FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2562, 265 aa 1>>>pF1KE2562 265 - 265 aa - 265 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.1681+/-0.00037; mu= -3.2502+/- 0.023 mean_var=227.4562+/-45.827, 0's: 0 Z-trim(120.7): 48 B-trim: 380 in 1/59 Lambda= 0.085040 statistics sampled from 36167 (36224) to 36167 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.425), width: 16 Scan time: 5.730 The best scores are: opt bits E(85289) NP_954654 (OMIM: 164040) nucleophosmin isoform 2 [ ( 265) 1765 228.8 7.8e-60 XP_005265977 (OMIM: 164040) PREDICTED: nucleophosm ( 230) 1504 196.8 3e-50 NP_001032827 (OMIM: 164040) nucleophosmin isoform ( 259) 1312 173.2 4.1e-43 NP_002511 (OMIM: 164040) nucleophosmin isoform 1 [ ( 294) 1312 173.3 4.5e-43 XP_011532866 (OMIM: 164040) PREDICTED: nucleophosm ( 230) 881 120.3 3.1e-27 NP_008924 (OMIM: 606456) nucleoplasmin-3 [Homo sap ( 178) 347 54.7 1.3e-07 XP_011542665 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 257 43.8 0.00033 NP_877724 (OMIM: 608073) nucleoplasmin-2 isoform 1 ( 214) 257 43.8 0.00033 XP_011542664 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 257 43.8 0.00033 XP_016868438 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 257 43.8 0.00033 XP_016868437 (OMIM: 608073) PREDICTED: nucleoplasm ( 214) 257 43.8 0.00033 NP_001273609 (OMIM: 608073) nucleoplasmin-2 isofor ( 214) 257 43.8 0.00033 XP_011542662 (OMIM: 608073) PREDICTED: nucleoplasm ( 289) 251 43.1 0.00069 NP_001273610 (OMIM: 608073) nucleoplasmin-2 isofor ( 136) 227 39.9 0.0029 NP_005372 (OMIM: 164035) nucleolin [Homo sapiens] ( 710) 232 41.1 0.007 >>NP_954654 (OMIM: 164040) nucleophosmin isoform 2 [Homo (265 aa) initn: 1765 init1: 1765 opt: 1765 Z-score: 1195.2 bits: 228.8 E(85289): 7.8e-60 Smith-Waterman score: 1765; 100.0% identity (100.0% similar) in 265 aa overlap (1-265:1-265) 10 20 30 40 50 60 pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 FDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_954 FDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFI 190 200 210 220 230 240 250 260 pF1KE2 NYVKNCFRMTDQEAIQDLWQWRKSL ::::::::::::::::::::::::: NP_954 NYVKNCFRMTDQEAIQDLWQWRKSL 250 260 >>XP_005265977 (OMIM: 164040) PREDICTED: nucleophosmin i (230 aa) initn: 1504 init1: 1504 opt: 1504 Z-score: 1023.0 bits: 196.8 E(85289): 3e-50 Smith-Waterman score: 1504; 100.0% identity (100.0% similar) in 228 aa overlap (1-228:1-228) 10 20 30 40 50 60 pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 FDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFI :::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKAH 190 200 210 220 230 250 260 pF1KE2 NYVKNCFRMTDQEAIQDLWQWRKSL >>NP_001032827 (OMIM: 164040) nucleophosmin isoform 3 [H (259 aa) initn: 1287 init1: 1287 opt: 1312 Z-score: 895.0 bits: 173.2 E(85289): 4.1e-43 Smith-Waterman score: 1436; 88.7% identity (88.7% similar) in 257 aa overlap (1-228:1-257) 10 20 30 40 50 60 pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD 130 140 150 160 170 180 190 200 210 pF1KE2 FDDEEAEEKAPVKK-----------------------------GQESFKKQEKTPKTPKG :::::::::::::: ::::::::::::::::: NP_001 FDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKG 190 200 210 220 230 240 220 230 240 250 260 pF1KE2 PSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL ::::::::::::::::: NP_001 PSSVEDIKAKMQASIEKAH 250 >>NP_002511 (OMIM: 164040) nucleophosmin isoform 1 [Homo (294 aa) initn: 1287 init1: 1287 opt: 1312 Z-score: 894.2 bits: 173.3 E(85289): 4.5e-43 Smith-Waterman score: 1697; 90.1% identity (90.1% similar) in 294 aa overlap (1-265:1-294) 10 20 30 40 50 60 pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEDSMDMDMSPLRPQNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDDD 130 140 150 160 170 180 190 200 210 pF1KE2 FDDEEAEEKAPVKK-----------------------------GQESFKKQEKTPKTPKG :::::::::::::: ::::::::::::::::: NP_002 FDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKG 190 200 210 220 230 240 220 230 240 250 260 pF1KE2 PSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL 250 260 270 280 290 >>XP_011532866 (OMIM: 164040) PREDICTED: nucleophosmin i (230 aa) initn: 856 init1: 856 opt: 881 Z-score: 609.9 bits: 120.3 E(85289): 3.1e-27 Smith-Waterman score: 1266; 87.4% identity (87.4% similar) in 230 aa overlap (65-265:1-230) 40 50 60 70 80 90 pF1KE2 NDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEI :::::::::::::::::::::::::::::: XP_011 MNYEGSPIKVTLATLKMSVQPTVSLGGFEI 10 20 30 100 110 120 130 140 150 pF1KE2 TPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGSKVPQK 40 50 60 70 80 90 160 170 180 190 pF1KE2 KVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKK-------------------- :::::::::::::::::::::::::::::::::::::::: XP_011 KVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPAKNAQKSNQNGKDS 100 110 120 130 140 150 200 210 220 230 240 pF1KE2 ---------GQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKN ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPSSTPRSKGQESFKKQEKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKN 160 170 180 190 200 210 250 260 pF1KE2 CFRMTDQEAIQDLWQWRKSL :::::::::::::::::::: XP_011 CFRMTDQEAIQDLWQWRKSL 220 230 >>NP_008924 (OMIM: 606456) nucleoplasmin-3 [Homo sapiens (178 aa) initn: 344 init1: 280 opt: 347 Z-score: 257.4 bits: 54.7 E(85289): 1.3e-07 Smith-Waterman score: 347; 40.8% identity (70.7% similar) in 147 aa overlap (10-146:30-176) 10 20 30 pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKAD-KDYHFKVDN-DEN .:. ....:::::.. ... :::.. :. NP_008 MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDA 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 EHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIKVTLATLKMSVQPTVSLGGFEITPPV :: :.: . : ::::: ..::. : :.. . : : .:.::.: :: .:: :.. ::: NP_008 EHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPV 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 VLRLKCGSGPVHISGQHLVAV------EEDAESEDEE--EEDVKLLSISGKRSAPGGGSK ..::: :::::.:.:.: ... ::..: :.:. ::.:.: : .. : NP_008 TFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEEEDSDEEEVELCPILPAKKQGGRP 130 140 150 160 170 160 170 180 190 200 210 pF1KE2 VPQKKVKLAADEDDDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPK >>XP_011542665 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa) initn: 327 init1: 175 opt: 257 Z-score: 196.6 bits: 43.8 E(85289): 0.00033 Smith-Waterman score: 280; 34.3% identity (60.2% similar) in 201 aa overlap (18-201:18-214) 10 20 30 40 50 pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADK-DYHFKVDNDENEH-QLSLRTVSLGAGAKDELH :.::::. .. . :. . . .. .: :.:. :: ::.:.: XP_011 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 IVEA-EAMNYEGSPIK-VTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHL :: : : . .. ::.:.:. :: : ::. : ...:::...:. ::::: .:::. XP_011 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 120 130 140 150 160 pF1KE2 VAV---------EEDAESEDEEEEDVKL--LSISGKRSAPGGGSK--VPQKKVKLAADED . ::..: :.::::: . .:: ....: : ::::....: . XP_011 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE2 DDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQ . ..:: : . .: .: : : ::: XP_011 LEKEEEEIRASVRDKSPVKKAKATARAK-KPG---FKK 190 200 210 230 240 250 260 pF1KE2 ASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL >>NP_877724 (OMIM: 608073) nucleoplasmin-2 isoform 1 [Ho (214 aa) initn: 327 init1: 175 opt: 257 Z-score: 196.6 bits: 43.8 E(85289): 0.00033 Smith-Waterman score: 280; 34.3% identity (60.2% similar) in 201 aa overlap (18-201:18-214) 10 20 30 40 50 pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADK-DYHFKVDNDENEH-QLSLRTVSLGAGAKDELH :.::::. .. . :. . . .. .: :.:. :: ::.:.: NP_877 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 IVEA-EAMNYEGSPIK-VTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHL :: : : . .. ::.:.:. :: : ::. : ...:::...:. ::::: .:::. NP_877 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 120 130 140 150 160 pF1KE2 VAV---------EEDAESEDEEEEDVKL--LSISGKRSAPGGGSK--VPQKKVKLAADED . ::..: :.::::: . .:: ....: : ::::....: . NP_877 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE2 DDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQ . ..:: : . .: .: : : ::: NP_877 LEKEEEEIRASVRDKSPVKKAKATARAK-KPG---FKK 190 200 210 230 240 250 260 pF1KE2 ASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL >>XP_011542664 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa) initn: 327 init1: 175 opt: 257 Z-score: 196.6 bits: 43.8 E(85289): 0.00033 Smith-Waterman score: 280; 34.3% identity (60.2% similar) in 201 aa overlap (18-201:18-214) 10 20 30 40 50 pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADK-DYHFKVDNDENEH-QLSLRTVSLGAGAKDELH :.::::. .. . :. . . .. .: :.:. :: ::.:.: XP_011 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 IVEA-EAMNYEGSPIK-VTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHL :: : : . .. ::.:.:. :: : ::. : ...:::...:. ::::: .:::. XP_011 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 120 130 140 150 160 pF1KE2 VAV---------EEDAESEDEEEEDVKL--LSISGKRSAPGGGSK--VPQKKVKLAADED . ::..: :.::::: . .:: ....: : ::::....: . XP_011 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE2 DDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQ . ..:: : . .: .: : : ::: XP_011 LEKEEEEIRASVRDKSPVKKAKATARAK-KPG---FKK 190 200 210 230 240 250 260 pF1KE2 ASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL >>XP_016868438 (OMIM: 608073) PREDICTED: nucleoplasmin-2 (214 aa) initn: 327 init1: 175 opt: 257 Z-score: 196.6 bits: 43.8 E(85289): 0.00033 Smith-Waterman score: 280; 34.3% identity (60.2% similar) in 201 aa overlap (18-201:18-214) 10 20 30 40 50 pF1KE2 MEDSMDMDMSPLRPQNYLFGCELKADK-DYHFKVDNDENEH-QLSLRTVSLGAGAKDELH :.::::. .. . :. . . .. .: :.:. :: ::.:.: XP_016 MNLSSASSTEEKAVTTVLWGCELSQERRTWTFRPQLEGKQSCRLLLHTICLGEKAKEEMH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 IVEA-EAMNYEGSPIK-VTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHL :: : : . .. ::.:.:. :: : ::. : ...:::...:. ::::: .:::. XP_016 RVEILPPANQEDKKMQPVTIASLQASVLPMVSMVGVQLSPPVTFQLRAGSGPVFLSGQER 70 80 90 100 110 120 120 130 140 150 160 pF1KE2 VAV---------EEDAESEDEEEEDVKL--LSISGKRSAPGGGSK--VPQKKVKLAADED . ::..: :.::::: . .:: ....: : ::::....: . XP_016 YEASDLTWEEEEEEEGEEEEEEEEDDEDEDADISLEEQSPVKQVKRLVPQKQASVAKKKK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE2 DDDDDEEDDDEDDDDDDFDDEEAEEKAPVKKGQESFKKQEKTPKTPKGPSSVEDIKAKMQ . ..:: : . .: .: : : ::: XP_016 LEKEEEEIRASVRDKSPVKKAKATARAK-KPG---FKK 190 200 210 230 240 250 260 pF1KE2 ASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDLWQWRKSL 265 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 10:58:27 2016 done: Tue Nov 8 10:58:28 2016 Total Scan time: 5.730 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]