FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1718, 224 aa 1>>>pF1KE1718 224 - 224 aa - 224 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0967+/-0.000413; mu= 14.2730+/- 0.025 mean_var=57.5582+/-11.886, 0's: 0 Z-trim(109.8): 39 B-trim: 70 in 2/47 Lambda= 0.169052 statistics sampled from 18013 (18050) to 18013 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.591), E-opt: 0.2 (0.212), width: 16 Scan time: 4.970 The best scores are: opt bits E(85289) NP_001315986 (OMIM: 123260) C-reactive protein iso ( 224) 1502 374.8 6.4e-104 NP_000558 (OMIM: 123260) C-reactive protein isofor ( 224) 1502 374.8 6.4e-104 NP_001630 (OMIM: 104770) serum amyloid P-component ( 223) 777 198.0 1.1e-50 NP_001315987 (OMIM: 123260) C-reactive protein iso ( 91) 435 114.4 6.4e-26 NP_002513 (OMIM: 602367) neuronal pentraxin-1 prec ( 432) 304 82.8 1e-15 NP_001013680 (OMIM: 613442) pentraxin-4 isoform 2 ( 473) 289 79.1 1.4e-14 NP_001315537 (OMIM: 613442) pentraxin-4 isoform 1 ( 478) 289 79.1 1.4e-14 NP_055108 (OMIM: 609474) neuronal pentraxin recept ( 500) 281 77.2 5.6e-14 NP_002514 (OMIM: 600750) neuronal pentraxin-2 prec ( 431) 277 76.2 9.7e-14 NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 266 73.9 3.9e-12 NP_002843 (OMIM: 602492) pentraxin-related protein ( 381) 250 69.6 8.4e-12 XP_016866574 (OMIM: 612243,616503) PREDICTED: G-pr (1116) 159 47.6 0.0001 NP_001027566 (OMIM: 612243,616503) G-protein coupl (1193) 159 47.6 0.00011 NP_065188 (OMIM: 612243,616503) G-protein coupled (1221) 159 47.6 0.00011 XP_005267118 (OMIM: 612243,616503) PREDICTED: G-pr (1222) 159 47.6 0.00011 NP_001027567 (OMIM: 612243,616503) G-protein coupl (1222) 159 47.6 0.00011 XP_006715581 (OMIM: 612243,616503) PREDICTED: G-pr (1223) 159 47.6 0.00011 XP_006715580 (OMIM: 612243,616503) PREDICTED: G-pr (1249) 159 47.6 0.00011 XP_011534266 (OMIM: 612243,616503) PREDICTED: G-pr (1250) 159 47.6 0.00011 NP_940971 (OMIM: 612243,616503) G-protein coupled (1250) 159 47.6 0.00011 XP_006715579 (OMIM: 612243,616503) PREDICTED: G-pr (1251) 159 47.6 0.00011 >>NP_001315986 (OMIM: 123260) C-reactive protein isoform (224 aa) initn: 1502 init1: 1502 opt: 1502 Z-score: 1986.7 bits: 374.8 E(85289): 6.4e-104 Smith-Waterman score: 1502; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224) 10 20 30 40 50 60 pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW 130 140 150 160 170 180 190 200 210 220 pF1KE1 DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP :::::::::::::::::::::::::::::::::::::::::::: NP_001 DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP 190 200 210 220 >>NP_000558 (OMIM: 123260) C-reactive protein isoform 1 (224 aa) initn: 1502 init1: 1502 opt: 1502 Z-score: 1986.7 bits: 374.8 E(85289): 6.4e-104 Smith-Waterman score: 1502; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224) 10 20 30 40 50 60 pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW 130 140 150 160 170 180 190 200 210 220 pF1KE1 DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP :::::::::::::::::::::::::::::::::::::::::::: NP_000 DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP 190 200 210 220 >>NP_001630 (OMIM: 104770) serum amyloid P-component pre (223 aa) initn: 769 init1: 582 opt: 777 Z-score: 1031.1 bits: 198.0 E(85289): 1.1e-50 Smith-Waterman score: 777; 51.3% identity (79.5% similar) in 224 aa overlap (1-223:1-222) 10 20 30 40 50 pF1KE1 MEKLLCFL-VLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYT :.: : .. ::::: .::..::.: :.::::.:: :..:.: .:: :::. ::.:.. :. NP_001 MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 ELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWE .:: :.::.::: :. .:::.:.. . ::. .: .. .: : ::::::.::: NP_001 DLS--RAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWE 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 SASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNM :.:::.:::..: : :.:.:..:: : :. .:.:::::::.::.:. :::.::.::.. : NP_001 SSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYM 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 WDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP :: :: :..: . : : :. :.:.:.::.::..: :. :: .: NP_001 WDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 180 190 200 210 220 >>NP_001315987 (OMIM: 123260) C-reactive protein isoform (91 aa) initn: 432 init1: 432 opt: 435 Z-score: 586.4 bits: 114.4 E(85289): 6.4e-26 Smith-Waterman score: 435; 79.8% identity (91.7% similar) in 84 aa overlap (1-84:1-84) 10 20 30 40 50 60 pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES :::::: ..... . . . . .: NP_001 LSSTRGPNVLNWRALKYEVQGEVFTKPQLWP 70 80 90 >>NP_002513 (OMIM: 602367) neuronal pentraxin-1 precurso (432 aa) initn: 223 init1: 138 opt: 304 Z-score: 403.2 bits: 82.8 E(85289): 1e-15 Smith-Waterman score: 304; 29.5% identity (61.4% similar) in 207 aa overlap (18-214:218-418) 10 20 30 40 pF1KE1 MEKLLCFLVLTSLSHAFGQTDM---SRKAFVFPKESDTSYVSLKAPL :: : .. ..:: ... :...: : NP_002 KGGPRNDTEERVKIETALTSLHQRISELEKGQKDNRPGDKFQLTFPLRTNYMYAKVKKSL 190 200 210 220 230 240 50 60 70 80 90 100 pF1KE1 TKPLKAFTVCLHFYTELSSTRGYSI-FSYATKRQDNE-ILIFWSKDIGYSFTVGGSEILF . . :::::. . . :.: : . ::::. : :: .:: :... . . .. . NP_002 PE-MYAFTVCM--WLKSSATPGVGTPFSYAVPGQANELVLIEWGNN---PMEILINDKVA 250 260 270 280 290 300 110 120 130 140 150 pF1KE1 EVPEVTVAPV--HICTSWESASGIVEFWVDG-KPRVRKSLKKGYTVGAEASIILGQEQDS ..: : :::..: . .:. : . :: . ..: . . .. ..::::::. NP_002 KLPFVINDGKWHHICVTWTTRDGVWEAYQDGTQGGSGENLAPYHPIKPQGVLVLGQEQDT 310 320 330 340 350 360 160 170 180 190 200 210 pF1KE1 FGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGP--FSPNVLNWRALKYEVQGEVF .::.:...:..::.... :.:: :.: :. .. . .: ::. : . :. : NP_002 LGGGFDATQAFVGELAHFNIWDRKLTPGEVYNLATCSTKALSGNVIAWAESHIEIYGGAT 370 380 390 400 410 420 220 pF1KE1 TKPQLWP NP_002 KWTFEACRQIN 430 >>NP_001013680 (OMIM: 613442) pentraxin-4 isoform 2 [Hom (473 aa) initn: 247 init1: 177 opt: 289 Z-score: 382.8 bits: 79.1 E(85289): 1.4e-14 Smith-Waterman score: 289; 30.4% identity (63.0% similar) in 181 aa overlap (27-198:268-443) 10 20 30 40 50 pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLH .:::. : . : :. .. :.:.. : NP_001 RVLSGTAPKDPRQQAWSPQVPGEICGVGPTLVFPNASTRNVVFLSPGFVTALRALSFCS- 240 250 260 270 280 290 60 70 80 90 100 110 pF1KE1 FYTELSSTRGYSIFSYATKRQDNEILIFWSKDI---GYSFTVGGSEILFEVPEVTVAPV- ... .: : ...::::. .::. :.. ..: : : :. . :.: . NP_001 -WVRTASGRLGTLLSYATEDNDNK-LVLHGRDSLLPGSIHFVIGDPAFRELPLQLLLDGQ 300 310 320 330 340 350 120 130 140 150 160 pF1KE1 --HICTSWESASGIVEFWVDGKPRVRKS---LKKGYTVGAEASIILGQEQDSFGGNFEGS :::. : :..: ..:. :. . ...:: . .:..::::::: ::.:..: NP_001 WHHICVIWTSTQG--RYWLHVDRRLVATGSRFREGYEIPPGGSLVLGQEQDSVGGGFDSS 360 370 380 390 400 410 170 180 190 200 210 220 pF1KE1 QSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP ...::..... .:: .: : :. .. .: : NP_001 EAFVGSMSGLAIWDRALVPGEVANLAIGKEFPTGAILTLANAALAGGFVQGANCTCLERC 420 430 440 450 460 470 NP_001 P >>NP_001315537 (OMIM: 613442) pentraxin-4 isoform 1 prec (478 aa) initn: 247 init1: 177 opt: 289 Z-score: 382.8 bits: 79.1 E(85289): 1.4e-14 Smith-Waterman score: 289; 30.4% identity (63.0% similar) in 181 aa overlap (27-198:273-448) 10 20 30 40 50 pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLH .:::. : . : :. .. :.:.. : NP_001 RVLSGTAPKDPRQQAWSPQVPGEICGVGPTLVFPNASTRNVVFLSPGFVTALRALSFCS- 250 260 270 280 290 300 60 70 80 90 100 110 pF1KE1 FYTELSSTRGYSIFSYATKRQDNEILIFWSKDI---GYSFTVGGSEILFEVPEVTVAPV- ... .: : ...::::. .::. :.. ..: : : :. . :.: . NP_001 -WVRTASGRLGTLLSYATEDNDNK-LVLHGRDSLLPGSIHFVIGDPAFRELPLQLLLDGQ 310 320 330 340 350 120 130 140 150 160 pF1KE1 --HICTSWESASGIVEFWVDGKPRVRKS---LKKGYTVGAEASIILGQEQDSFGGNFEGS :::. : :..: ..:. :. . ...:: . .:..::::::: ::.:..: NP_001 WHHICVIWTSTQG--RYWLHVDRRLVATGSRFREGYEIPPGGSLVLGQEQDSVGGGFDSS 360 370 380 390 400 410 170 180 190 200 210 220 pF1KE1 QSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP ...::..... .:: .: : :. .. .: : NP_001 EAFVGSMSGLAIWDRALVPGEVANLAIGKEFPTGAILTLANAALAGGFVQGANCTCLERC 420 430 440 450 460 470 NP_001 P >>NP_055108 (OMIM: 609474) neuronal pentraxin receptor [ (500 aa) initn: 255 init1: 165 opt: 281 Z-score: 371.9 bits: 77.2 E(85289): 5.6e-14 Smith-Waterman score: 281; 27.6% identity (59.6% similar) in 203 aa overlap (14-214:285-484) 10 20 30 40 pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAP : :.. : . . .: ... :. .. NP_055 ALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKIS--IPIRNNYMYARVRKA 260 270 280 290 300 310 50 60 70 80 90 100 pF1KE1 LTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFE : . : :::.:. . .. :.: . :::.. : :::... . . . .. . . NP_055 LPE-LYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLP 320 330 340 350 360 370 110 120 130 140 150 160 pF1KE1 VPEVTVAPVHICTSWESASGIVEFWVDGKPRVR-KSLKKGYTVGAEASIILGQEQDSFGG . . ::: .: . .:. . ::. . ..: . . .. .:::::::..:: NP_055 LSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGG 380 390 400 410 420 430 170 180 190 200 210 220 pF1KE1 NFEGSQSLVGDIGNVNMWDFVLSPDEINTIY-LGGPFSPNVLNWRALKYEVQGEVFTKPQ :...:..::::.. :.:: .:.: .. : .:. ::: :. :. : NP_055 RFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAF 440 450 460 470 480 490 pF1KE1 LWP NP_055 DVCKGRAKA 500 >>NP_002514 (OMIM: 600750) neuronal pentraxin-2 precurso (431 aa) initn: 244 init1: 149 opt: 277 Z-score: 367.7 bits: 76.2 E(85289): 9.7e-14 Smith-Waterman score: 277; 30.4% identity (57.9% similar) in 214 aa overlap (16-224:218-420) 10 20 30 40 pF1KE1 MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLT :: . : . . .: ... : ..: : NP_002 HNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVS--LPLRTNYLYGKIKKTLP 190 200 210 220 230 240 50 60 70 80 90 100 pF1KE1 KPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEI-LIFWSKDIGYSFTVGGSEILFEV . : :::.:: . . : : . ::::. : ::: :: :... . . .. . .. NP_002 E-LYAFTICLWLRSSASPGIG-TPFSYAVPGQANEIVLIEWGNN---PIELLINDKVAQL 250 260 270 280 290 300 110 120 130 140 150 160 pF1KE1 PEVTVAPV--HICTSWESASGIVEFWVDG-KPRVRKSLKKGYTVGAEASIILGQEQDSFG : . :::..: . .:. : . :: : . ..: . . . .:::::::. : NP_002 PLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVG 310 320 330 340 350 360 170 180 190 200 210 220 pF1KE1 GNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSP-NVLNWRALKYEVQGEVFTKP : :...:..::.... :.:: :: .:: .: . : :.. : . . .:: NP_002 GRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPW----VDNNVDVFGGA 370 380 390 400 410 pF1KE1 QLWP . :: NP_002 SKWPVETCEERLLDL 420 430 >>NP_699197 (OMIM: 611691) sushi, von Willebrand factor (3571 aa) initn: 211 init1: 147 opt: 266 Z-score: 339.0 bits: 73.9 E(85289): 3.9e-12 Smith-Waterman score: 266; 31.7% identity (64.0% similar) in 186 aa overlap (37-216:1438-1619) 10 20 30 40 50 60 pF1KE1 FLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRG :: : . : . :.:.: : :. . :. . NP_699 KCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVMLDGMLPS-LHALT-CT-FWMKSSDDMN 1410 1420 1430 1440 1450 1460 70 80 90 100 110 120 pF1KE1 YSI-FSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVH-ICTSWESASGI :. .:::. ... :.. . . :. . :.: : . . : :. . : : .: ::.:: NP_699 YGTPISYAVDNGSDNTLLLTDYN-GWVLYVNGREKITNCPSVNDGRWHHIAITWTSANGI 1470 1480 1490 1500 1510 1520 130 140 150 160 170 180 pF1KE1 VEFWVDGK-PRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFV . ..::: .:. : . . ....::::::. : .: ..:.::.:...:.::.: NP_699 WKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKKGEGFSPAESFVGSISQLNLWDYV 1530 1540 1550 1560 1570 1580 190 200 210 220 pF1KE1 LSPDEINTIYLGGPF---SPNVLNWRALKYEVQGEVFTKPQLWP :::...... . : . ::: : . . :.: NP_699 LSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVKIDSKSIFCSDCPRLGGSVPHLRT 1590 1600 1610 1620 1630 1640 NP_699 ASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLENGFHSA 1650 1660 1670 1680 1690 1700 224 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 23:25:22 2016 done: Mon Nov 7 23:25:23 2016 Total Scan time: 4.970 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]