FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6273, 192 aa 1>>>pF1KE6273 192 - 192 aa - 192 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7066+/-0.000942; mu= 10.0395+/- 0.056 mean_var=54.5233+/-11.225, 0's: 0 Z-trim(103.3): 28 B-trim: 437 in 1/46 Lambda= 0.173693 statistics sampled from 7336 (7357) to 7336 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.608), E-opt: 0.2 (0.226), width: 16 Scan time: 1.250 The best scores are: opt bits E(32554) CCDS33407.1 TRPM8 gene_id:79054|Hs108|chr2 (1104) 1137 293.1 4.2e-79 CCDS13710.1 TRPM2 gene_id:7226|Hs108|chr21 (1503) 609 160.7 3.8e-39 CCDS82681.1 TRPM2 gene_id:7226|Hs108|chr21 (1553) 609 160.7 4e-39 CCDS43835.1 TRPM3 gene_id:80036|Hs108|chr9 (1707) 450 120.9 4.3e-27 CCDS73725.1 TRPM7 gene_id:54822|Hs108|chr15 (1864) 443 119.2 1.6e-26 CCDS42035.1 TRPM7 gene_id:54822|Hs108|chr15 (1865) 443 119.2 1.6e-26 CCDS56098.1 TRPM4 gene_id:54795|Hs108|chr19 (1069) 437 117.6 2.6e-26 CCDS33073.1 TRPM4 gene_id:54795|Hs108|chr19 (1214) 437 117.6 2.9e-26 CCDS10024.2 TRPM1 gene_id:4308|Hs108|chr15 (1603) 430 115.9 1.3e-25 CCDS58346.1 TRPM1 gene_id:4308|Hs108|chr15 (1625) 430 115.9 1.3e-25 CCDS58347.1 TRPM1 gene_id:4308|Hs108|chr15 (1642) 430 115.9 1.3e-25 CCDS55318.1 TRPM6 gene_id:140803|Hs108|chr9 (2017) 374 101.9 2.7e-21 CCDS55319.1 TRPM6 gene_id:140803|Hs108|chr9 (2017) 374 101.9 2.7e-21 CCDS6647.1 TRPM6 gene_id:140803|Hs108|chr9 (2022) 374 101.9 2.7e-21 CCDS6637.1 TRPM3 gene_id:80036|Hs108|chr9 ( 230) 340 93.3 1.2e-19 CCDS65064.1 TRPM3 gene_id:80036|Hs108|chr9 (1556) 340 93.3 7.8e-19 CCDS6634.1 TRPM3 gene_id:80036|Hs108|chr9 (1566) 340 93.3 7.8e-19 CCDS6636.1 TRPM3 gene_id:80036|Hs108|chr9 (1569) 340 93.3 7.8e-19 CCDS6635.1 TRPM3 gene_id:80036|Hs108|chr9 (1579) 340 93.3 7.9e-19 CCDS31340.1 TRPM5 gene_id:29850|Hs108|chr11 (1165) 330 90.8 3.3e-18 >>CCDS33407.1 TRPM8 gene_id:79054|Hs108|chr2 (1104 aa) initn: 1137 init1: 1137 opt: 1137 Z-score: 1533.7 bits: 293.1 E(32554): 4.2e-79 Smith-Waterman score: 1137; 100.0% identity (100.0% similar) in 169 aa overlap (15-183:65-233) 10 20 30 40 pF1KE6 MKSFLPVHTIVLIRENVCKCGYAQSQHMEGTQINQSEKWNYKKH :::::::::::::::::::::::::::::: CCDS33 SYSESDLVNFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWNYKKH 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE6 TKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 TKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKN 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE6 FALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 FALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGI 160 170 180 190 200 210 170 180 190 pF1KE6 AAWGMVSNRDTLIRNCDAEVPVGQEEVC ::::::::::::::::::: CCDS33 AAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVE 220 230 240 250 260 270 >>CCDS13710.1 TRPM2 gene_id:7226|Hs108|chr21 (1503 aa) initn: 435 init1: 236 opt: 609 Z-score: 816.2 bits: 160.7 E(32554): 3.8e-39 Smith-Waterman score: 609; 53.3% identity (80.8% similar) in 167 aa overlap (17-177:88-254) 10 20 30 40 pF1KE6 MKSFLPVHTIVLIRENVCKCGYAQSQHME-GTQIN--QSEKWNYKK ::.:::.. ::.: .:. . :. .:. :: CCDS13 SLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPKK 60 70 80 90 100 110 50 60 70 80 90 100 pF1KE6 HTKEFPTDAFGDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGA :..:.:::::::: : :..: ::.:.: :: . ..:.:.:::: : .:::.::::::: CCDS13 HVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGA 120 130 140 150 160 170 110 120 130 140 150 160 pF1KE6 KNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEEN-IV ::: .:::...:: : :. .::. ::::.:::.: :.:: .::.::: ..: : .:. .. CCDS13 KNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELI 180 190 200 210 220 230 170 180 190 pF1KE6 AIGIAAWGMVSNRDTLIRNCDAEVPVGQEEVC .::.:.:: : :. :: CCDS13 TIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGV 240 250 260 270 280 290 >>CCDS82681.1 TRPM2 gene_id:7226|Hs108|chr21 (1553 aa) initn: 435 init1: 236 opt: 609 Z-score: 816.0 bits: 160.7 E(32554): 4e-39 Smith-Waterman score: 609; 53.3% identity (80.8% similar) in 167 aa overlap (17-177:88-254) 10 20 30 40 pF1KE6 MKSFLPVHTIVLIRENVCKCGYAQSQHME-GTQIN--QSEKWNYKK ::.:::.. ::.: .:. . :. .:. :: CCDS82 SLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKPHTFQGTQWDPKK 60 70 80 90 100 110 50 60 70 80 90 100 pF1KE6 HTKEFPTDAFGDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGA :..:.:::::::: : :..: ::.:.: :: . ..:.:.:::: : .:::.::::::: CCDS82 HVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLISVTGGA 120 130 140 150 160 170 110 120 130 140 150 160 pF1KE6 KNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEEN-IV ::: .:::...:: : :. .::. ::::.:::.: :.:: .::.::: ..: : .:. .. CCDS82 KNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYKEGELI 180 190 200 210 220 230 170 180 190 pF1KE6 AIGIAAWGMVSNRDTLIRNCDAEVPVGQEEVC .::.:.:: : :. :: CCDS82 TIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGV 240 250 260 270 280 290 >>CCDS43835.1 TRPM3 gene_id:80036|Hs108|chr9 (1707 aa) initn: 417 init1: 157 opt: 450 Z-score: 599.9 bits: 120.9 E(32554): 4.3e-27 Smith-Waterman score: 450; 44.5% identity (80.1% similar) in 146 aa overlap (35-177:121-264) 10 20 30 40 50 60 pF1KE6 LPVHTIVLIRENVCKCGYAQSQHMEGTQINQSEKWNYKKHTKEFPTDAFGDIQFETLGKK :::::. .:::. :::::: :.:. :.. CCDS43 RLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHS 100 110 120 130 140 150 70 80 90 100 110 120 pF1KE6 GK--YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSR-LIYI .: :.:.: :: ..: .:.:..:.:. :.:.::: :: .:: :.:.....:.. :: CCDS43 NKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKA 160 170 180 190 200 210 130 140 150 160 170 180 pF1KE6 AQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNCD :.. ::::.:::.. :.....:....:. . .:. .: .:::: ::.: :.. :: CCDS43 AMTTGAWIFTGGVNTGVIRHVGDALKDH--ASKSRGKICTIGIAPWGIVENQEDLIGRDV 220 230 240 250 260 190 pF1KE6 AEVPVGQEEVC CCDS43 VRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQ 270 280 290 300 310 320 >>CCDS73725.1 TRPM7 gene_id:54822|Hs108|chr15 (1864 aa) initn: 416 init1: 181 opt: 443 Z-score: 589.7 bits: 119.2 E(32554): 1.6e-26 Smith-Waterman score: 443; 39.3% identity (76.3% similar) in 173 aa overlap (12-177:47-217) 10 20 30 pF1KE6 MKSFLPVHTIVLIRENVCKCGYAQSQHME---GTQINQS-E :.....: . .. . : ..::. : CCDS73 VYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIE 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 KWNYKKHTKEFPTDAFGDIQFE--TLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLV .:. .:::.. ::::.: :.:. . . ..::.::: :: :.. .:: ..:... :.:: CCDS73 EWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLV 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 ISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRS ::: :: ..: :.::....... :: : . ::::::::.. :. :..:....... ::: CCDS73 ISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHA-SRS 140 150 160 170 180 190 160 170 180 190 pF1KE6 SEENIVAIGIAAWGMVSNRDTLIRNCDAEVPVGQEEVC :.. : .:::: ::.. ::. :. CCDS73 SRK-ICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVG 200 210 220 230 240 250 >>CCDS42035.1 TRPM7 gene_id:54822|Hs108|chr15 (1865 aa) initn: 416 init1: 181 opt: 443 Z-score: 589.7 bits: 119.2 E(32554): 1.6e-26 Smith-Waterman score: 443; 39.3% identity (76.3% similar) in 173 aa overlap (12-177:47-217) 10 20 30 pF1KE6 MKSFLPVHTIVLIRENVCKCGYAQSQHME---GTQINQS-E :.....: . .. . : ..::. : CCDS42 VYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKYSDVKLGDHFNQAIE 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 KWNYKKHTKEFPTDAFGDIQFE--TLGKKGKYIRLSCDTDAEILYELLTQHWHLKTPNLV .:. .:::.. ::::.: :.:. . . ..::.::: :: :.. .:: ..:... :.:: CCDS42 EWSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVILQLLLKEWQMELPKLV 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 ISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRS ::: :: ..: :.::....... :: : . ::::::::.. :. :..:....... ::: CCDS42 ISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVAKHVGDALKEHA-SRS 140 150 160 170 180 190 160 170 180 190 pF1KE6 SEENIVAIGIAAWGMVSNRDTLIRNCDAEVPVGQEEVC :.. : .:::: ::.. ::. :. CCDS42 SRK-ICTIGIAPWGVIENRNDLVGRDVVAPYQTLLNPLSKLNVLNNLHSHFILVDDGTVG 200 210 220 230 240 250 >>CCDS56098.1 TRPM4 gene_id:54795|Hs108|chr19 (1069 aa) initn: 376 init1: 223 opt: 437 Z-score: 585.9 bits: 117.6 E(32554): 2.6e-26 Smith-Waterman score: 437; 40.0% identity (68.2% similar) in 170 aa overlap (17-177:34-201) 10 20 30 pF1KE6 MKSFLPVHTIVLIRENVCKCGYAQSQH----ME---GTQINQSEKW .:.:: .. : :: :. . : CCDS56 PEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTV--W 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 NYKKHTKEFPTDAFGDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISV . :: : ::::.:...: :.: ....::: :: .: :.:. : ...::::.:: CCDS56 DSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 TGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEE ::. . .:. .. .. : :. ::: ::::.::: : :. ...: .:::. .. .. CCDS56 LGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGT 130 140 150 160 170 180 160 170 180 190 pF1KE6 NIVAIGIAAWGMVSNRDTLIRNCDAEVPVGQEEVC ..::.:.: ::.: :::::: CCDS56 KVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHG 190 200 210 220 230 240 >>CCDS33073.1 TRPM4 gene_id:54795|Hs108|chr19 (1214 aa) initn: 376 init1: 223 opt: 437 Z-score: 584.9 bits: 117.6 E(32554): 2.9e-26 Smith-Waterman score: 437; 40.0% identity (68.2% similar) in 170 aa overlap (17-177:34-201) 10 20 30 pF1KE6 MKSFLPVHTIVLIRENVCKCGYAQSQH----ME---GTQINQSEKW .:.:: .. : :: :. . : CCDS33 PEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTV--W 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 NYKKHTKEFPTDAFGDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISV . :: : ::::.:...: :.: ....::: :: .: :.:. : ...::::.:: CCDS33 DSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 TGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEE ::. . .:. .. .. : :. ::: ::::.::: : :. ...: .:::. .. .. CCDS33 LGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGT 130 140 150 160 170 180 160 170 180 190 pF1KE6 NIVAIGIAAWGMVSNRDTLIRNCDAEVPVGQEEVC ..::.:.: ::.: :::::: CCDS33 KVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHG 190 200 210 220 230 240 >>CCDS10024.2 TRPM1 gene_id:4308|Hs108|chr15 (1603 aa) initn: 406 init1: 167 opt: 430 Z-score: 573.3 bits: 115.9 E(32554): 1.3e-25 Smith-Waterman score: 444; 38.0% identity (69.3% similar) in 179 aa overlap (16-177:5-181) 10 20 30 40 pF1KE6 MKSFLPVHTIVLIRENVCKCGYAQSQHM-------------EGTQIN-QSEKWNYKKHTK : : :: .::. :. :.. : :::. :::. CCDS10 MKDSNRCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQ 10 20 30 40 50 60 70 80 90 100 pF1KE6 EFPTDAFGDIQFETLGKKGK--YIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAKN .:::..: ..:. : ..: :::.: :: . : .:... :.:. :.:.::: :: .: CCDS10 SYPTDSYGVLEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQN 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE6 FALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAIG : ..:.....:.. :: :.. ::::.:::. :.....:....:. : .:. . ::: CCDS10 FEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDH--SSKSRGRVCAIG 110 120 130 140 150 160 170 180 190 pF1KE6 IAAWGMVSNRDTLIRNCDAEVPVGQEEVC :: ::.: :.. :. CCDS10 IAPWGIVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLR 170 180 190 200 210 220 >>CCDS58346.1 TRPM1 gene_id:4308|Hs108|chr15 (1625 aa) initn: 406 init1: 167 opt: 430 Z-score: 573.2 bits: 115.9 E(32554): 1.3e-25 Smith-Waterman score: 444; 38.0% identity (69.3% similar) in 179 aa overlap (16-177:27-203) 10 20 30 pF1KE6 MKSFLPVHTIVLIRENVCKCGYAQSQHM-------------EGTQIN-Q : : :: .::. :. :.. : CCDS58 MGQKSWIEKTFCKRECIFVIPSMKDSNRCCCGQFTNQHIPPLPSATPSKNEEESKQVETQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE6 SEKWNYKKHTKEFPTDAFGDIQFETLGKKGK--YIRLSCDTDAEILYELLTQHWHLKTPN :::. :::. .:::..: ..:. : ..: :::.: :: . : .:... :.:. :. CCDS58 PEKWSVAKHTQSYPTDSYGVLEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 LVISVTGGAKNFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTIS :.::: :: .:: ..:.....:.. :: :.. ::::.:::. :.....:....:. : CCDS58 LLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDH--S 130 140 150 160 170 160 170 180 190 pF1KE6 RSSEENIVAIGIAAWGMVSNRDTLIRNCDAEVPVGQEEVC .:. . ::::: ::.: :.. :. CCDS58 SKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGT 180 190 200 210 220 230 192 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:40:55 2016 done: Tue Nov 8 11:40:55 2016 Total Scan time: 1.250 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]