FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6757, 533 aa 1>>>pF1KE6757 533 - 533 aa - 533 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6372+/-0.00125; mu= 4.5648+/- 0.074 mean_var=298.7557+/-58.726, 0's: 0 Z-trim(109.2): 53 B-trim: 166 in 1/51 Lambda= 0.074202 statistics sampled from 10675 (10704) to 10675 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.329), width: 16 Scan time: 2.290 The best scores are: opt bits E(32554) CCDS73265.1 USH1C gene_id:10083|Hs108|chr11 ( 533) 3516 390.7 2.3e-108 CCDS31438.1 USH1C gene_id:10083|Hs108|chr11 ( 552) 1881 215.6 1.2e-55 CCDS7825.1 USH1C gene_id:10083|Hs108|chr11 ( 899) 1881 215.9 1.6e-55 >>CCDS73265.1 USH1C gene_id:10083|Hs108|chr11 (533 aa) initn: 3516 init1: 3516 opt: 3516 Z-score: 2058.8 bits: 390.7 E(32554): 2.3e-108 Smith-Waterman score: 3516; 99.8% identity (100.0% similar) in 533 aa overlap (1-533:1-533) 10 20 30 40 50 60 pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 QKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 QKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 SKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 SKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 YSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS73 YSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKG 430 440 450 460 470 480 490 500 510 520 530 pF1KE6 DEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF :::::::::::::::::::.::::::::::::::::::::::::::::::::: CCDS73 DEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF 490 500 510 520 530 >>CCDS31438.1 USH1C gene_id:10083|Hs108|chr11 (552 aa) initn: 1834 init1: 1834 opt: 1881 Z-score: 1112.7 bits: 215.6 E(32554): 1.2e-55 Smith-Waterman score: 3468; 96.4% identity (96.6% similar) in 552 aa overlap (1-533:1-552) 10 20 30 40 50 60 pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 190 200 210 220 230 240 250 260 270 280 pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE-------------------GRELFMTD ::::::::::::::::::::::::::::::::: :::::::: CCDS31 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE6 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE6 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDG 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE6 GTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 GTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVV 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE6 VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVC ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: CCDS31 VSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVC 490 500 510 520 530 540 530 pF1KE6 PPKEYDDELTFF :::::::::::: CCDS31 PPKEYDDELTFF 550 >>CCDS7825.1 USH1C gene_id:10083|Hs108|chr11 (899 aa) initn: 2629 init1: 1834 opt: 1881 Z-score: 1110.3 bits: 215.9 E(32554): 1.6e-55 Smith-Waterman score: 2481; 84.6% identity (88.5% similar) in 469 aa overlap (1-441:1-467) 10 20 30 40 50 60 pF1KE6 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 AIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 GQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 TWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISH 190 200 210 220 230 240 250 260 270 280 pF1KE6 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKE-------------------GRELFMTD ::::::::::::::::::::::::::::::::: :::::::: CCDS78 VKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELFMTD 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE6 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 RERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEM 310 320 330 340 350 360 350 360 370 380 390 pF1KE6 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPK-------YDQGVEPELE ::::::::::::::::::::::::::::::::::::::::::: :: : : .. CCDS78 EQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKSFGWFYRYD-GKFPTIR 370 380 390 400 410 400 410 420 430 440 450 pF1KE6 PADDLDGGTEEQGE-QDFRKYEEGFD-PYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGG : . : ::.:: .. .. ... .. : . . :.:.. CCDS78 KKGK-DKKKAKYGSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRLAQEVSETERE 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE6 VDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGD CCDS78 DLEESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPLAPPLRRFAGGLHL 480 490 500 510 520 530 >-- initn: 851 init1: 809 opt: 814 Z-score: 493.0 bits: 101.7 E(32554): 3.9e-21 Smith-Waterman score: 814; 85.8% identity (90.5% similar) in 148 aa overlap (385-530:702-849) 360 370 380 390 400 410 pF1KE6 WEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQG--EQDFR : .:. :. : . : . : .:::: CCDS78 TFCPSPQPPRGPGVSTISKPVMVHQEPNFIYRPAVKSEVLPQEMLKRMVVYQTAFRQDFR 680 690 700 710 720 730 420 430 440 450 460 470 pF1KE6 KYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS78 KYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAE 740 750 760 770 780 790 480 490 500 510 520 530 pF1KE6 RHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVCPPKEYDDELTF :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::: CCDS78 RHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELAS 800 810 820 830 840 850 pF1KE6 F CCDS78 LPSSVAESPQPVRKLLEDRAAVHRHGFLLQLEPTDLLLKSKRGNQIHR 860 870 880 890 533 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:05:18 2016 done: Tue Nov 8 16:05:18 2016 Total Scan time: 2.290 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]