FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5784, 698 aa 1>>>pF1KE5784 698 - 698 aa - 698 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2107+/-0.000388; mu= 6.2160+/- 0.024 mean_var=176.8272+/-35.596, 0's: 0 Z-trim(118.2): 12 B-trim: 92 in 1/56 Lambda= 0.096449 statistics sampled from 30939 (30951) to 30939 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.363), width: 16 Scan time: 9.490 The best scores are: opt bits E(85289) NP_001257952 (OMIM: 606605) ATR-interacting protei ( 698) 4622 656.0 1.4e-187 NP_569055 (OMIM: 606605) ATR-interacting protein i ( 791) 4622 656.0 1.6e-187 NP_001257951 (OMIM: 606605) ATR-interacting protei ( 664) 4405 625.8 1.7e-178 NP_115542 (OMIM: 606605) ATR-interacting protein i ( 764) 3716 529.9 1.3e-149 >>NP_001257952 (OMIM: 606605) ATR-interacting protein is (698 aa) initn: 4622 init1: 4622 opt: 4622 Z-score: 3488.6 bits: 656.0 E(85289): 1.4e-187 Smith-Waterman score: 4622; 99.9% identity (100.0% similar) in 698 aa overlap (1-698:1-698) 10 20 30 40 50 60 pF1KE5 MSKNPSGKNRETVPIKDNFELEVLQAQYKELKEKMKVMEEEVLIKNGEIKILRDSLHQTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSKNPSGKNRETVPIKDNFELEVLQAQYKELKEKMKVMEEEVLIKNGEIKILRDSLHQTE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SVLEEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVLEEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERAN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 KLAAPSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLAAPSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 GREDSKPHSLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSSLSLCHLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GREDSKPHSLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSSLSLCHLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 SSSSESPAGTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVARNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSSSESPAGTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVARNE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 CSRDGDPAEGGRRAFPLCQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSRDGDPAEGGRRAFPLCQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 SCVSSGVETNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCVSSGVETNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 VHRLSDGDMTSALRGVADDQGQHPLLKMLLHLLAFSSAATGHLQASVLTQCLKVLVKLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHRLSDGDMTSALRGVADDQGQHPLLKMLLHLLAFSSAATGHLQASVLTQCLKVLVKLAE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 NTSCDFLPRFQCVFQVLPKCLSPETPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTSCDFLPRFQCVFQVLPKCLSPETPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 LLYMYITSRPDRVALETQWLQLEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVIRALTVM :::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::: NP_001 LLYMYITSRPDRVALETQWLQLEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVM 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 LHRQWLTVRRAGGPPRTDQQRRTVRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHRQWLTVRRAGGPPRTDQQRRTVRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMP 610 620 630 640 650 660 670 680 690 pF1KE5 GVSMLIRGLPDVTDCEEAALDDLCAAETDVEDPEVECG :::::::::::::::::::::::::::::::::::::: NP_001 GVSMLIRGLPDVTDCEEAALDDLCAAETDVEDPEVECG 670 680 690 >>NP_569055 (OMIM: 606605) ATR-interacting protein isofo (791 aa) initn: 4622 init1: 4622 opt: 4622 Z-score: 3487.8 bits: 656.0 E(85289): 1.6e-187 Smith-Waterman score: 4622; 99.9% identity (100.0% similar) in 698 aa overlap (1-698:94-791) 10 20 30 pF1KE5 MSKNPSGKNRETVPIKDNFELEVLQAQYKE :::::::::::::::::::::::::::::: NP_569 DTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKE 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE5 LKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 LKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSK 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE5 KLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 KLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFG 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE5 KTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDSWRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 KTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDSWRQ 250 260 270 280 290 300 220 230 240 250 260 270 pF1KE5 RSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGLRTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 RSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGLRTT 310 320 330 340 350 360 280 290 300 310 320 330 pF1KE5 GSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 GSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLV 370 380 390 400 410 420 340 350 360 370 380 390 pF1KE5 QFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALSILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 QFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALSILQ 430 440 450 460 470 480 400 410 420 430 440 450 pF1KE5 HLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLKMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 HLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLKMLL 490 500 510 520 530 540 460 470 480 490 500 510 pF1KE5 HLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPLPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 HLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPLPSV 550 560 570 580 590 600 520 530 540 550 560 570 pF1KE5 LLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVVWLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 LLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVVWLL 610 620 630 640 650 660 580 590 600 610 620 630 pF1KE5 AKLGVQSPLPPVTGSNCQCNVEVIRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDT :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: NP_569 AKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDT 670 680 690 700 710 720 640 650 660 670 680 690 pF1KE5 VLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAETDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_569 VLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAETDV 730 740 750 760 770 780 pF1KE5 EDPEVECG :::::::: NP_569 EDPEVECG 790 >>NP_001257951 (OMIM: 606605) ATR-interacting protein is (664 aa) initn: 4405 init1: 4405 opt: 4405 Z-score: 3325.7 bits: 625.8 E(85289): 1.7e-178 Smith-Waterman score: 4405; 99.8% identity (100.0% similar) in 664 aa overlap (35-698:1-664) 10 20 30 40 50 60 pF1KE5 PSGKNRETVPIKDNFELEVLQAQYKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLE :::::::::::::::::::::::::::::: NP_001 MKVMEEEVLIKNGEIKILRDSLHQTESVLE 10 20 30 70 80 90 100 110 120 pF1KE5 EQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE5 PSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGRED 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE5 SKPHSLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKPHSLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSS 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE5 ESPAGTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESPAGTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRD 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE5 GDPAEGGRRAFPLCQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDPAEGGRRAFPLCQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE5 SGVETNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGVETNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRL 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE5 SDGDMTSALRGVADDQGQHPLLKMLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDGDMTSALRGVADDQGQHPLLKMLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSC 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE5 DFLPRFQCVFQVLPKCLSPETPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFLPRFQCVFQVLPKCLSPETPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYM 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE5 YITSRPDRVALETQWLQLEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVIRALTVMLHRQ :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: NP_001 YITSRPDRVALETQWLQLEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQ 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE5 WLTVRRAGGPPRTDQQRRTVRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WLTVRRAGGPPRTDQQRRTVRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSM 580 590 600 610 620 630 670 680 690 pF1KE5 LIRGLPDVTDCEEAALDDLCAAETDVEDPEVECG :::::::::::::::::::::::::::::::::: NP_001 LIRGLPDVTDCEEAALDDLCAAETDVEDPEVECG 640 650 660 >>NP_115542 (OMIM: 606605) ATR-interacting protein isofo (764 aa) initn: 3711 init1: 3711 opt: 3716 Z-score: 2806.7 bits: 529.9 E(85289): 1.3e-149 Smith-Waterman score: 4367; 96.1% identity (96.1% similar) in 698 aa overlap (1-698:94-764) 10 20 30 pF1KE5 MSKNPSGKNRETVPIKDNFELEVLQAQYKE :::::::::::::::::::::::::::::: NP_115 DTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKE 70 80 90 100 110 120 40 50 60 70 80 90 pF1KE5 LKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSK 130 140 150 160 170 180 100 110 120 130 140 150 pF1KE5 KLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 KLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFG 190 200 210 220 230 240 160 170 180 190 200 210 pF1KE5 KTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDSWRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 KTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDSWRQ 250 260 270 280 290 300 220 230 240 250 260 270 pF1KE5 RSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGLRTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGLRTT 310 320 330 340 350 360 280 290 300 310 320 330 pF1KE5 GSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 GSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLV 370 380 390 400 410 420 340 350 360 370 380 390 pF1KE5 QFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALSILQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 QFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALSILQ 430 440 450 460 470 480 400 410 420 430 440 450 pF1KE5 HLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLKMLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 HLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLKMLL 490 500 510 520 530 540 460 470 480 490 500 510 pF1KE5 HLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPLPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 HLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPLPSV 550 560 570 580 590 600 520 530 540 550 560 570 pF1KE5 LLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVVWLL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVV--- 610 620 630 640 650 660 580 590 600 610 620 630 pF1KE5 AKLGVQSPLPPVTGSNCQCNVEVIRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDT :::::::::::::::::::::::::::::::::::: NP_115 ------------------------RALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDT 670 680 690 640 650 660 670 680 690 pF1KE5 VLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAETDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 VLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAETDV 700 710 720 730 740 750 pF1KE5 EDPEVECG :::::::: NP_115 EDPEVECG 760 698 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:37:31 2016 done: Tue Nov 8 06:37:32 2016 Total Scan time: 9.490 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]