FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5667, 523 aa 1>>>pF1KE5667 523 - 523 aa - 523 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9207+/-0.000502; mu= 9.8017+/- 0.031 mean_var=95.5551+/-19.136, 0's: 0 Z-trim(109.1): 45 B-trim: 12 in 1/54 Lambda= 0.131204 statistics sampled from 17174 (17214) to 17174 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.537), E-opt: 0.2 (0.202), width: 16 Scan time: 6.540 The best scores are: opt bits E(85289) NP_001245378 (OMIM: 604669) polycystic kidney dise ( 523) 3469 667.8 2.2e-191 XP_016864832 (OMIM: 604669) PREDICTED: polycystic ( 604) 2589 501.2 3.5e-141 NP_055201 (OMIM: 604669) polycystic kidney disease ( 613) 2589 501.2 3.6e-141 NP_001287850 (OMIM: 604669) polycystic kidney dise ( 624) 2589 501.2 3.6e-141 XP_011541620 (OMIM: 604669) PREDICTED: polycystic ( 590) 2295 445.6 1.9e-124 NP_001245377 (OMIM: 604669) polycystic kidney dise ( 602) 2199 427.4 5.8e-119 XP_016864833 (OMIM: 604669) PREDICTED: polycystic ( 564) 2188 425.3 2.3e-118 XP_011541623 (OMIM: 604669) PREDICTED: polycystic ( 564) 2188 425.3 2.3e-118 NP_000288 (OMIM: 173910,613095) polycystin-2 [Homo ( 968) 1231 244.2 1.3e-63 NP_001240766 (OMIM: 604532) polycystic kidney dise ( 758) 1221 242.3 3.8e-63 NP_057196 (OMIM: 604532) polycystic kidney disease ( 805) 1221 242.3 4.1e-63 XP_016864834 (OMIM: 604669) PREDICTED: polycystic ( 550) 1173 233.2 1.6e-60 XP_011530331 (OMIM: 173910,613095) PREDICTED: poly ( 728) 1136 226.2 2.6e-58 XP_016872364 (OMIM: 604532) PREDICTED: polycystic ( 710) 1129 224.9 6.3e-58 XP_011538625 (OMIM: 604532) PREDICTED: polycystic ( 710) 1129 224.9 6.3e-58 XP_011538627 (OMIM: 604532) PREDICTED: polycystic ( 687) 1106 220.5 1.3e-56 XP_011530332 (OMIM: 173910,613095) PREDICTED: poly ( 688) 983 197.3 1.3e-49 XP_016872365 (OMIM: 604532) PREDICTED: polycystic ( 649) 483 102.6 3.8e-21 XP_011530330 (OMIM: 173910,613095) PREDICTED: poly ( 893) 463 98.9 6.9e-20 NP_001265354 (OMIM: 607894) polycystic kidney dise (1774) 439 94.4 3e-18 NP_443124 (OMIM: 607894) polycystic kidney disease (2459) 439 94.5 4.1e-18 XP_005255427 (OMIM: 173900,601313) PREDICTED: poly (3288) 238 56.4 1.5e-06 XP_016878774 (OMIM: 173900,601313) PREDICTED: poly (3327) 238 56.4 1.5e-06 XP_011520839 (OMIM: 173900,601313) PREDICTED: poly (3329) 238 56.4 1.5e-06 XP_011520837 (OMIM: 173900,601313) PREDICTED: poly (3603) 238 56.5 1.6e-06 NP_612152 (OMIM: 609721) polycystic kidney disease (2849) 236 56.0 1.7e-06 XP_016867287 (OMIM: 609721) PREDICTED: polycystic (2920) 236 56.0 1.7e-06 XP_011520836 (OMIM: 173900,601313) PREDICTED: poly (4241) 238 56.5 1.9e-06 XP_011520834 (OMIM: 173900,601313) PREDICTED: poly (4287) 238 56.5 1.9e-06 NP_000287 (OMIM: 173900,601313) polycystin-1 isofo (4302) 238 56.5 1.9e-06 NP_001009944 (OMIM: 173900,601313) polycystin-1 is (4303) 238 56.5 1.9e-06 XP_011520832 (OMIM: 173900,601313) PREDICTED: poly (4311) 238 56.5 1.9e-06 XP_011520831 (OMIM: 173900,601313) PREDICTED: poly (4320) 238 56.5 1.9e-06 XP_011520830 (OMIM: 173900,601313) PREDICTED: poly (4321) 238 56.5 1.9e-06 NP_006062 (OMIM: 604670) polycystic kidney disease (2253) 206 50.3 7.1e-05 >>NP_001245378 (OMIM: 604669) polycystic kidney disease (523 aa) initn: 3469 init1: 3469 opt: 3469 Z-score: 3556.9 bits: 667.8 E(85289): 2.2e-191 Smith-Waterman score: 3469; 99.8% identity (99.8% similar) in 523 aa overlap (1-523:1-523) 10 20 30 40 50 60 pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 LACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKN ::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: NP_001 LACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 VLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEI 430 440 450 460 470 480 490 500 510 520 pF1KE5 QDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL ::::::::::::::::::::::::::::::::::::::::::: NP_001 QDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL 490 500 510 520 >>XP_016864832 (OMIM: 604669) PREDICTED: polycystic kidn (604 aa) initn: 3026 init1: 2576 opt: 2589 Z-score: 2655.6 bits: 501.2 E(85289): 3.5e-141 Smith-Waterman score: 2815; 81.6% identity (81.6% similar) in 555 aa overlap (1-454:1-555) 10 20 30 40 50 60 pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF 310 320 330 340 350 360 370 380 pF1KE5 LACWHIYYNNIIAITIFFAWIK-------------------------------------- :::::::::::::::::::::: XP_016 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA 370 380 390 400 410 420 pF1KE5 ------------------------------------------------------------ XP_016 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF 430 440 450 460 470 480 390 400 410 420 430 pF1KE5 ---NMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK ::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: XP_016 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK 490 500 510 520 530 540 440 450 460 470 480 490 pF1KE5 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA ::::::::::::::: XP_016 GSGDLAEQARREGFDENRQSLTLSPRLEQRCDSGLNILQTENQVILLPQPPKYLGLHANT 550 560 570 580 590 600 >>NP_055201 (OMIM: 604669) polycystic kidney disease 2-l (613 aa) initn: 3278 init1: 2576 opt: 2589 Z-score: 2655.5 bits: 501.2 E(85289): 3.6e-141 Smith-Waterman score: 2815; 81.6% identity (81.6% similar) in 555 aa overlap (1-454:1-555) 10 20 30 40 50 60 pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF 310 320 330 340 350 360 370 380 pF1KE5 LACWHIYYNNIIAITIFFAWIK-------------------------------------- :::::::::::::::::::::: NP_055 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA 370 380 390 400 410 420 pF1KE5 ------------------------------------------------------------ NP_055 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF 430 440 450 460 470 480 390 400 410 420 430 pF1KE5 ---NMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK ::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_055 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK 490 500 510 520 530 540 440 450 460 470 480 490 pF1KE5 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA ::::::::::::::: NP_055 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRDGTTTK 550 560 570 580 590 600 >-- initn: 285 init1: 265 opt: 265 Z-score: 278.1 bits: 61.3 E(85289): 9.4e-09 Smith-Waterman score: 265; 97.5% identity (100.0% similar) in 40 aa overlap (455-494:556-595) 430 440 450 460 470 480 pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY :::::::::::::::::::::::::::::: NP_055 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY 530 540 550 560 570 580 490 500 510 520 pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL :::::::::. NP_055 QPVTQEEFRDGTTTKYKMRFSECLTKRI 590 600 610 >>NP_001287850 (OMIM: 604669) polycystic kidney disease (624 aa) initn: 3455 init1: 2576 opt: 2589 Z-score: 2655.4 bits: 501.2 E(85289): 3.6e-141 Smith-Waterman score: 2815; 81.6% identity (81.6% similar) in 555 aa overlap (1-454:1-555) 10 20 30 40 50 60 pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF 310 320 330 340 350 360 370 380 pF1KE5 LACWHIYYNNIIAITIFFAWIK-------------------------------------- :::::::::::::::::::::: NP_001 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA 370 380 390 400 410 420 pF1KE5 ------------------------------------------------------------ NP_001 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF 430 440 450 460 470 480 390 400 410 420 430 pF1KE5 ---NMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK ::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK 490 500 510 520 530 540 440 450 460 470 480 490 pF1KE5 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA ::::::::::::::: NP_001 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA 550 560 570 580 590 600 >-- initn: 442 init1: 442 opt: 442 Z-score: 459.0 bits: 94.8 E(85289): 7.9e-19 Smith-Waterman score: 442; 100.0% identity (100.0% similar) in 69 aa overlap (455-523:556-624) 430 440 450 460 470 480 pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY :::::::::::::::::::::::::::::: NP_001 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY 530 540 550 560 570 580 490 500 510 520 pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL ::::::::::::::::::::::::::::::::::::::: NP_001 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL 590 600 610 620 >>XP_011541620 (OMIM: 604669) PREDICTED: polycystic kidn (590 aa) initn: 3222 init1: 2282 opt: 2295 Z-score: 2355.1 bits: 445.6 E(85289): 1.9e-124 Smith-Waterman score: 2521; 79.8% identity (80.0% similar) in 511 aa overlap (45-454:11-521) 20 30 40 50 60 70 pF1KE5 HKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEE .::::::::::::::::::::::::::::: XP_011 MAEASRWHRGVTFGMVNPHMYYLNKVMSSLFLDTSVPGEE 10 20 30 40 80 90 100 110 120 130 pF1KE5 RTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQL 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE5 KVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGV 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE5 YRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEF 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE5 PATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKS 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE5 IWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAI 290 300 310 320 330 340 380 pF1KE5 TIFFAWIK---------------------------------------------------- :::::::: XP_011 TIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVD 350 360 370 380 390 400 390 pF1KE5 -------------------------------------------------NMFLAIINDTY ::::::::::: XP_011 DFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTY 410 420 430 440 450 460 400 410 420 430 440 450 pF1KE5 SEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGF :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGF 470 480 490 500 510 520 460 470 480 490 500 510 pF1KE5 DENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKL : XP_011 DENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKL 530 540 550 560 570 580 >-- initn: 442 init1: 442 opt: 442 Z-score: 459.4 bits: 94.8 E(85289): 7.5e-19 Smith-Waterman score: 442; 100.0% identity (100.0% similar) in 69 aa overlap (455-523:522-590) 430 440 450 460 470 480 pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY :::::::::::::::::::::::::::::: XP_011 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY 500 510 520 530 540 550 490 500 510 520 pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL ::::::::::::::::::::::::::::::::::::::: XP_011 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL 560 570 580 590 >>NP_001245377 (OMIM: 604669) polycystic kidney disease (602 aa) initn: 3078 init1: 2199 opt: 2199 Z-score: 2256.7 bits: 427.4 E(85289): 5.8e-119 Smith-Waterman score: 2765; 78.5% identity (78.5% similar) in 577 aa overlap (1-476:1-555) 10 20 30 40 50 60 pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF :::::::::::::::::::::::::: :::::::::::: NP_001 VKKIKEFKSAYFKSIWNWLELLLLLL----------------------LKSTEKYSDFYF 310 320 330 370 380 pF1KE5 LACWHIYYNNIIAITIFFAWIK-------------------------------------- :::::::::::::::::::::: NP_001 LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA 340 350 360 370 380 390 pF1KE5 ------------------------------------------------------------ NP_001 YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF 400 410 420 430 440 450 390 400 410 420 430 pF1KE5 ---NMFLAIINDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK ::::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK 460 470 480 490 500 510 440 450 460 470 480 490 pF1KE5 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA ::::::::::::::::::::::::::::::::::::: NP_001 GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA 520 530 540 550 560 570 500 510 520 pF1KE5 VELEKELHYINLKLNQVVRKVSAL NP_001 VELEKELHYINLKLNQVVRKVSAL 580 590 600 >-- initn: 294 init1: 294 opt: 294 Z-score: 307.9 bits: 66.8 E(85289): 2.1e-10 Smith-Waterman score: 294; 100.0% identity (100.0% similar) in 47 aa overlap (477-523:556-602) 450 460 470 480 490 500 pF1KE5 QARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKEL :::::::::::::::::::::::::::::: NP_001 QARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKEL 530 540 550 560 570 580 510 520 pF1KE5 HYINLKLNQVVRKVSAL ::::::::::::::::: NP_001 HYINLKLNQVVRKVSAL 590 600 >>XP_016864833 (OMIM: 604669) PREDICTED: polycystic kidn (564 aa) initn: 3054 init1: 2175 opt: 2188 Z-score: 2245.9 bits: 425.3 E(85289): 2.3e-118 Smith-Waterman score: 2414; 79.4% identity (79.4% similar) in 495 aa overlap (61-454:1-495) 40 50 60 70 80 90 pF1KE5 ELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKF :::::::::::::::::::::::::::::: XP_016 MSSLFLDTSVPGEERTNFKSIRSITDFWKF 10 20 30 100 110 120 130 140 150 pF1KE5 MEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE5 MSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSE 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE5 TKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVK 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE5 LLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVA 220 230 240 250 260 270 340 350 360 370 380 pF1KE5 VSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIK-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFN 280 290 300 310 320 330 pF1KE5 ------------------------------------------------------------ XP_016 KTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIV 340 350 360 370 380 390 390 400 pF1KE5 ---------------------------------NMFLAIINDTYSEVKADYSIGRRPDFE ::::::::::::::::::::::: ::: XP_016 LGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSIGRRLDFE 400 410 420 430 440 450 410 420 430 440 450 460 pF1KE5 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE ::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE 460 470 480 490 500 510 470 480 490 500 510 520 pF1KE5 RLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL XP_016 RLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL 520 530 540 550 560 >-- initn: 442 init1: 442 opt: 442 Z-score: 459.8 bits: 94.8 E(85289): 7.2e-19 Smith-Waterman score: 442; 100.0% identity (100.0% similar) in 69 aa overlap (455-523:496-564) 430 440 450 460 470 480 pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY :::::::::::::::::::::::::::::: XP_016 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY 470 480 490 500 510 520 490 500 510 520 pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL ::::::::::::::::::::::::::::::::::::::: XP_016 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL 530 540 550 560 >>XP_011541623 (OMIM: 604669) PREDICTED: polycystic kidn (564 aa) initn: 3054 init1: 2175 opt: 2188 Z-score: 2245.9 bits: 425.3 E(85289): 2.3e-118 Smith-Waterman score: 2414; 79.4% identity (79.4% similar) in 495 aa overlap (61-454:1-495) 40 50 60 70 80 90 pF1KE5 ELLLYFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKF :::::::::::::::::::::::::::::: XP_011 MSSLFLDTSVPGEERTNFKSIRSITDFWKF 10 20 30 100 110 120 130 140 150 pF1KE5 MEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEGPLLEGLYWDSWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSL 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE5 MSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSECYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSE 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE5 TKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVK 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE5 LLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVA 220 230 240 250 260 270 340 350 360 370 380 pF1KE5 VSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIK-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VSFNTYYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFN 280 290 300 310 320 330 pF1KE5 ------------------------------------------------------------ XP_011 KTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIV 340 350 360 370 380 390 390 400 pF1KE5 ---------------------------------NMFLAIINDTYSEVKADYSIGRRPDFE ::::::::::::::::::::::: ::: XP_011 LGDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKADYSIGRRLDFE 400 410 420 430 440 450 410 420 430 440 450 460 pF1KE5 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE ::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE 460 470 480 490 500 510 470 480 490 500 510 520 pF1KE5 RLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL XP_011 RLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL 520 530 540 550 560 >-- initn: 442 init1: 442 opt: 442 Z-score: 459.8 bits: 94.8 E(85289): 7.2e-19 Smith-Waterman score: 442; 100.0% identity (100.0% similar) in 69 aa overlap (455-523:496-564) 430 440 450 460 470 480 pF1KE5 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY :::::::::::::::::::::::::::::: XP_011 FRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDY 470 480 490 500 510 520 490 500 510 520 pF1KE5 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL ::::::::::::::::::::::::::::::::::::::: XP_011 QPVTQEEFRELFLYAVELEKELHYINLKLNQVVRKVSAL 530 540 550 560 >>NP_000288 (OMIM: 173910,613095) polycystin-2 [Homo sap (968 aa) initn: 1183 init1: 582 opt: 1231 Z-score: 1263.1 bits: 244.2 E(85289): 1.3e-63 Smith-Waterman score: 1231; 45.0% identity (77.5% similar) in 382 aa overlap (21-401:213-591) 10 20 30 40 50 pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMV .: . ..:.::. :..::: :::::.::. NP_000 QPPRVAWAERLVRGLRGLWGTRLMEESSTNREKYLKSVLRELVTYLLFLIVLCILTYGMM 190 200 210 220 230 240 60 70 80 90 100 110 pF1KE5 NPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQL . ..:: ...::.::::: : :.::::.. :. ::::: :: ::.:::: .:: NP_000 SSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTE 250 260 270 280 290 300 120 130 140 150 160 170 pF1KE5 YNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGL . : : :.:::.::::::.:::.:::..:.. ..... ..::: :. ..:: . :: NP_000 AD--NRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP 310 320 330 340 350 360 180 190 200 210 220 pF1KE5 QINTEWRYST-SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTR . .: : :.. .. :. :::....: ..:: . ::... :: . .:. : :. :::: NP_000 RNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTR 370 380 390 400 410 420 230 240 250 260 270 280 pF1KE5 VIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITF . :::::.::::.::::..::..:::::::.. :::: .::.:::. .:.:.:.::: : NP_000 ATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIF 430 440 450 460 470 480 290 300 310 320 330 340 pF1KE5 CIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL :.:.: ....:. .:. : ::.:.:: :......: ::...: : . .. .:: :.: NP_000 CFFIFYYVVEEILEIRIHKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLL-QFL 490 500 510 520 530 350 360 370 380 390 400 pF1KE5 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSEVKADYSIGRRPDFE .. . . .: :: :.: .::: :.:.::.::: . . .: :.:.... .: NP_000 EDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFG 540 550 560 570 580 590 410 420 430 440 450 460 pF1KE5 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE NP_000 FAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPI 600 610 620 630 640 650 >-- initn: 150 init1: 101 opt: 201 Z-score: 209.4 bits: 49.3 E(85289): 6.3e-05 Smith-Waterman score: 201; 31.4% identity (66.7% similar) in 159 aa overlap (366-522:659-802) 340 350 360 370 380 390 pF1KE5 YYNVQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSE ::..... . .:: . ::::::::::::: NP_000 FQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFV-FFMFFILL-NMFLAIINDTYSE 630 640 650 660 670 680 400 410 420 430 440 450 pF1KE5 VKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKT--KGSGDLAEQARREGF ::.: . .. ..::. .:...:...: :..::: :. ... .:.: : .: NP_000 VKSDLA-QQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKL-------NF 690 700 710 720 730 460 470 480 490 500 510 pF1KE5 DENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEKELHYINLKL :: . :. . . ..: . ... :: : .:..: ... .:::: . ..: NP_000 DELR-QDLKGKGHTDAEIEAIFTKYD-QDGDQELTEHEHQQM---RDDLEKEREDLDLDH 740 750 760 770 780 790 520 pF1KE5 NQVVRKVSAL ... : .:. NP_000 SSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSI 800 810 820 830 840 850 >>NP_001240766 (OMIM: 604532) polycystic kidney disease (758 aa) initn: 1051 init1: 819 opt: 1221 Z-score: 1254.6 bits: 242.3 E(85289): 3.8e-63 Smith-Waterman score: 1221; 45.9% identity (76.3% similar) in 379 aa overlap (21-398:46-421) 10 20 30 40 50 pF1KE5 MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMV .:. : :::.:::.:..::...:.::.::. NP_001 ASISVKASEASLPCPLGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMT 20 30 40 50 60 70 60 70 80 90 100 110 pF1KE5 NPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQL . :: .:::: ::: : :.. ..:..: :..::: : .::::..::: .:::::.: NP_001 SSSAYYYTKVMSELFLHT--PSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSL 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE5 YNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGL . . : :::::.::::::.:::::::..: :. .:. . :: :. .:. :: NP_001 GH-GSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGP 140 150 160 170 180 190 180 190 200 210 220 pF1KE5 QINTEWRYSTSNTNSPW-HWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTR .: : : ... . . ::: : : .::: . : :.. . . . :. . :. :::: NP_001 FNGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTR 200 210 220 230 240 250 230 240 250 260 270 280 pF1KE5 VIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITF :.:::::.::::.::::..:::.::::::: . :::. .:::.:::: .:.::..::. : NP_001 VVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIF 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE5 CIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLL :.:.: ....:. ... . :..:::: :.:...:: .:::.:. . .... :.:.:: NP_001 CVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLL 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE5 KSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKNMFLAIINDTYSEVKADYSIGRRPDFE .. . :.:: ::: :. :::. :...:::::: . .: :...... NP_001 QQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILG 380 390 400 410 420 430 410 420 430 440 450 460 pF1KE5 LGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKE NP_001 FAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPA 440 450 460 470 480 490 >-- initn: 147 init1: 93 opt: 191 Z-score: 200.9 bits: 47.4 E(85289): 0.00019 Smith-Waterman score: 191; 28.1% identity (62.3% similar) in 167 aa overlap (302-458:428-588) 280 290 300 310 320 330 pF1KE5 LRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLCFVAV : : : .: .. . .: ::. . NP_001 NLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVE 400 410 420 430 440 450 340 350 360 370 380 pF1KE5 SFNTYYN---VQIFLLLGQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKNMFLAI .:.:. . .:. ..::.. .. .. . . . : .. .::. . :::::: NP_001 NFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTY----VFFVFFVLL-NMFLAI 460 470 480 490 500 510 390 400 410 420 430 440 pF1KE5 INDTYSEVKADYSIGRRPDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSG------ ::::::::: . . :.. ...:. ..::.:...: ..::.: . .. .:. .: NP_001 INDTYSEVKEELA-GQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQF 520 530 540 550 560 570 450 460 470 480 490 500 pF1KE5 -DLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVE :... :. : :.:: NP_001 EDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEK 580 590 600 610 620 630 523 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:41:43 2016 done: Tue Nov 8 05:41:44 2016 Total Scan time: 6.540 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]