Result of FASTA (omim) for
pFN21AE6475
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6475, 473 aa
1>>>pF1KE6475 473 - 473 aa - 473 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.5498+/-0.000462; mu= 21.9834+/- 0.028
mean_var=63.9848+/-13.762, 0's: 0 Z-trim(109.1): 49 B-trim: 665 in 1/49
Lambda= 0.160338
statistics sampled from 17216 (17265) to 17216 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.559), E-opt: 0.2 (0.202), width: 16
Scan time: 5.470
The best scores are: opt bits E(85289)
NP_001308716 (OMIM: 604943,613865) prestin isoform ( 653) 3032 710.8 2.8e-204
NP_001161434 (OMIM: 604943,613865) prestin isoform ( 712) 3032 710.9 2.9e-204
NP_996767 (OMIM: 604943,613865) prestin isoform c ( 516) 2827 663.3 4.4e-190
NP_996766 (OMIM: 604943,613865) prestin isoform b ( 685) 2827 663.4 5.4e-190
XP_011514472 (OMIM: 604943,613865) PREDICTED: pres ( 744) 2827 663.5 5.7e-190
NP_945350 (OMIM: 604943,613865) prestin isoform a ( 744) 2827 663.5 5.7e-190
NP_996768 (OMIM: 604943,613865) prestin isoform d ( 335) 2109 497.1 3.2e-140
NP_001035544 (OMIM: 610068) solute carrier family ( 738) 1291 308.1 5.2e-83
NP_602298 (OMIM: 610068) solute carrier family 26 ( 740) 1291 308.1 5.2e-83
NP_599025 (OMIM: 610068) solute carrier family 26 ( 758) 1291 308.2 5.3e-83
NP_075062 (OMIM: 610068) solute carrier family 26 ( 759) 1291 308.2 5.3e-83
XP_011514169 (OMIM: 126650,214700) PREDICTED: chlo ( 764) 1251 298.9 3.2e-80
NP_000102 (OMIM: 126650,214700) chloride anion exc ( 764) 1251 298.9 3.2e-80
XP_016867807 (OMIM: 274600,600791,605646) PREDICTE ( 754) 1240 296.4 1.9e-79
NP_000432 (OMIM: 274600,600791,605646) pendrin [Ho ( 780) 1224 292.7 2.5e-78
XP_005250482 (OMIM: 274600,600791,605646) PREDICTE ( 780) 1224 292.7 2.5e-78
XP_006716088 (OMIM: 274600,600791,605646) PREDICTE ( 423) 1152 275.8 1.6e-73
XP_011507426 (OMIM: 608481) PREDICTED: solute carr ( 466) 1123 269.1 1.8e-71
NP_443166 (OMIM: 608481) solute carrier family 26 ( 791) 1123 269.3 2.7e-71
NP_599152 (OMIM: 608481) solute carrier family 26 ( 887) 1123 269.4 2.9e-71
XP_011507423 (OMIM: 608481) PREDICTED: solute carr ( 702) 870 210.7 1e-53
NP_001269285 (OMIM: 608479) anion exchange transpo ( 656) 822 199.6 2.2e-50
NP_439897 (OMIM: 608479) anion exchange transporte ( 656) 822 199.6 2.2e-50
NP_599028 (OMIM: 608479) anion exchange transporte ( 663) 822 199.6 2.2e-50
XP_011512596 (OMIM: 606766,608480) PREDICTED: test ( 944) 745 181.9 6.5e-45
NP_000103 (OMIM: 222600,226900,256050,600972,60671 ( 739) 736 179.8 2.3e-44
XP_016864680 (OMIM: 222600,226900,256050,600972,60 ( 739) 736 179.8 2.3e-44
NP_443193 (OMIM: 606766,608480) testis anion trans ( 970) 697 170.9 1.5e-41
XP_016865724 (OMIM: 606766,608480) PREDICTED: test ( 970) 697 170.9 1.5e-41
NP_001180405 (OMIM: 606766,608480) testis anion tr ( 970) 697 170.9 1.5e-41
NP_998778 (OMIM: 167030,610130) sulfate anion tran ( 701) 695 170.3 1.6e-41
NP_071325 (OMIM: 167030,610130) sulfate anion tran ( 701) 695 170.3 1.6e-41
XP_011507424 (OMIM: 608481) PREDICTED: solute carr ( 627) 691 169.3 2.8e-41
NP_001268662 (OMIM: 610068) solute carrier family ( 651) 608 150.1 1.7e-35
NP_001268661 (OMIM: 610068) solute carrier family ( 723) 598 147.8 9.2e-35
NP_001159821 (OMIM: 610117) sodium-independent sul ( 606) 396 101.0 9.4e-21
NP_775897 (OMIM: 610117) sodium-independent sulfat ( 606) 396 101.0 9.4e-21
NP_001159820 (OMIM: 610117) sodium-independent sul ( 606) 396 101.0 9.4e-21
NP_001159819 (OMIM: 610117) sodium-independent sul ( 606) 396 101.0 9.4e-21
XP_016879996 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 336 87.2 1.5e-16
XP_006721896 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 336 87.2 1.5e-16
NP_602297 (OMIM: 167030,610130) sulfate anion tran ( 224) 331 85.6 1.5e-16
XP_016879995 (OMIM: 610117) PREDICTED: sodium-inde ( 677) 336 87.2 1.5e-16
XP_016879994 (OMIM: 610117) PREDICTED: sodium-inde ( 696) 336 87.2 1.6e-16
NP_619732 (OMIM: 606766,608480) testis anion trans ( 865) 310 81.3 1.2e-14
NP_001269286 (OMIM: 608479) anion exchange transpo ( 355) 216 59.2 2.2e-08
XP_011522956 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 206 57.0 1.3e-07
XP_011522955 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 206 57.0 1.3e-07
XP_011522954 (OMIM: 610117) PREDICTED: sodium-inde ( 465) 206 57.0 1.3e-07
>>NP_001308716 (OMIM: 604943,613865) prestin isoform f [ (653 aa)
initn: 3032 init1: 3032 opt: 3032 Z-score: 3788.6 bits: 710.8 E(85289): 2.8e-204
Smith-Waterman score: 3032; 100.0% identity (100.0% similar) in 472 aa overlap (1-472:1-472)
10 20 30 40 50 60
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
370 380 390 400 410 420
430 440 450 460 470
pF1KE6 ILLVILATGFLFESLPQTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQR
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLVILATGFLFESLPQTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLG
430 440 450 460 470 480
NP_001 KLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARR
490 500 510 520 530 540
>>NP_001161434 (OMIM: 604943,613865) prestin isoform e [ (712 aa)
initn: 3032 init1: 3032 opt: 3032 Z-score: 3788.1 bits: 710.9 E(85289): 2.9e-204
Smith-Waterman score: 3032; 100.0% identity (100.0% similar) in 472 aa overlap (1-472:1-472)
10 20 30 40 50 60
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
370 380 390 400 410 420
430 440 450 460 470
pF1KE6 ILLVILATGFLFESLPQTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQR
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLVILATGFLFESLPQTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLG
430 440 450 460 470 480
NP_001 KLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARR
490 500 510 520 530 540
>>NP_996767 (OMIM: 604943,613865) prestin isoform c [Hom (516 aa)
initn: 3022 init1: 2826 opt: 2827 Z-score: 3533.6 bits: 663.3 E(85289): 4.4e-190
Smith-Waterman score: 2958; 93.7% identity (93.7% similar) in 504 aa overlap (1-472:1-504)
10 20 30 40 50 60
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
370 380 390 400 410 420
430 440
pF1KE6 ILLVILATGFLFESLPQ--------------------------------TIWLTTFVSSL
::::::::::::::::: :::::::::::
NP_996 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
430 440 450 460 470 480
450 460 470
pF1KE6 FLGLDYGLITAVIIALLTVIYRTQR
::::::::::::::::::::::::
NP_996 FLGLDYGLITAVIIALLTVIYRTQSFHTEMTRRWRP
490 500 510
>>NP_996766 (OMIM: 604943,613865) prestin isoform b [Hom (685 aa)
initn: 3022 init1: 2826 opt: 2827 Z-score: 3532.0 bits: 663.4 E(85289): 5.4e-190
Smith-Waterman score: 2958; 93.7% identity (93.7% similar) in 504 aa overlap (1-472:1-504)
10 20 30 40 50 60
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
370 380 390 400 410 420
430 440
pF1KE6 ILLVILATGFLFESLPQ--------------------------------TIWLTTFVSSL
::::::::::::::::: :::::::::::
NP_996 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
430 440 450 460 470 480
450 460 470
pF1KE6 FLGLDYGLITAVIIALLTVIYRTQR
::::::::::::::::::::::::
NP_996 FLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQI
490 500 510 520 530 540
>>XP_011514472 (OMIM: 604943,613865) PREDICTED: prestin (744 aa)
initn: 3022 init1: 2826 opt: 2827 Z-score: 3531.5 bits: 663.5 E(85289): 5.7e-190
Smith-Waterman score: 2958; 93.7% identity (93.7% similar) in 504 aa overlap (1-472:1-504)
10 20 30 40 50 60
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
370 380 390 400 410 420
430 440
pF1KE6 ILLVILATGFLFESLPQ--------------------------------TIWLTTFVSSL
::::::::::::::::: :::::::::::
XP_011 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
430 440 450 460 470 480
450 460 470
pF1KE6 FLGLDYGLITAVIIALLTVIYRTQR
::::::::::::::::::::::::
XP_011 FLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQI
490 500 510 520 530 540
>>NP_945350 (OMIM: 604943,613865) prestin isoform a [Hom (744 aa)
initn: 3022 init1: 2826 opt: 2827 Z-score: 3531.5 bits: 663.5 E(85289): 5.7e-190
Smith-Waterman score: 2958; 93.7% identity (93.7% similar) in 504 aa overlap (1-472:1-504)
10 20 30 40 50 60
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
370 380 390 400 410 420
430 440
pF1KE6 ILLVILATGFLFESLPQ--------------------------------TIWLTTFVSSL
::::::::::::::::: :::::::::::
NP_945 ILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSL
430 440 450 460 470 480
450 460 470
pF1KE6 FLGLDYGLITAVIIALLTVIYRTQR
::::::::::::::::::::::::
NP_945 FLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQI
490 500 510 520 530 540
>>NP_996768 (OMIM: 604943,613865) prestin isoform d [Hom (335 aa)
initn: 2109 init1: 2109 opt: 2109 Z-score: 2638.5 bits: 497.1 E(85289): 3.2e-140
Smith-Waterman score: 2109; 99.7% identity (100.0% similar) in 325 aa overlap (1-325:1-325)
10 20 30 40 50 60
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_996 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
::::::::::::::::::::::::.
NP_996 TGISAGFNLKESYNVDVVGTLPLGFHTEMTRRWRP
310 320 330
>>NP_001035544 (OMIM: 610068) solute carrier family 26 m (738 aa)
initn: 1385 init1: 868 opt: 1291 Z-score: 1611.4 bits: 308.1 E(85289): 5.2e-83
Smith-Waterman score: 1340; 43.8% identity (75.5% similar) in 489 aa overlap (16-472:8-488)
10 20 30 40 50 60
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLKQAFTCTPKKIRNI
:..:::.... :.: : ..: . . . . :. . .
NP_001 MDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWRTWLQCSRARAYAL
10 20 30 40
70 80 90 100 110 120
pF1KE6 IYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPV
. . ::. ::: : ....::::.::.:....:::::::.:.::..::.::::::::::
NP_001 LLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPV
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 IMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNGTEARDALRVKVAM
..: ..:::::::.: :::.:.:.:.:. :.:. . . .: : :::: ::.::
NP_001 FIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET----ARDAARVQVAS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE6 SVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGI
....: :..: ::. .::::. ::.::::::.::::::.::.:.:::.::.. . .::
NP_001 TLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGP
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE6 FSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMG
.:..:... : .. . .: .. .. .. .:. : .:......:: ::: :..... .
NP_001 LSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGA
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE6 TGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKT
:::: :..::. ..:::::..: ::.::. :.:.:: . .:..::.:::...::..:
NP_001 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE6 LANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLM
.: .:::.::.::::.:::: : ::..:: : .:::.:::::::.:::..:.:: ..::.
NP_001 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF
350 360 370 380 390 400
430 440
pF1KE6 ILLVILATGFLFESLPQT--------------------------------IWLTTFVSSL
:::.:. : ::..::.. :::.::....
NP_001 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI
410 420 430 440 450 460
450 460 470
pF1KE6 FLGLDYGLITAVIIALLTVIYRTQR
.:.:: ::..:::..:: :. :::
NP_001 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS
470 480 490 500 510 520
>>NP_602298 (OMIM: 610068) solute carrier family 26 memb (740 aa)
initn: 1385 init1: 868 opt: 1291 Z-score: 1611.3 bits: 308.1 E(85289): 5.2e-83
Smith-Waterman score: 1340; 43.8% identity (75.5% similar) in 489 aa overlap (16-472:29-509)
10 20 30 40
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLK
:..:::.... :.: : ..: . . .
NP_602 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWR
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 QAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAV
. :. . .. . ::. ::: : ....::::.::.:....:::::::.:.::..
NP_602 TWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 PPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNG
::.::::::::::..: ..:::::::.: :::.:.:.:.:. :.:. . . .: :
NP_602 PPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET--
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLK
:::: ::.:: ....: :..: ::. .::::. ::.::::::.::::::.::.:.::
NP_602 --ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 YLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLP
:.::.. . .:: .:..:... : .. . .: .. .. .. .:. : .:......::
NP_602 YVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLP
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE6 APIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIA
::: :..... .:::: :..::. ..:::::..: ::.::. :.:.:: . .:..::
NP_602 MPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE6 IVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTG
.:::...::..: .: .:::.::.::::.:::: : ::..:: : .:::.:::::::.::
NP_602 VVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTG
360 370 380 390 400 410
410 420 430
pF1KE6 GKTQLAGCLASLMILLVILATGFLFESLPQT-----------------------------
:..:.:: ..::.:::.:. : ::..::..
NP_602 GNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRA
420 430 440 450 460 470
440 450 460 470
pF1KE6 ---IWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQR
:::.::.....:.:: ::..:::..:: :. :::
NP_602 DLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYS
480 490 500 510 520 530
NP_602 EAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQ
540 550 560 570 580 590
>>NP_599025 (OMIM: 610068) solute carrier family 26 memb (758 aa)
initn: 1385 init1: 868 opt: 1291 Z-score: 1611.2 bits: 308.2 E(85289): 5.3e-83
Smith-Waterman score: 1340; 43.8% identity (75.5% similar) in 489 aa overlap (16-472:29-509)
10 20 30 40
pF1KE6 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLK
:..:::.... :.: : ..: . . .
NP_599 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWR
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 QAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAV
. :. . .. . ::. ::: : ....::::.::.:....:::::::.:.::..
NP_599 TWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGL
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 PPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNG
::.::::::::::..: ..:::::::.: :::.:.:.:.:. :.:. . . .: :
NP_599 PPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET--
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLK
:::: ::.:: ....: :..: ::. .::::. ::.::::::.::::::.::.:.::
NP_599 --ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 YLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLP
:.::.. . .:: .:..:... : .. . .: .. .. .. .:. : .:......::
NP_599 YVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLP
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE6 APIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIA
::: :..... .:::: :..::. ..:::::..: ::.::. :.:.:: . .:..::
NP_599 MPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE6 IVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTG
.:::...::..: .: .:::.::.::::.:::: : ::..:: : .:::.:::::::.::
NP_599 VVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTG
360 370 380 390 400 410
410 420 430
pF1KE6 GKTQLAGCLASLMILLVILATGFLFESLPQT-----------------------------
:..:.:: ..::.:::.:. : ::..::..
NP_599 GNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRA
420 430 440 450 460 470
440 450 460 470
pF1KE6 ---IWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQR
:::.::.....:.:: ::..:::..:: :. :::
NP_599 DLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYS
480 490 500 510 520 530
NP_599 EAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQ
540 550 560 570 580 590
473 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:39:41 2016 done: Tue Nov 8 13:39:42 2016
Total Scan time: 5.470 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]