FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6383, 329 aa 1>>>pF1KE6383 329 - 329 aa - 329 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1587+/-0.000332; mu= 17.1097+/- 0.021 mean_var=68.2713+/-13.783, 0's: 0 Z-trim(114.8): 16 B-trim: 270 in 1/52 Lambda= 0.155223 statistics sampled from 24784 (24797) to 24784 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.291), width: 16 Scan time: 6.280 The best scores are: opt bits E(85289) NP_001032728 (OMIM: 607858) presenilins-associated ( 329) 2285 520.5 1.9e-147 XP_016862290 (OMIM: 607858) PREDICTED: presenilins ( 344) 2015 460.1 3.1e-129 NP_001311366 (OMIM: 607858) presenilins-associated ( 295) 1584 363.5 3.1e-100 XP_016862291 (OMIM: 607858) PREDICTED: presenilins ( 310) 1583 363.3 3.8e-100 NP_001311367 (OMIM: 607858) presenilins-associated ( 283) 1437 330.6 2.4e-90 NP_001311365 (OMIM: 607858) presenilins-associated ( 345) 1437 330.6 2.9e-90 XP_016862289 (OMIM: 607858) PREDICTED: presenilins ( 360) 1437 330.6 3e-90 NP_061092 (OMIM: 607858) presenilins-associated rh ( 379) 1437 330.7 3.1e-90 XP_005247639 (OMIM: 607858) PREDICTED: presenilins ( 394) 1437 330.7 3.2e-90 XP_016862292 (OMIM: 607858) PREDICTED: presenilins ( 153) 657 155.7 5.7e-38 >>NP_001032728 (OMIM: 607858) presenilins-associated rho (329 aa) initn: 2285 init1: 2285 opt: 2285 Z-score: 2768.2 bits: 520.5 E(85289): 1.9e-147 Smith-Waterman score: 2285; 100.0% identity (100.0% similar) in 329 aa overlap (1-329:1-329) 10 20 30 40 50 60 pF1KE6 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 CLWRVPSLQRTMIRYFTSNPASSVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLWRVPSLQRTMIRYFTSNPASSVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 IPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGH 250 260 270 280 290 300 310 320 pF1KE6 ELIWKNREPLVKIWHEIRTNGPKKGGGSK ::::::::::::::::::::::::::::: NP_001 ELIWKNREPLVKIWHEIRTNGPKKGGGSK 310 320 >>XP_016862290 (OMIM: 607858) PREDICTED: presenilins-ass (344 aa) initn: 2060 init1: 2015 opt: 2015 Z-score: 2441.1 bits: 460.1 E(85289): 3.1e-129 Smith-Waterman score: 2015; 99.7% identity (100.0% similar) in 293 aa overlap (1-293:1-293) 10 20 30 40 50 60 pF1KE6 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 CLWRVPSLQRTMIRYFTSNPASSVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLWRVPSLQRTMIRYFTSNPASSVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 IPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGH ::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_016 IPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGMISLYTWR 250 260 270 280 290 300 310 320 pF1KE6 ELIWKNREPLVKIWHEIRTNGPKKGGGSK XP_016 LACCLLGHGLACSADLLPLLGSRHVTLLQLQAKTGNVLGDESVF 310 320 330 340 >>NP_001311366 (OMIM: 607858) presenilins-associated rho (295 aa) initn: 1602 init1: 1582 opt: 1584 Z-score: 1920.5 bits: 363.5 E(85289): 3.1e-100 Smith-Waterman score: 1991; 89.7% identity (89.7% similar) in 329 aa overlap (1-329:1-295) 10 20 30 40 50 60 pF1KE6 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 CLWRVPSLQRTMIRYFTSNPASSVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTK :::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLWRVPSLQRTMIRYFTSNPASSVISNFVSYVGKVATGRYGPSLGA-------------- 190 200 210 220 250 260 270 280 290 300 pF1KE6 IPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGH :::::::::::::::::::::::::::::::::::::::: NP_001 --------------------ALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGH 230 240 250 260 310 320 pF1KE6 ELIWKNREPLVKIWHEIRTNGPKKGGGSK ::::::::::::::::::::::::::::: NP_001 ELIWKNREPLVKIWHEIRTNGPKKGGGSK 270 280 290 >>XP_016862291 (OMIM: 607858) PREDICTED: presenilins-ass (310 aa) initn: 1786 init1: 1582 opt: 1583 Z-score: 1919.0 bits: 363.3 E(85289): 3.8e-100 Smith-Waterman score: 1721; 88.1% identity (88.4% similar) in 293 aa overlap (1-293:1-259) 10 20 30 40 50 60 pF1KE6 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 CLWRVPSLQRTMIRYFTSNPASSVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTK :::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLWRVPSLQRTMIRYFTSNPASSVISNFVSYVGKVATGRYGPSLGA-------------- 190 200 210 220 250 260 270 280 290 300 pF1KE6 IPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGH ::::::::::::::::::::::::::::::::. XP_016 --------------------ALKAIIAMDTAGMILGWKFFDHAAHLGGALFGMISLYTWR 230 240 250 260 310 320 pF1KE6 ELIWKNREPLVKIWHEIRTNGPKKGGGSK XP_016 LACCLLGHGLACSADLLPLLGSRHVTLLQLQAKTGNVLGDESVF 270 280 290 300 310 >>NP_001311367 (OMIM: 607858) presenilins-associated rho (283 aa) initn: 1482 init1: 1437 opt: 1437 Z-score: 1742.8 bits: 330.6 E(85289): 2.4e-90 Smith-Waterman score: 1466; 81.5% identity (81.9% similar) in 276 aa overlap (1-226:1-276) 10 20 30 40 50 60 pF1KE6 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 130 140 150 160 170 180 190 200 pF1KE6 CLWRVPSLQRTMIRYFTSNPASSV------------------------------------ ::::::::::::::::::::::.: NP_001 CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL 190 200 210 220 230 240 210 220 230 240 250 pF1KE6 --------------ISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF :::::::::::::::::::::: NP_001 GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGAMVCYLRS 250 260 270 280 260 270 280 290 300 310 pF1KE6 LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL >>NP_001311365 (OMIM: 607858) presenilins-associated rho (345 aa) initn: 1938 init1: 1437 opt: 1437 Z-score: 1741.6 bits: 330.6 E(85289): 2.9e-90 Smith-Waterman score: 1879; 81.7% identity (87.5% similar) in 345 aa overlap (1-329:1-345) 10 20 30 40 50 60 pF1KE6 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 130 140 150 160 170 180 190 200 210 220 pF1KE6 CLWRVPSLQRTMIRYFTSNPASSVI------SNFVSY-VGKVATGRY-----GPS----L ::::::::::::::::::::::.:. :.: . . ..:.. : . : : NP_001 CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE6 GASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAA : . . :.: . . .. . . . : :::::::::::::::::::::::: NP_001 GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGAALKAIIAMDTAGMILGWKFFDHAA 250 260 270 280 290 300 290 300 310 320 pF1KE6 HLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK ::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK 310 320 330 340 >>XP_016862289 (OMIM: 607858) PREDICTED: presenilins-ass (360 aa) initn: 1668 init1: 1437 opt: 1437 Z-score: 1741.3 bits: 330.6 E(85289): 3e-90 Smith-Waterman score: 1609; 79.3% identity (86.1% similar) in 309 aa overlap (1-293:1-309) 10 20 30 40 50 60 pF1KE6 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 130 140 150 160 170 180 190 200 210 220 pF1KE6 CLWRVPSLQRTMIRYFTSNPASSVI------SNFVSY-VGKVATGRY-----GPS----L ::::::::::::::::::::::.:. :.: . . ..:.. : . : : XP_016 CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE6 GASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAA : . . :.: . . .. . . . : :::::::::::::::::::::::: XP_016 GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGAALKAIIAMDTAGMILGWKFFDHAA 250 260 270 280 290 300 290 300 310 320 pF1KE6 HLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK ::::::::. XP_016 HLGGALFGMISLYTWRLACCLLGHGLACSADLLPLLGSRHVTLLQLQAKTGNVLGDESVF 310 320 330 340 350 360 >>NP_061092 (OMIM: 607858) presenilins-associated rhombo (379 aa) initn: 1457 init1: 1437 opt: 1437 Z-score: 1741.0 bits: 330.7 E(85289): 3.1e-90 Smith-Waterman score: 2039; 85.9% identity (86.1% similar) in 361 aa overlap (1-311:1-361) 10 20 30 40 50 60 pF1KE6 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 130 140 150 160 170 180 190 200 pF1KE6 CLWRVPSLQRTMIRYFTSNPASSV------------------------------------ ::::::::::::::::::::::.: NP_061 CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL 190 200 210 220 230 240 210 220 230 240 250 pF1KE6 --------------ISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF :::::::::::::::::::::::::::::::::::::::::::::: NP_061 GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE6 LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_061 LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL 310 320 330 340 350 360 320 pF1KE6 VKIWHEIRTNGPKKGGGSK : NP_061 VKIWHEIRTNGPKKGGGSK 370 >>XP_005247639 (OMIM: 607858) PREDICTED: presenilins-ass (394 aa) initn: 2023 init1: 1437 opt: 1437 Z-score: 1740.8 bits: 330.7 E(85289): 3.2e-90 Smith-Waterman score: 1900; 84.8% identity (85.4% similar) in 343 aa overlap (1-293:1-343) 10 20 30 40 50 60 pF1KE6 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF 130 140 150 160 170 180 190 200 pF1KE6 CLWRVPSLQRTMIRYFTSNPASSV------------------------------------ ::::::::::::::::::::::.: XP_005 CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL 190 200 210 220 230 240 210 220 230 240 250 pF1KE6 --------------ISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF :::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE6 LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL ::::::::::::::::::::::::::::::::::::::::::. XP_005 LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGMISLYTWRLACCLLGHGL 310 320 330 340 350 360 320 pF1KE6 VKIWHEIRTNGPKKGGGSK XP_005 ACSADLLPLLGSRHVTLLQLQAKTGNVLGDESVF 370 380 390 >>XP_016862292 (OMIM: 607858) PREDICTED: presenilins-ass (153 aa) initn: 657 init1: 657 opt: 657 Z-score: 802.7 bits: 155.7 E(85289): 5.7e-38 Smith-Waterman score: 657; 99.0% identity (100.0% similar) in 102 aa overlap (192-293:1-102) 170 180 190 200 210 220 pF1KE6 LSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASSVISNFVSYVGKVATGRYG :::::::::::::::::::::::::::::: XP_016 MIRYFTSNPASSVISNFVSYVGKVATGRYG 10 20 30 230 240 250 260 270 280 pF1KE6 PSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAGMILGWKFFD 40 50 60 70 80 90 290 300 310 320 pF1KE6 HAAHLGGALFGIWYVTYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK :::::::::::. XP_016 HAAHLGGALFGMISLYTWRLACCLLGHGLACSADLLPLLGSRHVTLLQLQAKTGNVLGDE 100 110 120 130 140 150 329 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:46:36 2016 done: Tue Nov 8 12:46:36 2016 Total Scan time: 6.280 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]