FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6185, 164 aa 1>>>pF1KE6185 164 - 164 aa - 164 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9372+/-0.00033; mu= 13.8167+/- 0.020 mean_var=54.4997+/-10.962, 0's: 0 Z-trim(113.6): 64 B-trim: 0 in 0/53 Lambda= 0.173731 statistics sampled from 22983 (23047) to 22983 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.663), E-opt: 0.2 (0.27), width: 16 Scan time: 4.600 The best scores are: opt bits E(85289) NP_001034658 (OMIM: 615781,616106) AP-1 complex su ( 154) 933 241.5 4.3e-64 NP_003907 (OMIM: 300629) AP-1 complex subunit sigm ( 157) 776 202.1 3.1e-52 NP_001259000 (OMIM: 300629) AP-1 complex subunit s ( 160) 768 200.1 1.3e-51 XP_005274671 (OMIM: 300629) PREDICTED: AP-1 comple ( 195) 767 199.9 1.8e-51 XP_016885415 (OMIM: 300629) PREDICTED: AP-1 comple ( 189) 766 199.7 2.1e-51 NP_001274 (OMIM: 603531,609313) AP-1 complex subun ( 158) 761 198.4 4.2e-51 XP_016885414 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 762 198.7 4.4e-51 XP_011543901 (OMIM: 300629) PREDICTED: AP-1 comple ( 202) 762 198.7 4.4e-51 XP_011508902 (OMIM: 615781,616106) PREDICTED: AP-1 ( 108) 647 169.7 1.2e-42 NP_004060 (OMIM: 600740,602242) AP-2 complex subun ( 142) 453 121.2 6.6e-28 NP_001288010 (OMIM: 600740,602242) AP-2 complex su ( 144) 446 119.4 2.3e-27 NP_001288005 (OMIM: 600740,602242) AP-2 complex su ( 158) 446 119.4 2.5e-27 NP_001121598 (OMIM: 607243,614067) AP-4 complex su ( 144) 366 99.4 2.5e-21 NP_001241658 (OMIM: 607243,614067) AP-4 complex su ( 144) 366 99.4 2.5e-21 NP_001241657 (OMIM: 607243,614067) AP-4 complex su ( 144) 366 99.4 2.5e-21 NP_005820 (OMIM: 602416) AP-3 complex subunit sigm ( 193) 348 94.9 7.2e-20 NP_001305022 (OMIM: 601507) AP-3 complex subunit s ( 162) 322 88.4 5.7e-18 XP_016864513 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 322 88.5 8.6e-18 XP_011541438 (OMIM: 601507) PREDICTED: AP-3 comple ( 262) 322 88.5 8.6e-18 NP_001275 (OMIM: 601507) AP-3 complex subunit sigm ( 193) 319 87.6 1.1e-17 NP_001288007 (OMIM: 600740,602242) AP-2 complex su ( 156) 311 85.6 3.7e-17 XP_011524726 (OMIM: 600740,602242) PREDICTED: AP-2 ( 158) 311 85.6 3.8e-17 XP_011524725 (OMIM: 600740,602242) PREDICTED: AP-2 ( 172) 311 85.6 4e-17 NP_001241656 (OMIM: 607243,614067) AP-4 complex su ( 149) 291 80.6 1.2e-15 XP_005267350 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 289 80.1 1.7e-15 XP_011534674 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 289 80.1 1.7e-15 XP_011534673 (OMIM: 607243,614067) PREDICTED: AP-4 ( 159) 289 80.1 1.7e-15 NP_009008 (OMIM: 607243,614067) AP-4 complex subun ( 159) 289 80.1 1.7e-15 NP_001241655 (OMIM: 607243,614067) AP-4 complex su ( 135) 268 74.8 5.8e-14 NP_001305023 (OMIM: 601507) AP-3 complex subunit s ( 157) 268 74.8 6.6e-14 NP_001002924 (OMIM: 601507) AP-3 complex subunit s ( 171) 260 72.8 2.8e-13 NP_067586 (OMIM: 600740,602242) AP-2 complex subun ( 104) 185 53.9 8.4e-08 NP_001305020 (OMIM: 601507) AP-3 complex subunit s ( 169) 167 49.5 2.9e-06 XP_016864514 (OMIM: 601507) PREDICTED: AP-3 comple ( 238) 167 49.6 3.9e-06 NP_001305019 (OMIM: 601507) AP-3 complex subunit s ( 125) 158 47.2 1.1e-05 NP_001258664 (OMIM: 615472) coatomer subunit zeta- ( 160) 154 46.3 2.7e-05 NP_057141 (OMIM: 615472) coatomer subunit zeta-1 i ( 177) 153 46.0 3.5e-05 NP_001258665 (OMIM: 615472) coatomer subunit zeta- ( 185) 153 46.0 3.6e-05 XP_016874486 (OMIM: 615472) PREDICTED: coatomer su ( 180) 152 45.8 4.2e-05 NP_001258663 (OMIM: 615472) coatomer subunit zeta- ( 154) 139 42.5 0.00035 NP_057513 (OMIM: 615526) coatomer subunit zeta-2 [ ( 210) 135 41.5 0.00091 NP_001020376 (OMIM: 601024) AP-2 complex subunit m ( 433) 127 39.7 0.0068 NP_004059 (OMIM: 601024) AP-2 complex subunit mu i ( 435) 127 39.7 0.0068 >>NP_001034658 (OMIM: 615781,616106) AP-1 complex subuni (154 aa) initn: 933 init1: 933 opt: 933 Z-score: 1271.6 bits: 241.5 E(85289): 4.3e-64 Smith-Waterman score: 933; 100.0% identity (100.0% similar) in 143 aa overlap (1-143:1-143) 10 20 30 40 50 60 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG 70 80 90 100 110 120 130 140 150 160 pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA ::::::::::::::::::::::: NP_001 GEIQETSKKIAVKAIEDSDMLQETMEEYMNKPTF 130 140 150 >>NP_003907 (OMIM: 300629) AP-1 complex subunit sigma-2 (157 aa) initn: 776 init1: 776 opt: 776 Z-score: 1058.8 bits: 202.1 E(85289): 3.1e-52 Smith-Waterman score: 776; 74.3% identity (93.2% similar) in 148 aa overlap (2-149:1-148) 10 20 30 40 50 60 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK ..:.:::::::::::::::. : :::.::::::.:: .:.: . ::..:..::.::: NP_003 MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYK 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG ::::::::::::.:::::.::::.::::::::::::.::::::::::::::::::::..: NP_003 RYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLG 60 70 80 90 100 110 130 140 150 160 pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA ::.:::::: ..::::..:.:::. .:: NP_003 GEVQETSKKNVLKAIEQADLLQEEAETPRSVLEEIGLT 120 130 140 150 >>NP_001259000 (OMIM: 300629) AP-1 complex subunit sigma (160 aa) initn: 783 init1: 751 opt: 768 Z-score: 1047.9 bits: 200.1 E(85289): 1.3e-51 Smith-Waterman score: 768; 70.7% identity (89.8% similar) in 157 aa overlap (2-158:1-152) 10 20 30 40 50 60 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK ..:.:::::::::::::::. : :::.::::::.:: .:.: . ::..:..::.::: NP_001 MQFMLLFSRQGKLRLQKWYVPLSDKEKKKITRELVQTVLARKPKMCSFLEWRDLKIVYK 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG ::::::::::::.:::::.::::.::::::::::::.::::::::::::::::::::..: NP_001 RYASLYFCCAIEDQDNELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLG 60 70 80 90 100 110 130 140 150 160 pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA ::.:::::: ..::::..:.:::. ... ::: NP_001 GEVQETSKKNVLKAIEQADLLQED-----AKEAETPRSVLEEIGLT 120 130 140 150 160 >>XP_005274671 (OMIM: 300629) PREDICTED: AP-1 complex su (195 aa) initn: 786 init1: 754 opt: 767 Z-score: 1045.2 bits: 199.9 E(85289): 1.8e-51 Smith-Waterman score: 767; 75.7% identity (93.8% similar) in 144 aa overlap (2-145:43-186) 10 20 30 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKI ..:.:::::::::::::::. : :::.::: XP_005 SLPQHGDRGFPFAAAAAAGQAPPRPRPAAAMQFMLLFSRQGKLRLQKWYVPLSDKEKKKI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELL :::.:: .:.: . ::..:..::.:::::::::::::::.:::::.::::.::::::: XP_005 TRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 DKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENRLSPRGR :::::.::::::::::::::::::::..:::.:::::: ..::::..:.::: : XP_005 DKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEPRHEYFNV 140 150 160 170 180 190 160 pF1KE6 DCSEPRSCHCTLA XP_005 PVY >>XP_016885415 (OMIM: 300629) PREDICTED: AP-1 complex su (189 aa) initn: 785 init1: 753 opt: 766 Z-score: 1044.0 bits: 199.7 E(85289): 2.1e-51 Smith-Waterman score: 766; 74.7% identity (93.8% similar) in 146 aa overlap (2-147:43-188) 10 20 30 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKI ..:.:::::::::::::::. : :::.::: XP_016 SLPQHGDRGFPFAAAAAAGQAPPRPRPAAAMQFMLLFSRQGKLRLQKWYVPLSDKEKKKI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELL :::.:: .:.: . ::..:..::.:::::::::::::::.:::::.::::.::::::: XP_016 TRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 DKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENRLSPRGR :::::.::::::::::::::::::::..:::.:::::: ..::::..:.:::. .: XP_016 DKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQESFFSS 140 150 160 170 180 160 pF1KE6 DCSEPRSCHCTLA >>NP_001274 (OMIM: 603531,609313) AP-1 complex subunit s (158 aa) initn: 761 init1: 761 opt: 761 Z-score: 1038.5 bits: 198.4 E(85289): 4.2e-51 Smith-Waterman score: 761; 71.1% identity (94.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK :..:.:::::::::::::::.. ::::::..::..:..:.: . ::..:..::.::: NP_001 MMRFMLLFSRQGKLRLQKWYLATSDKERKKMVRELMQVVLARKPKMCSFLEWRDLKVVYK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG ::::::::::::.:::::.:::..::::::::::::.::::::::::::::::::::..: NP_001 RYASLYFCCAIEGQDNELITLELIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLMG 70 80 90 100 110 120 130 140 150 160 pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA :..:.:::: ..::::..:.:::. ::: NP_001 GDVQDTSKKSVLKAIEQADLLQEEDESPRSVLEEMGLA 130 140 150 >>XP_016885414 (OMIM: 300629) PREDICTED: AP-1 complex su (202 aa) initn: 762 init1: 762 opt: 762 Z-score: 1038.2 bits: 198.7 E(85289): 4.4e-51 Smith-Waterman score: 762; 76.1% identity (94.4% similar) in 142 aa overlap (2-143:43-184) 10 20 30 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKI ..:.:::::::::::::::. : :::.::: XP_016 SLPQHGDRGFPFAAAAAAGQAPPRPRPAAAMQFMLLFSRQGKLRLQKWYVPLSDKEKKKI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELL :::.:: .:.: . ::..:..::.:::::::::::::::.:::::.::::.::::::: XP_016 TRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 DKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENRLSPRGR :::::.::::::::::::::::::::..:::.:::::: ..::::..:.::: XP_016 DKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEKTETMYHS 140 150 160 170 180 190 160 pF1KE6 DCSEPRSCHCTLA XP_016 KSFIGFKKAY 200 >>XP_011543901 (OMIM: 300629) PREDICTED: AP-1 complex su (202 aa) initn: 762 init1: 762 opt: 762 Z-score: 1038.2 bits: 198.7 E(85289): 4.4e-51 Smith-Waterman score: 762; 76.1% identity (94.4% similar) in 142 aa overlap (2-143:43-184) 10 20 30 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKI ..:.:::::::::::::::. : :::.::: XP_011 SLPQHGDRGFPFAAAAAAGQAPPRPRPAAAMQFMLLFSRQGKLRLQKWYVPLSDKEKKKI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE6 TREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELL :::.:: .:.: . ::..:..::.:::::::::::::::.:::::.::::.::::::: XP_011 TRELVQTVLARKPKMCSFLEWRDLKIVYKRYASLYFCCAIEDQDNELITLEIIHRYVELL 80 90 100 110 120 130 100 110 120 130 140 150 pF1KE6 DKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQENRLSPRGR :::::.::::::::::::::::::::..:::.:::::: ..::::..:.::: XP_011 DKYFGSVCELDIIFNFEKAYFILDEFLLGGEVQETSKKNVLKAIEQADLLQEKTETMYHS 140 150 160 170 180 190 160 pF1KE6 DCSEPRSCHCTLA XP_011 KSFIGFKKAY 200 >>XP_011508902 (OMIM: 615781,616106) PREDICTED: AP-1 com (108 aa) initn: 647 init1: 647 opt: 647 Z-score: 886.6 bits: 169.7 E(85289): 1.2e-42 Smith-Waterman score: 647; 98.0% identity (99.0% similar) in 100 aa overlap (1-100:1-100) 10 20 30 40 50 60 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG :::::::::::::::::::::::::::::::::::::. : XP_011 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNTMEEYMNKPTF 70 80 90 100 130 140 150 160 pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA >>NP_004060 (OMIM: 600740,602242) AP-2 complex subunit s (142 aa) initn: 467 init1: 452 opt: 453 Z-score: 622.0 bits: 121.2 E(85289): 6.6e-28 Smith-Waterman score: 453; 44.4% identity (78.9% similar) in 142 aa overlap (1-142:1-139) 10 20 30 40 50 60 pF1KE6 MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYK ::.:::. .: :: :: :::. . : :..:. .:. .. : . ..::.....:..:. NP_004 MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 RYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIG :::.:::: .. .::.: :: .: .::.:..:: ::::::..::: :.: ..::.... NP_004 RYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLA 70 80 90 100 110 120 130 140 150 160 pF1KE6 GEIQETSKKIAVKAIEDSDMLQENRLSPRGRDCSEPRSCHCTLA :::.:::. .:.... ::: NP_004 GEIRETSQ---TKVLKQLLMLQSLE 130 140 164 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 10:10:32 2016 done: Tue Nov 8 10:10:33 2016 Total Scan time: 4.600 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]