Result of FASTA (omim) for
pFN21AE6757
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6757, 533 aa
1>>>pF1KE6757 533 - 533 aa - 533 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.1549+/-0.000571; mu= -3.9634+/- 0.035
mean_var=385.3305+/-79.917, 0's: 0 Z-trim(116.8): 76 B-trim: 675 in 1/54
Lambda= 0.065337
statistics sampled from 28200 (28275) to 28200 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.332), width: 16
Scan time: 8.910
The best scores are: opt bits E(85289)
NP_001284693 (OMIM: 276900,276904,602092,605242) h ( 533) 3516 346.3 1.3e-94
XP_016872562 (OMIM: 276900,276904,602092,605242) P ( 695) 2695 269.1 3.2e-71
XP_011518136 (OMIM: 276900,276904,602092,605242) P ( 470) 1881 192.1 3.1e-48
NP_005700 (OMIM: 276900,276904,602092,605242) harm ( 552) 1881 192.2 3.4e-48
XP_016872563 (OMIM: 276900,276904,602092,605242) P ( 553) 1881 192.2 3.4e-48
XP_011518134 (OMIM: 276900,276904,602092,605242) P ( 603) 1881 192.3 3.6e-48
XP_016872561 (OMIM: 276900,276904,602092,605242) P ( 714) 1881 192.4 4.1e-48
NP_710142 (OMIM: 276900,276904,602092,605242) harm ( 899) 1881 192.5 4.7e-48
XP_016872564 (OMIM: 276900,276904,602092,605242) P ( 956) 1881 192.5 4.9e-48
NP_079171 (OMIM: 276901,605472,612971) PDZ domain- ( 517) 343 47.2 0.00014
XP_016872157 (OMIM: 276901,605472,612971) PREDICTE ( 528) 343 47.2 0.00015
XP_011538485 (OMIM: 276901,605472,612971) PREDICTE ( 533) 343 47.2 0.00015
XP_011538484 (OMIM: 276901,605472,612971) PREDICTE ( 539) 343 47.2 0.00015
XP_011538483 (OMIM: 276901,605472,612971) PREDICTE ( 544) 343 47.2 0.00015
XP_005270222 (OMIM: 276901,605472,612971) PREDICTE ( 561) 343 47.3 0.00015
XP_016872156 (OMIM: 276901,605472,612971) PREDICTE ( 573) 343 47.3 0.00015
XP_011538481 (OMIM: 276901,605472,612971) PREDICTE ( 677) 343 47.4 0.00017
XP_011538480 (OMIM: 276901,605472,612971) PREDICTE (1032) 343 47.6 0.00023
NP_001182192 (OMIM: 276901,605472,612971) PDZ doma (1033) 343 47.6 0.00023
XP_011538479 (OMIM: 276901,605472,612971) PREDICTE (1033) 343 47.6 0.00023
>>NP_001284693 (OMIM: 276900,276904,602092,605242) harmo (533 aa)
initn: 3516 init1: 3516 opt: 3516 Z-score: 1819.3 bits: 346.3 E(85289): 1.3e-94
Smith-Waterman score: 3516; 99.8% identity (100.0% similar) in 533 aa overlap (1-533:1-533)
10 20 30 40 50 60
pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 QKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 SKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 YSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKG
430 440 450 460 470 480
490 500 510 520 530
pF1KE6 DEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF
:::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_001 DEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF
490 500 510 520 530
>>XP_016872562 (OMIM: 276900,276904,602092,605242) PREDI (695 aa)
initn: 2693 init1: 2693 opt: 2695 Z-score: 1399.7 bits: 269.1 E(85289): 3.2e-71
Smith-Waterman score: 2695; 98.1% identity (98.6% similar) in 420 aa overlap (1-417:1-420)
10 20 30 40 50 60
pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 QKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWG
310 320 330 340 350 360
370 380 390 400 410
pF1KE6 SKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQ---DFRKYEEG
::::::::::::::::::::::::::::::::::::::::::::::::: : .: . :
XP_016 SKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQKGKDKKKAKYG
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE6 FDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGI
XP_016 SLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETEREDLEESEKIQYWVE
430 440 450 460 470 480
>>XP_011518136 (OMIM: 276900,276904,602092,605242) PREDI (470 aa)
initn: 1834 init1: 1834 opt: 1881 Z-score: 987.0 bits: 192.1 E(85289): 3.1e-48
Smith-Waterman score: 2645; 95.6% identity (95.6% similar) in 428 aa overlap (1-409:1-428)
10 20 30 40 50 60
pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
190 200 210 220 230 240
250 260 270 280
pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE-------------------GRELFMTD
::::::::::::::::::::::::::::::::: ::::::::
XP_011 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE6 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE6 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE6 GTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV
::::::::
XP_011 GTEEQGEQLLDGFIVTMANSQPSGRAVRDSLSPSSWNAKSPGNASGYPWP
430 440 450 460 470
>>NP_005700 (OMIM: 276900,276904,602092,605242) harmonin (552 aa)
initn: 1834 init1: 1834 opt: 1881 Z-score: 986.2 bits: 192.2 E(85289): 3.4e-48
Smith-Waterman score: 3468; 96.4% identity (96.6% similar) in 552 aa overlap (1-533:1-552)
10 20 30 40 50 60
pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
190 200 210 220 230 240
250 260 270 280
pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE-------------------GRELFMTD
::::::::::::::::::::::::::::::::: ::::::::
NP_005 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE6 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE6 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE6 GTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE6 VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVC
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_005 VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVC
490 500 510 520 530 540
530
pF1KE6 PPKEYDDELTFF
::::::::::::
NP_005 PPKEYDDELTFF
550
>>XP_016872563 (OMIM: 276900,276904,602092,605242) PREDI (553 aa)
initn: 1834 init1: 1834 opt: 1881 Z-score: 986.2 bits: 192.2 E(85289): 3.4e-48
Smith-Waterman score: 2647; 93.8% identity (94.3% similar) in 439 aa overlap (1-417:1-439)
10 20 30 40 50 60
pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
190 200 210 220 230 240
250 260 270 280
pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE-------------------GRELFMTD
::::::::::::::::::::::::::::::::: ::::::::
XP_016 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE6 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE6 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
370 380 390 400 410 420
410 420 430 440 450
pF1KE6 GTEEQGEQ---DFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIG
:::::::: : .: . :
XP_016 GTEEQGEQKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEV
430 440 450 460 470 480
>>XP_011518134 (OMIM: 276900,276904,602092,605242) PREDI (603 aa)
initn: 2647 init1: 1834 opt: 1881 Z-score: 985.7 bits: 192.3 E(85289): 3.6e-48
Smith-Waterman score: 3093; 87.6% identity (87.6% similar) in 565 aa overlap (1-495:1-565)
10 20 30 40 50 60
pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
190 200 210 220 230 240
250 260 270 280
pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE-------------------GRELFMTD
::::::::::::::::::::::::::::::::: ::::::::
XP_011 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE6 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE6 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
370 380 390 400 410 420
410
pF1KE6 GTEEQGEQ---------------------------------------------------D
:::::::: :
XP_011 GTEEQGEQKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQED
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE6 FRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGA
490 500 510 520 530 540
480 490 500 510 520 530
pF1KE6 AERHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVCPPKEYDDEL
:::::::::::::::::::::::::
XP_011 AERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDEL
550 560 570 580 590 600
>>XP_016872561 (OMIM: 276900,276904,602092,605242) PREDI (714 aa)
initn: 1834 init1: 1834 opt: 1881 Z-score: 984.9 bits: 192.4 E(85289): 4.1e-48
Smith-Waterman score: 2647; 93.8% identity (94.3% similar) in 439 aa overlap (1-417:1-439)
10 20 30 40 50 60
pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
190 200 210 220 230 240
250 260 270 280
pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE-------------------GRELFMTD
::::::::::::::::::::::::::::::::: ::::::::
XP_016 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE6 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE6 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG
370 380 390 400 410 420
410 420 430 440 450
pF1KE6 GTEEQGEQ---DFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIG
:::::::: : .: . :
XP_016 GTEEQGEQKGKDKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEV
430 440 450 460 470 480
>>NP_710142 (OMIM: 276900,276904,602092,605242) harmonin (899 aa)
initn: 2629 init1: 1834 opt: 1881 Z-score: 983.7 bits: 192.5 E(85289): 4.7e-48
Smith-Waterman score: 2481; 84.6% identity (88.5% similar) in 469 aa overlap (1-441:1-467)
10 20 30 40 50 60
pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_710 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_710 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_710 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_710 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
190 200 210 220 230 240
250 260 270 280
pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE-------------------GRELFMTD
::::::::::::::::::::::::::::::::: ::::::::
NP_710 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE6 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_710 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
310 320 330 340 350 360
350 360 370 380 390
pF1KE6 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK-------YDQGVEPELE
::::::::::::::::::::::::::::::::::::::::::: :: : : ..
NP_710 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYD-GKFPTIR
370 380 390 400 410
400 410 420 430 440 450
pF1KE6 PADDLDGGTEEQGE-QDFRKYEEGFD-PYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGG
: . : ::.:: .. .. ... .. : . . :.:..
NP_710 KKGK-DKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETERE
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE6 VDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGD
NP_710 DLEESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPLAPPLRRFAGGLHL
480 490 500 510 520 530
>--
initn: 851 init1: 809 opt: 814 Z-score: 440.1 bits: 91.9 E(85289): 8.9e-18
Smith-Waterman score: 814; 85.8% identity (90.5% similar) in 148 aa overlap (385-530:702-849)
360 370 380 390 400 410
pF1KE6 WEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQG--EQDFR
: .:. :. : . : . : .::::
NP_710 TFCPSPQPPRGPGVSTISKPVMVHQEPNFIYRPAVKSEVLPQEMLKRMVVYQTAFRQDFR
680 690 700 710 720 730
420 430 440 450 460 470
pF1KE6 KYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_710 KYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAE
740 750 760 770 780 790
480 490 500 510 520 530
pF1KE6 RHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVCPPKEYDDELTF
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
NP_710 RHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELAS
800 810 820 830 840 850
pF1KE6 F
NP_710 LPSSVAESPQPVRKLLEDRAAVHRHGFLLQLEPTDLLLKSKRGNQIHR
860 870 880 890
>>XP_016872564 (OMIM: 276900,276904,602092,605242) PREDI (956 aa)
initn: 2629 init1: 1834 opt: 1881 Z-score: 983.4 bits: 192.5 E(85289): 4.9e-48
Smith-Waterman score: 2481; 84.6% identity (88.5% similar) in 469 aa overlap (1-441:1-467)
10 20 30 40 50 60
pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH
190 200 210 220 230 240
250 260 270 280
pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE-------------------GRELFMTD
::::::::::::::::::::::::::::::::: ::::::::
XP_016 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE6 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM
310 320 330 340 350 360
350 360 370 380 390
pF1KE6 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK-------YDQGVEPELE
::::::::::::::::::::::::::::::::::::::::::: :: : : ..
XP_016 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYD-GKFPTIR
370 380 390 400 410
400 410 420 430 440 450
pF1KE6 PADDLDGGTEEQGE-QDFRKYEEGFD-PYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGG
: . : ::.:: .. .. ... .. : . . :.:..
XP_016 KKGK-DKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETERE
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE6 VDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGD
XP_016 DLEESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPLAPPLRRFAGGLHL
480 490 500 510 520 530
>--
initn: 851 init1: 809 opt: 814 Z-score: 439.8 bits: 91.9 E(85289): 9.3e-18
Smith-Waterman score: 814; 85.8% identity (90.5% similar) in 148 aa overlap (385-530:702-849)
360 370 380 390 400 410
pF1KE6 WEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQG--EQDFR
: .:. :. : . : . : .::::
XP_016 TFCPSPQPPRGPGVSTISKPVMVHQEPNFIYRPAVKSEVLPQEMLKRMVVYQTAFRQDFR
680 690 700 710 720 730
420 430 440 450 460 470
pF1KE6 KYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAE
740 750 760 770 780 790
480 490 500 510 520 530
pF1KE6 RHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVCPPKEYDDELTF
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
XP_016 RHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELAS
800 810 820 830 840 850
pF1KE6 F
XP_016 LPSSVAESPQPVRKLLEDRAAVHRHGFLLQLEPTVNRQAGHRALCVPAACSGHLLPTLSA
860 870 880 890 900 910
>>NP_079171 (OMIM: 276901,605472,612971) PDZ domain-cont (517 aa)
initn: 382 init1: 218 opt: 343 Z-score: 203.0 bits: 47.2 E(85289): 0.00014
Smith-Waterman score: 343; 29.8% identity (62.6% similar) in 238 aa overlap (85-314:84-317)
60 70 80 90 100 110
pF1KE6 RLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEG-LGLSVRGGLEFGCGLF
.. ::... : : ::.::::: : : :.:
NP_079 PPRGIRASSPMGRVILINSPIEANSDESDIIHSVRVEK-SPAGRLGFSVRGGSEHGLGIF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 ISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVK
.:.. .:..:. .:: :::.:...:: :. : : ..... ... . . ::..: .:
NP_079 VSKVEEGSSAERAGLCVGDKITEVNGLSLESTTMGSAVKVLTSSSRLHMMVRRMGRVPGI
120 130 140 150 160 170
180 190 200 210 220
pF1KE6 SSPDEPLTWQYV--DQFVSESGGVRGSLGSPGNRENKEKKV--FISLVGSRGLGCSISSG
. : :: : ..: :. : : : . :. ... . . . :: .: .:
NP_079 KFSKEKTTWVDVVNRRLVVEKCG---STPSDTSSEDGVRRIVHLYTTSDDFCLGFNIRGG
180 190 200 210 220
230 240 250 260 270 280
pF1KE6 PIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEAR
::..:.: :.:. : :...:::.. .::: :....:... :.. . . . .
NP_079 KEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIK
230 240 250 260 270 280
290 300 310 320 330 340
pF1KE6 Q--RELQRQELLMQK-RLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVE
. : .:.. . : :: .::.
NP_079 ETGRYPAYKEMVSEYCWLDRLSNGVLQQLSPASESSSSVSSCASSAPYSSGSLPSDRMDI
290 300 310 320 330 340
533 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:05:19 2016 done: Tue Nov 8 16:05:20 2016
Total Scan time: 8.910 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]