDICTED: amiloride-s ( 770) 4303 909.6 0 NP_001259001 (OMIM: 104610) amiloride-sensitive am ( 770) 4303 909.6 0 XP_016867433 (OMIM: 104610) PREDICTED: amiloride-s ( 770) 4303 909.6 0 XP_016867435 (OMIM: 104610) PREDICTED: amiloride-s ( 770) 4303 909.6 0 NP_033720 (OMIM: 602268) retina-specific copper am ( 756) 1357 293.7 1.9e-78 NP_003725 (OMIM: 603735) membrane primary amine ox ( 763) 1346 291.4 9.3e-78 NP_001264660 (OMIM: 603735) membrane primary amine ( 634) 905 199.1 4.6e-50 NP_001149 (OMIM: 602268) retina-specific copper am ( 729) 872 192.3 6.1e-48 XP_011523722 (OMIM: 603735) PREDICTED: membrane pr ( 665) 702 156.7 2.8e-37 XP_011523721 (OMIM: 603735) PREDICTED: membrane pr ( 794) 702 156.8 3.3e-37 NP_001264661 (OMIM: 603735) membrane primary amine ( 220) 639 143.3 1e-33 >>XP_016867436 (OMIM: 104610) PREDICTED: amiloride-sensi (751 aa) initn: 5253 init1: 5253 opt: 5253 Z-score: 5931.8 bits: 1108.3 E(85289): 0 Smith-Waterman score: 5253; 99.7% identity (99.9% similar) in 751 aa overlap (1-751:1-751) 10 20 30 40 50 60 pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_016 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: XP_016 ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD 670 680 690 700 710 720 730 740 750 pF1KB5 NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV ::::::::::::::::::::::::::::::: XP_016 NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV 730 740 750 >>NP_001082 (OMIM: 104610) amiloride-sensitive amine oxi (751 aa) initn: 5253 init1: 5253 opt: 5253 Z-score: 5931.8 bits: 1108.3 E(85289): 0 Smith-Waterman score: 5253; 99.7% identity (99.9% similar) in 751 aa overlap (1-751:1-751) 10 20 30 40 50 60 pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: NP_001 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWDPPVVFEQFLHNNENI :::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::: NP_001 ADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENI 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRD 670 680 690 700 710 720 730 740 750 pF1KB5 NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV ::::::::::::::::::::::::::::::: NP_001 NGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV 730 740 750 >>XP_016867434 (OMIM: 104610) PREDICTED: amiloride-sensi (770 aa) initn: 4303 init1: 4303 opt: 4303 Z-score: 4858.2 bits: 909.6 E(85289): 0 Smith-Waterman score: 5205; 97.3% identity (97.4% similar) in 770 aa overlap (1-751:1-770) 10 20 30 40 50 60 pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_016 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM 550 560 570 580 590 600 610 620 630 640 pF1KB5 ADQVLPPGWQEEQAITWAR-------------------YPLAVTKYRESELCSSSIYHQN ::::::::::::::::::: :::::::::::::::::::::: XP_016 ADQVLPPGWQEEQAITWARTEGGQPRALSQAASPVPGRYPLAVTKYRESELCSSSIYHQN 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB5 DPWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF 670 680 690 700 710 720 710 720 730 740 750 pF1KB5 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV 730 740 750 760 770 >>NP_001259001 (OMIM: 104610) amiloride-sensitive amine (770 aa) initn: 4303 init1: 4303 opt: 4303 Z-score: 4858.2 bits: 909.6 E(85289): 0 Smith-Waterman score: 5205; 97.3% identity (97.4% similar) in 770 aa overlap (1-751:1-770) 10 20 30 40 50 60 pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: NP_001 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM 550 560 570 580 590 600 610 620 630 640 pF1KB5 ADQVLPPGWQEEQAITWAR-------------------YPLAVTKYRESELCSSSIYHQN ::::::::::::::::::: :::::::::::::::::::::: NP_001 ADQVLPPGWQEEQAITWARTEGGQPRALSQAASPVPGRYPLAVTKYRESELCSSSIYHQN 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB5 DPWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF 670 680 690 700 710 720 710 720 730 740 750 pF1KB5 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV 730 740 750 760 770 >>XP_016867433 (OMIM: 104610) PREDICTED: amiloride-sensi (770 aa) initn: 4303 init1: 4303 opt: 4303 Z-score: 4858.2 bits: 909.6 E(85289): 0 Smith-Waterman score: 5205; 97.3% identity (97.4% similar) in 770 aa overlap (1-751:1-770) 10 20 30 40 50 60 pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_016 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM 550 560 570 580 590 600 610 620 630 640 pF1KB5 ADQVLPPGWQEEQAITWAR-------------------YPLAVTKYRESELCSSSIYHQN ::::::::::::::::::: :::::::::::::::::::::: XP_016 ADQVLPPGWQEEQAITWARTEGGQPRALSQAASPVPGRYPLAVTKYRESELCSSSIYHQN 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB5 DPWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF 670 680 690 700 710 720 710 720 730 740 750 pF1KB5 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV 730 740 750 760 770 >>XP_016867435 (OMIM: 104610) PREDICTED: amiloride-sensi (770 aa) initn: 4303 init1: 4303 opt: 4303 Z-score: 4858.2 bits: 909.6 E(85289): 0 Smith-Waterman score: 5205; 97.3% identity (97.4% similar) in 770 aa overlap (1-751:1-770) 10 20 30 40 50 60 pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENIT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRSYRLQIHSM :::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::: XP_016 NPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSM 550 560 570 580 590 600 610 620 630 640 pF1KB5 ADQVLPPGWQEEQAITWAR-------------------YPLAVTKYRESELCSSSIYHQN ::::::::::::::::::: :::::::::::::::::::::: XP_016 ADQVLPPGWQEEQAITWARTEGGQPRALSQAASPVPGRYPLAVTKYRESELCSSSIYHQN 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB5 DPWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNF 670 680 690 700 710 720 710 720 730 740 750 pF1KB5 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV 730 740 750 760 770 >>NP_033720 (OMIM: 602268) retina-specific copper amine (756 aa) initn: 1870 init1: 480 opt: 1357 Z-score: 1529.5 bits: 293.7 E(85289): 1.9e-78 Smith-Waterman score: 1915; 42.8% identity (68.9% similar) in 739 aa overlap (19-746:44-755) 10 20 30 40 pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFL :.: : : .. .:.::: .:: :: :: NP_033 LITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPH--PGQSQLFADLSREELTAVMRFL 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH .. : .. . . : .: .:. :: : .: ::.: :.::: :...:: : . NP_033 TQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREALAIVLFGGQPQ 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL :::.:..::::: : ::: .. : : . ::. ::.. ... :.:. : .:: NP_033 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLKEVELPKAPIFL 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGY--FLHPTGLELLVDHGS ..: :.. . :: . ..:::. ::.: .:. . . . : ::::.:::::.:: . NP_033 SST-FNY---NGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLELLLDHRA 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH : .::.:.::.: :..:.. .: :.. .:...:: . ::: .: .: : : . NP_033 LDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRV--PLPPPNGASS-----LRSRN 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER .: : .: :.. : :.: .. ..:: :. . :::.: :::....:.: ::: NP_033 SP-GPLP-PLQFS------PQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGER 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD ::::::::: :..::. .: : :.::: ..::: .. :. :.::: ::..: .: NP_033 IAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVD-IHILV 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB5 ADDPVHY-PRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYI . :. : :.:.:: :.::::: : ... .::.:: ...::.:..:.: ::::: NP_033 GKGAVQLLPGAVCVFEEAQGLPLRRHHNY-LQN--HFYGGLASSALVVRSVSSVGNYDYI 420 430 440 450 460 470 480 490 500 510 520 pF1KB5 WDFIFYPNGVMEAKMHATGYVHATFYT--PEGLRHGTRLHTHLIGNIHTHLVHYRVDLDV :::..::::..:...:::::....: ::: :.:. ...:..::: :...:::: NP_033 WDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDV 470 480 490 500 510 520 530 540 550 560 570 580 pF1KB5 AGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSP :: :: . .. .. .. ::.:.: . .: : . . : .:: . ::.:: ..: NP_033 AGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASN 530 540 550 560 570 580 590 600 610 620 630 640 pF1KB5 QENPWGHKRSYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQND : : :::.:.::.:::: .: . :.:..:.:: :.::. .: : ::::::::: NP_033 QTNAWGHQRGYRIQIHSPLGIHIPLESDMERALSWGRYQLVVTQRKEEESQSSSIYHQND 590 600 610 620 630 640 650 660 670 680 690 700 pF1KB5 PWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFF : : :.: .:. :::.. .::::::::..::::::.::::::.: :: :::::::.::: NP_033 IWTPTVTFADFI-NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFF 650 660 670 680 690 700 710 720 730 740 750 pF1KB5 PEDPSLASRDTVIVWP-RDNGPNYVQRW--IPEDRDCSMP--PPFSYNGTYRPV ::::. : .: .: : .. .:. : .: :::::.: NP_033 DEDPSIFSPGSVYFEKGQDAGLCSINPVACLPDLAAC-VPDLPPFSYHGF 710 720 730 740 750 >>NP_003725 (OMIM: 603735) membrane primary amine oxidas (763 aa) initn: 1438 init1: 633 opt: 1346 Z-score: 1517.0 bits: 291.4 E(85289): 9.3e-78 Smith-Waterman score: 1852; 40.1% identity (66.2% similar) in 736 aa overlap (21-746:46-759) 10 20 30 40 pF1KB5 MPALGWAVAAILMLQTAMAEPS--PGTLPRKAGVFSDLSNQELKAVHSFL :: : : : .. .:.::: .:: :: :: NP_003 TIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFL 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH .. : .. . . : :: .:. :: : .: ::.: :.::: :..::: : . NP_003 TQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQ 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL :::.:..::::: : ::: .. : : . ::. :: . . . . : . .: NP_003 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLL 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEG--YFLHPTGLELLVDHGS . : . : :. .::::. ::.: .:. . . : .::: .::::::.: . NP_003 HHC--CFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKA 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB5 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH : ..:....:.:.:..: : .: .. : :.::.. : ::. .. :: NP_003 LDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPP----- 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER : :.: : :.:::: ..:. : . :.:.: : . :: ....:.: ::: NP_003 ---G--PAP-----PLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGER 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD ..::.:.:::.:.:::..::.: :.:.: :.:.:. : :. :.::: ::..: . NP_003 LVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLE 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB5 ADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIW .. : :.:.::. :.::::: .. .. ....:: :::.:. ::. ::::.: NP_003 SQAPKTIRDAFCVFEQNQGLPLRRHHSDLYS---HYFGGLAETVLVVRSMSTLLNYDYVW 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB5 DFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGT : .:.:.:..: ...::::. ..: ..:... : .:..::: .:..::::::: NP_003 DTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGL 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB5 KNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQEN .: . .: . .. ::::.:.. . . . :.:::: :.:: ..: . : NP_003 ENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSN 540 550 560 570 580 590 590 600 610 620 630 640 pF1KB5 PWGHKRSYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWD ::: :.::.:. :.: . :: . . ....: :: ::::. .: : :::...::::: NP_003 KWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWA 600 610 620 630 640 650 650 660 670 680 690 700 pF1KB5 PPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPED : : : .:. :::.: ..:::::::.:::::::.::::::.: ::.:::.:::.::: :: NP_003 PTVDFSDFI-NNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDED 660 670 680 690 700 710 710 720 730 740 750 pF1KB5 PSLASRDTVIVW-PRDNGPNYVQRW--IPEDRDCSMP--PPFSYNGTYRPV ::. : :.. .: : :. .:. :. : : ::..: NP_003 PSFYSADSIYFRGDQDAGACEVNPLACLPQAAACA-PDLPAFSHGGFSHN 720 730 740 750 760 >>NP_001264660 (OMIM: 603735) membrane primary amine oxi (634 aa) initn: 1395 init1: 476 opt: 905 Z-score: 1019.9 bits: 199.1 E(85289): 4.6e-50 Smith-Waterman score: 1411; 37.1% identity (64.6% similar) in 604 aa overlap (21-619:46-629) 10 20 30 40 pF1KB5 MPALGWAVAAILMLQTAMAEPS--PGTLPRKAGVFSDLSNQELKAVHSFL :: : : : .. .:.::: .:: :: :: NP_001 TIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFL 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH .. : .. . . : :: .:. :: : .: ::.: :.::: :..::: : . NP_001 TQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQ 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL :::.:..::::: : ::: .. : : . ::. :: . . . . : . .: NP_001 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLL 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEG--YFLHPTGLELLVDHGS . : . : :. .::::. ::.: .:. . . : .::: .::::::.: . NP_001 HHC--CFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKA 200 210 220 230 240 250 230 240 250 260 270 280 pF1KB5 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH : ..:....:.:.:..: : .: .. : :.::.. : ::. .. :: NP_001 LDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPP----- 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER : :.: : :.:::: ..:. : . :.:.: : . :: ....:.: ::: NP_001 ---G--PAP-----PLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGER 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD ..::.:.:::.:.:::..::.: :.:.: :.:.:. : :. :.::: ::..: . NP_001 LVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLE 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB5 ADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIW .. : :.:.::. :.::::: .. .. ....:: :::.:. ::. ::::.: NP_001 SQAPKTIRDAFCVFEQNQGLPLRRHHSDLYS---HYFGGLAETVLVVRSMSTLLNYDYVW 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB5 DFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGT : .:.:.:..: ...::::. ..: ..:... : .:..::: .:..::::::: NP_001 DTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGL 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB5 KNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQEN .: . .: . .. ::::.:.. . . . :.:::: :.:: ..: . : NP_001 ENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSN 540 550 560 570 580 590 590 600 610 620 630 640 pF1KB5 PWGHKRSYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWD ::: :.::.:. :.: . :: . . ....: : NP_001 KWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERIWWPG 600 610 620 630 650 660 670 680 690 700 pF1KB5 PPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPED >>NP_001149 (OMIM: 602268) retina-specific copper amine (729 aa) initn: 1766 init1: 354 opt: 872 Z-score: 981.7 bits: 192.3 E(85289): 6.1e-48 Smith-Waterman score: 1785; 41.3% identity (66.6% similar) in 739 aa overlap (19-746:44-728) 10 20 30 40 pF1KB5 MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFL :.: : : .. .:.::: .:: :: :: NP_001 LITIFALAYVLLTSPGGSSQPPHCPSVSHRAQPWPH--PGQSQLFADLSREELTAVMRFL 20 30 40 50 60 70 50 60 70 80 90 100 pF1KB5 WSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEH .. : .. . . : .: .:. :: : .: ::.: :.::: :...:: : . NP_001 TQRLGPGLVDAAQAQPSDNCIFSVELQLPPKAAALAHLDRGSPPPAREALAIVLFGGQPQ 80 90 100 110 120 130 110 120 130 140 150 160 pF1KB5 PNVTEFAVGPLPGPCYMRALS-PRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFL :::.:..::::: : ::: .. : : . ::. ::.. ... :.:. : .:: NP_001 PNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLRAEFTQMWRHLKEVELPKAPIFL 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB5 NTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGY--FLHPTGLELLVDHGS ..: :.. . :: . ..:::. ::.: .:. . . . : ::::.:::::.:: . NP_001 SST-FNY---NGSTLAAVHATPRGLRSGDRATWMALYHNISGVGLFLHPVGLELLLDHRA 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 TDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSH : .::.:.::.: :..:.. .: :.. .:...:: . ::: .: .: : : . NP_001 LDPAHWTVQQVFYLGHYYADLGQLEREFKSGRLEVVRV--PLPPPNGASS-----LRSRN 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 KPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGER .: : .: :.. : :.: .. ..:: :. . :::.: :::....:.: ::: NP_001 SP-GPLP-PLQFS------PQGSQYSVQGNLVVSSLWSFTFGHGVFSGLRIFDVRFQGER 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 IAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYD ::::::::: :..::. .: : :.::: ..::: .. :. :.::: ::..: .: NP_001 IAYEVSVQECVSIYGADSPKTMLTRYLDSSFGLGRNSRGLVRGVDCPYQATMVD-IHILV 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB5 ADDPVHY-PRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYI . :. : :.:.:: :.::::: : ... .::.:: ...::.:..:.: ::::: NP_001 GKGAVQLLPGAVCVFEEAQGLPLRRHHNY-LQN--HFYGGLASSALVVRSVSSVGNYDYI 420 430 440 450 460 470 480 490 500 510 520 pF1KB5 WDFIFYPNGVMEAKMHATGYVHATFYT--PEGLRHGTRLHTHLIGNIHTHLVHYRVDLDV :::..::::..:...:::::....: ::: :.:. ...:..::: :...:::: NP_001 WDFVLYPNGALEGRVHATGYINTAFLKGGEEGLLFGNRVGERVLGTVHTHAFHFKLDLDV 470 480 490 500 510 520 530 540 550 560 570 580 pF1KB5 AGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSP :: :: . .. .. .. ::.:.: . .: : . . : .:: . ::.:: ..: NP_001 AGLKNWVVAEDVVFKPVAAPWNPEHWLQRPQLTRQVLGKEDLTAFSLGSPLPRYLYLASN 530 540 550 560 570 580 590 600 610 620 630 640 pF1KB5 QENPWGHKRSYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQND : : :::.:.:.: .::. .: : ::::::::: NP_001 QTNAWGHQRGYQL---------------------------VVTQRKEEESQSSSIYHQND 590 600 610 620 650 660 670 680 690 700 pF1KB5 PWDPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFF : : :.: .:. :::.. .::::::::..::::::.::::::.: :: :::::::.::: NP_001 IWTPTVTFADFI-NNETLLGEDLVAWVTASFLHIPHAEDIPNTVTLGNRVGFLLRPYNFF 630 640 650 660 670 680 710 720 730 740 750 pF1KB5 PEDPSLASRDTVIVWP-RDNGPNYVQRW--IPEDRDCSMP--PPFSYNGTYRPV ::::. : .: .: : .. .:. : .: :::::.: NP_001 DEDPSIFSPGSVYFEKGQDAGLCSINPVACLPDLAAC-VPDLPPFSYHGF 690 700 710 720 751 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:17:36 2016 done: Tue Nov 8 06:17:37 2016 Total Scan time: 9.270 Total Display time: 0.190 Function used was FASTA [36.3.4 Apr, 2011]