Result of FASTA (omim) for
pFN21AE2675
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2675, 324 aa
1>>>pF1KE2675 324 - 324 aa - 324 aa
Library: /omim/omim.rfq.tfa
61265892 residues in 86068 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0251+/-0.000397; mu= 17.8113+/- 0.025
mean_var=70.9100+/-14.557, 0's: 0 Z-trim(113.3): 31 B-trim: 696 in 2/48
Lambda= 0.152307
statistics sampled from 22713 (22738) to 22713 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.644), E-opt: 0.2 (0.264), width: 16
Scan time: 7.760
The best scores are: opt bits E(86068)
NP_001291972 (OMIM: 617084) transmembrane protein ( 324) 2176 487.3 1.9e-137
NP_004863 (OMIM: 617084) transmembrane protein 59 ( 323) 2149 481.3 1.1e-135
NP_001291979 (OMIM: 617084) transmembrane protein ( 257) 1309 296.7 3.5e-80
XP_006711114 (OMIM: 617084) PREDICTED: transmembra ( 256) 1282 290.8 2.1e-78
NP_001291978 (OMIM: 617084) transmembrane protein ( 193) 1269 287.8 1.2e-77
NP_001291981 (OMIM: 617084) transmembrane protein ( 192) 1242 281.9 7.6e-76
NP_001291980 (OMIM: 617084) transmembrane protein ( 192) 1242 281.9 7.6e-76
NP_001291995 (OMIM: 617084) transmembrane protein ( 145) 904 207.5 1.4e-53
NP_036241 (OMIM: 617096) transmembrane protein 59- ( 342) 380 92.7 1.2e-18
>>NP_001291972 (OMIM: 617084) transmembrane protein 59 i (324 aa)
initn: 2176 init1: 2176 opt: 2176 Z-score: 2588.8 bits: 487.3 E(86068): 1.9e-137
Smith-Waterman score: 2176; 100.0% identity (100.0% similar) in 324 aa overlap (1-324:1-324)
10 20 30 40 50 60
pF1KE2 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRNFLEDGESDGFLRCLSLNSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRNFLEDGESDGFLRCLSLNSG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 WILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVV
250 260 270 280 290 300
310 320
pF1KE2 RSKTEDHEEAGPLPTKVNLAHSEI
::::::::::::::::::::::::
NP_001 RSKTEDHEEAGPLPTKVNLAHSEI
310 320
>>NP_004863 (OMIM: 617084) transmembrane protein 59 isof (323 aa)
initn: 1419 init1: 1419 opt: 2149 Z-score: 2556.8 bits: 481.3 E(86068): 1.1e-135
Smith-Waterman score: 2149; 99.4% identity (99.4% similar) in 324 aa overlap (1-324:1-323)
10 20 30 40 50 60
pF1KE2 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 QSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRNFLEDGESDGFLRCLSLNSG
:::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
NP_004 QSKPEIQYAPHLEQEPTNLRESSLSKMSY-LQMRNSQAHRNFLEDGESDGFLRCLSLNSG
190 200 210 220 230
250 260 270 280 290 300
pF1KE2 WILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 WILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVV
240 250 260 270 280 290
310 320
pF1KE2 RSKTEDHEEAGPLPTKVNLAHSEI
::::::::::::::::::::::::
NP_004 RSKTEDHEEAGPLPTKVNLAHSEI
300 310 320
>>NP_001291979 (OMIM: 617084) transmembrane protein 59 i (257 aa)
initn: 1281 init1: 1281 opt: 1309 Z-score: 1560.6 bits: 296.7 E(86068): 3.5e-80
Smith-Waterman score: 1554; 79.3% identity (79.3% similar) in 324 aa overlap (1-324:1-257)
10 20 30 40 50 60
pF1KE2 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
:::
NP_001 YPK---------------------------------------------------------
130 140 150 160 170 180
pF1KE2 LPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------LMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
70 80 90 100 110
190 200 210 220 230 240
pF1KE2 QSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRNFLEDGESDGFLRCLSLNSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRNFLEDGESDGFLRCLSLNSG
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE2 WILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVV
180 190 200 210 220 230
310 320
pF1KE2 RSKTEDHEEAGPLPTKVNLAHSEI
::::::::::::::::::::::::
NP_001 RSKTEDHEEAGPLPTKVNLAHSEI
240 250
>>XP_006711114 (OMIM: 617084) PREDICTED: transmembrane p (256 aa)
initn: 1177 init1: 746 opt: 1282 Z-score: 1528.6 bits: 290.8 E(86068): 2.1e-78
Smith-Waterman score: 1527; 78.7% identity (78.7% similar) in 324 aa overlap (1-324:1-256)
10 20 30 40 50 60
pF1KE2 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
:::
XP_006 YPK---------------------------------------------------------
130 140 150 160 170 180
pF1KE2 LPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ----------LMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
70 80 90 100 110
190 200 210 220 230 240
pF1KE2 QSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRNFLEDGESDGFLRCLSLNSG
:::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
XP_006 QSKPEIQYAPHLEQEPTNLRESSLSKMSY-LQMRNSQAHRNFLEDGESDGFLRCLSLNSG
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE2 WILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVV
180 190 200 210 220 230
310 320
pF1KE2 RSKTEDHEEAGPLPTKVNLAHSEI
::::::::::::::::::::::::
XP_006 RSKTEDHEEAGPLPTKVNLAHSEI
240 250
>>NP_001291978 (OMIM: 617084) transmembrane protein 59 i (193 aa)
initn: 1269 init1: 1269 opt: 1269 Z-score: 1514.8 bits: 287.8 E(86068): 1.2e-77
Smith-Waterman score: 1269; 100.0% identity (100.0% similar) in 193 aa overlap (132-324:1-193)
110 120 130 140 150 160
pF1KE2 EAYSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSF
::::::::::::::::::::::::::::::
NP_001 MSLMPKMHLLFPLTLVRSFWSDMMDSAQSF
10 20 30
170 180 190 200 210 220
pF1KE2 ITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRN
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE2 FLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDL
100 110 120 130 140 150
290 300 310 320
pF1KE2 EFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
:::::::::::::::::::::::::::::::::::::::::::
NP_001 EFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
160 170 180 190
>>NP_001291981 (OMIM: 617084) transmembrane protein 59 i (192 aa)
initn: 746 init1: 746 opt: 1242 Z-score: 1482.8 bits: 281.9 E(86068): 7.6e-76
Smith-Waterman score: 1242; 99.0% identity (99.0% similar) in 193 aa overlap (132-324:1-192)
110 120 130 140 150 160
pF1KE2 EAYSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSF
::::::::::::::::::::::::::::::
NP_001 MSLMPKMHLLFPLTLVRSFWSDMMDSAQSF
10 20 30
170 180 190 200 210 220
pF1KE2 ITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRN
::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
NP_001 ITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSY-LQMRNSQAHRN
40 50 60 70 80
230 240 250 260 270 280
pF1KE2 FLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDL
90 100 110 120 130 140
290 300 310 320
pF1KE2 EFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
:::::::::::::::::::::::::::::::::::::::::::
NP_001 EFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
150 160 170 180 190
>>NP_001291980 (OMIM: 617084) transmembrane protein 59 i (192 aa)
initn: 746 init1: 746 opt: 1242 Z-score: 1482.8 bits: 281.9 E(86068): 7.6e-76
Smith-Waterman score: 1242; 99.0% identity (99.0% similar) in 193 aa overlap (132-324:1-192)
110 120 130 140 150 160
pF1KE2 EAYSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSF
::::::::::::::::::::::::::::::
NP_001 MSLMPKMHLLFPLTLVRSFWSDMMDSAQSF
10 20 30
170 180 190 200 210 220
pF1KE2 ITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRN
::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::
NP_001 ITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSY-LQMRNSQAHRN
40 50 60 70 80
230 240 250 260 270 280
pF1KE2 FLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDL
90 100 110 120 130 140
290 300 310 320
pF1KE2 EFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
:::::::::::::::::::::::::::::::::::::::::::
NP_001 EFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
150 160 170 180 190
>>NP_001291995 (OMIM: 617084) transmembrane protein 59 i (145 aa)
initn: 949 init1: 903 opt: 904 Z-score: 1083.1 bits: 207.5 E(86068): 1.4e-53
Smith-Waterman score: 904; 88.7% identity (92.1% similar) in 151 aa overlap (1-151:1-144)
10 20 30 40 50 60
pF1KE2 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 LPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
::::::::::. . . : .:.: :
NP_001 LPFAELRQEQV-----RNNTAFQTSLLR--WH
130 140
190 200 210 220 230 240
pF1KE2 QSKPEIQYAPHLEQEPTNLRESSLSKMSSDLQMRNSQAHRNFLEDGESDGFLRCLSLNSG
>>NP_036241 (OMIM: 617096) transmembrane protein 59-like (342 aa)
initn: 533 init1: 221 opt: 380 Z-score: 455.7 bits: 92.7 E(86068): 1.2e-18
Smith-Waterman score: 545; 33.5% identity (58.6% similar) in 319 aa overlap (16-296:7-323)
10 20 30 40 50
pF1KE2 MAAPKGSLWVRTQLGLPPLLLLTMALAG---GSGTASAEAFDSVLGDTASCHRACQLTYP
.:: ::: . ::. .:. .. . : :::: .:. :.
NP_036 MAAVALMPPPLLLLLLLASPPAASAPSARDPFAPQLGDTQNCQLRCR-DRD
10 20 30 40 50
60 70 80 90 100
pF1KE2 LHTYPKEEELY--------------ACQRGCRLFSICQFVDDGIDLNRTKLECESACTEA
: :.. : ::.:::::::::.:: . : :. :::.::.::
NP_036 LGPQPSQAGLEGASESPYDRAVLISACERGCRLFSICRFVARSSKPNATQTECEAACVEA
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE2 YSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFIT
: . :: :: :: .: : .:.. . :. : . : : .. .:...:::.:..
NP_036 YVKEAEQQACSHGCWSQPAEPEPEQKRKVLEAPSGALSL-LDLFSTLCNDLVNSAQGFVS
120 130 140 150 160
170 180 190 200
pF1KE2 SSWTFYLQADDGKIVIFQSKPEIQ----YAPHLEQEPTNLRESS-------------LSK
:.::.:::.:.::.:.::..: .. . .:.. .. : : :.:
NP_036 STWTYYLQTDNGKVVVFQTQPIVESLGFQGGRLQRVEVTWRGSHPEALEVHVDPVGPLDK
170 180 190 200 210 220
210 220 230 240 250 260
pF1KE2 M-SSDLQMRNSQAHRNFLEDGESDGFLRCLSLNSG---WILTTTLVLSVMVLLWICCATV
. .. .....:. . :. ... :: :.: :: :::. : :::.:.::. :.:.
NP_036 VRKAKIRVKTSSKAKVESEEPQDNDFLSCMSRRSGLPRWILACCLFLSVLVMLWLSCSTL
230 240 250 260 270 280
270 280 290 300 310 320
pF1KE2 ATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHS
.:: :.. . :.. :: : :: :
NP_036 VTAPGQHLKFQPLTLEQHKGFMMEPDWPLYPPPSHACEDSLPPYKLKLDLTKL
290 300 310 320 330 340
pF1KE2 EI
324 residues in 1 query sequences
61265892 residues in 86068 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Feb 2 14:39:49 2017 done: Thu Feb 2 14:39:50 2017
Total Scan time: 7.760 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]