FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5288, 233 aa 1>>>pF1KE5288 233 - 233 aa - 233 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3282+/-0.000282; mu= 16.5092+/- 0.018 mean_var=98.8778+/-20.085, 0's: 0 Z-trim(120.1): 76 B-trim: 206 in 1/56 Lambda= 0.128981 statistics sampled from 34811 (34890) to 34811 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.762), E-opt: 0.2 (0.409), width: 16 Scan time: 7.290 The best scores are: opt bits E(85289) XP_016861343 (OMIM: 610122) PREDICTED: 5-hydroxytr ( 233) 1592 305.6 4.6e-83 NP_872343 (OMIM: 610122) 5-hydroxytryptamine recep ( 279) 1585 304.4 1.3e-82 NP_001138615 (OMIM: 610122) 5-hydroxytryptamine re ( 404) 1585 304.6 1.7e-82 NP_001157118 (OMIM: 610122) 5-hydroxytryptamine re ( 454) 1491 287.1 3.3e-77 NP_938055 (OMIM: 610123) 5-hydroxytryptamine recep ( 441) 974 190.9 3e-48 NP_001243542 (OMIM: 610123) 5-hydroxytryptamine re ( 456) 974 190.9 3.1e-48 NP_938056 (OMIM: 610123) 5-hydroxytryptamine recep ( 456) 974 190.9 3.1e-48 NP_872395 (OMIM: 610123) 5-hydroxytryptamine recep ( 471) 974 190.9 3.1e-48 NP_001243543 (OMIM: 610123) 5-hydroxytryptamine re ( 482) 974 190.9 3.2e-48 NP_570126 (OMIM: 610121) 5-hydroxytryptamine recep ( 447) 530 108.3 2.2e-23 NP_998786 (OMIM: 182139) 5-hydroxytryptamine recep ( 516) 227 52.0 2.3e-06 NP_001155244 (OMIM: 182139) 5-hydroxytryptamine re ( 463) 220 50.6 5.3e-06 NP_000860 (OMIM: 182139) 5-hydroxytryptamine recep ( 484) 220 50.6 5.5e-06 XP_011520457 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 290) 176 42.2 0.0011 XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 176 42.3 0.0014 XP_011508826 (OMIM: 100720,253290,616321,616322,61 ( 390) 163 39.9 0.0074 NP_001298125 (OMIM: 100720,253290,616321,616322,61 ( 416) 163 40.0 0.0077 NP_001243586 (OMIM: 100720,253290,616321,616322,61 ( 502) 163 40.1 0.0088 NP_000742 (OMIM: 100720,253290,616321,616322,61632 ( 517) 163 40.1 0.0089 >>XP_016861343 (OMIM: 610122) PREDICTED: 5-hydroxytrypta (233 aa) initn: 1592 init1: 1592 opt: 1592 Z-score: 1612.2 bits: 305.6 E(85289): 4.6e-83 Smith-Waterman score: 1592; 100.0% identity (100.0% similar) in 233 aa overlap (1-233:1-233) 10 20 30 40 50 60 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 PRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGG 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 SEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 190 200 210 220 230 >>NP_872343 (OMIM: 610122) 5-hydroxytryptamine receptor (279 aa) initn: 1585 init1: 1585 opt: 1585 Z-score: 1604.2 bits: 304.4 E(85289): 1.3e-82 Smith-Waterman score: 1585; 100.0% identity (100.0% similar) in 232 aa overlap (2-233:48-279) 10 20 30 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALS :::::::::::::::::::::::::::::: NP_872 GWSASANWTPSISPSMDRGERSPSALSPTQVAIRRRCRPSPYVVNFLVPSGILIAIDALS 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE5 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE5 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL 140 150 160 170 180 190 160 170 180 190 200 210 pF1KE5 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL 200 210 220 230 240 250 220 230 pF1KE5 LFRLYLLFMASSIITVICLWNT :::::::::::::::::::::: NP_872 LFRLYLLFMASSIITVICLWNT 260 270 >>NP_001138615 (OMIM: 610122) 5-hydroxytryptamine recept (404 aa) initn: 1585 init1: 1585 opt: 1585 Z-score: 1602.2 bits: 304.6 E(85289): 1.7e-82 Smith-Waterman score: 1585; 100.0% identity (100.0% similar) in 232 aa overlap (2-233:173-404) 10 20 30 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALS :::::::::::::::::::::::::::::: NP_001 TRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALS 150 160 170 180 190 200 40 50 60 70 80 90 pF1KE5 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL 210 220 230 240 250 260 100 110 120 130 140 150 pF1KE5 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL 270 280 290 300 310 320 160 170 180 190 200 210 pF1KE5 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL 330 340 350 360 370 380 220 230 pF1KE5 LFRLYLLFMASSIITVICLWNT :::::::::::::::::::::: NP_001 LFRLYLLFMASSIITVICLWNT 390 400 >>NP_001157118 (OMIM: 610122) 5-hydroxytryptamine recept (454 aa) initn: 1502 init1: 1029 opt: 1491 Z-score: 1507.0 bits: 287.1 E(85289): 3.3e-77 Smith-Waterman score: 1491; 95.3% identity (95.7% similar) in 234 aa overlap (2-233:221-454) 10 20 30 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALS :::::::::::::::::::::::::::::: NP_001 TRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALS 200 210 220 230 240 250 40 50 60 70 80 pF1KE5 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHP--SRDQKRGVYF :::::::::::::::::::::::::::::::::::::::::::: : . :::: NP_001 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYF 260 270 280 290 300 310 90 100 110 120 130 140 pF1KE5 ALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGP 320 330 340 350 360 370 150 160 170 180 190 200 pF1KE5 GLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMD 380 390 400 410 420 430 210 220 230 pF1KE5 ALLFRLYLLFMASSIITVICLWNT :::::::::::::::::::::::: NP_001 ALLFRLYLLFMASSIITVICLWNT 440 450 >>NP_938055 (OMIM: 610123) 5-hydroxytryptamine receptor (441 aa) initn: 1262 init1: 974 opt: 974 Z-score: 987.3 bits: 190.9 E(85289): 3e-48 Smith-Waterman score: 1248; 81.9% identity (90.5% similar) in 232 aa overlap (2-233:226-441) 10 20 30 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALS ::::: ::: ::.:.:::::.:.:::::: NP_938 THGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRR--RPSLYVINLLVPSGFLVAIDALS 200 210 220 230 240 250 40 50 60 70 80 90 pF1KE5 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL ::::..::: .:::.:.::::.::::::.::::...: :. :::::: NP_938 FYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTP----LI----------GVYFAL 260 270 280 290 100 110 120 130 140 150 pF1KE5 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL :::::::::::::::::::::::::: :::::::::::::.. :::::::::: :::::: NP_938 CLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGL 300 310 320 330 340 350 160 170 180 190 200 210 pF1KE5 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL :::::::::::::::::::::.::::::::::::::::::::::::::::.::::::::. NP_938 TPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAM 360 370 380 390 400 410 220 230 pF1KE5 LFRLYLLFMASSIITVICLWNT :::::::::::::::::::::: NP_938 LFRLYLLFMASSIITVICLWNT 420 430 440 >>NP_001243542 (OMIM: 610123) 5-hydroxytryptamine recept (456 aa) initn: 1262 init1: 974 opt: 974 Z-score: 987.1 bits: 190.9 E(85289): 3.1e-48 Smith-Waterman score: 1248; 81.9% identity (90.5% similar) in 232 aa overlap (2-233:241-456) 10 20 30 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALS ::::: ::: ::.:.:::::.:.:::::: NP_001 THGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRR--RPSLYVINLLVPSGFLVAIDALS 220 230 240 250 260 40 50 60 70 80 90 pF1KE5 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL ::::..::: .:::.:.::::.::::::.::::...: :. :::::: NP_001 FYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTP----LI----------GVYFAL 270 280 290 300 310 100 110 120 130 140 150 pF1KE5 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL :::::::::::::::::::::::::: :::::::::::::.. :::::::::: :::::: NP_001 CLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGL 320 330 340 350 360 370 160 170 180 190 200 210 pF1KE5 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL :::::::::::::::::::::.::::::::::::::::::::::::::::.::::::::. NP_001 TPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAM 380 390 400 410 420 430 220 230 pF1KE5 LFRLYLLFMASSIITVICLWNT :::::::::::::::::::::: NP_001 LFRLYLLFMASSIITVICLWNT 440 450 >>NP_938056 (OMIM: 610123) 5-hydroxytryptamine receptor (456 aa) initn: 1262 init1: 974 opt: 974 Z-score: 987.1 bits: 190.9 E(85289): 3.1e-48 Smith-Waterman score: 1248; 81.9% identity (90.5% similar) in 232 aa overlap (2-233:241-456) 10 20 30 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALS ::::: ::: ::.:.:::::.:.:::::: NP_938 THGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRR--RPSLYVINLLVPSGFLVAIDALS 220 230 240 250 260 40 50 60 70 80 90 pF1KE5 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL ::::..::: .:::.:.::::.::::::.::::...: :. :::::: NP_938 FYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTP----LI----------GVYFAL 270 280 290 300 310 100 110 120 130 140 150 pF1KE5 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL :::::::::::::::::::::::::: :::::::::::::.. :::::::::: :::::: NP_938 CLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGL 320 330 340 350 360 370 160 170 180 190 200 210 pF1KE5 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL :::::::::::::::::::::.::::::::::::::::::::::::::::.::::::::. NP_938 TPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAM 380 390 400 410 420 430 220 230 pF1KE5 LFRLYLLFMASSIITVICLWNT :::::::::::::::::::::: NP_938 LFRLYLLFMASSIITVICLWNT 440 450 >>NP_872395 (OMIM: 610123) 5-hydroxytryptamine receptor (471 aa) initn: 1262 init1: 974 opt: 974 Z-score: 986.9 bits: 190.9 E(85289): 3.1e-48 Smith-Waterman score: 1248; 81.9% identity (90.5% similar) in 232 aa overlap (2-233:256-471) 10 20 30 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALS ::::: ::: ::.:.:::::.:.:::::: NP_872 THGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRR--RPSLYVINLLVPSGFLVAIDALS 230 240 250 260 270 280 40 50 60 70 80 90 pF1KE5 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL ::::..::: .:::.:.::::.::::::.::::...: :. :::::: NP_872 FYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTP----LI----------GVYFAL 290 300 310 320 100 110 120 130 140 150 pF1KE5 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL :::::::::::::::::::::::::: :::::::::::::.. :::::::::: :::::: NP_872 CLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGL 330 340 350 360 370 380 160 170 180 190 200 210 pF1KE5 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL :::::::::::::::::::::.::::::::::::::::::::::::::::.::::::::. NP_872 TPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAM 390 400 410 420 430 440 220 230 pF1KE5 LFRLYLLFMASSIITVICLWNT :::::::::::::::::::::: NP_872 LFRLYLLFMASSIITVICLWNT 450 460 470 >>NP_001243543 (OMIM: 610123) 5-hydroxytryptamine recept (482 aa) initn: 1262 init1: 974 opt: 974 Z-score: 986.8 bits: 190.9 E(85289): 3.2e-48 Smith-Waterman score: 1248; 81.9% identity (90.5% similar) in 232 aa overlap (2-233:267-482) 10 20 30 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALS ::::: ::: ::.:.:::::.:.:::::: NP_001 THGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRR--RPSLYVINLLVPSGFLVAIDALS 240 250 260 270 280 290 40 50 60 70 80 90 pF1KE5 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL ::::..::: .:::.:.::::.::::::.::::...: :. :::::: NP_001 FYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTP----LI----------GVYFAL 300 310 320 330 340 100 110 120 130 140 150 pF1KE5 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL :::::::::::::::::::::::::: :::::::::::::.. :::::::::: :::::: NP_001 CLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGL 350 360 370 380 390 400 160 170 180 190 200 210 pF1KE5 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL :::::::::::::::::::::.::::::::::::::::::::::::::::.::::::::. NP_001 TPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAM 410 420 430 440 450 460 220 230 pF1KE5 LFRLYLLFMASSIITVICLWNT :::::::::::::::::::::: NP_001 LFRLYLLFMASSIITVICLWNT 470 480 >>NP_570126 (OMIM: 610121) 5-hydroxytryptamine receptor (447 aa) initn: 813 init1: 527 opt: 530 Z-score: 540.7 bits: 108.3 E(85289): 2.2e-23 Smith-Waterman score: 982; 69.8% identity (79.3% similar) in 232 aa overlap (2-233:241-447) 10 20 30 pF1KE5 MVAIRRRCRPSPYVVNFLVPSGILIAIDALS ::::: ::: :..:.::::..:.:::::: NP_570 TQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRR--RPSLYIINLLVPSSFLVAIDALS 220 230 240 250 260 40 50 60 70 80 90 pF1KE5 FYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFAL :::: :: : ::::.:.::::.::::::::::::..: : : ::::: NP_570 FYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGT--------PLIS------VYFAL 270 280 290 300 310 100 110 120 130 140 150 pF1KE5 CLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGL :::::: :::::.:::.::::::::: :.::::::::::::. :::::::::::::: :: NP_570 CLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGL 320 330 340 350 360 370 160 170 180 190 200 210 pF1KE5 TPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDAL : ::::: ::: ::. :: :.: ::: ::..: .:::::::::::.: NP_570 TLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQL---------MELWVQFSHAMDTL 380 390 400 410 420 220 230 pF1KE5 LFRLYLLFMASSIITVICLWNT :::::::::::::.::: :::: NP_570 LFRLYLLFMASSILTVIVLWNT 430 440 233 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 23:26:24 2016 done: Mon Nov 7 23:26:25 2016 Total Scan time: 7.290 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]