Result of FASTA (omim) for
pFN21AE5539
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5539, 373 aa
1>>>pF1KE5539 373 - 373 aa - 373 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9053+/-0.00038; mu= 18.8262+/- 0.024
mean_var=63.3922+/-12.850, 0's: 0 Z-trim(112.7): 38 B-trim: 0 in 0/51
Lambda= 0.161085
statistics sampled from 21665 (21701) to 21665 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.626), E-opt: 0.2 (0.254), width: 16
Scan time: 6.270
The best scores are: opt bits E(85289)
NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme ( 373) 2715 639.7 3.1e-183
NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme ( 386) 1933 458.0 1.6e-128
XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 442) 1636 389.0 1.1e-107
NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme ( 382) 1521 362.3 1.1e-99
XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 455) 1429 340.9 3.4e-93
XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 227) 1371 327.2 2.2e-89
NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme ( 384) 1253 300.0 6.1e-81
XP_016884392 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 524) 1253 300.1 7.8e-81
NP_001257340 (OMIM: 607110) DNA dC->dU-editing enz ( 357) 1203 288.3 1.8e-77
NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme ( 190) 1066 256.3 4.2e-68
XP_005261394 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 202) 860 208.4 1.1e-53
NP_065712 (OMIM: 605257,605258) single-stranded DN ( 198) 490 122.5 8.7e-28
XP_016884132 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 101) 420 106.0 4e-23
NP_001006667 (OMIM: 608993) DNA dC->dU-editing enz ( 101) 420 106.0 4e-23
XP_006724353 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 317) 421 106.6 8.4e-23
XP_016884393 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 457) 421 106.7 1.1e-22
NP_006780 (OMIM: 604797) C->U-editing enzyme APOBE ( 224) 402 102.0 1.4e-21
NP_001159474 (OMIM: 610976) DNA dC->dU-editing enz ( 182) 388 98.7 1.1e-20
NP_861438 (OMIM: 610976) DNA dC->dU-editing enzyme ( 183) 388 98.7 1.1e-20
NP_001159475 (OMIM: 610976) DNA dC->dU-editing enz ( 200) 388 98.7 1.2e-20
XP_011528294 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 200) 388 98.7 1.2e-20
XP_011528293 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 388 98.8 1.2e-20
XP_011528292 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 388 98.8 1.2e-20
NP_001317272 (OMIM: 605257,605258) single-stranded ( 188) 370 94.5 2.1e-19
XP_011519075 (OMIM: 605257,605258) PREDICTED: sing ( 145) 364 93.1 4.4e-19
NP_663745 (OMIM: 607109) DNA dC->dU-editing enzyme ( 199) 356 91.3 2.1e-18
NP_001257335 (OMIM: 607109) DNA dC->dU-editing enz ( 181) 353 90.6 3.1e-18
NP_001159476 (OMIM: 610976) DNA dC->dU-editing enz ( 154) 319 82.6 6.5e-16
NP_001635 (OMIM: 600130) C->U-editing enzyme APOBE ( 236) 302 78.8 1.4e-14
NP_001291495 (OMIM: 600130) C->U-editing enzyme AP ( 236) 302 78.8 1.4e-14
NP_005880 (OMIM: 600130) C->U-editing enzyme APOBE ( 191) 296 77.4 3.1e-14
>>NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme APO (373 aa)
initn: 2715 init1: 2715 opt: 2715 Z-score: 3410.5 bits: 639.7 E(85289): 3.1e-183
Smith-Waterman score: 2715; 99.5% identity (100.0% similar) in 373 aa overlap (1-373:1-373)
10 20 30 40 50 60
pF1KE5 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAA
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
NP_660 QPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 RLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAFL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 HRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPISWKRGVFRN
::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::
NP_660 HRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFRN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 QVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 QVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 IFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEPFKPWKGLKYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_660 IFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEPFKPWKGLKYN
310 320 330 340 350 360
370
pF1KE5 FLFLDSKLQEILE
:::::::::::::
NP_660 FLFLDSKLQEILE
370
>>NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme APO (386 aa)
initn: 2682 init1: 1906 opt: 1933 Z-score: 2428.1 bits: 458.0 E(85289): 1.6e-128
Smith-Waterman score: 2082; 76.9% identity (86.3% similar) in 386 aa overlap (1-373:1-386)
10 20 30 40 50
pF1KE5 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRG---
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:::
NP_689 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
60 70 80 90 100
pF1KE5 ---------QVYSQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
.:: . :.:::::::::::::.::: . :::::::::.:: ::.:...::
NP_689 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE5 SEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPF
.::::::::::::::::: .::.: .: :: .::::::::: :.::::::::: .:::::
NP_689 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPF
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE5 MPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKH
::::::::::: :::::::::::::::::::::::::::: :: :::::::::::::.::
NP_689 MPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKH
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE5 HSPISWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEV
:: . ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 HSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEV
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE5 AEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYND
::::::::::::::::::: ::::::::::: :::::::::.::::::: ::.::::.:
NP_689 AEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSD
310 320 330 340 350 360
350 360 370
pF1KE5 DEPFKPWKGLKYNFLFLDSKLQEILE
::::::::::. :: .: .:.:::.
NP_689 DEPFKPWKGLQTNFRLLKRRLREILQ
370 380
>>XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (442 aa)
initn: 2701 init1: 1636 opt: 1636 Z-score: 2054.3 bits: 389.0 E(85289): 1.1e-107
Smith-Waterman score: 2299; 82.5% identity (83.0% similar) in 405 aa overlap (38-373:38-442)
10 20 30 40 50 60
pF1KE5 TVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYSQPEHHAE
::::::::::::::::::::::::::::::
XP_011 TVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYSQPEHHAE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 MCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWE
::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::
XP_011 MCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISAARLYYYWE
70 80 90 100 110 120
130 140 150
pF1KE5 RDYRRALCRLSQAGARVKIMDDE-------------------------------------
:::::::::::::::::::::::
XP_011 RDYRRALCRLSQAGARVKIMDDEGERWRGQGSVSGRNSMKDGWICNAMAGGVPGQPAGAG
130 140 150 160 170 180
160 170
pF1KE5 --------------------------------EFAYCWENFVYSEGQPFMPWYKFDDNYA
::::::::::::::::::::::::::::
XP_011 PALTATDSQETRPGSAGPGSGQSLTASCLFVSEFAYCWENFVYSEGQPFMPWYKFDDNYA
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE5 FLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPISWKRGVF
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
XP_011 FLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVF
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE5 RNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVN
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE5 LTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEPFKPWKGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEPFKPWKGLK
370 380 390 400 410 420
360 370
pF1KE5 YNFLFLDSKLQEILE
:::::::::::::::
XP_011 YNFLFLDSKLQEILE
430 440
>--
initn: 268 init1: 268 opt: 268 Z-score: 336.1 bits: 71.1 E(85289): 5.6e-12
Smith-Waterman score: 268; 100.0% identity (100.0% similar) in 37 aa overlap (1-37:1-37)
10 20 30 40 50 60
pF1KE5 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYS
:::::::::::::::::::::::::::::::::::::
XP_011 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAA
XP_011 QPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISAA
70 80 90 100 110 120
>>NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme APO (382 aa)
initn: 1464 init1: 959 opt: 1521 Z-score: 1910.7 bits: 362.3 E(85289): 1.1e-99
Smith-Waterman score: 1521; 59.8% identity (76.2% similar) in 383 aa overlap (1-373:1-378)
10 20 30 40 50
pF1KE5 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::::::
NP_004 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
.:..:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF
::::::::::::::::::::::::::::: ::::::::::::.::: ::::::::.::::
NP_004 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 LHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPI--SWKRGV
:::::::::: :. : : :.:.: . : ...::. .: . . . . . . :
NP_004 LHRTLKEILRYLMD---PDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGF
190 200 210 220 230
240 250 260 270 280 290
pF1KE5 FRNQVDPETHC-----HAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPE--CAGEVAEF
. :.. . : ::: ::. . :.: :.:::. ::::: ::::: :
NP_004 LCNEAK-NLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAF
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE5 LARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEP
: ....: : ::.::.: . : :.:.:. : . ::.: :: : .:.:::..::: . :
NP_004 LQENTHVRLRIFAARIYDY-DPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCP
300 310 320 330 340 350
360 370
pF1KE5 FKPWKGLKYNFLFLDSKLQEILE
:.:: ::. . :...:. ::.
NP_004 FQPWDGLEEHSQALSGRLRAILQNQGN
360 370 380
>>XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU-edit (455 aa)
initn: 2600 init1: 1427 opt: 1429 Z-score: 1794.1 bits: 340.9 E(85289): 3.4e-93
Smith-Waterman score: 1779; 66.8% identity (74.8% similar) in 401 aa overlap (42-373:56-455)
20 30 40 50 60 70
pF1KE5 MYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYSQPEHHAEMCFL
.:: :. ... : .:: . :.:::::::
XP_016 ILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVLPKRQSN-HRQEVYFRFENHAEMCFL
30 40 50 60 70 80
80 90 100 110 120 130
pF1KE5 SWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYR
::::::.::: . :::::::::.:: ::.:...::.::::::::::::::::: .::.:
XP_016 SWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWR
90 100 110 120 130 140
140 150
pF1KE5 RALCRLSQAGARVKIMDDE-----------------------------------------
.: :: .::::::::: :
XP_016 WVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLRDGWICNAMAGGVPGQPAGVGLALI
150 160 170 180 190 200
160 170 180
pF1KE5 ----------------------------EFAYCWENFVYSEGQPFMPWYKFDDNYAFLHR
.::::::::: .:::::::::::::::: :::
XP_016 ATDSQETRPGRAGPGSGESLSASHLFISDFAYCWENFVCNEGQPFMPWYKFDDNYASLHR
210 220 230 240 250 260
190 200 210 220 230 240
pF1KE5 TLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPISWKRGVFRNQV
::::::::::::::::::::::::: :: :::::::::::::.:::: . :::::::::
XP_016 TLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQV
270 280 290 300 310 320
250 260 270 280 290 300
pF1KE5 DPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIF
330 340 350 360 370 380
310 320 330 340 350 360
pF1KE5 TARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEPFKPWKGLKYNFL
:::: ::::::::::: :::::::::.::::::: ::.::::.:::::::::::. ::
XP_016 TARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFR
390 400 410 420 430 440
370
pF1KE5 FLDSKLQEILE
.: .:.:::.
XP_016 LLKRRLREILQ
450
>--
initn: 193 init1: 169 opt: 193 Z-score: 241.7 bits: 53.7 E(85289): 1e-06
Smith-Waterman score: 193; 56.4% identity (72.7% similar) in 55 aa overlap (1-54:1-55)
10 20 30 40 50
pF1KE5 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .:
XP_016 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
XP_016 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
70 80 90 100 110 120
>>XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (227 aa)
initn: 1371 init1: 1371 opt: 1371 Z-score: 1725.5 bits: 327.2 E(85289): 2.2e-89
Smith-Waterman score: 1371; 99.5% identity (100.0% similar) in 189 aa overlap (1-189:1-189)
10 20 30 40 50 60
pF1KE5 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAA
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
XP_016 QPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISAA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 RLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAFL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 HRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPISWKRGVFRN
:::::::::
XP_016 HRTLKEILRATSIHLRGRPPHSLGSPTWLLPSPWHNRICHKTGRKWA
190 200 210 220
>>NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme APO (384 aa)
initn: 1302 init1: 460 opt: 1253 Z-score: 1574.1 bits: 300.0 E(85289): 6.1e-81
Smith-Waterman score: 1253; 50.3% identity (72.8% similar) in 386 aa overlap (1-373:1-380)
10 20 30 40 50 60
pF1KE5 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYS
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
NP_068 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYS
10 20 30 40 50 60
70 80 90 100 110
pF1KE5 QPEHHAEMCFLSWFCG-NQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
. ..: :: :. :: .: . ...::..::.:: :. .: ::.: :.::::: .
NP_068 ELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 ARLYYYWERDYRRALCRLSQA--GAR--VKIMDDEEFAYCWENFVYSEGQPFMPWYKFDD
:::::.:. ::..:: : : : : .:::. .:: .:: .::::. . : :: ..
NP_068 ARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 NYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPI--SW
: .:: : ::::. :. : : :.:.: . ::.:..::. .: ... . . .
NP_068 YYILLHIMLGEILRHSMD---PPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQ
190 200 210 220 230
240 250 260 270 280
pF1KE5 KRGVFRNQVDPETHC-----HAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVA
.:: . ::. :. : ::: :::. . :. . .:.:: .:::::: :: :.:
NP_068 RRGFLCNQA-PHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMA
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE5 EFLARHSNVNLTIFTARLYYFWDTDY-QEGLRSLSQEGASVEIMGYKDFKYCWENFVYND
.:......:.: :::::.: : :::::.:.. ::.. :: :..::.::..:: ..
NP_068 KFISKNKHVSLCIFTARIYD--DQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQ
300 310 320 330 340 350
350 360 370
pF1KE5 DEPFKPWKGLKYNFLFLDSKLQEILE
::.:: :: . :...:. ::.
NP_068 GCPFQPWDGLDEHSQDLSGRLRAILQNQEN
360 370 380
>>XP_016884392 (OMIM: 607113) PREDICTED: DNA dC->dU-edit (524 aa)
initn: 1302 init1: 460 opt: 1253 Z-score: 1572.2 bits: 300.1 E(85289): 7.8e-81
Smith-Waterman score: 1253; 50.3% identity (72.8% similar) in 386 aa overlap (1-373:1-380)
10 20 30 40 50 60
pF1KE5 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQVYS
::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::
XP_016 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYS
10 20 30 40 50 60
70 80 90 100 110
pF1KE5 QPEHHAEMCFLSWFCG-NQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
. ..: :: :. :: .: . ...::..::.:: :. .: ::.: :.::::: .
XP_016 ELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 ARLYYYWERDYRRALCRLSQA--GAR--VKIMDDEEFAYCWENFVYSEGQPFMPWYKFDD
:::::.:. ::..:: : : : : .:::. .:: .:: .::::. . : :: ..
XP_016 ARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 NYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPI--SW
: .:: : ::::. :. : : :.:.: . ::.:..::. .: ... . . .
XP_016 YYILLHIMLGEILRHSMD---PPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQ
190 200 210 220 230
240 250 260 270 280
pF1KE5 KRGVFRNQVDPETHC-----HAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVA
.:: . ::. :. : ::: :::. . :. . .:.:: .:::::: :: :.:
XP_016 RRGFLCNQA-PHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMA
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE5 EFLARHSNVNLTIFTARLYYFWDTDY-QEGLRSLSQEGASVEIMGYKDFKYCWENFVYND
.:......:.: :::::.: : :::::.:.. ::.. :: :..::.::..:: ..
XP_016 KFISKNKHVSLCIFTARIYD--DQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQ
300 310 320 330 340 350
350 360 370
pF1KE5 DEPFKPWKGLKYNFLFLDSKLQEILE
::.:: :: . :...:. ::.
XP_016 GCPFQPWDGLDEHSQDLSGRLRAILQVRASSLCPVPHRPPPPPLSPAPCLPLCSEPPLGS
360 370 380 390 400 410
>>NP_001257340 (OMIM: 607110) DNA dC->dU-editing enzyme (357 aa)
initn: 1438 init1: 956 opt: 1203 Z-score: 1511.8 bits: 288.3 E(85289): 1.8e-77
Smith-Waterman score: 1508; 60.1% identity (76.6% similar) in 376 aa overlap (1-373:1-353)
10 20 30 40 50
pF1KE5 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::::::
NP_001 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE5 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
.:..:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE5 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF
::::::::::::::::::::::::::::: ::::::::::::.::: ::::::::.::::
NP_001 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE5 LHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPISWKRGVFR
:::::::::: :. : : :.:.: . : ...::. .: . . . : :.
NP_001 LHRTLKEILRYLMD---PDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGT---W---VLM
190 200 210 220 230
240 250 260 270 280 290
pF1KE5 NQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPE--CAGEVAEFLARHSNV
.: : ....:.. :.: :.:::. ::::: ::::: :: ....:
NP_001 DQ-------H-----MGFLCNE-LDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHV
240 250 260 270
300 310 320 330 340 350
pF1KE5 NLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEPFKPWKGL
: ::.::.: . : :.:.:. : . ::.: :: : .:.:::..::: . ::.:: ::
NP_001 RLRIFAARIYDY-DPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCPFQPWDGL
280 290 300 310 320 330
360 370
pF1KE5 KYNFLFLDSKLQEILE
. . :...:. ::.
NP_001 EEHSQALSGRLRAILQNQGN
340 350
>>NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme APO (190 aa)
initn: 1646 init1: 1064 opt: 1066 Z-score: 1343.6 bits: 256.3 E(85289): 4.2e-68
Smith-Waterman score: 1066; 78.5% identity (89.8% similar) in 186 aa overlap (188-373:5-190)
160 170 180 190 200 210
pF1KE5 NFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESW
.::::.:::: :::.:::: .: :::.:
NP_055 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETW
10 20 30
220 230 240 250 260 270
pF1KE5 LCFTMEVVKHHSPISWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSW
::::.: .:..: .::: :::::::: :::::::::::::::::::::::.:.:::::::
NP_055 LCFTVEGIKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSW
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE5 SPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFK
::::.::::::::::::::::::::::::::: ::::::::::::..:::: :.:::
NP_055 SPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFK
100 110 120 130 140 150
340 350 360 370
pF1KE5 YCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
::::::::::.:::::::::: :: .: .:.: :.
NP_055 YCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
160 170 180 190
373 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 01:37:41 2016 done: Tue Nov 8 01:37:42 2016
Total Scan time: 6.270 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]