FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5676, 579 aa 1>>>pF1KE5676 579 - 579 aa - 579 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2671+/-0.000522; mu= 14.5904+/- 0.032 mean_var=155.4899+/-29.938, 0's: 0 Z-trim(113.3): 218 B-trim: 125 in 1/50 Lambda= 0.102854 statistics sampled from 22261 (22552) to 22261 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.264), width: 16 Scan time: 7.300 The best scores are: opt bits E(85289) XP_011542782 (OMIM: 601533) PREDICTED: disintegrin ( 579) 4117 623.9 4.3e-178 XP_005273525 (OMIM: 601533) PREDICTED: disintegrin ( 705) 2990 456.8 1.1e-127 XP_011542781 (OMIM: 601533) PREDICTED: disintegrin ( 609) 2930 447.8 4.7e-125 NP_001265042 (OMIM: 601533) disintegrin and metall ( 716) 1803 280.7 1.1e-74 NP_001455 (OMIM: 601533) disintegrin and metallopr ( 735) 1803 280.7 1.2e-74 NP_001265043 (OMIM: 601533) disintegrin and metall ( 672) 1801 280.3 1.3e-74 XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801) 780 128.9 6.1e-29 NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819) 780 128.9 6.2e-29 XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821) 780 128.9 6.2e-29 XP_016870955 (OMIM: 602267) PREDICTED: disintegrin ( 779) 672 112.9 4e-24 NP_001157961 (OMIM: 602267) disintegrin and metall ( 742) 671 112.7 4.3e-24 NP_001100 (OMIM: 602267) disintegrin and metallopr ( 824) 671 112.8 4.6e-24 XP_011537419 (OMIM: 602267) PREDICTED: disintegrin ( 863) 671 112.8 4.7e-24 XP_016870954 (OMIM: 602267) PREDICTED: disintegrin ( 889) 671 112.8 4.8e-24 XP_011542673 (OMIM: 606188) PREDICTED: disintegrin ( 522) 654 110.0 2e-23 XP_011542672 (OMIM: 606188) PREDICTED: disintegrin ( 542) 654 110.0 2e-23 XP_011542671 (OMIM: 606188) PREDICTED: disintegrin ( 673) 654 110.1 2.3e-23 XP_016868465 (OMIM: 606188) PREDICTED: disintegrin ( 715) 654 110.2 2.4e-23 XP_006716337 (OMIM: 606188) PREDICTED: disintegrin ( 728) 654 110.2 2.4e-23 XP_011542670 (OMIM: 606188) PREDICTED: disintegrin ( 728) 654 110.2 2.4e-23 XP_016868464 (OMIM: 606188) PREDICTED: disintegrin ( 732) 654 110.2 2.4e-23 XP_005273437 (OMIM: 606188) PREDICTED: disintegrin ( 736) 654 110.2 2.4e-23 XP_016868463 (OMIM: 606188) PREDICTED: disintegrin ( 741) 654 110.2 2.5e-23 XP_011542669 (OMIM: 606188) PREDICTED: disintegrin ( 746) 654 110.2 2.5e-23 NP_001291280 (OMIM: 606188) disintegrin and metall ( 754) 654 110.2 2.5e-23 XP_006716336 (OMIM: 606188) PREDICTED: disintegrin ( 767) 654 110.2 2.5e-23 NP_055080 (OMIM: 606188) disintegrin and metallopr ( 775) 654 110.2 2.5e-23 NP_003808 (OMIM: 607310) disintegrin and metallopr ( 754) 646 109.0 5.7e-23 XP_016869432 (OMIM: 607310) PREDICTED: disintegrin ( 755) 646 109.0 5.7e-23 NP_003804 (OMIM: 603713) disintegrin and metallopr ( 722) 645 108.8 6.1e-23 XP_005273439 (OMIM: 606188) PREDICTED: disintegrin ( 621) 625 105.8 4.3e-22 NP_001275904 (OMIM: 602714) disintegrin and metall ( 735) 622 105.4 6.6e-22 NP_001275903 (OMIM: 602714) disintegrin and metall ( 737) 622 105.4 6.6e-22 NP_067673 (OMIM: 602714) disintegrin and metallopr ( 738) 622 105.4 6.6e-22 XP_016872194 (OMIM: 602714) PREDICTED: disintegrin ( 753) 622 105.5 6.7e-22 NP_001275902 (OMIM: 602714) disintegrin and metall ( 906) 622 105.6 7.5e-22 NP_003465 (OMIM: 602714) disintegrin and metallopr ( 909) 622 105.6 7.5e-22 XP_011532984 (OMIM: 603640) PREDICTED: disintegrin ( 651) 601 102.3 5.3e-21 XP_016865498 (OMIM: 603640) PREDICTED: disintegrin ( 651) 601 102.3 5.3e-21 NP_150377 (OMIM: 603640) disintegrin and metallopr ( 918) 601 102.4 6.6e-21 XP_005266060 (OMIM: 603640) PREDICTED: disintegrin ( 955) 601 102.5 6.7e-21 NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787) 597 101.8 9e-21 XP_011527670 (OMIM: 607114) PREDICTED: disintegrin ( 800) 597 101.8 9.1e-21 XP_011527675 (OMIM: 607114) PREDICTED: disintegrin ( 492) 589 100.3 1.5e-20 NP_001248395 (OMIM: 605548) disintegrin and metall ( 633) 590 100.6 1.6e-20 NP_001265056 (OMIM: 604778) disintegrin and metall ( 820) 591 100.9 1.7e-20 NP_001124176 (OMIM: 604778) disintegrin and metall ( 820) 591 100.9 1.7e-20 NP_055084 (OMIM: 604778) disintegrin and metallopr ( 820) 591 100.9 1.7e-20 NP_001265055 (OMIM: 604778) disintegrin and metall ( 820) 591 100.9 1.7e-20 XP_011529858 (OMIM: 604778) PREDICTED: disintegrin ( 820) 591 100.9 1.7e-20 >>XP_011542782 (OMIM: 601533) PREDICTED: disintegrin and (579 aa) initn: 4117 init1: 4117 opt: 4117 Z-score: 3318.3 bits: 623.9 E(85289): 4.3e-178 Smith-Waterman score: 4117; 100.0% identity (100.0% similar) in 579 aa overlap (1-579:1-579) 10 20 30 40 50 60 pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 KSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 CAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICID 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 GVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIAVE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 FASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 ASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFF 490 500 510 520 530 540 550 560 570 pF1KE5 IIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG ::::::::::::::::::::::::::::::::::::::: XP_011 IIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG 550 560 570 >>XP_005273525 (OMIM: 601533) PREDICTED: disintegrin and (705 aa) initn: 2988 init1: 2988 opt: 2990 Z-score: 2413.5 bits: 456.8 E(85289): 1.1e-127 Smith-Waterman score: 3220; 79.4% identity (79.4% similar) in 611 aa overlap (95-579:95-705) 70 80 90 100 110 120 pF1KE5 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS :::::::::::::::::::::::::::::: XP_005 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVE------------- ::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHV 130 140 150 160 170 180 pF1KE5 ------------------------------------------------------------ XP_005 IVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEAN 190 200 210 220 230 240 pF1KE5 -----------------------------------------------------HPRTISL ::::::: XP_005 ELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISL 250 260 270 280 290 300 180 190 200 210 220 230 pF1KE5 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS 310 320 330 340 350 360 240 250 260 270 280 290 pF1KE5 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG 370 380 390 400 410 420 300 310 320 330 340 350 pF1KE5 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC 430 440 450 460 470 480 360 370 380 390 400 410 pF1KE5 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIA 490 500 510 520 530 540 420 430 440 450 460 470 pF1KE5 VEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH 550 560 570 580 590 600 480 490 500 510 520 530 pF1KE5 CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIP 610 620 630 640 650 660 540 550 560 570 pF1KE5 FFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG ::::::::::::::::::::::::::::::::::::::::: XP_005 FFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG 670 680 690 700 >-- initn: 635 init1: 635 opt: 635 Z-score: 524.9 bits: 107.4 E(85289): 1.7e-22 Smith-Waterman score: 635; 100.0% identity (100.0% similar) in 94 aa overlap (1-94:1-94) 10 20 30 40 50 60 pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF :::::::::::::::::::::::::::::::::: XP_005 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES XP_005 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYI 130 140 150 160 170 180 >>XP_011542781 (OMIM: 601533) PREDICTED: disintegrin and (609 aa) initn: 2903 init1: 2903 opt: 2930 Z-score: 2366.2 bits: 447.8 E(85289): 4.7e-125 Smith-Waterman score: 4047; 95.1% identity (95.1% similar) in 609 aa overlap (1-579:1-609) 10 20 30 40 50 60 pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 KSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAGSN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 CAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWICID 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 GVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEAD-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLI 370 380 390 400 410 420 420 430 440 450 pF1KE5 ----------------------GHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRC :::::::::::::::::::::::::::::::::::::: XP_011 CKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRC 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE5 VSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAI 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE5 PARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQ 550 560 570 580 590 600 pF1KE5 PESESEPKG ::::::::: XP_011 PESESEPKG >>NP_001265042 (OMIM: 601533) disintegrin and metallopro (716 aa) initn: 2341 init1: 1774 opt: 1803 Z-score: 1461.6 bits: 280.7 E(85289): 1.1e-74 Smith-Waterman score: 3331; 78.6% identity (78.6% similar) in 641 aa overlap (76-579:76-716) 50 60 70 80 90 100 pF1KE5 SYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSV :::::::::::::::::::::::::::::: NP_001 SYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSV 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE5 VMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSF 110 120 130 140 150 160 170 pF1KE5 KLQSVE------------------------------------------------------ :::::: NP_001 KLQSVEYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEAN 170 180 190 200 210 220 pF1KE5 -----------------------------------------------------HPRTISL ::::::: NP_001 ELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISL 230 240 250 260 270 280 180 190 200 210 220 230 pF1KE5 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS 290 300 310 320 330 340 240 250 260 270 280 290 pF1KE5 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG 350 360 370 380 390 400 300 310 320 330 340 350 pF1KE5 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC 410 420 430 440 450 460 360 370 380 390 400 410 pF1KE5 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEAD------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGK 470 480 490 500 510 520 420 430 440 pF1KE5 ------------------------GHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQ :::::::::::::::::::::::::::::::::::: NP_001 LICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQ 530 540 550 560 570 580 450 460 470 480 490 500 pF1KE5 RCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPV 590 600 610 620 630 640 510 520 530 540 550 560 pF1KE5 AIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD 650 660 670 680 690 700 570 pF1KE5 EQPESESEPKG ::::::::::: NP_001 EQPESESEPKG 710 >-- initn: 492 init1: 492 opt: 492 Z-score: 410.2 bits: 86.1 E(85289): 4.1e-16 Smith-Waterman score: 492; 100.0% identity (100.0% similar) in 75 aa overlap (1-75:1-75) 10 20 30 40 50 60 pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF ::::::::::::::: NP_001 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 >>NP_001455 (OMIM: 601533) disintegrin and metalloprotei (735 aa) initn: 2339 init1: 1774 opt: 1803 Z-score: 1461.4 bits: 280.7 E(85289): 1.2e-74 Smith-Waterman score: 3150; 75.7% identity (75.7% similar) in 641 aa overlap (95-579:95-735) 70 80 90 100 110 120 pF1KE5 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS :::::::::::::::::::::::::::::: NP_001 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVE------------- ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHV 130 140 150 160 170 180 pF1KE5 ------------------------------------------------------------ NP_001 IVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEAN 190 200 210 220 230 240 pF1KE5 -----------------------------------------------------HPRTISL ::::::: NP_001 ELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISL 250 260 270 280 290 300 180 190 200 210 220 230 pF1KE5 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS 310 320 330 340 350 360 240 250 260 270 280 290 pF1KE5 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG 370 380 390 400 410 420 300 310 320 330 340 350 pF1KE5 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC 430 440 450 460 470 480 360 370 380 390 400 410 pF1KE5 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEAD------ :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGK 490 500 510 520 530 540 420 430 440 pF1KE5 ------------------------GHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQ :::::::::::::::::::::::::::::::::::: NP_001 LICKYVGKFLLQIPRATIIYANISGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQ 550 560 570 580 590 600 450 460 470 480 490 500 pF1KE5 RCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPV 610 620 630 640 650 660 510 520 530 540 550 560 pF1KE5 AIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD 670 680 690 700 710 720 570 pF1KE5 EQPESESEPKG ::::::::::: NP_001 EQPESESEPKG 730 >-- initn: 635 init1: 635 opt: 635 Z-score: 524.7 bits: 107.4 E(85289): 1.7e-22 Smith-Waterman score: 635; 100.0% identity (100.0% similar) in 94 aa overlap (1-94:1-94) 10 20 30 40 50 60 pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF :::::::::::::::::::::::::::::::::: NP_001 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES NP_001 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYI 130 140 150 160 170 180 >>NP_001265043 (OMIM: 601533) disintegrin and metallopro (672 aa) initn: 2118 init1: 1753 opt: 1801 Z-score: 1460.3 bits: 280.3 E(85289): 1.3e-74 Smith-Waterman score: 2909; 74.0% identity (74.0% similar) in 611 aa overlap (95-579:95-672) 70 80 90 100 110 120 pF1KE5 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS :::::::::::::::::::::::::::::: NP_001 FLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVS 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVE------------- ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYIEMHV 130 140 150 160 170 180 pF1KE5 ------------------------------------------------------------ NP_001 IVEKQLYNHMGSDTTVVAQKVFQLIGLTNAIFVSFNITIILSSLELWIDENKIATTGEAN 190 200 210 220 230 240 pF1KE5 -----------------------------------------------------HPRTISL ::::::: NP_001 ELLHTFLRWKTSYLVLRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHPRTISL 250 260 270 280 290 300 180 190 200 210 220 230 pF1KE5 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFIS 310 320 330 340 350 360 240 250 260 270 280 290 pF1KE5 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATCRFKAG 370 380 390 400 410 420 300 310 320 330 340 350 pF1KE5 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQWIC 430 440 450 460 470 480 360 370 380 390 400 410 pF1KE5 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIA :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCE-------- 490 500 510 520 530 420 430 440 450 460 470 pF1KE5 VEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH ::::::::::::::::::::::::::::::::::: NP_001 -------------------------VCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH 540 550 560 570 480 490 500 510 520 530 pF1KE5 CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIP 580 590 600 610 620 630 540 550 560 570 pF1KE5 FFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG ::::::::::::::::::::::::::::::::::::::::: NP_001 FFIIFCVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG 640 650 660 670 >-- initn: 635 init1: 635 opt: 635 Z-score: 525.2 bits: 107.3 E(85289): 1.6e-22 Smith-Waterman score: 635; 100.0% identity (100.0% similar) in 94 aa overlap (1-94:1-94) 10 20 30 40 50 60 pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF :::::::::::::::::::::::::::::::::: NP_001 MQKNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEHPRTISLES NP_001 ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIESRDLSFKLQSVEPQQDFAKYI 130 140 150 160 170 180 >>XP_011542984 (OMIM: 602713,612775) PREDICTED: disinteg (801 aa) initn: 1253 init1: 464 opt: 780 Z-score: 640.6 bits: 128.9 E(85289): 6.1e-29 Smith-Waterman score: 980; 34.2% identity (62.3% similar) in 438 aa overlap (176-577:318-732) 150 160 170 180 190 200 pF1KE5 KKADVSLYNEKDIESRDLSFKLQSVEHPRTISLESLAVILAQLLSLSMGITYDDINKCQC :..:..: :.:. :. ..:...:: :.: XP_011 KKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSC 290 300 310 320 330 340 210 220 230 240 250 260 pF1KE5 SGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAK .. :::: : :: . ::.:: ::: .. .. ..:: : :. : .. . ::: XP_011 GAKSCIMNSGA---SGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPS-CGNKL 350 360 370 380 390 400 270 280 290 300 310 320 pF1KE5 LEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEE ..::::::::: ..: : . ::. .::..:. ..:: : ::..: :. .:: . : XP_011 VDAGEECDCGTPKECEL--DPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE 410 420 430 440 450 460 330 340 350 360 370 380 pF1KE5 CDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSEC ::.:::::::: : . ..:.:.:: :. : .:.:. : :: ::.... .:..: XP_011 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 470 480 490 500 510 520 390 400 410 420 430 pF1KE5 YSHLNSKTDVSGNCGISDSGYTQCEADGHLC---------------IAVEFASDHADSQK . ..::: : ::::.: . : .: . . :: :. . . . . : XP_011 FIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTK 530 540 550 560 570 580 440 450 460 470 pF1KE5 MW---------------IKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDK-CNDRGVCNNK : ...::.::..:.::: .::..: :.::: ..: :. .::::.. XP_011 CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSN 590 600 610 620 630 640 480 490 500 510 520 530 pF1KE5 KHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFF :.::: .. ::.: ... :::.::: : ... .. . . :: XP_011 KNCHCENGWAPPNCETKGY---GGSVDSG-----------PTYNEMNTALRDGLLVF-FF 650 660 670 680 540 550 560 570 pF1KE5 LFIPFFIIFCVLIAIMVKVNFQR---KKWRTEDYSSD--EQPESESEPKG :..: .: :... .. . .. : .: :.. : :: .: . .: XP_011 LIVP--LIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTP 690 700 710 720 730 740 XP_011 PREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT 750 760 770 780 790 800 >-- initn: 340 init1: 286 opt: 345 Z-score: 291.7 bits: 64.4 E(85289): 1.6e-09 Smith-Waterman score: 345; 35.2% identity (63.7% similar) in 193 aa overlap (13-198:15-203) 10 20 30 40 50 pF1KE5 MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEG---IESQASYKIVIEGKP :... :...: .: .: .. .:. .:.:: : ::: XP_011 MSLGKRLRDETFAAGFQQTSHLSSY--EIITPWRLTRERREAPRPYSKQVSYVIQAEGKE 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 YTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGL . ..: . :..::..: ::.:. : . ..:: :::.::.:: .: . .: : :: XP_011 HIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 RGVLQFENVSYGIEPLESSVGFEHVIYQVK--HKKADVSLYNEKDIESRDLSFKLQSVEH ::.:..::.:::::::..: :::.::.. .:. ..::::.. . : . : XP_011 RGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNKDIEKE--TAKDEEEEP 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 PR-TISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFE : : :. ..: : . . :. : XP_011 PSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLN 180 190 200 210 220 230 >>NP_003807 (OMIM: 602713,612775) disintegrin and metall (819 aa) initn: 1253 init1: 464 opt: 780 Z-score: 640.5 bits: 128.9 E(85289): 6.2e-29 Smith-Waterman score: 980; 34.2% identity (62.3% similar) in 438 aa overlap (176-577:336-750) 150 160 170 180 190 200 pF1KE5 KKADVSLYNEKDIESRDLSFKLQSVEHPRTISLESLAVILAQLLSLSMGITYDDINKCQC :..:..: :.:. :. ..:...:: :.: NP_003 KKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSC 310 320 330 340 350 360 210 220 230 240 250 260 pF1KE5 SGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAK .. :::: : :: . ::.:: ::: .. .. ..:: : :. : .. . ::: NP_003 GAKSCIMNSGA---SGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPS-CGNKL 370 380 390 400 410 420 270 280 290 300 310 320 pF1KE5 LEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEE ..::::::::: ..: : . ::. .::..:. ..:: : ::..: :. .:: . : NP_003 VDAGEECDCGTPKECEL--DPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE 430 440 450 460 470 330 340 350 360 370 380 pF1KE5 CDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSEC ::.:::::::: : . ..:.:.:: :. : .:.:. : :: ::.... .:..: NP_003 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 480 490 500 510 520 530 390 400 410 420 430 pF1KE5 YSHLNSKTDVSGNCGISDSGYTQCEADGHLC---------------IAVEFASDHADSQK . ..::: : ::::.: . : .: . . :: :. . . . . : NP_003 FIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTK 540 550 560 570 580 590 440 450 460 470 pF1KE5 MW---------------IKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDK-CNDRGVCNNK : ...::.::..:.::: .::..: :.::: ..: :. .::::.. NP_003 CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSN 600 610 620 630 640 650 480 490 500 510 520 530 pF1KE5 KHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFF :.::: .. ::.: ... :::.::: : ... .. . . :: NP_003 KNCHCENGWAPPNCETKGY---GGSVDSG-----------PTYNEMNTALRDGLLVF-FF 660 670 680 690 700 540 550 560 570 pF1KE5 LFIPFFIIFCVLIAIMVKVNFQR---KKWRTEDYSSD--EQPESESEPKG :..: .: :... .. . .. : .: :.. : :: .: . .: NP_003 LIVP--LIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTP 710 720 730 740 750 760 NP_003 PREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT 770 780 790 800 810 >-- initn: 340 init1: 286 opt: 352 Z-score: 297.2 bits: 65.4 E(85289): 8.1e-10 Smith-Waterman score: 352; 35.2% identity (62.4% similar) in 210 aa overlap (2-198:16-221) 10 20 30 40 pF1KE5 MWRVLFLLSG--LG----GLRMDSNFDSLPVQITVPEKIRSIIKEG : .:. : : :: :... :...: .: .: .. .:. NP_003 MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSY--EIITPWRLTRERREA 10 20 30 40 50 50 60 70 80 90 pF1KE5 ---IESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRVYSYSGTGIMKPLDQDFQNFCHYQG .:.:: : ::: . ..: . :..::..: ::.:. : . ..:: :::.: NP_003 PRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRG 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE5 YIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLESSVGFEHVIYQVK--HKKADVSLYN :.:: .: . .: : ::::.:..::.:::::::..: :::.::.. .:. . NP_003 YVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVS 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE5 EKDIESRDLSFKLQSVEHPR-TISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMN .::::.. . : . : : : :. ..: : . . :. : NP_003 NKDIEKE--TAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVR 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE5 PEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAKLEAGEECD NP_003 EEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRR 240 250 260 270 280 290 >>XP_016869431 (OMIM: 602713,612775) PREDICTED: disinteg (821 aa) initn: 1253 init1: 464 opt: 780 Z-score: 640.5 bits: 128.9 E(85289): 6.2e-29 Smith-Waterman score: 980; 34.2% identity (62.3% similar) in 438 aa overlap (176-577:338-752) 150 160 170 180 190 200 pF1KE5 KKADVSLYNEKDIESRDLSFKLQSVEHPRTISLESLAVILAQLLSLSMGITYDDINKCQC :..:..: :.:. :. ..:...:: :.: XP_016 KKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDGRDCSC 310 320 330 340 350 360 210 220 230 240 250 260 pF1KE5 SGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAK .. :::: : :: . ::.:: ::: .. .. ..:: : :. : .. . ::: XP_016 GAKSCIMNSGA---SGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPS-CGNKL 370 380 390 400 410 420 270 280 290 300 310 320 pF1KE5 LEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEE ..::::::::: ..: : . ::. .::..:. ..:: : ::..: :. .:: . : XP_016 VDAGEECDCGTPKECEL--DPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSE 430 440 450 460 470 480 330 340 350 360 370 380 pF1KE5 CDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSEC ::.:::::::: : . ..:.:.:: :. : .:.:. : :: ::.... .:..: XP_016 CDVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDC 490 500 510 520 530 540 390 400 410 420 430 pF1KE5 YSHLNSKTDVSGNCGISDSGYTQCEADGHLC---------------IAVEFASDHADSQK . ..::: : ::::.: . : .: . . :: :. . . . . : XP_016 FIEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTK 550 560 570 580 590 600 440 450 460 470 pF1KE5 MW---------------IKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDK-CNDRGVCNNK : ...::.::..:.::: .::..: :.::: ..: :. .::::.. XP_016 CWGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSN 610 620 630 640 650 660 480 490 500 510 520 530 pF1KE5 KHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFF :.::: .. ::.: ... :::.::: : ... .. . . :: XP_016 KNCHCENGWAPPNCETKGY---GGSVDSG-----------PTYNEMNTALRDGLLVF-FF 670 680 690 700 540 550 560 570 pF1KE5 LFIPFFIIFCVLIAIMVKVNFQR---KKWRTEDYSSD--EQPESESEPKG :..: .: :... .. . .. : .: :.. : :: .: . .: XP_016 LIVP--LIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTP 710 720 730 740 750 760 XP_016 PREVPIYANRFAVPTYAAKQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT 770 780 790 800 810 820 >-- initn: 340 init1: 286 opt: 340 Z-score: 287.6 bits: 63.7 E(85289): 2.8e-09 Smith-Waterman score: 340; 39.0% identity (65.4% similar) in 159 aa overlap (44-198:67-223) 20 30 40 50 60 70 pF1KE5 LRMDSNFDSLPVQITVPEKIRSIIKEGIESQASYKIVIEGKPYTVNLMQ-KNFLPHNFRV :.:: : ::: . ..: . :..::..: : XP_016 QQTSHLSSYEIITPWRLTRERREAPRPYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVV 40 50 60 70 80 90 80 90 100 110 120 130 pF1KE5 YSYSGTGIMKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQFENVSYGIEPLES :.:. : . ..:: :::.::.:: .: . .: : ::::.:..::.:::::::.. XP_016 YTYNKEGTLITDHPNIQNHCHYRGYVEGVHNSSIALSDCFGLRGLLHLENASYGIEPLQN 100 110 120 130 140 150 140 150 160 170 180 pF1KE5 SVGFEHVIYQVK--HKKADVSLYNEKDIESRDLSFKLQSVEHPR-TISLESLAVILAQLL : :::.::.. .:. ..::::.. . : . : : : :. ..: : XP_016 SSHFEHIIYRMDDVYKEPLKCGVSNKDIEKE--TAKDEEEEPPSMTQLLRRRRAVLPQTR 160 170 180 190 200 210 190 200 210 220 230 240 pF1KE5 SLSMGITYDDINKCQCSGAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQP . . :. : XP_016 YVELFIVVDKERYDMMGRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLIN 220 230 240 250 260 270 >>XP_016870955 (OMIM: 602267) PREDICTED: disintegrin and (779 aa) initn: 725 init1: 251 opt: 672 Z-score: 554.1 bits: 112.9 E(85289): 4e-24 Smith-Waterman score: 672; 30.3% identity (58.1% similar) in 370 aa overlap (181-530:393-745) 160 170 180 190 200 pF1KE5 SLYNEKDIESRDLSFKLQSVEHPRTISLESLAVILAQLLSLSMGITYDD-INKCQCS--- .: .:. .. ..:. .:. .. :.:. XP_016 GTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDENVQGCRCQERF 370 380 390 400 410 420 210 220 230 240 250 260 pF1KE5 -GAVCIMNPEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDPFFKQQAVCGNAK .. ::: .: : ..::.:: . :. . .: :: : : :. . :::: XP_016 EAGRCIMAG-SIGSSFPRMFSDCSQAYLESFLERPQSVCLANAPDLSHLVGGP-VCGNLF 430 440 450 460 470 480 270 280 290 300 310 320 pF1KE5 LEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEE .: ::.:::: .:: . ::. .::.. :..::.: ::..: ..:::. . XP_016 VERGEQCDCGPPEDCR---NRCCNSTTCQLAEGAQCAHGTCCQECKVKPAGELCRPKKDM 490 500 510 520 530 330 340 350 360 370 380 pF1KE5 CDLPEYCNGSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDTFGKEVEFGPSEC ::: :.:.: :::. . ..: ::. . : .:.: . .:: .: . . : XP_016 CDLEEFCDGRHPECPEDAFQENGTPCSGGY--CYNGACPTLAQQCQAFWGPGGQAAEESC 540 550 560 570 580 590 390 400 410 420 430 pF1KE5 YSHLNSKTDVSGNCGISD-----SGYTQCEADGH-----LCIA-VEFASDHADSQKMW-I .:. :. .: : : ::.. . .::. : : :. . . XP_016 FSY-----DILPGCKASRYRADMCGVLQCKGGQQPLGRAICIVDVCHALTTEDGTAYEPV 600 610 620 630 640 650 440 450 460 470 480 490 pF1KE5 KDGTSCGSNKVCRNQRCVS-SSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCS-VQ .:: :: .::: . :: . : . .:.. .:...::::.:..::: :.. :: :. . XP_016 PEGTRCGPEKVCWKGRCQDLHVYRSSNCSA-QCHNHGVCNHKQECHCHAGWAPPHCAKLL 660 670 680 690 700 500 510 520 530 540 550 pF1KE5 SDLWPGGSIDSGNFPP-VAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIM ... . .. :: .. :: :. ...: .:.: XP_016 TEVHAAPPRPGALRPPSISSPAAT-EHVVVQSI---RPQRHSRAHSTVAQGHPAKLSNLS 710 720 730 740 750 760 560 570 pF1KE5 VKVNFQRKKWRTEDYSSDEQPESESEPKG XP_016 LASWECQCKVPGPP 770 579 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:45:34 2016 done: Tue Nov 8 05:45:35 2016 Total Scan time: 7.300 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]