FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2760, 251 aa 1>>>pF1KE2760 251 - 251 aa - 251 aa Library: /omim/omim.rfq.tfa 64236559 residues in 92054 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6282+/-0.000275; mu= 19.4078+/- 0.017 mean_var=66.3537+/-13.328, 0's: 0 Z-trim(119.1): 35 B-trim: 0 in 0/51 Lambda= 0.157450 statistics sampled from 33913 (33955) to 33913 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.369), width: 16 Scan time: 3.120 The best scores are: opt bits E(92054) NP_001257340 (OMIM: 607110) DNA dC->dU-editing enz ( 357) 1378 321.2 1.7e-87 NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme ( 382) 1378 321.2 1.8e-87 XP_016884131 (OMIM: 608993) DNA dC->dU-editing enz ( 227) 1140 266.9 2.4e-71 XP_024307947 (OMIM: 608993) DNA dC->dU-editing enz ( 373) 1127 264.2 2.6e-70 NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme ( 373) 1127 264.2 2.6e-70 NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme ( 386) 760 180.8 3.3e-45 NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme ( 190) 710 169.2 5.2e-42 XP_024307946 (OMIM: 608993) DNA dC->dU-editing enz ( 442) 703 167.9 2.9e-41 XP_016884085 (OMIM: 609900) DNA dC->dU-editing enz ( 455) 677 162.0 1.8e-39 NP_001336367 (OMIM: 607113) DNA dC->dU-editing enz ( 194) 652 156.0 4.9e-38 NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme ( 384) 654 156.7 5.9e-38 XP_016884392 (OMIM: 607113) DNA dC->dU-editing enz ( 524) 654 156.8 7.4e-38 NP_001336365 (OMIM: 607113) DNA dC->dU-editing enz ( 373) 609 146.5 6.9e-35 XP_024307986 (OMIM: 607750) DNA dC->dU-editing enz ( 227) 557 134.5 1.7e-31 NP_001350710 (OMIM: 609900) DNA dC->dU-editing enz ( 202) 530 128.3 1.1e-29 NP_065712 (OMIM: 605257,605258) single-stranded DN ( 198) 413 101.7 1.1e-21 NP_001336366 (OMIM: 607113) DNA dC->dU-editing enz ( 317) 403 99.6 7.5e-21 XP_016884393 (OMIM: 607113) DNA dC->dU-editing enz ( 457) 403 99.8 9.7e-21 NP_663745 (OMIM: 607109) DNA dC->dU-editing enzyme ( 199) 379 94.0 2.3e-19 NP_001257335 (OMIM: 607109) DNA dC->dU-editing enz ( 181) 364 90.6 2.3e-18 XP_011528292 (OMIM: 610976) DNA dC->dU-editing enz ( 203) 339 84.9 1.3e-16 XP_011528293 (OMIM: 610976) DNA dC->dU-editing enz ( 203) 339 84.9 1.3e-16 NP_001159474 (OMIM: 610976) DNA dC->dU-editing enz ( 182) 336 84.2 1.9e-16 NP_861438 (OMIM: 610976) DNA dC->dU-editing enzyme ( 183) 336 84.2 1.9e-16 XP_011528294 (OMIM: 610976) DNA dC->dU-editing enz ( 200) 336 84.2 2e-16 NP_001159475 (OMIM: 610976) DNA dC->dU-editing enz ( 200) 336 84.2 2e-16 NP_006780 (OMIM: 604797) C->U-editing enzyme APOBE ( 224) 335 84.0 2.6e-16 NP_001317272 (OMIM: 605257,605258) single-stranded ( 188) 313 79.0 7.3e-15 NP_001291495 (OMIM: 600130) C->U-editing enzyme AP ( 236) 310 78.4 1.4e-14 NP_001635 (OMIM: 600130) C->U-editing enzyme APOBE ( 236) 310 78.4 1.4e-14 XP_011519075 (OMIM: 605257,605258) single-stranded ( 145) 307 77.5 1.5e-14 NP_005880 (OMIM: 600130) C->U-editing enzyme APOBE ( 191) 295 74.9 1.3e-13 NP_001159476 (OMIM: 610976) DNA dC->dU-editing enz ( 154) 249 64.4 1.5e-10 XP_016884132 (OMIM: 608993) DNA dC->dU-editing enz ( 101) 233 60.6 1.4e-09 NP_001006667 (OMIM: 608993) DNA dC->dU-editing enz ( 101) 233 60.6 1.4e-09 >>NP_001257340 (OMIM: 607110) DNA dC->dU-editing enzyme (357 aa) initn: 1378 init1: 1378 opt: 1378 Z-score: 1692.2 bits: 321.2 E(92054): 1.7e-87 Smith-Waterman score: 1378; 95.5% identity (97.0% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_001 ARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPG :::::::::: . .:: NP_001 LHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCN 190 200 210 220 230 240 >-- initn: 380 init1: 181 opt: 333 Z-score: 409.4 bits: 83.8 E(92054): 5e-16 Smith-Waterman score: 373; 39.9% identity (63.6% similar) in 173 aa overlap (20-190:201-353) 10 20 30 40 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLL ::.:.:.. : :.::::: .: .: NP_001 WYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEV--ER-LDNGT 180 190 200 210 220 50 60 70 80 90 100 pF1KE2 WDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPD--CVAKLAEF : :. : .: :: : :.: . ...:::.::.:: . :.... : NP_001 W---VLMDQ---------HMGFL---C-NELDPAQIYRVTWFISWSPCFSWGCAGEVRAF 230 240 250 260 270 110 120 130 140 150 160 pF1KE2 LSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQ :.:. .: : : :::.: : . :..:: : .:::.:.:: :.:: :::..::: .: NP_001 LQENTHVRLRIFAARIYDY-DPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCP 280 290 300 310 320 330 170 180 190 200 210 220 pF1KE2 FMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGS :.:: ..:. : :. ::. NP_001 FQPWDGLEEHSQALSGRLRAILQNQGN 340 350 >>NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme APO (382 aa) initn: 1378 init1: 1378 opt: 1378 Z-score: 1691.8 bits: 321.2 E(92054): 1.8e-87 Smith-Waterman score: 1378; 95.5% identity (97.0% similar) in 199 aa overlap (1-199:1-199) 10 20 30 40 50 60 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA :.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_004 ARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPG :::::::::: . .:: NP_004 LHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCN 190 200 210 220 230 240 >-- initn: 352 init1: 181 opt: 392 Z-score: 481.4 bits: 97.2 E(92054): 4.8e-20 Smith-Waterman score: 392; 38.5% identity (65.4% similar) in 179 aa overlap (20-190:201-378) 10 20 30 40 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLL ::.:.:.. : :.:::::. . . .: NP_004 WYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVL 180 190 200 210 220 230 50 60 70 80 90 100 pF1KE2 WDT--GVF--RGQVYFEPQY--HAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPD--CV : : . ... . : :::. ::. . :: . ...:::.::.:: . :. NP_004 MDQHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCA 240 250 260 270 280 290 110 120 130 140 150 160 pF1KE2 AKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFV ... ::.:. .: : : :::.: : . :..:: : .:::.:.:: :.:: :::..:: NP_004 GEVRAFLQENTHVRLRIFAARIYDY-DPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFV 300 310 320 330 340 170 180 190 200 210 220 pF1KE2 YNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRS : .: :.:: ..:. : :. ::. NP_004 YRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN 350 360 370 380 >>XP_016884131 (OMIM: 608993) DNA dC->dU-editing enzyme (227 aa) initn: 1145 init1: 952 opt: 1140 Z-score: 1402.6 bits: 266.9 E(92054): 2.4e-71 Smith-Waterman score: 1140; 75.6% identity (85.3% similar) in 217 aa overlap (1-216:1-214) 10 20 30 40 50 60 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY :.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::::: XP_016 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA .:..:::::::::::::::::::::::::::::::::::::::::::.::::::::::: XP_016 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF ::::::::::::::::::::::::::::: ::::::::::::.::: ::::::::.:::: XP_016 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF 120 130 140 150 160 170 190 200 210 220 230 pF1KE2 LHRTLKEILRLRIFSVAFTA-AMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVP :::::::::: :. . . .: .: ::.: : XP_016 LHRTLKEILRAT--SIHLRGRPPHSLGSPTWLLPSPWHNRICHKTGRKWA 180 190 200 210 220 240 250 pF1KE2 GKCVRSFRRTHT >>XP_024307947 (OMIM: 608993) DNA dC->dU-editing enzyme (373 aa) initn: 1125 init1: 952 opt: 1127 Z-score: 1383.8 bits: 264.2 E(92054): 2.6e-70 Smith-Waterman score: 1127; 82.6% identity (90.5% similar) in 190 aa overlap (1-190:1-189) 10 20 30 40 50 60 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY :.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::::: XP_024 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA .:..:::::::::::::::::::::::::::::::::::::::::::.::::::::::: XP_024 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF ::::::::::::::::::::::::::::: ::::::::::::.::: ::::::::.:::: XP_024 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 LHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPG :::::::::: XP_024 LHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFR 180 190 200 210 220 230 >-- initn: 694 init1: 694 opt: 694 Z-score: 852.3 bits: 165.8 E(92054): 1.1e-40 Smith-Waterman score: 694; 50.3% identity (73.2% similar) in 183 aa overlap (7-189:190-372) 10 20 30 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLC :::: :: :: .:.: :::. .::: XP_024 VYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLC 160 170 180 190 200 210 40 50 60 70 80 90 pF1KE2 YEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTP . ... . .: . : ::::.:: : . ::: ::::::: . : ...::..::.: XP_024 FTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSP 220 230 240 250 260 270 100 110 120 130 140 150 pF1KE2 CPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYC ::.:....::::..: ::.::: .:::::.:. ::...: ::: :: :.:: :..: :: XP_024 CPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYC 280 290 300 310 320 330 160 170 180 190 200 210 pF1KE2 WENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSW :::::::. . : :: . :. :: :.::: XP_024 WENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE 340 350 360 370 220 230 240 250 pF1KE2 TRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT >>NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme APO (373 aa) initn: 1125 init1: 952 opt: 1127 Z-score: 1383.8 bits: 264.2 E(92054): 2.6e-70 Smith-Waterman score: 1127; 82.6% identity (90.5% similar) in 190 aa overlap (1-190:1-189) 10 20 30 40 50 60 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY :.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::::: NP_660 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA .:..:::::::::::::::::::::::::::::::::::::::::::.::::::::::: NP_660 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF ::::::::::::::::::::::::::::: ::::::::::::.::: ::::::::.:::: NP_660 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 LHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPG :::::::::: NP_660 LHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFR 180 190 200 210 220 230 >-- initn: 694 init1: 694 opt: 694 Z-score: 852.3 bits: 165.8 E(92054): 1.1e-40 Smith-Waterman score: 694; 50.3% identity (73.2% similar) in 183 aa overlap (7-189:190-372) 10 20 30 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLC :::: :: :: .:.: :::. .::: NP_660 VYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLC 160 170 180 190 200 210 40 50 60 70 80 90 pF1KE2 YEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTP . ... . .: . : ::::.:: : . ::: ::::::: . : ...::..::.: NP_660 FTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSP 220 230 240 250 260 270 100 110 120 130 140 150 pF1KE2 CPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYC ::.:....::::..: ::.::: .:::::.:. ::...: ::: :: :.:: :..: :: NP_660 CPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYC 280 290 300 310 320 330 160 170 180 190 200 210 pF1KE2 WENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSW :::::::. . : :: . :. :: :.::: NP_660 WENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE 340 350 360 370 220 230 240 250 pF1KE2 TRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT >>NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme APO (386 aa) initn: 1076 init1: 749 opt: 760 Z-score: 933.1 bits: 180.8 E(92054): 3.3e-45 Smith-Waterman score: 1133; 71.1% identity (80.9% similar) in 235 aa overlap (1-213:1-235) 10 20 30 40 50 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRG--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 ---------QVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL .:::. . :::::::::::::.::: . :::::::::.:: ::.:...:: NP_689 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 SEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQF .::::::::::::::::: .::.: .: :: .:::::::::::.::::::::: :::: : NP_689 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPF 130 140 150 160 170 180 170 180 190 200 210 pF1KE2 MPWYKFDENYAFLHRTLKEILRL-------RIFSVAFTAAMRSCA---SWTWFLLCSWTR :::::::.::: :::::::::: .:: : ...:. :: : . NP_689 MPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKH 190 200 210 220 230 240 220 230 240 250 pF1KE2 PRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT NP_689 HSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEV 250 260 270 280 290 300 >-- initn: 587 init1: 558 opt: 564 Z-score: 692.5 bits: 136.3 E(92054): 8.4e-32 Smith-Waterman score: 564; 48.3% identity (76.8% similar) in 151 aa overlap (40-190:236-386) 10 20 30 40 50 60 pF1KE2 ERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEM .. . .: .. ::::.:: : . ::: NP_689 EAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAER 210 220 230 240 250 260 70 80 90 100 110 120 pF1KE2 CFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWER ::::::: . : ...::..::.:::.:....::::..: ::.::: .::: :.:. NP_689 CFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDT 270 280 290 300 310 320 130 140 150 160 170 180 pF1KE2 DYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEIL ::...:: ::: :: :::: :..:. ::.::::.. . : :: .. :. .:.: :.::: NP_689 DYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREIL 330 340 350 360 370 380 190 200 210 220 230 240 pF1KE2 RLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRT . NP_689 Q >>NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme APO (190 aa) initn: 676 init1: 676 opt: 710 Z-score: 875.8 bits: 169.2 E(92054): 5.2e-42 Smith-Waterman score: 710; 53.9% identity (74.3% similar) in 191 aa overlap (1-190:1-190) 10 20 30 40 50 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVK-IKRGRSNLLWDTGVFRGQV :::::::::. :: ::: .:.: :. ::::. :. ::: :: . : :::::.:: NP_055 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR-RSVVSWKTGVFRNQV 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 YFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTIS : . ::: ::::::: . : .:.::..::.:::::....::::..: ::.::: NP_055 DSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 AARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYA .:::::. :...: ::: :. :.:::::.: :::::::::... : :: . :. NP_055 TARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 FLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVP .:.: :.: :. NP_055 LLKRRLRESLQ 180 190 >>XP_024307946 (OMIM: 608993) DNA dC->dU-editing enzyme (442 aa) initn: 1101 init1: 703 opt: 703 Z-score: 862.4 bits: 167.9 E(92054): 2.9e-41 Smith-Waterman score: 967; 60.3% identity (66.1% similar) in 257 aa overlap (1-188:1-256) 10 20 30 40 50 60 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY :.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::::: XP_024 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA .:..:::::::::::::::::::::::::::::::::::::::::::.::::::::::: XP_024 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA 60 70 80 90 100 110 130 140 150 pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYE----------------------------- ::::::::::::::::::::::::::::: : XP_024 ARLYYYWERDYRRALCRLSQAGARVKIMDDEGERWRGQGSVSGRNSMKDGWICNAMAGGV 120 130 140 150 160 170 160 170 pF1KE2 ----------------------------------------EFAYCWENFVYNEGQQFMPW :::::::::::.::: :::: XP_024 PGQPAGAGPALTATDSQETRPGSAGPGSGQSLTASCLFVSEFAYCWENFVYSEGQPFMPW 180 190 200 210 220 230 180 190 200 210 220 230 pF1KE2 YKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGA ::::.:::::::::::: XP_024 YKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSP 240 250 260 270 280 290 >-- initn: 1107 init1: 703 opt: 703 Z-score: 862.4 bits: 167.9 E(92054): 2.9e-41 Smith-Waterman score: 703; 50.3% identity (73.5% similar) in 185 aa overlap (5-189:257-441) 10 20 30 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTW .::::: :: :: .:.: :::. .: XP_024 NFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESW 230 240 250 260 270 280 40 50 60 70 80 90 pF1KE2 LCYEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSW ::. ... . .: . : ::::.:: : . ::: ::::::: . : ...::..:: XP_024 LCFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSW 290 300 310 320 330 340 100 110 120 130 140 150 pF1KE2 TPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFA .:::.:....::::..: ::.::: .:::::.:. ::...: ::: :: :.:: :..: XP_024 SPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFK 350 360 370 380 390 400 160 170 180 190 200 210 pF1KE2 YCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLC :::::::::. . : :: . :. :: :.::: XP_024 YCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE 410 420 430 440 220 230 240 250 pF1KE2 SWTRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT >>XP_016884085 (OMIM: 609900) DNA dC->dU-editing enzyme (455 aa) initn: 1159 init1: 675 opt: 677 Z-score: 830.3 bits: 162.0 E(92054): 1.8e-39 Smith-Waterman score: 961; 58.7% identity (65.1% similar) in 269 aa overlap (1-188:1-269) 10 20 30 40 50 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRG--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 ---------QVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL .:::. . :::::::::::::.::: . :::::::::.:: ::.:...:: XP_016 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL 70 80 90 100 110 120 110 120 130 140 150 pF1KE2 SEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYE----------------- .::::::::::::::::: .::.: .: :: .::::::::::: XP_016 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR 130 140 150 160 170 180 pF1KE2 ----------------------------------------------------EFAYCWEN .::::::: XP_016 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE2 FVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRP :: :::: ::::::::.::: :::::::: XP_016 FVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWL 250 260 270 280 290 300 >-- initn: 1159 init1: 675 opt: 677 Z-score: 830.3 bits: 162.0 E(92054): 1.8e-39 Smith-Waterman score: 677; 47.8% identity (74.7% similar) in 186 aa overlap (5-190:270-455) 10 20 30 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTW .::::: :: :: .:.: ::. .: XP_016 NFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESW 240 250 260 270 280 290 40 50 60 70 80 90 pF1KE2 LCYEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSW ::. ... . .: .. ::::.:: : . ::: ::::::: . : ...::..:: XP_016 LCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSW 300 310 320 330 340 350 100 110 120 130 140 150 pF1KE2 TPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFA .:::.:....::::..: ::.::: .::: :.:. ::...:: ::: :: :::: :..:. XP_016 SPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFV 360 370 380 390 400 410 160 170 180 190 200 210 pF1KE2 YCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLC ::.::::.. . : :: .. :. .:.: :.:::. XP_016 SCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ 420 430 440 450 220 230 240 250 pF1KE2 SWTRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT >>NP_001336367 (OMIM: 607113) DNA dC->dU-editing enzyme (194 aa) initn: 511 init1: 355 opt: 652 Z-score: 804.4 bits: 156.0 E(92054): 4.9e-38 Smith-Waterman score: 652; 50.3% identity (70.8% similar) in 195 aa overlap (1-190:1-194) 10 20 30 40 50 60 pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY :.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::::: NP_001 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPPLDAKIFRGQVY 10 20 30 40 50 70 80 90 100 110 pF1KE2 FEPQYHAEMCFLSWFCG-NQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTIS : .:: :: :. :: .: . ...::..::.:: :. .: ::.: :.::::: NP_001 SELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 AARLYYYWERDYRRALCRLSQA--GAR--VKIMDYEEFAYCWENFVYNEGQQFMPWYKFD .:::::.:. ::..:: : : : : .:::.:.:: .:: .:::.. . : :: .. NP_001 VARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 ENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASP . : .:: : :::: NP_001 KYYILLHIMLGEILR 180 190 251 residues in 1 query sequences 64236559 residues in 92054 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Aug 1 17:04:06 2019 done: Thu Aug 1 17:04:06 2019 Total Scan time: 3.120 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]