FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5166, 157 aa 1>>>pF1KE5166 157 - 157 aa - 157 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0391+/-0.00032; mu= 9.6796+/- 0.020 mean_var=97.7280+/-19.564, 0's: 0 Z-trim(117.4): 22 B-trim: 0 in 0/58 Lambda= 0.129737 statistics sampled from 29350 (29372) to 29350 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.344), width: 16 Scan time: 4.650 The best scores are: opt bits E(85289) NP_001269881 (OMIM: 616010) COP9 signalosome compl ( 157) 1028 201.8 3.6e-52 XP_016860206 (OMIM: 616010) PREDICTED: COP9 signal ( 157) 1028 201.8 3.6e-52 NP_001269878 (OMIM: 616010) COP9 signalosome compl ( 230) 1028 202.0 4.9e-52 XP_016860205 (OMIM: 616010) PREDICTED: COP9 signal ( 264) 1028 202.0 5.5e-52 NP_073567 (OMIM: 616010) COP9 signalosome complex ( 264) 1028 202.0 5.5e-52 NP_001269880 (OMIM: 616010) COP9 signalosome compl ( 209) 1016 199.7 2.2e-51 XP_011509940 (OMIM: 616010) PREDICTED: COP9 signal ( 171) 705 141.4 6.2e-34 XP_011509941 (OMIM: 616010) PREDICTED: COP9 signal ( 171) 705 141.4 6.2e-34 XP_011509942 (OMIM: 616010) PREDICTED: COP9 signal ( 171) 705 141.4 6.2e-34 XP_006712756 (OMIM: 616010) PREDICTED: COP9 signal ( 278) 705 141.6 9e-34 NP_001295310 (OMIM: 616010) COP9 signalosome compl ( 278) 705 141.6 9e-34 NP_001269879 (OMIM: 616010) COP9 signalosome compl ( 273) 698 140.3 2.2e-33 XP_005253751 (OMIM: 616009) PREDICTED: COP9 signal ( 275) 605 122.8 3.9e-28 NP_001157567 (OMIM: 616009) COP9 signalosome compl ( 275) 605 122.8 3.9e-28 NP_001157566 (OMIM: 616009) COP9 signalosome compl ( 275) 605 122.8 3.9e-28 NP_057403 (OMIM: 616009) COP9 signalosome complex ( 275) 605 122.8 3.9e-28 NP_001157565 (OMIM: 616009) COP9 signalosome compl ( 275) 605 122.8 3.9e-28 >>NP_001269881 (OMIM: 616010) COP9 signalosome complex s (157 aa) initn: 1028 init1: 1028 opt: 1028 Z-score: 1057.5 bits: 201.8 E(85289): 3.6e-52 Smith-Waterman score: 1028; 100.0% identity (100.0% similar) in 157 aa overlap (1-157:1-157) 10 20 30 40 50 60 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSS 70 80 90 100 110 120 130 140 150 pF1KE5 AQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH ::::::::::::::::::::::::::::::::::::: NP_001 AQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH 130 140 150 >>XP_016860206 (OMIM: 616010) PREDICTED: COP9 signalosom (157 aa) initn: 1028 init1: 1028 opt: 1028 Z-score: 1057.5 bits: 201.8 E(85289): 3.6e-52 Smith-Waterman score: 1028; 100.0% identity (100.0% similar) in 157 aa overlap (1-157:1-157) 10 20 30 40 50 60 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSS 70 80 90 100 110 120 130 140 150 pF1KE5 AQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH ::::::::::::::::::::::::::::::::::::: XP_016 AQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH 130 140 150 >>NP_001269878 (OMIM: 616010) COP9 signalosome complex s (230 aa) initn: 1028 init1: 1028 opt: 1028 Z-score: 1055.2 bits: 202.0 E(85289): 4.9e-52 Smith-Waterman score: 1028; 100.0% identity (100.0% similar) in 157 aa overlap (1-157:74-230) 10 20 30 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVY :::::::::::::::::::::::::::::: NP_001 YIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVY 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE5 TDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQ 110 120 130 140 150 160 100 110 120 130 140 150 pF1KE5 YKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVK 170 180 190 200 210 220 pF1KE5 GLVSSRH ::::::: NP_001 GLVSSRH 230 >>XP_016860205 (OMIM: 616010) PREDICTED: COP9 signalosom (264 aa) initn: 1028 init1: 1028 opt: 1028 Z-score: 1054.3 bits: 202.0 E(85289): 5.5e-52 Smith-Waterman score: 1028; 100.0% identity (100.0% similar) in 157 aa overlap (1-157:108-264) 10 20 30 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVY :::::::::::::::::::::::::::::: XP_016 YIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVY 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE5 TDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQ 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE5 YKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVK 200 210 220 230 240 250 pF1KE5 GLVSSRH ::::::: XP_016 GLVSSRH 260 >>NP_073567 (OMIM: 616010) COP9 signalosome complex subu (264 aa) initn: 1028 init1: 1028 opt: 1028 Z-score: 1054.3 bits: 202.0 E(85289): 5.5e-52 Smith-Waterman score: 1028; 100.0% identity (100.0% similar) in 157 aa overlap (1-157:108-264) 10 20 30 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVY :::::::::::::::::::::::::::::: NP_073 YIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVY 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE5 TDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 TDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQ 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE5 YKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 YKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVK 200 210 220 230 240 250 pF1KE5 GLVSSRH ::::::: NP_073 GLVSSRH 260 >>NP_001269880 (OMIM: 616010) COP9 signalosome complex s (209 aa) initn: 1016 init1: 1016 opt: 1016 Z-score: 1043.6 bits: 199.7 E(85289): 2.2e-51 Smith-Waterman score: 1016; 99.4% identity (100.0% similar) in 156 aa overlap (2-157:54-209) 10 20 30 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYT .::::::::::::::::::::::::::::: NP_001 GSALTALISQVLEAPGVYVFGELLELANVQECIPYSVLLKDLEMRNLRELEDLIIEAVYT 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE5 DIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQY 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE5 KENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKG 150 160 170 180 190 200 pF1KE5 LVSSRH :::::: NP_001 LVSSRH >>XP_011509940 (OMIM: 616010) PREDICTED: COP9 signalosom (171 aa) initn: 736 init1: 705 opt: 705 Z-score: 730.3 bits: 141.4 E(85289): 6.2e-34 Smith-Waterman score: 705; 94.6% identity (99.1% similar) in 111 aa overlap (1-111:1-111) 10 20 30 40 50 60 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSS :::::::::::::::::::::::::::::::::::::::::::::.. ... XP_011 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEIACFQREKRDVPLLN 70 80 90 100 110 120 130 140 150 pF1KE5 AQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH XP_011 LITTAFFWLPTSRRHSKPPHPPRLRRWSSSWLNGSVPLTLSRGSPPRRCPK 130 140 150 160 170 >>XP_011509941 (OMIM: 616010) PREDICTED: COP9 signalosom (171 aa) initn: 736 init1: 705 opt: 705 Z-score: 730.3 bits: 141.4 E(85289): 6.2e-34 Smith-Waterman score: 705; 94.6% identity (99.1% similar) in 111 aa overlap (1-111:1-111) 10 20 30 40 50 60 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSS :::::::::::::::::::::::::::::::::::::::::::::.. ... XP_011 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEIACFQREKRDVPLLN 70 80 90 100 110 120 130 140 150 pF1KE5 AQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH XP_011 LITTAFFWLPTSRRHSKPPHPPRLRRWSSSWLNGSVPLTLSRGSPPRRCPK 130 140 150 160 170 >>XP_011509942 (OMIM: 616010) PREDICTED: COP9 signalosom (171 aa) initn: 736 init1: 705 opt: 705 Z-score: 730.3 bits: 141.4 E(85289): 6.2e-34 Smith-Waterman score: 705; 94.6% identity (99.1% similar) in 111 aa overlap (1-111:1-111) 10 20 30 40 50 60 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSS :::::::::::::::::::::::::::::::::::::::::::::.. ... XP_011 NNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEIACFQREKRDVPLLN 70 80 90 100 110 120 130 140 150 pF1KE5 AQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH XP_011 LITTAFFWLPTSRRHSKPPHPPRLRRWSSSWLNGSVPLTLSRGSPPRRCPK 130 140 150 160 170 >>XP_006712756 (OMIM: 616010) PREDICTED: COP9 signalosom (278 aa) initn: 736 init1: 705 opt: 705 Z-score: 727.3 bits: 141.6 E(85289): 9e-34 Smith-Waterman score: 705; 94.6% identity (99.1% similar) in 111 aa overlap (1-111:108-218) 10 20 30 pF1KE5 MKCIPYSVLLKDLEMRNLRELEDLIIEAVY :::::::::::::::::::::::::::::: XP_006 YIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVY 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE5 TDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQ 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE5 YKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVK :::::::::::::::.. ... XP_006 YKENHNRTQQQVEAEIACFQREKRDVPLLNLITTAFFWLPTSRRHSKPPHPPRLRRWSSS 200 210 220 230 240 250 157 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 22:13:11 2016 done: Mon Nov 7 22:13:12 2016 Total Scan time: 4.650 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]