FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6271, 182 aa 1>>>pF1KE6271 182 - 182 aa - 182 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5127+/-0.000421; mu= 16.9858+/- 0.026 mean_var=61.1703+/-12.235, 0's: 0 Z-trim(110.6): 148 B-trim: 17 in 1/52 Lambda= 0.163985 statistics sampled from 18785 (18948) to 18785 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.611), E-opt: 0.2 (0.222), width: 16 Scan time: 3.460 The best scores are: opt bits E(85289) XP_011542782 (OMIM: 601533) PREDICTED: disintegrin ( 579) 486 123.9 4.7e-28 XP_011542781 (OMIM: 601533) PREDICTED: disintegrin ( 609) 486 123.9 4.8e-28 NP_001265043 (OMIM: 601533) disintegrin and metall ( 672) 486 123.9 5.2e-28 XP_005273525 (OMIM: 601533) PREDICTED: disintegrin ( 705) 486 123.9 5.4e-28 NP_001265042 (OMIM: 601533) disintegrin and metall ( 716) 486 123.9 5.5e-28 NP_001455 (OMIM: 601533) disintegrin and metallopr ( 735) 486 123.9 5.6e-28 XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801) 344 90.4 7.7e-18 NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819) 344 90.4 7.8e-18 XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821) 344 90.4 7.8e-18 NP_068566 (OMIM: 604779) disintegrin and metallopr ( 790) 258 70.0 1e-11 XP_011529861 (OMIM: 604778) PREDICTED: disintegrin ( 820) 254 69.1 2e-11 NP_001265054 (OMIM: 604778) disintegrin and metall ( 820) 254 69.1 2e-11 NP_001124176 (OMIM: 604778) disintegrin and metall ( 820) 254 69.1 2e-11 XP_011529862 (OMIM: 604778) PREDICTED: disintegrin ( 820) 254 69.1 2e-11 NP_001265056 (OMIM: 604778) disintegrin and metall ( 820) 254 69.1 2e-11 NP_001124177 (OMIM: 604778) disintegrin and metall ( 820) 254 69.1 2e-11 XP_011529859 (OMIM: 604778) PREDICTED: disintegrin ( 820) 254 69.1 2e-11 XP_011529858 (OMIM: 604778) PREDICTED: disintegrin ( 820) 254 69.1 2e-11 NP_055084 (OMIM: 604778) disintegrin and metallopr ( 820) 254 69.1 2e-11 XP_011529863 (OMIM: 604778) PREDICTED: disintegrin ( 820) 254 69.1 2e-11 NP_001265055 (OMIM: 604778) disintegrin and metall ( 820) 254 69.1 2e-11 NP_001124175 (OMIM: 604778) disintegrin and metall ( 820) 254 69.1 2e-11 NP_003805 (OMIM: 603712) disintegrin and metallopr ( 776) 247 67.4 6.1e-11 XP_005268208 (OMIM: 603712) PREDICTED: disintegrin ( 776) 247 67.4 6.1e-11 NP_003804 (OMIM: 603713) disintegrin and metallopr ( 722) 235 64.6 4.1e-10 NP_003808 (OMIM: 607310) disintegrin and metallopr ( 754) 220 61.0 5e-09 XP_016869432 (OMIM: 607310) PREDICTED: disintegrin ( 755) 220 61.0 5e-09 NP_068547 (OMIM: 606188) disintegrin and metallopr ( 540) 212 59.0 1.4e-08 XP_005273439 (OMIM: 606188) PREDICTED: disintegrin ( 621) 212 59.1 1.6e-08 XP_011542671 (OMIM: 606188) PREDICTED: disintegrin ( 673) 212 59.1 1.7e-08 XP_011542670 (OMIM: 606188) PREDICTED: disintegrin ( 728) 212 59.1 1.8e-08 XP_006716337 (OMIM: 606188) PREDICTED: disintegrin ( 728) 212 59.1 1.8e-08 XP_016868464 (OMIM: 606188) PREDICTED: disintegrin ( 732) 212 59.1 1.8e-08 NP_055294 (OMIM: 606393) ADAM DEC1 isoform 1 precu ( 470) 210 58.5 1.8e-08 XP_005273437 (OMIM: 606188) PREDICTED: disintegrin ( 736) 212 59.1 1.8e-08 XP_016868463 (OMIM: 606188) PREDICTED: disintegrin ( 741) 212 59.1 1.8e-08 XP_011542669 (OMIM: 606188) PREDICTED: disintegrin ( 746) 212 59.1 1.8e-08 NP_001291280 (OMIM: 606188) disintegrin and metall ( 754) 212 59.1 1.9e-08 XP_006716336 (OMIM: 606188) PREDICTED: disintegrin ( 767) 212 59.1 1.9e-08 NP_055080 (OMIM: 606188) disintegrin and metallopr ( 775) 212 59.1 1.9e-08 XP_011527669 (OMIM: 607114) PREDICTED: disintegrin ( 812) 209 58.5 3.2e-08 XP_016870955 (OMIM: 602267) PREDICTED: disintegrin ( 779) 202 56.8 9.8e-08 XP_011537419 (OMIM: 602267) PREDICTED: disintegrin ( 863) 202 56.8 1.1e-07 XP_016870954 (OMIM: 602267) PREDICTED: disintegrin ( 889) 202 56.8 1.1e-07 NP_001157961 (OMIM: 602267) disintegrin and metall ( 742) 199 56.1 1.5e-07 NP_001100 (OMIM: 602267) disintegrin and metallopr ( 824) 199 56.1 1.7e-07 XP_016883570 (OMIM: 607114) PREDICTED: disintegrin ( 547) 197 55.5 1.7e-07 NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787) 197 55.6 2.2e-07 NP_001269376 (OMIM: 607114) disintegrin and metall ( 812) 197 55.6 2.3e-07 NP_079496 (OMIM: 607114) disintegrin and metallopr ( 813) 197 55.6 2.3e-07 >>XP_011542782 (OMIM: 601533) PREDICTED: disintegrin and (579 aa) initn: 468 init1: 468 opt: 486 Z-score: 624.7 bits: 123.9 E(85289): 4.7e-28 Smith-Waterman score: 486; 45.0% identity (74.0% similar) in 169 aa overlap (1-169:1-167) 10 20 30 40 50 60 pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL :. .: ::. :: :. . ... ...:::.::.: .: : . : :.:.:.:::..: XP_011 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF ...:::.:: ::.:. :: .. .. :. :::::: .:.: : .: :.:::: ::: XP_011 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL ::.::::::.:::. :::.:::.:.. .::. : . : ..: .:. XP_011 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEHPRTISL 130 140 150 160 170 pF1KE6 ML XP_011 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS 180 190 200 210 220 230 >>XP_011542781 (OMIM: 601533) PREDICTED: disintegrin and (609 aa) initn: 468 init1: 468 opt: 486 Z-score: 624.4 bits: 123.9 E(85289): 4.8e-28 Smith-Waterman score: 486; 45.0% identity (74.0% similar) in 169 aa overlap (1-169:1-167) 10 20 30 40 50 60 pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL :. .: ::. :: :. . ... ...:::.::.: .: : . : :.:.:.:::..: XP_011 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF ...:::.:: ::.:. :: .. .. :. :::::: .:.: : .: :.:::: ::: XP_011 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL ::.::::::.:::. :::.:::.:.. .::. : . : ..: .:. XP_011 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEHPRTISL 130 140 150 160 170 pF1KE6 ML XP_011 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS 180 190 200 210 220 230 >>NP_001265043 (OMIM: 601533) disintegrin and metallopro (672 aa) initn: 468 init1: 468 opt: 486 Z-score: 623.8 bits: 123.9 E(85289): 5.2e-28 Smith-Waterman score: 486; 45.0% identity (74.0% similar) in 169 aa overlap (1-169:1-167) 10 20 30 40 50 60 pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL :. .: ::. :: :. . ... ...:::.::.: .: : . : :.:.:.:::..: NP_001 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF ...:::.:: ::.:. :: .. .. :. :::::: .:.: : .: :.:::: ::: NP_001 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL ::.::::::.:::. :::.:::.:.. .::. : . : ..: .:. NP_001 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEPQQDFAK 130 140 150 160 170 pF1KE6 ML NP_001 YIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIA 180 190 200 210 220 230 >>XP_005273525 (OMIM: 601533) PREDICTED: disintegrin and (705 aa) initn: 468 init1: 468 opt: 486 Z-score: 623.6 bits: 123.9 E(85289): 5.4e-28 Smith-Waterman score: 486; 45.0% identity (74.0% similar) in 169 aa overlap (1-169:1-167) 10 20 30 40 50 60 pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL :. .: ::. :: :. . ... ...:::.::.: .: : . : :.:.:.:::..: XP_005 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF ...:::.:: ::.:. :: .. .. :. :::::: .:.: : .: :.:::: ::: XP_005 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL ::.::::::.:::. :::.:::.:.. .::. : . : ..: .:. XP_005 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEPQQDFAK 130 140 150 160 170 pF1KE6 ML XP_005 YIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIA 180 190 200 210 220 230 >>NP_001265042 (OMIM: 601533) disintegrin and metallopro (716 aa) initn: 468 init1: 468 opt: 486 Z-score: 623.5 bits: 123.9 E(85289): 5.5e-28 Smith-Waterman score: 486; 45.0% identity (74.0% similar) in 169 aa overlap (1-169:1-167) 10 20 30 40 50 60 pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL :. .: ::. :: :. . ... ...:::.::.: .: : . : :.:.:.:::..: NP_001 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF ...:::.:: ::.:. :: .. .. :. :::::: .:.: : .: :.:::: ::: NP_001 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL ::.::::::.:::. :::.:::.:.. .::. : . : ..: .:. NP_001 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEYNHMGSD 130 140 150 160 170 pF1KE6 ML NP_001 TTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEANELLHTFLRWKTSY 180 190 200 210 220 230 >>NP_001455 (OMIM: 601533) disintegrin and metalloprotei (735 aa) initn: 468 init1: 468 opt: 486 Z-score: 623.3 bits: 123.9 E(85289): 5.6e-28 Smith-Waterman score: 486; 45.0% identity (74.0% similar) in 169 aa overlap (1-169:1-167) 10 20 30 40 50 60 pF1KE6 MFLLLALLTELGRLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHL :. .: ::. :: :. . ... ...:::.::.: .: : . : :.:.:.:::..: NP_001 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQF ...:::.:: ::.:. :: .. .. :. :::::: .:.: : .: :.:::: ::: NP_001 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 ENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIIL ::.::::::.:::. :::.:::.:.. .::. : . : ..: .:. NP_001 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLY--NEKDIESRDLSFKLQSVEPQQDFAK 130 140 150 160 170 pF1KE6 ML NP_001 YIEMHVIVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIA 180 190 200 210 220 230 >>XP_011542984 (OMIM: 602713,612775) PREDICTED: disinteg (801 aa) initn: 334 init1: 306 opt: 344 Z-score: 441.3 bits: 90.4 E(85289): 7.7e-18 Smith-Waterman score: 344; 46.2% identity (78.8% similar) in 104 aa overlap (43-145:46-149) 20 30 40 50 60 70 pF1KE6 RLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHLGK-QSFLPQNFL ... :.: .:. . .:: . ...::..:. XP_011 FQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFV 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE6 VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVE :::::. :.: . : .. ::::.::. :: ..:: : ::::.:..:: ::::::.. XP_011 VYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQ 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 SSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIILML .:..::::::.: . XP_011 NSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRY 140 150 160 170 180 190 >>NP_003807 (OMIM: 602713,612775) disintegrin and metall (819 aa) initn: 334 init1: 306 opt: 344 Z-score: 441.1 bits: 90.4 E(85289): 7.8e-18 Smith-Waterman score: 344; 46.2% identity (78.8% similar) in 104 aa overlap (43-145:64-167) 20 30 40 50 60 70 pF1KE6 RLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHLGK-QSFLPQNFL ... :.: .:. . .:: . ...::..:. NP_003 FQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFV 40 50 60 70 80 90 80 90 100 110 120 130 pF1KE6 VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVE :::::. :.: . : .. ::::.::. :: ..:: : ::::.:..:: ::::::.. NP_003 VYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQ 100 110 120 130 140 150 140 150 160 170 180 pF1KE6 SSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIILML .:..::::::.: . NP_003 NSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRY 160 170 180 190 200 210 >>XP_016869431 (OMIM: 602713,612775) PREDICTED: disinteg (821 aa) initn: 334 init1: 306 opt: 344 Z-score: 441.1 bits: 90.4 E(85289): 7.8e-18 Smith-Waterman score: 344; 46.2% identity (78.8% similar) in 104 aa overlap (43-145:66-169) 20 30 40 50 60 70 pF1KE6 RLQAHEGSEGIFLHVTVPRKIKSNDSEVSERKMIYIITIDGQPYTLHLGK-QSFLPQNFL ... :.: .:. . .:: . ...::..:. XP_016 FQQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFV 40 50 60 70 80 90 80 90 100 110 120 130 pF1KE6 VYTYNETGSLHSVSPYFMMHCHYQGYAAEFPNSFVTLSICSGLRGFLQFENISYGIEPVE :::::. :.: . : .. ::::.::. :: ..:: : ::::.:..:: ::::::.. XP_016 VYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQ 100 110 120 130 140 150 140 150 160 170 180 pF1KE6 SSARFEHIIYQMKNNDPNVSILAVNYSHIWQKDQPYKVPLNSQVTVIILML .:..::::::.: . XP_016 NSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRY 160 170 180 190 200 210 >>NP_068566 (OMIM: 604779) disintegrin and metalloprotei (790 aa) initn: 116 init1: 116 opt: 258 Z-score: 331.4 bits: 70.0 E(85289): 1e-11 Smith-Waterman score: 258; 32.2% identity (65.0% similar) in 177 aa overlap (1-168:13-187) 10 20 30 40 pF1KE6 MFLLLA---LLTELGR-LQAHEGSEGIFLHVTVPRKIKSNDSEVSE-- ..:::. :: ::. . : .: .::.:.:. : .::. NP_068 MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKL-SFRGEVQGVV 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 RKMIYIITIDGQPYTLHL-GKQSFLPQNFLVYTYNETGSLHSVSPYFMMHCHYQGYAAEF . :.. . :. ..::: :. .::... :....: : : ::. :.:.: . : NP_068 SPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKES 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 PNSFVTLSIC-SGLRGFLQFENISYGIEPVESSARFEHIIYQMKNNDPNVSILAVNYSHI .: .:.: : .:::: .... : :::...: :::..: .:... . .. ... ..: NP_068 LDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEI 120 130 140 150 160 170 170 180 pF1KE6 -WQKDQPYKVPLNSQVTVIILML :: ::. NP_068 EWQM-APYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMD 180 190 200 210 220 230 182 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:39:55 2016 done: Tue Nov 8 11:39:56 2016 Total Scan time: 3.460 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]