Result of FASTA (omim) for
pFN21AE6374
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6374, 439 aa
1>>>pF1KE6374 439 - 439 aa - 439 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5742+/-0.000388; mu= 16.8042+/- 0.024
mean_var=95.9673+/-18.846, 0's: 0 Z-trim(115.0): 211 B-trim: 148 in 1/52
Lambda= 0.130922
statistics sampled from 24880 (25119) to 24880 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.665), E-opt: 0.2 (0.295), width: 16
Scan time: 7.250
The best scores are: opt bits E(85289)
XP_016870801 (OMIM: 609198) PREDICTED: ADAMTS-like (1796) 2954 569.1 3.3e-161
XP_016870800 (OMIM: 609198) PREDICTED: ADAMTS-like (1811) 2954 569.1 3.3e-161
NP_443098 (OMIM: 609198) ADAMTS-like protein 1 iso ( 525) 2558 493.8 4.4e-139
NP_001035362 (OMIM: 609198) ADAMTS-like protein 1 (1762) 2558 494.3 1.1e-138
XP_016870803 (OMIM: 609198) PREDICTED: ADAMTS-like (1495) 2416 467.4 1.1e-130
XP_011516366 (OMIM: 609198) PREDICTED: ADAMTS-like (1813) 2416 467.5 1.3e-130
XP_016870799 (OMIM: 609198) PREDICTED: ADAMTS-like (1814) 2416 467.5 1.3e-130
XP_011516365 (OMIM: 609198) PREDICTED: ADAMTS-like (1828) 2416 467.5 1.3e-130
NP_001288039 (OMIM: 609199) ADAMTS-like protein 3 (1682) 1812 353.3 2.7e-96
NP_997400 (OMIM: 609199) ADAMTS-like protein 3 iso (1691) 1812 353.3 2.7e-96
XP_016870802 (OMIM: 609198) PREDICTED: ADAMTS-like (1612) 1470 288.7 7.3e-77
XP_011520127 (OMIM: 609199) PREDICTED: ADAMTS-like (1413) 1036 206.7 3.1e-52
XP_011520126 (OMIM: 609199) PREDICTED: ADAMTS-like (1697) 1036 206.8 3.6e-52
XP_011520125 (OMIM: 609199) PREDICTED: ADAMTS-like (1701) 1036 206.8 3.6e-52
XP_016877923 (OMIM: 609199) PREDICTED: ADAMTS-like (1709) 1036 206.8 3.6e-52
XP_011520124 (OMIM: 609199) PREDICTED: ADAMTS-like (1718) 1036 206.8 3.6e-52
XP_006722980 (OMIM: 277600,608990) PREDICTED: A di ( 784) 945 189.3 3.1e-47
XP_016882829 (OMIM: 277600,608990) PREDICTED: A di ( 624) 938 187.9 6.5e-47
XP_016882828 (OMIM: 277600,608990) PREDICTED: A di ( 626) 938 187.9 6.5e-47
XP_016882827 (OMIM: 277600,608990) PREDICTED: A di (1103) 938 188.1 9.8e-47
NP_112219 (OMIM: 277600,608990) A disintegrin and (1103) 938 188.1 9.8e-47
XP_016877924 (OMIM: 609199) PREDICTED: ADAMTS-like (1526) 785 159.3 6.2e-38
NP_620687 (OMIM: 607510) A disintegrin and metallo (1224) 757 154.0 2.1e-36
XP_011541424 (OMIM: 605008) PREDICTED: A disintegr ( 827) 661 135.7 4.5e-31
XP_016865396 (OMIM: 606184) PREDICTED: A disintegr (1112) 660 135.6 6.3e-31
XP_016865395 (OMIM: 606184) PREDICTED: A disintegr (1467) 660 135.7 7.7e-31
NP_112217 (OMIM: 606184) A disintegrin and metallo (1594) 660 135.7 8.2e-31
XP_016865394 (OMIM: 606184) PREDICTED: A disintegr (1631) 660 135.7 8.4e-31
XP_011541426 (OMIM: 605008) PREDICTED: A disintegr ( 673) 654 134.3 9.6e-31
XP_011541425 (OMIM: 605008) PREDICTED: A disintegr ( 738) 654 134.3 1e-30
NP_055087 (OMIM: 605009) A disintegrin and metallo (1686) 658 135.4 1.1e-30
XP_005254194 (OMIM: 605009) PREDICTED: A disintegr (1689) 658 135.4 1.1e-30
XP_011541423 (OMIM: 605008) PREDICTED: A disintegr ( 863) 654 134.4 1.2e-30
XP_011541422 (OMIM: 605008) PREDICTED: A disintegr ( 868) 654 134.4 1.2e-30
XP_011541421 (OMIM: 605008) PREDICTED: A disintegr ( 892) 654 134.4 1.2e-30
XP_011541419 (OMIM: 605008) PREDICTED: A disintegr ( 966) 654 134.4 1.3e-30
NP_922932 (OMIM: 605008) A disintegrin and metallo (1117) 654 134.5 1.4e-30
XP_011541416 (OMIM: 605008) PREDICTED: A disintegr (1117) 654 134.5 1.4e-30
XP_011541415 (OMIM: 605008) PREDICTED: A disintegr (1117) 654 134.5 1.4e-30
NP_001269281 (OMIM: 277600,608990) A disintegrin a ( 590) 641 131.8 4.8e-30
XP_016878478 (OMIM: 607512,615458) PREDICTED: A di ( 809) 617 127.4 1.4e-28
XP_016878477 (OMIM: 607512,615458) PREDICTED: A di ( 809) 617 127.4 1.4e-28
XP_011521226 (OMIM: 607512,615458) PREDICTED: A di ( 978) 617 127.4 1.6e-28
NP_001313287 (OMIM: 607512,615458) A disintegrin a (1049) 617 127.5 1.7e-28
XP_011521225 (OMIM: 607512,615458) PREDICTED: A di (1049) 617 127.5 1.7e-28
NP_955387 (OMIM: 607512,615458) A disintegrin and (1221) 617 127.5 1.9e-28
NP_001275536 (OMIM: 225100,225200,610113) ADAMTS-l (1035) 587 121.8 8.5e-27
XP_005254929 (OMIM: 607511,613195) PREDICTED: A di (1122) 587 121.8 9e-27
XP_016877464 (OMIM: 607511,613195) PREDICTED: A di (1166) 587 121.8 9.3e-27
NP_598377 (OMIM: 607513) A disintegrin and metallo (1213) 572 119.0 6.8e-26
>>XP_016870801 (OMIM: 609198) PREDICTED: ADAMTS-like pro (1796 aa)
initn: 2954 init1: 2954 opt: 2954 Z-score: 3015.2 bits: 569.1 E(85289): 3.3e-161
Smith-Waterman score: 2954; 99.8% identity (99.8% similar) in 412 aa overlap (22-433:73-484)
10 20 30 40 50
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGG
::::::::::::::::::::::::::::::
XP_016 FLREFTLIRRESLHEDFLSDLLNSHKTEDSSSRTARSEEDRDGLWDAWGPWSECSRTCGG
50 60 70 80 90 100
60 70 80 90 100 110
pF1KE6 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
110 120 130 140 150 160
120 130 140 150 160 170
pF1KE6 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
170 180 190 200 210 220
180 190 200 210 220 230
pF1KE6 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
230 240 250 260 270 280
240 250 260 270 280 290
pF1KE6 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
290 300 310 320 330 340
300 310 320 330 340 350
pF1KE6 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
350 360 370 380 390 400
360 370 380 390 400 410
pF1KE6 QECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPI
410 420 430 440 450 460
420 430
pF1KE6 AQPCNIFDCPKWLAQEWSPVTVPSFFVH
::::::::::::::::::: ::
XP_016 AQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIV
470 480 490 500 510 520
>--
initn: 429 init1: 212 opt: 307 Z-score: 313.1 bits: 69.1 E(85289): 1.1e-10
Smith-Waterman score: 342; 34.5% identity (57.6% similar) in 139 aa overlap (298-432:642-775)
270 280 290 300 310 320
pF1KE6 AGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDL
.. :. : :: .:::: : . . : .
XP_016 CYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK
620 630 640 650 660 670
330 340 350 360 370 380
pF1KE6 RSNRVVADQYCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSC-
.. . . .. : . .: :. ::::::::::: :. :: .:: :.:.: : :
XP_016 QTREPAEENLC---VTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCS
680 690 700 710 720
390 400 410 420 430
pF1KE6 --VEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPVTVPSFFVH
. .... : ..: : :: .: :: :.:: : .:.: .
XP_016 HLLSREMNETVILADEL-C-RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKRE
730 740 750 760 770 780
XP_016 VLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRS
790 800 810 820 830 840
>--
initn: 275 init1: 185 opt: 299 Z-score: 305.0 bits: 67.6 E(85289): 3e-10
Smith-Waterman score: 299; 26.8% identity (50.0% similar) in 254 aa overlap (193-439:1418-1660)
170 180 190 200 210 220
pF1KE6 DHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSD-DTVVAIPYGSRHIRLVLKG
.. :.:: . .:.. : :.. :::
XP_016 RAANLHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQ---LVLD-
1390 1400 1410 1420 1430 1440
230 240 250 260 270
pF1KE6 PDHLYLETKTLQGTKGEN-SLSSTGTFLVDNSSVDFQKFPDKEILRMA---GPLTADFIV
: . : ..: : . : .: ... . . .::..: : ..:
XP_016 PGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSC
1450 1460 1470 1480 1490 1500
280 290 300 310 320 330
pF1KE6 KIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQ
.: ... . : . : . :::.::. : : .: : .. :
XP_016 LAQNEAGVLMQKASLVIQD--YWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPA
1510 1520 1530 1540 1550
340 350 360 370 380 390
pF1KE6 YCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVT
.: ...: . :: ::.:: .: :.::. :::::.:.: :.: . .: :
XP_016 HC---AGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGIST
1560 1570 1580 1590 1600 1610
400 410 420 430
pF1KE6 SVEEWKCMYTPKMPI-AQPCNIFDCPKWLAQEWSPVTVPSFFVH
: . : . : :. .: :: : .: . :. . : . :
XP_016 PVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI
1620 1630 1640 1650 1660 1670
XP_016 TLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKA
1680 1690 1700 1710 1720 1730
>--
initn: 287 init1: 163 opt: 223 Z-score: 227.4 bits: 53.2 E(85289): 6.3e-06
Smith-Waterman score: 223; 33.3% identity (50.9% similar) in 114 aa overlap (312-422:777-885)
290 300 310 320 330 340
pF1KE6 SGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYY
::::: : . : .. .::
XP_016 RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC-----KQRMADGSFLEL
750 760 770 780 790 800
350 360 370 380 390
pF1KE6 PENI--KPKPKLQE-CNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV
::.. :: :. :. : ::..: . :: ::.::: : :.:.. : . : : :
XP_016 PETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVV
810 820 830 840 850 860
400 410 420 430
pF1KE6 EEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
. : : .:: . : .
XP_016 NSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFA
870 880 890 900 910 920
>>XP_016870800 (OMIM: 609198) PREDICTED: ADAMTS-like pro (1811 aa)
initn: 2954 init1: 2954 opt: 2954 Z-score: 3015.1 bits: 569.1 E(85289): 3.3e-161
Smith-Waterman score: 2954; 99.8% identity (99.8% similar) in 412 aa overlap (22-433:88-499)
10 20 30 40 50
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGG
::::::::::::::::::::::::::::::
XP_016 FLREFTLIRRESLHEDFLSDLLNSHKTEDSSSRTARSEEDRDGLWDAWGPWSECSRTCGG
60 70 80 90 100 110
60 70 80 90 100 110
pF1KE6 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
120 130 140 150 160 170
120 130 140 150 160 170
pF1KE6 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
180 190 200 210 220 230
180 190 200 210 220 230
pF1KE6 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
240 250 260 270 280 290
240 250 260 270 280 290
pF1KE6 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
300 310 320 330 340 350
300 310 320 330 340 350
pF1KE6 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
360 370 380 390 400 410
360 370 380 390 400 410
pF1KE6 QECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPI
420 430 440 450 460 470
420 430
pF1KE6 AQPCNIFDCPKWLAQEWSPVTVPSFFVH
::::::::::::::::::: ::
XP_016 AQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIV
480 490 500 510 520 530
>--
initn: 429 init1: 212 opt: 307 Z-score: 313.1 bits: 69.1 E(85289): 1.1e-10
Smith-Waterman score: 342; 34.5% identity (57.6% similar) in 139 aa overlap (298-432:657-790)
270 280 290 300 310 320
pF1KE6 AGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDL
.. :. : :: .:::: : . . : .
XP_016 CYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK
630 640 650 660 670 680
330 340 350 360 370 380
pF1KE6 RSNRVVADQYCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSC-
.. . . .. : . .: :. ::::::::::: :. :: .:: :.:.: : :
XP_016 QTREPAEENLC---VTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCS
690 700 710 720 730 740
390 400 410 420 430
pF1KE6 --VEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPVTVPSFFVH
. .... : ..: : :: .: :: :.:: : .:.: .
XP_016 HLLSREMNETVILADEL-C-RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKRE
750 760 770 780 790 800
XP_016 VLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRS
810 820 830 840 850 860
>--
initn: 275 init1: 185 opt: 299 Z-score: 304.9 bits: 67.6 E(85289): 3e-10
Smith-Waterman score: 299; 26.8% identity (50.0% similar) in 254 aa overlap (193-439:1433-1675)
170 180 190 200 210 220
pF1KE6 DHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSD-DTVVAIPYGSRHIRLVLKG
.. :.:: . .:.. : :.. :::
XP_016 RAANLHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQ---LVLD-
1410 1420 1430 1440 1450
230 240 250 260 270
pF1KE6 PDHLYLETKTLQGTKGEN-SLSSTGTFLVDNSSVDFQKFPDKEILRMA---GPLTADFIV
: . : ..: : . : .: ... . . .::..: : ..:
XP_016 PGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSC
1460 1470 1480 1490 1500 1510
280 290 300 310 320 330
pF1KE6 KIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQ
.: ... . : . : . :::.::. : : .: : .. :
XP_016 LAQNEAGVLMQKASLVIQD--YWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPA
1520 1530 1540 1550 1560 1570
340 350 360 370 380 390
pF1KE6 YCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVT
.: ...: . :: ::.:: .: :.::. :::::.:.: :.: . .: :
XP_016 HC---AGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGIST
1580 1590 1600 1610 1620 1630
400 410 420 430
pF1KE6 SVEEWKCMYTPKMPI-AQPCNIFDCPKWLAQEWSPVTVPSFFVH
: . : . : :. .: :: : .: . :. . : . :
XP_016 PVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI
1640 1650 1660 1670 1680 1690
XP_016 TLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKA
1700 1710 1720 1730 1740 1750
>--
initn: 287 init1: 163 opt: 223 Z-score: 227.3 bits: 53.2 E(85289): 6.4e-06
Smith-Waterman score: 223; 33.3% identity (50.9% similar) in 114 aa overlap (312-422:792-900)
290 300 310 320 330 340
pF1KE6 SGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYY
::::: : . : .. .::
XP_016 RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC-----KQRMADGSFLEL
770 780 790 800 810
350 360 370 380 390
pF1KE6 PENI--KPKPKLQE-CNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV
::.. :: :. :. : ::..: . :: ::.::: : :.:.. : . : : :
XP_016 PETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVV
820 830 840 850 860 870
400 410 420 430
pF1KE6 EEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
. : : .:: . : .
XP_016 NSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFA
880 890 900 910 920 930
>>NP_443098 (OMIM: 609198) ADAMTS-like protein 1 isoform (525 aa)
initn: 3082 init1: 2558 opt: 2558 Z-score: 2617.9 bits: 493.8 E(85289): 4.4e-139
Smith-Waterman score: 3052; 96.0% identity (96.0% similar) in 450 aa overlap (1-433:1-450)
10 20 30 40 50 60
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP
310 320 330 340 350 360
370 380 390 400
pF1KE6 A-----------------RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
: ::::::::::::::::::::::::::::::::::::::::::
NP_443 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
370 380 390 400 410 420
410 420 430
pF1KE6 MYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
::::::::::::::::::::::::::: ::
NP_443 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP
430 440 450 460 470 480
>>NP_001035362 (OMIM: 609198) ADAMTS-like protein 1 isof (1762 aa)
initn: 3082 init1: 2558 opt: 2558 Z-score: 2611.0 bits: 494.3 E(85289): 1.1e-138
Smith-Waterman score: 3052; 96.0% identity (96.0% similar) in 450 aa overlap (1-433:1-450)
10 20 30 40 50 60
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP
310 320 330 340 350 360
370 380 390 400
pF1KE6 A-----------------RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
: ::::::::::::::::::::::::::::::::::::::::::
NP_001 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
370 380 390 400 410 420
410 420 430
pF1KE6 MYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
::::::::::::::::::::::::::: ::
NP_001 MYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKP
430 440 450 460 470 480
>--
initn: 429 init1: 212 opt: 307 Z-score: 313.2 bits: 69.1 E(85289): 1e-10
Smith-Waterman score: 342; 34.5% identity (57.6% similar) in 139 aa overlap (298-432:608-741)
270 280 290 300 310 320
pF1KE6 AGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDL
.. :. : :: .:::: : . . : .
NP_001 CYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK
580 590 600 610 620 630
330 340 350 360 370 380
pF1KE6 RSNRVVADQYCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSC-
.. . . .. : . .: :. ::::::::::: :. :: .:: :.:.: : :
NP_001 QTREPAEENLC---VTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCS
640 650 660 670 680 690
390 400 410 420 430
pF1KE6 --VEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPVTVPSFFVH
. .... : ..: : :: .: :: :.:: : .:.: .
NP_001 HLLSREMNETVILADEL-C-RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKRE
700 710 720 730 740 750
NP_001 VLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRS
760 770 780 790 800 810
>--
initn: 275 init1: 185 opt: 299 Z-score: 305.1 bits: 67.6 E(85289): 3e-10
Smith-Waterman score: 299; 26.8% identity (50.0% similar) in 254 aa overlap (193-439:1384-1626)
170 180 190 200 210 220
pF1KE6 DHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSD-DTVVAIPYGSRHIRLVLKG
.. :.:: . .:.. : :.. :::
NP_001 RAANLHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQ---LVLD-
1360 1370 1380 1390 1400
230 240 250 260 270
pF1KE6 PDHLYLETKTLQGTKGEN-SLSSTGTFLVDNSSVDFQKFPDKEILRMA---GPLTADFIV
: . : ..: : . : .: ... . . .::..: : ..:
NP_001 PGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSC
1410 1420 1430 1440 1450 1460
280 290 300 310 320 330
pF1KE6 KIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQ
.: ... . : . : . :::.::. : : .: : .. :
NP_001 LAQNEAGVLMQKASLVIQD--YWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPA
1470 1480 1490 1500 1510 1520
340 350 360 370 380 390
pF1KE6 YCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVT
.: ...: . :: ::.:: .: :.::. :::::.:.: :.: . .: :
NP_001 HC---AGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGIST
1530 1540 1550 1560 1570 1580
400 410 420 430
pF1KE6 SVEEWKCMYTPKMPI-AQPCNIFDCPKWLAQEWSPVTVPSFFVH
: . : . : :. .: :: : .: . :. . : . :
NP_001 PVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI
1590 1600 1610 1620 1630 1640
NP_001 TLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKA
1650 1660 1670 1680 1690 1700
>--
initn: 287 init1: 163 opt: 223 Z-score: 227.5 bits: 53.2 E(85289): 6.2e-06
Smith-Waterman score: 223; 33.3% identity (50.9% similar) in 114 aa overlap (312-422:743-851)
290 300 310 320 330 340
pF1KE6 SGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYY
::::: : . : .. .::
NP_001 RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC-----KQRMADGSFLEL
720 730 740 750 760
350 360 370 380 390
pF1KE6 PENI--KPKPKLQE-CNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV
::.. :: :. :. : ::..: . :: ::.::: : :.:.. : . : : :
NP_001 PETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVV
770 780 790 800 810 820
400 410 420 430
pF1KE6 EEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
. : : .:: . : .
NP_001 NSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFA
830 840 850 860 870 880
>>XP_016870803 (OMIM: 609198) PREDICTED: ADAMTS-like pro (1495 aa)
initn: 2940 init1: 2416 opt: 2416 Z-score: 2467.0 bits: 467.4 E(85289): 1.1e-130
Smith-Waterman score: 2910; 95.8% identity (95.8% similar) in 429 aa overlap (22-433:88-516)
10 20 30 40 50
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGG
::::::::::::::::::::::::::::::
XP_016 FLREFTLIRRESLHEDFLSDLLNSHKTEDSSSRTARSEEDRDGLWDAWGPWSECSRTCGG
60 70 80 90 100 110
60 70 80 90 100 110
pF1KE6 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
120 130 140 150 160 170
120 130 140 150 160 170
pF1KE6 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
180 190 200 210 220 230
180 190 200 210 220 230
pF1KE6 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
240 250 260 270 280 290
240 250 260 270 280 290
pF1KE6 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
300 310 320 330 340 350
300 310 320 330 340 350
pF1KE6 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
360 370 380 390 400 410
360 370 380 390
pF1KE6 QECNLDPCPA-----------------RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
:::::::::: :::::::::::::::::::::::::::::::::
XP_016 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
420 430 440 450 460 470
400 410 420 430
pF1KE6 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
:::::::::::::::::::::::::::::::::::: ::
XP_016 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT
480 490 500 510 520 530
XP_016 GGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAW
540 550 560 570 580 590
>--
initn: 453 init1: 212 opt: 307 Z-score: 314.2 bits: 69.0 E(85289): 9.2e-11
Smith-Waterman score: 342; 34.5% identity (57.6% similar) in 139 aa overlap (298-432:674-807)
270 280 290 300 310 320
pF1KE6 AGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDL
.. :. : :: .:::: : . . : .
XP_016 CYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK
650 660 670 680 690 700
330 340 350 360 370 380
pF1KE6 RSNRVVADQYCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSC-
.. . . .. : . .: :. ::::::::::: :. :: .:: :.:.: : :
XP_016 QTREPAEENLC---VTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCS
710 720 730 740 750 760
390 400 410 420 430
pF1KE6 --VEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPVTVPSFFVH
. .... : ..: : :: .: :: :.:: : .:.: .
XP_016 HLLSREMNETVILADEL-C-RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKRE
770 780 790 800 810
XP_016 VLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRS
820 830 840 850 860 870
>--
initn: 287 init1: 163 opt: 223 Z-score: 228.4 bits: 53.2 E(85289): 5.5e-06
Smith-Waterman score: 223; 33.3% identity (50.9% similar) in 114 aa overlap (312-422:809-917)
290 300 310 320 330 340
pF1KE6 SGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYY
::::: : . : .. .::
XP_016 RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC-----KQRMADGSFLEL
780 790 800 810 820 830
350 360 370 380 390
pF1KE6 PENI--KPKPKLQE-CNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV
::.. :: :. :. : ::..: . :: ::.::: : :.:.. : . : : :
XP_016 PETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVV
840 850 860 870 880 890
400 410 420 430
pF1KE6 EEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
. : : .:: . : .
XP_016 NSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFA
900 910 920 930 940 950
>>XP_011516366 (OMIM: 609198) PREDICTED: ADAMTS-like pro (1813 aa)
initn: 2940 init1: 2416 opt: 2416 Z-score: 2465.9 bits: 467.5 E(85289): 1.3e-130
Smith-Waterman score: 2910; 95.8% identity (95.8% similar) in 429 aa overlap (22-433:73-501)
10 20 30 40 50
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGG
::::::::::::::::::::::::::::::
XP_011 FLREFTLIRRESLHEDFLSDLLNSHKTEDSSSRTARSEEDRDGLWDAWGPWSECSRTCGG
50 60 70 80 90 100
60 70 80 90 100 110
pF1KE6 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
110 120 130 140 150 160
120 130 140 150 160 170
pF1KE6 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
170 180 190 200 210 220
180 190 200 210 220 230
pF1KE6 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
230 240 250 260 270 280
240 250 260 270 280 290
pF1KE6 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
290 300 310 320 330 340
300 310 320 330 340 350
pF1KE6 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
350 360 370 380 390 400
360 370 380 390
pF1KE6 QECNLDPCPA-----------------RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
:::::::::: :::::::::::::::::::::::::::::::::
XP_011 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
410 420 430 440 450 460
400 410 420 430
pF1KE6 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
:::::::::::::::::::::::::::::::::::: ::
XP_011 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT
470 480 490 500 510 520
XP_011 GGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAW
530 540 550 560 570 580
>--
initn: 429 init1: 212 opt: 307 Z-score: 313.1 bits: 69.1 E(85289): 1.1e-10
Smith-Waterman score: 342; 34.5% identity (57.6% similar) in 139 aa overlap (298-432:659-792)
270 280 290 300 310 320
pF1KE6 AGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDL
.. :. : :: .:::: : . . : .
XP_011 CYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK
630 640 650 660 670 680
330 340 350 360 370 380
pF1KE6 RSNRVVADQYCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSC-
.. . . .. : . .: :. ::::::::::: :. :: .:: :.:.: : :
XP_011 QTREPAEENLC---VTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCS
690 700 710 720 730 740
390 400 410 420 430
pF1KE6 --VEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPVTVPSFFVH
. .... : ..: : :: .: :: :.:: : .:.: .
XP_011 HLLSREMNETVILADEL-C-RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKRE
750 760 770 780 790 800
XP_011 VLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRS
810 820 830 840 850 860
>--
initn: 275 init1: 185 opt: 299 Z-score: 304.9 bits: 67.6 E(85289): 3e-10
Smith-Waterman score: 299; 26.8% identity (50.0% similar) in 254 aa overlap (193-439:1435-1677)
170 180 190 200 210 220
pF1KE6 DHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSD-DTVVAIPYGSRHIRLVLKG
.. :.:: . .:.. : :.. :::
XP_011 RAANLHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQ---LVLD-
1410 1420 1430 1440 1450 1460
230 240 250 260 270
pF1KE6 PDHLYLETKTLQGTKGEN-SLSSTGTFLVDNSSVDFQKFPDKEILRMA---GPLTADFIV
: . : ..: : . : .: ... . . .::..: : ..:
XP_011 PGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSC
1470 1480 1490 1500 1510 1520
280 290 300 310 320 330
pF1KE6 KIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQ
.: ... . : . : . :::.::. : : .: : .. :
XP_011 LAQNEAGVLMQKASLVIQD--YWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPA
1530 1540 1550 1560 1570
340 350 360 370 380 390
pF1KE6 YCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVT
.: ...: . :: ::.:: .: :.::. :::::.:.: :.: . .: :
XP_011 HC---AGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGIST
1580 1590 1600 1610 1620 1630
400 410 420 430
pF1KE6 SVEEWKCMYTPKMPI-AQPCNIFDCPKWLAQEWSPVTVPSFFVH
: . : . : :. .: :: : .: . :. . : . :
XP_011 PVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI
1640 1650 1660 1670 1680 1690
XP_011 TLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKA
1700 1710 1720 1730 1740 1750
>--
initn: 287 init1: 163 opt: 223 Z-score: 227.3 bits: 53.2 E(85289): 6.4e-06
Smith-Waterman score: 223; 33.3% identity (50.9% similar) in 114 aa overlap (312-422:794-902)
290 300 310 320 330 340
pF1KE6 SGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYY
::::: : . : .. .::
XP_011 RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC-----KQRMADGSFLEL
770 780 790 800 810
350 360 370 380 390
pF1KE6 PENI--KPKPKLQE-CNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV
::.. :: :. :. : ::..: . :: ::.::: : :.:.. : . : : :
XP_011 PETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVV
820 830 840 850 860 870
400 410 420 430
pF1KE6 EEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
. : : .:: . : .
XP_011 NSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFA
880 890 900 910 920 930
>>XP_016870799 (OMIM: 609198) PREDICTED: ADAMTS-like pro (1814 aa)
initn: 2940 init1: 2416 opt: 2416 Z-score: 2465.9 bits: 467.5 E(85289): 1.3e-130
Smith-Waterman score: 2910; 95.8% identity (95.8% similar) in 429 aa overlap (22-433:74-502)
10 20 30 40 50
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGG
::::::::::::::::::::::::::::::
XP_016 FLREFTLIRRESLHEDFLSDLLNSHKTEDSSSRTARSEEDRDGLWDAWGPWSECSRTCGG
50 60 70 80 90 100
60 70 80 90 100 110
pF1KE6 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
110 120 130 140 150 160
120 130 140 150 160 170
pF1KE6 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
170 180 190 200 210 220
180 190 200 210 220 230
pF1KE6 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
230 240 250 260 270 280
240 250 260 270 280 290
pF1KE6 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
290 300 310 320 330 340
300 310 320 330 340 350
pF1KE6 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
350 360 370 380 390 400
360 370 380 390
pF1KE6 QECNLDPCPA-----------------RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
:::::::::: :::::::::::::::::::::::::::::::::
XP_016 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
410 420 430 440 450 460
400 410 420 430
pF1KE6 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
:::::::::::::::::::::::::::::::::::: ::
XP_016 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT
470 480 490 500 510 520
XP_016 GGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAW
530 540 550 560 570 580
>--
initn: 429 init1: 212 opt: 307 Z-score: 313.1 bits: 69.1 E(85289): 1.1e-10
Smith-Waterman score: 342; 34.5% identity (57.6% similar) in 139 aa overlap (298-432:660-793)
270 280 290 300 310 320
pF1KE6 AGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDL
.. :. : :: .:::: : . . : .
XP_016 CYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK
630 640 650 660 670 680
330 340 350 360 370 380
pF1KE6 RSNRVVADQYCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSC-
.. . . .. : . .: :. ::::::::::: :. :: .:: :.:.: : :
XP_016 QTREPAEENLC---VTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCS
690 700 710 720 730 740
390 400 410 420 430
pF1KE6 --VEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPVTVPSFFVH
. .... : ..: : :: .: :: :.:: : .:.: .
XP_016 HLLSREMNETVILADEL-C-RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKRE
750 760 770 780 790 800
XP_016 VLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRS
810 820 830 840 850 860
>--
initn: 275 init1: 185 opt: 299 Z-score: 304.9 bits: 67.6 E(85289): 3e-10
Smith-Waterman score: 299; 26.8% identity (50.0% similar) in 254 aa overlap (193-439:1436-1678)
170 180 190 200 210 220
pF1KE6 DHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSD-DTVVAIPYGSRHIRLVLKG
.. :.:: . .:.. : :.. :::
XP_016 RAANLHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQ---LVLD-
1410 1420 1430 1440 1450 1460
230 240 250 260 270
pF1KE6 PDHLYLETKTLQGTKGEN-SLSSTGTFLVDNSSVDFQKFPDKEILRMA---GPLTADFIV
: . : ..: : . : .: ... . . .::..: : ..:
XP_016 PGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSC
1470 1480 1490 1500 1510 1520
280 290 300 310 320 330
pF1KE6 KIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQ
.: ... . : . : . :::.::. : : .: : .. :
XP_016 LAQNEAGVLMQKASLVIQD--YWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPA
1530 1540 1550 1560 1570
340 350 360 370 380 390
pF1KE6 YCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVT
.: ...: . :: ::.:: .: :.::. :::::.:.: :.: . .: :
XP_016 HC---AGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGIST
1580 1590 1600 1610 1620 1630
400 410 420 430
pF1KE6 SVEEWKCMYTPKMPI-AQPCNIFDCPKWLAQEWSPVTVPSFFVH
: . : . : :. .: :: : .: . :. . : . :
XP_016 PVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI
1640 1650 1660 1670 1680 1690
XP_016 TLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKA
1700 1710 1720 1730 1740 1750
>--
initn: 287 init1: 163 opt: 223 Z-score: 227.3 bits: 53.2 E(85289): 6.4e-06
Smith-Waterman score: 223; 33.3% identity (50.9% similar) in 114 aa overlap (312-422:795-903)
290 300 310 320 330 340
pF1KE6 SGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYY
::::: : . : .. .::
XP_016 RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC-----KQRMADGSFLEL
770 780 790 800 810
350 360 370 380 390
pF1KE6 PENI--KPKPKLQE-CNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV
::.. :: :. :. : ::..: . :: ::.::: : :.:.. : . : : :
XP_016 PETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVV
820 830 840 850 860 870
400 410 420 430
pF1KE6 EEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
. : : .:: . : .
XP_016 NSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFA
880 890 900 910 920 930
>>XP_011516365 (OMIM: 609198) PREDICTED: ADAMTS-like pro (1828 aa)
initn: 2940 init1: 2416 opt: 2416 Z-score: 2465.9 bits: 467.5 E(85289): 1.3e-130
Smith-Waterman score: 2910; 95.8% identity (95.8% similar) in 429 aa overlap (22-433:88-516)
10 20 30 40 50
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGG
::::::::::::::::::::::::::::::
XP_011 FLREFTLIRRESLHEDFLSDLLNSHKTEDSSSRTARSEEDRDGLWDAWGPWSECSRTCGG
60 70 80 90 100 110
60 70 80 90 100 110
pF1KE6 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPV
120 130 140 150 160 170
120 130 140 150 160 170
pF1KE6 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVK
180 190 200 210 220 230
180 190 200 210 220 230
pF1KE6 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKT
240 250 260 270 280 290
240 250 260 270 280 290
pF1KE6 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQF
300 310 320 330 340 350
300 310 320 330 340 350
pF1KE6 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKL
360 370 380 390 400 410
360 370 380 390
pF1KE6 QECNLDPCPA-----------------RWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
:::::::::: :::::::::::::::::::::::::::::::::
XP_011 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
420 430 440 450 460 470
400 410 420 430
pF1KE6 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
:::::::::::::::::::::::::::::::::::: ::
XP_011 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHT
480 490 500 510 520 530
XP_011 GGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAW
540 550 560 570 580 590
>--
initn: 429 init1: 212 opt: 307 Z-score: 313.0 bits: 69.1 E(85289): 1.1e-10
Smith-Waterman score: 342; 34.5% identity (57.6% similar) in 139 aa overlap (298-432:674-807)
270 280 290 300 310 320
pF1KE6 AGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDL
.. :. : :: .:::: : . . : .
XP_011 CYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNK
650 660 670 680 690 700
330 340 350 360 370 380
pF1KE6 RSNRVVADQYCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSC-
.. . . .. : . .: :. ::::::::::: :. :: .:: :.:.: : :
XP_011 QTREPAEENLC---VTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCS
710 720 730 740 750 760
390 400 410 420 430
pF1KE6 --VEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPVTVPSFFVH
. .... : ..: : :: .: :: :.:: : .:.: .
XP_011 HLLSREMNETVILADEL-C-RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKRE
770 780 790 800 810
XP_011 VLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRS
820 830 840 850 860 870
>--
initn: 275 init1: 185 opt: 299 Z-score: 304.9 bits: 67.6 E(85289): 3.1e-10
Smith-Waterman score: 299; 26.8% identity (50.0% similar) in 254 aa overlap (193-439:1450-1692)
170 180 190 200 210 220
pF1KE6 DHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSD-DTVVAIPYGSRHIRLVLKG
.. :.:: . .:.. : :.. :::
XP_011 RAANLHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQ---LVLD-
1420 1430 1440 1450 1460 1470
230 240 250 260 270
pF1KE6 PDHLYLETKTLQGTKGEN-SLSSTGTFLVDNSSVDFQKFPDKEILRMA---GPLTADFIV
: . : ..: : . : .: ... . . .::..: : ..:
XP_011 PGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSC
1480 1490 1500 1510 1520 1530
280 290 300 310 320 330
pF1KE6 KIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQ
.: ... . : . : . :::.::. : : .: : .. :
XP_011 LAQNEAGVLMQKASLVIQD--YWWSVDRLATCSASCGNRGVQQPRLRC--LLNSTEVNPA
1540 1550 1560 1570 1580 1590
340 350 360 370 380 390
pF1KE6 YCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVT
.: ...: . :: ::.:: .: :.::. :::::.:.: :.: . .: :
XP_011 HC---AGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGIST
1600 1610 1620 1630 1640
400 410 420 430
pF1KE6 SVEEWKCMYTPKMPI-AQPCNIFDCPKWLAQEWSPVTVPSFFVH
: . : . : :. .: :: : .: . :. . : . :
XP_011 PVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI
1650 1660 1670 1680 1690 1700
XP_011 TLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKA
1710 1720 1730 1740 1750 1760
>--
initn: 287 init1: 163 opt: 223 Z-score: 227.3 bits: 53.2 E(85289): 6.4e-06
Smith-Waterman score: 223; 33.3% identity (50.9% similar) in 114 aa overlap (312-422:809-917)
290 300 310 320 330 340
pF1KE6 SGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYY
::::: : . : .. .::
XP_011 RQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC-----KQRMADGSFLEL
780 790 800 810 820 830
350 360 370 380 390
pF1KE6 PENI--KPKPKLQE-CNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV
::.. :: :. :. : ::..: . :: ::.::: : :.:.. : . : : :
XP_011 PETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVV
840 850 860 870 880 890
400 410 420 430
pF1KE6 EEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
. : : .:: . : .
XP_011 NSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFA
900 910 920 930 940 950
>>NP_001288039 (OMIM: 609199) ADAMTS-like protein 3 isof (1682 aa)
initn: 2181 init1: 1806 opt: 1812 Z-score: 1849.8 bits: 353.3 E(85289): 2.7e-96
Smith-Waterman score: 2157; 63.4% identity (84.0% similar) in 443 aa overlap (8-433:50-492)
10 20 30
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWD
: : .: . .::..::.::.:: ::
NP_001 PLPQTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNTRSDEDKDGNWD
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 AWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHN
::: ::.:::::::::::::::::....:::.::::.:::: ::::.: :::::::::.:
NP_001 AWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYN
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 DVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLC
::...:..::::: ::: ::.:::.:.: .::::::::::::::: :.::::::::.:
NP_001 DVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGIC
140 150 160 170 180 190
160 170 180 190 200 210
pF1KE6 QIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRL
: ::::.::::..:::::::: :::::::::::: ::..: : ...:.:.: ::: .:.
NP_001 QAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPLGSRSVRI
200 210 220 230 240 250
220 230 240 250 260 270
pF1KE6 VLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIV
..::: ::..:.:::::.:::.:..: :.:::.:..:.::. ... ... ::: ::::
NP_001 TVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPLMADFIF
260 270 280 290 300 310
280 290 300 310 320 330
pF1KE6 KIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQY
: : ... ::.:::.::::: :.::.::::::..::::::::.:::: :.: .::: :.:
NP_001 KTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHY
320 330 340 350 360 370
340 350 360 370 380
pF1KE6 CHYYPENIKPKPKLQECNLDPCPA-----------------RWEATPWTACSSSCGGGIQ
:::::::.::::::.::..::::. ::: .:::::: :::::::
NP_001 CHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQ
380 390 400 410 420 430
390 400 410 420 430
pF1KE6 SRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
:. ::::...:.. .::::::::.:: . : ::.::::::.:.::: ::
NP_001 RRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLR
440 450 460 470 480 490
NP_001 YRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEET
500 510 520 530 540 550
>--
initn: 248 init1: 166 opt: 343 Z-score: 350.2 bits: 75.9 E(85289): 9e-13
Smith-Waterman score: 343; 38.0% identity (58.9% similar) in 129 aa overlap (301-428:648-768)
280 290 300 310 320 330
pF1KE6 LTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSN
:. . : ::.::: ::.: . : : ....
NP_001 RPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQ
620 630 640 650 660 670
340 350 360 370 380 390
pF1KE6 RVVADQYCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEED
..: :. : . .: : :: .::: ::.. : ::..:: :::.: : :..
NP_001 QTVNDSLCDMVH---RPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP-
680 690 700 710 720 730
400 410 420 430
pF1KE6 IQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPVTVPSFFVH
:.. . : .: : : :: :::: : .::
NP_001 --GETPAPPE-EC-RDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQL
740 750 760 770 780
NP_001 LTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRL
790 800 810 820 830 840
>--
initn: 248 init1: 194 opt: 285 Z-score: 291.0 bits: 64.9 E(85289): 1.8e-09
Smith-Waterman score: 285; 29.7% identity (55.2% similar) in 172 aa overlap (257-423:1387-1547)
230 240 250 260 270 280
pF1KE6 LETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNS--GS
...:...:. . : .:.. :. .:
NP_001 VSLENEGTYVCIATNALGKAVATSVLHLLERRWPESRIVFLQG--HKKYILQATNTRTNS
1360 1370 1380 1390 1400 1410
290 300 310 320 330 340
pF1KE6 ADSTVQFIFYQPIIHRWRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQYCHYYPE
: : . .:. :. .. :::::: : .. .: . ... :.. : .
NP_001 NDPTGEPPPQEPF---WEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQ-
1420 1430 1440 1450 1460
350 360 370 380 390 400
pF1KE6 NIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
:: .. ::. ::::: .. :. :: ::: : .:: :.: . .: : : :
NP_001 --KPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC
1470 1480 1490 1500 1510 1520
410 420 430
pF1KE6 MYTPK-MPIA-QPCNIFDCPKWLAQEWSPVTVPSFFVH
.:: :.. .:: : .:
NP_001 --APKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKR
1530 1540 1550 1560 1570 1580
>--
initn: 224 init1: 96 opt: 226 Z-score: 230.8 bits: 53.8 E(85289): 4.1e-06
Smith-Waterman score: 226; 30.5% identity (51.7% similar) in 118 aa overlap (309-422:771-882)
280 290 300 310 320 330
pF1KE6 IRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV---VAD
:: ::::: : . : .: .. ..:
NP_001 EECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSD
750 760 770 780 790 800
340 350 360 370 380 390
pF1KE6 QYCHYYPENIKPKPKLQE-CNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
. :. :: . .. : :: . . :. :: ::: ::: : : . .:.
NP_001 ELCQ------GPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGR
810 820 830 840 850
400 410 420 430
pF1KE6 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
. : : : .:... :.. .: :
NP_001 RIPLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRI
860 870 880 890 900 910
>>NP_997400 (OMIM: 609199) ADAMTS-like protein 3 isoform (1691 aa)
initn: 2181 init1: 1806 opt: 1812 Z-score: 1849.8 bits: 353.3 E(85289): 2.7e-96
Smith-Waterman score: 2157; 63.4% identity (84.0% similar) in 443 aa overlap (8-433:50-492)
10 20 30
pF1KE6 MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWD
: : .: . .::..::.::.:: ::
NP_997 PLPQTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNTRSDEDKDGNWD
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE6 AWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHN
::: ::.:::::::::::::::::....:::.::::.:::: ::::.: :::::::::.:
NP_997 AWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYN
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE6 DVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLC
::...:..::::: ::: ::.:::.:.: .::::::::::::::: :.::::::::.:
NP_997 DVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGIC
140 150 160 170 180 190
160 170 180 190 200 210
pF1KE6 QIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRL
: ::::.::::..:::::::: :::::::::::: ::..: : ...:.:.: ::: .:.
NP_997 QAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPLGSRSVRI
200 210 220 230 240 250
220 230 240 250 260 270
pF1KE6 VLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIV
..::: ::..:.:::::.:::.:..: :.:::.:..:.::. ... ... ::: ::::
NP_997 TVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPLMADFIF
260 270 280 290 300 310
280 290 300 310 320 330
pF1KE6 KIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQY
: : ... ::.:::.::::: :.::.::::::..::::::::.:::: :.: .::: :.:
NP_997 KTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHY
320 330 340 350 360 370
340 350 360 370 380
pF1KE6 CHYYPENIKPKPKLQECNLDPCPA-----------------RWEATPWTACSSSCGGGIQ
:::::::.::::::.::..::::. ::: .:::::: :::::::
NP_997 CHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQ
380 390 400 410 420 430
390 400 410 420 430
pF1KE6 SRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
:. ::::...:.. .::::::::.:: . : ::.::::::.:.::: ::
NP_997 RRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLR
440 450 460 470 480 490
NP_997 YRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEET
500 510 520 530 540 550
>--
initn: 248 init1: 166 opt: 343 Z-score: 350.2 bits: 75.9 E(85289): 9.1e-13
Smith-Waterman score: 343; 38.0% identity (58.9% similar) in 129 aa overlap (301-428:648-768)
280 290 300 310 320 330
pF1KE6 LTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSN
:. . : ::.::: ::.: . : : ....
NP_997 RPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQ
620 630 640 650 660 670
340 350 360 370 380 390
pF1KE6 RVVADQYCHYYPENIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEED
..: :. : . .: : :: .::: ::.. : ::..:: :::.: : :..
NP_997 QTVNDSLCDMVH---RPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP-
680 690 700 710 720 730
400 410 420 430
pF1KE6 IQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPVTVPSFFVH
:.. . : .: : : :: :::: : .::
NP_997 --GETPAPPE-EC-RDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQL
740 750 760 770 780
NP_997 LTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRL
790 800 810 820 830 840
>--
initn: 248 init1: 194 opt: 285 Z-score: 291.0 bits: 64.9 E(85289): 1.8e-09
Smith-Waterman score: 285; 29.7% identity (55.2% similar) in 172 aa overlap (257-423:1387-1547)
230 240 250 260 270 280
pF1KE6 LETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNS--GS
...:...:. . : .:.. :. .:
NP_997 VSLENEGTYVCIATNALGKAVATSVLHLLERRWPESRIVFLQG--HKKYILQATNTRTNS
1360 1370 1380 1390 1400 1410
290 300 310 320 330 340
pF1KE6 ADSTVQFIFYQPIIHRWRETDFFPCSATCGG-GYQLTSAECYDLRSNRVVADQYCHYYPE
: : . .:. :. .. :::::: : .. .: . ... :.. : .
NP_997 NDPTGEPPPQEPF---WEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQ-
1420 1430 1440 1450 1460
350 360 370 380 390 400
pF1KE6 NIKPKPKLQECNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC
:: .. ::. ::::: .. :. :: ::: : .:: :.: . .: : : :
NP_997 --KPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC
1470 1480 1490 1500 1510 1520
410 420 430
pF1KE6 MYTPK-MPIA-QPCNIFDCPKWLAQEWSPVTVPSFFVH
.:: :.. .:: : .:
NP_997 --APKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKR
1530 1540 1550 1560 1570 1580
>--
initn: 224 init1: 96 opt: 226 Z-score: 230.8 bits: 53.8 E(85289): 4.1e-06
Smith-Waterman score: 226; 30.5% identity (51.7% similar) in 118 aa overlap (309-422:771-882)
280 290 300 310 320 330
pF1KE6 IRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV---VAD
:: ::::: : . : .: .. ..:
NP_997 EECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSD
750 760 770 780 790 800
340 350 360 370 380 390
pF1KE6 QYCHYYPENIKPKPKLQE-CNLDPCPARWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH
. :. :: . .. : :: . . :. :: ::: ::: : : . .:.
NP_997 ELCQ------GPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGR
810 820 830 840 850
400 410 420 430
pF1KE6 VTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPVTVPSFFVH
. : : : .:... :.. .: :
NP_997 RIPLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRI
860 870 880 890 900 910
439 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:42:07 2016 done: Tue Nov 8 12:42:08 2016
Total Scan time: 7.250 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]