FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5673, 543 aa 1>>>pF1KE5673 543 - 543 aa - 543 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6318+/-0.000432; mu= 22.3726+/- 0.027 mean_var=63.6648+/-13.285, 0's: 0 Z-trim(109.8): 31 B-trim: 99 in 1/50 Lambda= 0.160740 statistics sampled from 18010 (18030) to 18010 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.211), width: 16 Scan time: 9.420 The best scores are: opt bits E(85289) NP_000051 (OMIM: 253260,609019) biotinidase isofor ( 543) 3746 878.0 0 NP_001268652 (OMIM: 253260,609019) biotinidase iso ( 545) 3658 857.6 0 NP_001268653 (OMIM: 253260,609019) biotinidase iso ( 545) 3652 856.2 0 NP_001268654 (OMIM: 253260,609019) biotinidase iso ( 523) 3608 846.0 0 XP_011532343 (OMIM: 253260,609019) PREDICTED: biot ( 523) 3608 846.0 0 XP_016862577 (OMIM: 253260,609019) PREDICTED: biot ( 523) 3608 846.0 0 NP_001310511 (OMIM: 253260,609019) biotinidase iso ( 523) 3608 846.0 0 NP_001268655 (OMIM: 253260,609019) biotinidase iso ( 179) 1054 253.3 4.6e-67 NP_004657 (OMIM: 603570) pantetheinase precursor [ ( 513) 995 240.0 1.3e-62 XP_011534533 (OMIM: 603571) PREDICTED: vascular no ( 459) 990 238.8 2.7e-62 XP_016866896 (OMIM: 603571) PREDICTED: vascular no ( 520) 990 238.9 3e-62 NP_004656 (OMIM: 603571) vascular non-inflammatory ( 520) 990 238.9 3e-62 XP_006715656 (OMIM: 603571) PREDICTED: vascular no ( 467) 920 222.6 2.1e-57 NP_511043 (OMIM: 603571) vascular non-inflammatory ( 467) 920 222.6 2.1e-57 NP_001229279 (OMIM: 603571) vascular non-inflammat ( 299) 539 134.1 6.1e-31 NP_001278632 (OMIM: 606592) vascular non-inflammat ( 243) 364 93.4 8.6e-19 NP_001278631 (OMIM: 606592) vascular non-inflammat ( 243) 364 93.4 8.6e-19 XP_016866897 (OMIM: 603571) PREDICTED: vascular no ( 282) 203 56.1 1.7e-07 XP_016866898 (OMIM: 603571) PREDICTED: vascular no ( 282) 203 56.1 1.7e-07 >>NP_000051 (OMIM: 253260,609019) biotinidase isoform 3 (543 aa) initn: 3746 init1: 3746 opt: 3746 Z-score: 4692.3 bits: 878.0 E(85289): 0 Smith-Waterman score: 3746; 100.0% identity (100.0% similar) in 543 aa overlap (1-543:1-543) 10 20 30 40 50 60 pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY 490 500 510 520 530 540 pF1KE5 ERD ::: NP_000 ERD >>NP_001268652 (OMIM: 253260,609019) biotinidase isoform (545 aa) initn: 3658 init1: 3658 opt: 3658 Z-score: 4582.0 bits: 857.6 E(85289): 0 Smith-Waterman score: 3658; 99.8% identity (100.0% similar) in 531 aa overlap (13-543:15-545) 10 20 30 40 50 pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYY .::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPEGGGTSRRLLPMQSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 VAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 NFTRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFTRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 CHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 RFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 ANVHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANVHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSH 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 SKFLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKFLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 SNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEA 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 TGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGR 490 500 510 520 530 540 540 pF1KE5 LYERD ::::: NP_001 LYERD >>NP_001268653 (OMIM: 253260,609019) biotinidase isoform (545 aa) initn: 3652 init1: 3652 opt: 3652 Z-score: 4574.5 bits: 856.2 E(85289): 0 Smith-Waterman score: 3652; 99.8% identity (100.0% similar) in 530 aa overlap (14-543:16-545) 10 20 30 40 50 pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYY .:::::::::::::::::::::::::::::::::::::::::::: NP_001 MARKETQLIIKMNHLARFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 VAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAAVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 NFTRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFTRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 CHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAG 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 RFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFGIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 ANVHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANVHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSH 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 SKFLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKFLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 SNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNGLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEA 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 TGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGIFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGR 490 500 510 520 530 540 540 pF1KE5 LYERD ::::: NP_001 LYERD >>NP_001268654 (OMIM: 253260,609019) biotinidase isoform (523 aa) initn: 3608 init1: 3608 opt: 3608 Z-score: 4519.6 bits: 846.0 E(85289): 0 Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 523 aa overlap (21-543:1-523) 10 20 30 40 50 60 pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA :::::::::::::::::::::::::::::::::::::::: NP_001 MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA 10 20 30 40 70 80 90 100 110 120 pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY 470 480 490 500 510 520 pF1KE5 ERD ::: NP_001 ERD >>XP_011532343 (OMIM: 253260,609019) PREDICTED: biotinid (523 aa) initn: 3608 init1: 3608 opt: 3608 Z-score: 4519.6 bits: 846.0 E(85289): 0 Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 523 aa overlap (21-543:1-523) 10 20 30 40 50 60 pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA :::::::::::::::::::::::::::::::::::::::: XP_011 MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA 10 20 30 40 70 80 90 100 110 120 pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY 470 480 490 500 510 520 pF1KE5 ERD ::: XP_011 ERD >>XP_016862577 (OMIM: 253260,609019) PREDICTED: biotinid (523 aa) initn: 3608 init1: 3608 opt: 3608 Z-score: 4519.6 bits: 846.0 E(85289): 0 Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 523 aa overlap (21-543:1-523) 10 20 30 40 50 60 pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA :::::::::::::::::::::::::::::::::::::::: XP_016 MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA 10 20 30 40 70 80 90 100 110 120 pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY 470 480 490 500 510 520 pF1KE5 ERD ::: XP_016 ERD >>NP_001310511 (OMIM: 253260,609019) biotinidase isoform (523 aa) initn: 3608 init1: 3608 opt: 3608 Z-score: 4519.6 bits: 846.0 E(85289): 0 Smith-Waterman score: 3608; 100.0% identity (100.0% similar) in 523 aa overlap (21-543:1-523) 10 20 30 40 50 60 pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA :::::::::::::::::::::::::::::::::::::::: NP_001 MSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA 10 20 30 40 70 80 90 100 110 120 pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE5 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE5 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE5 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE5 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE5 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG 410 420 430 440 450 460 490 500 510 520 530 540 pF1KE5 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY 470 480 490 500 510 520 pF1KE5 ERD ::: NP_001 ERD >>NP_001268655 (OMIM: 253260,609019) biotinidase isoform (179 aa) initn: 1046 init1: 1046 opt: 1054 Z-score: 1324.9 bits: 253.3 E(85289): 4.6e-67 Smith-Waterman score: 1054; 93.5% identity (95.9% similar) in 170 aa overlap (1-167:1-170) 10 20 30 40 50 60 pF1KE5 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQR--LSCMAI-RGDMFLVANLGTKE ::::::::::::::::::::::::::::::::::. :: . . :::. NP_001 TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVIPAFFLSRLRVHRGDLSQGPEAVTC 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 PCHSSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFA >>NP_004657 (OMIM: 603570) pantetheinase precursor [Homo (513 aa) initn: 1146 init1: 611 opt: 995 Z-score: 1244.9 bits: 240.0 E(85289): 1.3e-62 Smith-Waterman score: 1323; 43.1% identity (72.0% similar) in 490 aa overlap (58-543:25-483) 30 40 50 60 70 80 pF1KE5 LALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQEALELMN ..:::::: .:: :. .::.::: ::: NP_004 MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMN 10 20 30 40 50 90 100 110 120 130 140 pF1KE5 QNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRWNPCLEPH .:::: : . .::.. ..::: :::.:.:.::.: :.::.:. .:.:.: : :: . . NP_004 RNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEV-NWIPCNNRN 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE5 RFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVFSNNGTLV ::..: : .::::.: .....:::.: :.:: .:::.:: :::::.::.:::...: :: NP_004 RFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLV 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE5 DRYRKHNLYF-EAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRDYKVKHV ::.:.::.. : :.:: . ...::.: : : ::::::::::: :::. ...:..: . NP_004 ARYHKQNLFMGENQFNVPKEPEIVTFNTTF-GSFGIFTCFDILFHDPAVTLVKDFHVDTI 180 190 200 210 220 230 270 280 290 300 310 320 pF1KE5 VYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESFWYH-DM :.:::::: :: :.:.:...:.:... .: ::.:.:.: ::::::..: : .: :: NP_004 VFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDM 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE5 ENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPYCEKDAQEVHCDEATK .. ...:...:. .. :::: ... : :. . :: . NP_004 KTEEGKLLLSQL---------------DSHPSHSA---VVNWTSY----ASSI---EALS 300 310 320 390 400 410 420 430 440 pF1KE5 WNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYE-RPTLSKELYALGVFD .. :.. ...:.::.: . : : ::.. :::.: :. .. .:.::::.:: NP_004 ---SGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFD 330 340 350 360 370 380 450 460 470 480 490 500 pF1KE5 GLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFE-FHLWGNFSTSYIFPLFLTSG :::::.: ::.:.:.:..: ...:::. :. :: : : :.:.:.:.:: : : NP_004 GLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSE 390 400 410 420 430 440 510 520 530 540 pF1KE5 MTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD : .: .. .: .. . :. ..:..:.:::::.: NP_004 NQL-APGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIV 450 460 470 480 490 500 NP_004 IAPIVCSLSW 510 >>XP_011534533 (OMIM: 603571) PREDICTED: vascular non-in (459 aa) initn: 921 init1: 381 opt: 990 Z-score: 1239.3 bits: 238.8 E(85289): 2.7e-62 Smith-Waterman score: 1184; 41.3% identity (71.4% similar) in 455 aa overlap (58-506:26-451) 30 40 50 60 70 80 pF1KE5 LALFLCGCYVVALGAHTGEESVADHHEAEYYVAAVYEHPSILSLNPLALISRQEALELMN ..:::::: :: . . .:...::.::: XP_011 MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETPVSQEDALNLMN 10 20 30 40 50 90 100 110 120 130 140 pF1KE5 QNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNFTRTSIYPFLDFMPSPQVVRWNPCLEPH .:.:: : . ::.. ..::: :::...:..::: ...:.:. .:.::: : :: .:: XP_011 ENIDILETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQV-NWIPCQDPH 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE5 RFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCHSSDPRCPKDGRYQFNTNVVFSNNGTLV ::. : : ::::.: ......:::: :.::.: : :: .: .:.:::::....: :: XP_011 RFGHTPVQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQYNTNVVYNTEGKLV 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE5 DRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRFGIFTCFDILFFDPAIRVLRDYKVKHVV ::.:..:: : :.:: : .:.::.: : :::::::::::.:.::.. ...:..: .. XP_011 ARYHKYHLYSEPQFNVPEKPELVTFNTAF-GRFGIFTCFDIFFYDPGVTLVKDFHVDTIL 180 190 200 210 220 230 270 280 290 300 310 320 pF1KE5 YPTAWMNQLPLLAAIEIQKAFAVAFGINVLAANVHHPVLGMTGSGIHTPLESFWYH-DME .:::::: ::::.:::...:.:...:.:.:.::.:: :.::::::..: :: ::. XP_011 FPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMK 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE5 NPKSHLIIAQVAKNPVGLIGAENATGETDPSHSKFLKILSGDPY-CEKDAQEVHCDEATK . ..:....: ..:.. .. .:.. . ... .: :. .:. XP_011 TELGKLLLSEVDSHPLSSLAYPTAVNWN--AYATTIK-----PFPVQKN----------- 300 310 320 330 390 400 410 420 430 440 pF1KE5 WNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSNGLCCYLLYERPTLSKE---LYALGV ::.. . :.:... .. . : : ::.. :::.: :. :.:: .:.::. XP_011 -------TFRGFISRDGFNFTELFENAGNLTVCQKELCCHLSYR--MLQKEENEVYVLGA 340 350 360 370 380 450 460 470 480 490 500 pF1KE5 FDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATGIFE-FHLWGNFSTSYIFPLFLT : ::: . : :::.:..: .. :::. . :. :: : : :.:.: :.:: : XP_011 FTGLHGRRRREYWQVCTLLKCKTTNLTTCGRPVETASTRFEMFSLSGTFGTEYVFPEVLL 390 400 410 420 430 440 510 520 530 540 pF1KE5 SGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLYERD . . : XP_011 TEIHLSPGKFEQT 450 543 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 04:12:28 2016 done: Tue Nov 8 04:12:29 2016 Total Scan time: 9.420 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]