FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5641, 583 aa 1>>>pF1KE5641 583 - 583 aa - 583 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2345+/-0.000482; mu= 19.6844+/- 0.030 mean_var=90.8779+/-18.399, 0's: 0 Z-trim(110.0): 421 B-trim: 59 in 1/49 Lambda= 0.134538 statistics sampled from 17806 (18271) to 17806 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.587), E-opt: 0.2 (0.214), width: 16 Scan time: 8.880 The best scores are: opt bits E(85289) NP_002824 (OMIM: 600768) tyrosine-protein phosphat ( 593) 3908 769.7 0 NP_001193768 (OMIM: 176891,600263) receptor-type t (1448) 657 139.0 1e-31 XP_005250576 (OMIM: 176891,600263) PREDICTED: rece (2308) 657 139.2 1.4e-31 NP_001193767 (OMIM: 176891,600263) receptor-type t (1455) 638 135.4 1.3e-30 XP_016867966 (OMIM: 176891,600263) PREDICTED: rece (2301) 638 135.6 1.8e-30 NP_002842 (OMIM: 176891,600263) receptor-type tyro (2315) 638 135.6 1.8e-30 XP_016862453 (OMIM: 176886) PREDICTED: receptor-ty (1329) 592 126.4 5.9e-28 XP_005265410 (OMIM: 176886) PREDICTED: receptor-ty (1416) 592 126.4 6.2e-28 NP_002832 (OMIM: 176886) receptor-type tyrosine-pr (1445) 592 126.4 6.3e-28 XP_016862452 (OMIM: 176886) PREDICTED: receptor-ty (1456) 592 126.4 6.3e-28 XP_016862451 (OMIM: 176886) PREDICTED: receptor-ty (1458) 592 126.4 6.3e-28 XP_016862450 (OMIM: 176886) PREDICTED: receptor-ty (1485) 592 126.4 6.4e-28 XP_011534671 (OMIM: 603271) PREDICTED: tyrosine-pr ( 970) 589 125.7 7.1e-28 XP_016876428 (OMIM: 603271) PREDICTED: tyrosine-pr ( 970) 589 125.7 7.1e-28 XP_016876427 (OMIM: 603271) PREDICTED: tyrosine-pr (1051) 589 125.7 7.5e-28 XP_006720074 (OMIM: 603271) PREDICTED: tyrosine-pr (1051) 589 125.7 7.5e-28 XP_011534670 (OMIM: 603271) PREDICTED: tyrosine-pr (1051) 589 125.7 7.5e-28 XP_005267344 (OMIM: 603271) PREDICTED: tyrosine-pr (1174) 589 125.8 8.1e-28 NP_008970 (OMIM: 603271) tyrosine-protein phosphat (1174) 589 125.8 8.1e-28 XP_011534669 (OMIM: 603271) PREDICTED: tyrosine-pr (1174) 589 125.8 8.1e-28 XP_016857430 (OMIM: 603155,613611) PREDICTED: tyro (1187) 564 120.9 2.4e-26 NP_005392 (OMIM: 603155,613611) tyrosine-protein p (1187) 564 120.9 2.4e-26 XP_011526460 (OMIM: 601576) PREDICTED: receptor-ty (1157) 518 112.0 1.1e-23 XP_005259667 (OMIM: 601576) PREDICTED: receptor-ty (1497) 518 112.1 1.4e-23 XP_005259666 (OMIM: 601576) PREDICTED: receptor-ty (1501) 518 112.1 1.4e-23 NP_570923 (OMIM: 601576) receptor-type tyrosine-pr (1501) 518 112.1 1.4e-23 XP_016882565 (OMIM: 601576) PREDICTED: receptor-ty (1505) 518 112.1 1.4e-23 NP_570925 (OMIM: 601576) receptor-type tyrosine-pr (1505) 518 112.1 1.4e-23 XP_016882564 (OMIM: 601576) PREDICTED: receptor-ty (1517) 518 112.1 1.4e-23 XP_011526459 (OMIM: 601576) PREDICTED: receptor-ty (1517) 518 112.1 1.4e-23 XP_016882563 (OMIM: 601576) PREDICTED: receptor-ty (1521) 518 112.1 1.4e-23 XP_016882562 (OMIM: 601576) PREDICTED: receptor-ty (1697) 518 112.1 1.5e-23 XP_005259664 (OMIM: 601576) PREDICTED: receptor-ty (1906) 518 112.2 1.6e-23 NP_570924 (OMIM: 601576) receptor-type tyrosine-pr (1910) 518 112.2 1.6e-23 XP_016882561 (OMIM: 601576) PREDICTED: receptor-ty (1910) 518 112.2 1.6e-23 XP_005259663 (OMIM: 601576) PREDICTED: receptor-ty (1910) 518 112.2 1.6e-23 XP_016882560 (OMIM: 601576) PREDICTED: receptor-ty (1919) 518 112.2 1.6e-23 XP_016882559 (OMIM: 601576) PREDICTED: receptor-ty (1923) 518 112.2 1.6e-23 XP_016882558 (OMIM: 601576) PREDICTED: receptor-ty (1930) 518 112.2 1.6e-23 XP_016882557 (OMIM: 601576) PREDICTED: receptor-ty (1935) 518 112.2 1.6e-23 XP_005259657 (OMIM: 601576) PREDICTED: receptor-ty (1935) 518 112.2 1.6e-23 XP_016882555 (OMIM: 601576) PREDICTED: receptor-ty (1939) 518 112.2 1.6e-23 XP_016882556 (OMIM: 601576) PREDICTED: receptor-ty (1939) 518 112.2 1.6e-23 XP_016882554 (OMIM: 601576) PREDICTED: receptor-ty (1939) 518 112.2 1.6e-23 NP_002841 (OMIM: 601576) receptor-type tyrosine-pr (1948) 518 112.2 1.6e-23 XP_016857436 (OMIM: 179590,616001) PREDICTED: rece (1618) 517 111.9 1.6e-23 NP_001316068 (OMIM: 179590,616001) receptor-type t (1623) 517 111.9 1.6e-23 XP_016857438 (OMIM: 179590,616001) PREDICTED: rece (1623) 517 111.9 1.6e-23 XP_016857435 (OMIM: 179590,616001) PREDICTED: rece (1627) 517 111.9 1.6e-23 NP_001316066 (OMIM: 179590,616001) receptor-type t (1629) 517 111.9 1.6e-23 >>NP_002824 (OMIM: 600768) tyrosine-protein phosphatase (593 aa) initn: 3908 init1: 3908 opt: 3908 Z-score: 4105.8 bits: 769.7 E(85289): 0 Smith-Waterman score: 3908; 99.7% identity (99.8% similar) in 583 aa overlap (1-583:11-593) 10 20 30 40 50 pF1KE5 MAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR :::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYADFELDLGKKVLNLLKGAFP :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: NP_002 KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 IDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::: NP_002 IDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT 490 500 510 520 530 540 540 550 560 570 580 pF1KE5 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ 550 560 570 580 590 >>NP_001193768 (OMIM: 176891,600263) receptor-type tyros (1448 aa) initn: 616 init1: 291 opt: 657 Z-score: 690.6 bits: 139.0 E(85289): 1e-31 Smith-Waterman score: 657; 38.0% identity (67.0% similar) in 303 aa overlap (275-563:838-1124) 250 260 270 280 290 300 pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRRE :. :... .: . . ..:. ::.:... NP_001 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFEEVQSC 810 820 830 840 850 860 310 320 330 340 350 pF1KE5 N-PVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINASFMDGYKQ . .: : : : : .:::: .. :..::::.. ..:. ::::::...:::.. NP_001 TVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINANYVDGYNR 870 880 890 900 910 920 360 370 380 390 400 410 pF1KE5 KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGF .:::..::::..: .::: :.::..: :::: : . : ::::: :::: :. ..: NP_001 PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSEEYGN 930 940 950 960 970 980 420 430 440 450 460 470 pF1KE5 LTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGVPSSAASL . ::. .:. . .: .. ..::. . :: : ::.... .:::.::: . . NP_001 FLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPV 990 1000 1010 1020 1030 1040 480 490 500 510 520 530 pF1KE5 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT . :.: . . ::. :.:::::::.:::::. :: : :... :: NP_001 LTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT 1050 1060 1070 1080 1090 540 550 560 570 580 pF1KE5 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ .:.: ....:.:: . .:: ::: : . ...: NP_001 VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPA 1100 1110 1120 1130 1140 1150 NP_001 GKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYI 1160 1170 1180 1190 1200 1210 >-- initn: 371 init1: 179 opt: 383 Z-score: 403.2 bits: 85.9 E(85289): 1e-15 Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:1173-1413) 280 290 300 310 320 330 pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK . ... : :::: ... ....:: ... NP_001 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS 1150 1160 1170 1180 1190 1200 340 350 360 370 380 390 pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG ::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. . NP_001 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA 1210 1220 1230 1240 1250 1260 400 410 420 430 440 450 pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF . . ::: .:: : . :: .. :. ... .: .. .. :.. .: :: NP_001 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF 1270 1280 1290 1300 1310 460 470 480 490 500 510 pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG : .::. : : . .... :.... .: : :..:: : .: NP_001 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG 1320 1330 1340 1350 1360 520 530 540 550 560 570 pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS :::.: . :::. ....:.:... . .: . ::: : ::.:: NP_001 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP 1370 1380 1390 1400 1410 1420 580 pF1KE5 GQNLLAVESQ NP_001 STSLDSNGAALPDGNIAESLESLV 1430 1440 >>XP_005250576 (OMIM: 176891,600263) PREDICTED: receptor (2308 aa) initn: 616 init1: 291 opt: 657 Z-score: 688.0 bits: 139.2 E(85289): 1.4e-31 Smith-Waterman score: 657; 38.0% identity (67.0% similar) in 303 aa overlap (275-563:1698-1984) 250 260 270 280 290 300 pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRRE :. :... .: . . ..:. ::.:... XP_005 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFEEVQSC 1670 1680 1690 1700 1710 1720 310 320 330 340 350 pF1KE5 N-PVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINASFMDGYKQ . .: : : : : .:::: .. :..::::.. ..:. ::::::...:::.. XP_005 TVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINANYVDGYNR 1730 1740 1750 1760 1770 1780 360 370 380 390 400 410 pF1KE5 KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGF .:::..::::..: .::: :.::..: :::: : . : ::::: :::: :. ..: XP_005 PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSEEYGN 1790 1800 1810 1820 1830 1840 420 430 440 450 460 470 pF1KE5 LTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGVPSSAASL . ::. .:. . .: .. ..::. . :: : ::.... .:::.::: . . XP_005 FLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPV 1850 1860 1870 1880 1890 1900 480 490 500 510 520 530 pF1KE5 IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT . :.: . . ::. :.:::::::.:::::. :: : :... :: XP_005 LTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT 1910 1920 1930 1940 1950 540 550 560 570 580 pF1KE5 LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ .:.: ....:.:: . .:: ::: : . ...: XP_005 VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPA 1960 1970 1980 1990 2000 2010 XP_005 GKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYI 2020 2030 2040 2050 2060 2070 >-- initn: 371 init1: 179 opt: 383 Z-score: 400.6 bits: 86.1 E(85289): 1.4e-15 Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:2033-2273) 280 290 300 310 320 330 pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK . ... : :::: ... ....:: ... XP_005 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS 2010 2020 2030 2040 2050 2060 340 350 360 370 380 390 pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG ::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. . XP_005 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA 2070 2080 2090 2100 2110 2120 400 410 420 430 440 450 pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF . . ::: .:: : . :: .. :. ... .: .. .. :.. .: :: XP_005 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF 2130 2140 2150 2160 2170 460 470 480 490 500 510 pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG : .::. : : . .... :.... .: : :..:: : .: XP_005 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG 2180 2190 2200 2210 2220 520 530 540 550 560 570 pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS :::.: . :::. ....:.:... . .: . ::: : ::.:: XP_005 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP 2230 2240 2250 2260 2270 2280 580 pF1KE5 GQNLLAVESQ XP_005 STSLDSNGAALPDGNIAESLESLV 2290 2300 >>NP_001193767 (OMIM: 176891,600263) receptor-type tyros (1455 aa) initn: 616 init1: 291 opt: 638 Z-score: 670.6 bits: 135.4 E(85289): 1.3e-30 Smith-Waterman score: 640; 37.1% identity (65.2% similar) in 310 aa overlap (275-563:838-1131) 250 260 270 280 290 300 pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRR- :. :... .: . . ..:. ::.: ... NP_001 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEF 810 820 830 840 850 860 310 320 330 340 350 pF1KE5 -------ENPVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINAS .: : : : : .:::: .. :..::::.. ..:. ::::::. NP_001 YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINAN 870 880 890 900 910 920 360 370 380 390 400 410 pF1KE5 FMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKD ..:::.. .:::..::::..: .::: :.::..: :::: : . : ::::: :::: : NP_001 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--AD 930 940 950 960 970 980 420 430 440 450 460 pF1KE5 SRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGV . ..: . ::. .:. . .: .. ..::. . :: : ::.... .:::.:: NP_001 GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGV 990 1000 1010 1020 1030 1040 470 480 490 500 510 520 pF1KE5 PSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLA : . .. :.: . . ::. :.:::::::.:::::. :: : NP_001 PEYSLPVLTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQ 1050 1060 1070 1080 1090 530 540 550 560 570 580 pF1KE5 QLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ :... ::.:.: ....:.:: . .:: ::: : . ...: NP_001 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNA 1100 1110 1120 1130 1140 1150 NP_001 LLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS 1160 1170 1180 1190 1200 1210 >-- initn: 371 init1: 179 opt: 383 Z-score: 403.1 bits: 85.9 E(85289): 1e-15 Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:1180-1420) 280 290 300 310 320 330 pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK . ... : :::: ... ....:: ... NP_001 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS 1150 1160 1170 1180 1190 1200 340 350 360 370 380 390 pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG ::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. . NP_001 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA 1210 1220 1230 1240 1250 1260 400 410 420 430 440 450 pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF . . ::: .:: : . :: .. :. ... .: .. .. :.. .: :: NP_001 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF 1270 1280 1290 1300 1310 1320 460 470 480 490 500 510 pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG : .::. : : . .... :.... .: : :..:: : .: NP_001 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG 1330 1340 1350 1360 1370 520 530 540 550 560 570 pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS :::.: . :::. ....:.:... . .: . ::: : ::.:: NP_001 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP 1380 1390 1400 1410 1420 1430 580 pF1KE5 GQNLLAVESQ NP_001 STSLDSNGAALPDGNIAESLESLV 1440 1450 >>XP_016867966 (OMIM: 176891,600263) PREDICTED: receptor (2301 aa) initn: 616 init1: 291 opt: 638 Z-score: 668.1 bits: 135.6 E(85289): 1.8e-30 Smith-Waterman score: 640; 37.1% identity (65.2% similar) in 310 aa overlap (275-563:1684-1977) 250 260 270 280 290 300 pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRR- :. :... .: . . ..:. ::.: ... XP_016 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEF 1660 1670 1680 1690 1700 1710 310 320 330 340 350 pF1KE5 -------ENPVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINAS .: : : : : .:::: .. :..::::.. ..:. ::::::. XP_016 YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINAN 1720 1730 1740 1750 1760 1770 360 370 380 390 400 410 pF1KE5 FMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKD ..:::.. .:::..::::..: .::: :.::..: :::: : . : ::::: :::: : XP_016 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--AD 1780 1790 1800 1810 1820 1830 420 430 440 450 460 pF1KE5 SRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGV . ..: . ::. .:. . .: .. ..::. . :: : ::.... .:::.:: XP_016 GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGV 1840 1850 1860 1870 1880 1890 470 480 490 500 510 520 pF1KE5 PSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLA : . .. :.: . . ::. :.:::::::.:::::. :: : XP_016 PEYSLPVLTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQ 1900 1910 1920 1930 530 540 550 560 570 580 pF1KE5 QLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ :... ::.:.: ....:.:: . .:: ::: : . ...: XP_016 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNA 1940 1950 1960 1970 1980 1990 XP_016 LLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS 2000 2010 2020 2030 2040 2050 >-- initn: 371 init1: 179 opt: 383 Z-score: 400.6 bits: 86.1 E(85289): 1.4e-15 Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:2026-2266) 280 290 300 310 320 330 pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK . ... : :::: ... ....:: ... XP_016 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS 2000 2010 2020 2030 2040 2050 340 350 360 370 380 390 pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG ::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. . XP_016 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA 2060 2070 2080 2090 2100 2110 400 410 420 430 440 450 pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF . . ::: .:: : . :: .. :. ... .: .. .. :.. .: :: XP_016 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF 2120 2130 2140 2150 2160 2170 460 470 480 490 500 510 pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG : .::. : : . .... :.... .: : :..:: : .: XP_016 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG 2180 2190 2200 2210 520 530 540 550 560 570 pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS :::.: . :::. ....:.:... . .: . ::: : ::.:: XP_016 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP 2220 2230 2240 2250 2260 2270 580 pF1KE5 GQNLLAVESQ XP_016 STSLDSNGAALPDGNIAESLESLV 2280 2290 2300 >>NP_002842 (OMIM: 176891,600263) receptor-type tyrosine (2315 aa) initn: 616 init1: 291 opt: 638 Z-score: 668.1 bits: 135.6 E(85289): 1.8e-30 Smith-Waterman score: 640; 37.1% identity (65.2% similar) in 310 aa overlap (275-563:1698-1991) 250 260 270 280 290 300 pF1KE5 NGHPDRFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYV-NARQKQGIYEEYEDIRR- :. :... .: . . ..:. ::.: ... NP_002 TAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEF 1670 1680 1690 1700 1710 1720 310 320 330 340 350 pF1KE5 -------ENPVG-TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK---RSGHTQTDYINAS .: : : : : .:::: .. :..::::.. ..:. ::::::. NP_002 YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKL-TDYINAN 1730 1740 1750 1760 1770 1780 360 370 380 390 400 410 pF1KE5 FMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKD ..:::.. .:::..::::..: .::: :.::..: :::: : . : ::::: :::: : NP_002 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--AD 1790 1800 1810 1820 1830 1840 420 430 440 450 460 pF1KE5 SRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER---QK-----RQVTHFQFLSWPDYGV . ..: . ::. .:. . .: .. ..::. . :: : ::.... .:::.:: NP_002 GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGV 1850 1860 1870 1880 1890 1900 470 480 490 500 510 520 pF1KE5 PSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLA : . .. :.: . . ::. :.:::::::.:::::. :: : NP_002 PEYSLPVLTFVRKAAYAKRHAVG-------------PVVVHCSAGVGRTGTYIVLDSMLQ 1910 1920 1930 1940 1950 530 540 550 560 570 580 pF1KE5 QLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ :... ::.:.: ....:.:: . .:: ::: : . ...: NP_002 QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNA 1960 1970 1980 1990 2000 2010 NP_002 LLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS 2020 2030 2040 2050 2060 2070 >-- initn: 371 init1: 179 opt: 383 Z-score: 400.6 bits: 86.1 E(85289): 1.4e-15 Smith-Waterman score: 383; 30.1% identity (60.6% similar) in 259 aa overlap (309-562:2040-2280) 280 290 300 310 320 330 pF1KE5 QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK . ... : :::: ... ....:: ... NP_002 NALLIPGPAGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS 2010 2020 2030 2040 2050 2060 340 350 360 370 380 390 pF1KE5 RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG ::. :::::::.. :: :.: .: :: :: .: .::: :.:.... ..:: .. . NP_002 LSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA 2070 2080 2090 2100 2110 2120 400 410 420 430 440 450 pF1KE5 RRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLE---IHNTEERQKRQVTHF . . ::: .:: : . :: .. :. ... .: .. .. :.. .: :: NP_002 EDEF-VYWP-NKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHF 2130 2140 2150 2160 2170 2180 460 470 480 490 500 510 pF1KE5 QFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTG : .::. : : . .... :.... .: : :..:: : .: NP_002 QCPKWPNPDSPIS--KTFELISVIKEE--------AANRDG-----PMIVHDEHGGVTAG 2190 2200 2210 2220 2230 520 530 540 550 560 570 pF1KE5 TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS :::.: . :::. ....:.:... . .: . ::: : ::.:: NP_002 TFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENP 2240 2250 2260 2270 2280 2290 580 pF1KE5 GQNLLAVESQ NP_002 STSLDSNGAALPDGNIAESLESLV 2300 2310 >>XP_016862453 (OMIM: 176886) PREDICTED: receptor-type t (1329 aa) initn: 629 init1: 307 opt: 592 Z-score: 622.9 bits: 126.4 E(85289): 5.9e-28 Smith-Waterman score: 668; 36.7% identity (64.7% similar) in 343 aa overlap (258-575:690-1015) 230 240 250 260 270 280 pF1KE5 YVKIDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHV-PGP---HAMTIQELVD : : .. .:. . : : .:. ....: XP_016 RFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVK 660 670 680 690 700 710 290 300 310 320 330 pF1KE5 YVN---ARQKQGIYEEYEDIRR---ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLT ... . ...:. :..:...: . . . : : : : .:::: .. :..:::: XP_016 HIGELYSNNQHGFSEDFEEVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLR 720 730 740 750 760 770 340 350 360 370 380 390 pF1KE5 KRSGHT--QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE :. ..:::::...:::.. .:::.:::::..:..::: :.:::.. .::: : . XP_016 PLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLV 780 790 800 810 820 830 400 410 420 430 440 pF1KE5 EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER--QK-----R : ::::: :::: :.. . .: . :: ... : . :.::. . :: : XP_016 EKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR 840 850 860 870 880 890 450 460 470 480 490 500 pF1KE5 Q----VTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVV : : .... .:::.::: : .. :.: :. : .. :: :..: XP_016 QNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RS------------SAARMPETGPVLV 900 910 920 930 940 510 520 530 540 550 560 pF1KE5 HCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE :::::.:::::. .: : :... .:.::. ....:::: . .:: ::: : . :.:: XP_016 HCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE 950 960 970 980 990 1000 570 580 pF1KE5 -FAEKEGMVSSGQNLLAVESQ . :: :::.: XP_016 AILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEK 1010 1020 1030 1040 1050 1060 >-- initn: 381 init1: 218 opt: 371 Z-score: 391.0 bits: 83.5 E(85289): 4.8e-15 Smith-Waterman score: 371; 31.3% identity (57.6% similar) in 278 aa overlap (317-582:1059-1319) 290 300 310 320 330 340 pF1KE5 ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTD : :::: ..: ...:: :. : :: XP_016 GGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTD 1030 1040 1050 1060 1070 1080 350 360 370 380 390 400 pF1KE5 YINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW :::::.. :: ..: .: :: :: .: .::: :.:.... .::: . .. . :: XP_016 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF-VYW 1090 1100 1110 1120 1130 1140 410 420 430 440 450 460 pF1KE5 PLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN-----TEERQKRQVTHFQFLSWPDY : ...: .: ::: .. . . .. . ::. :.. .: ::: .::. XP_016 PSREESMNCEAF-TVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP 1150 1160 1170 1180 1190 1200 470 480 490 500 510 520 pF1KE5 GVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDIC .: : : .... :.... :.. : : .:: : .: .:.: XP_016 DAPIS--STFELINVIKEE---ALTRDG----------PTIVHDEYGAVSAGMLCALTTL 1210 1220 1230 1240 1250 530 540 550 560 570 pF1KE5 LAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF-AEKE---GMVSSGQN- :::. ....:::... . .: . ::: : :::.: . . :: : .. .: XP_016 SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNG 1260 1270 1280 1290 1300 1310 580 pF1KE5 --LLAVESQ :.: :: XP_016 AVLIADESDPAESMESLV 1320 >>XP_005265410 (OMIM: 176886) PREDICTED: receptor-type t (1416 aa) initn: 629 init1: 307 opt: 592 Z-score: 622.5 bits: 126.4 E(85289): 6.2e-28 Smith-Waterman score: 668; 36.7% identity (64.7% similar) in 343 aa overlap (258-575:777-1102) 230 240 250 260 270 280 pF1KE5 YVKIDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHV-PGP---HAMTIQELVD : : .. .:. . : : .:. ....: XP_005 LTFVCLILLIAVLVYWRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVK 750 760 770 780 790 800 290 300 310 320 330 pF1KE5 YVN---ARQKQGIYEEYEDIRR---ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLT ... . ...:. :..:...: . . . : : : : .:::: .. :..:::: XP_005 HIGELYSNNQHGFSEDFEEVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLR 810 820 830 840 850 860 340 350 360 370 380 390 pF1KE5 KRSGHT--QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE :. ..:::::...:::.. .:::.:::::..:..::: :.:::.. .::: : . XP_005 PLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLV 870 880 890 900 910 920 400 410 420 430 440 pF1KE5 EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER--QK-----R : ::::: :::: :.. . .: . :: ... : . :.::. . :: : XP_005 EKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR 930 940 950 960 970 980 450 460 470 480 490 500 pF1KE5 Q----VTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVV : : .... .:::.::: : .. :.: :. : .. :: :..: XP_005 QNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RS------------SAARMPETGPVLV 990 1000 1010 1020 510 520 530 540 550 560 pF1KE5 HCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE :::::.:::::. .: : :... .:.::. ....:::: . .:: ::: : . :.:: XP_005 HCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE 1030 1040 1050 1060 1070 1080 570 580 pF1KE5 -FAEKEGMVSSGQNLLAVESQ . :: :::.: XP_005 AILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEK 1090 1100 1110 1120 1130 1140 >-- initn: 381 init1: 218 opt: 371 Z-score: 390.7 bits: 83.5 E(85289): 5e-15 Smith-Waterman score: 371; 31.3% identity (57.6% similar) in 278 aa overlap (317-582:1146-1406) 290 300 310 320 330 340 pF1KE5 ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTD : :::: ..: ...:: :. : :: XP_005 GGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTD 1120 1130 1140 1150 1160 1170 350 360 370 380 390 400 pF1KE5 YINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW :::::.. :: ..: .: :: :: .: .::: :.:.... .::: . .. . :: XP_005 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF-VYW 1180 1190 1200 1210 1220 1230 410 420 430 440 450 460 pF1KE5 PLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN-----TEERQKRQVTHFQFLSWPDY : ...: .: ::: .. . . .. . ::. :.. .: ::: .::. XP_005 PSREESMNCEAF-TVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP 1240 1250 1260 1270 1280 1290 470 480 490 500 510 520 pF1KE5 GVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDIC .: : : .... :.... :.. : : .:: : .: .:.: XP_005 DAPIS--STFELINVIKEE---ALTRDG----------PTIVHDEYGAVSAGMLCALTTL 1300 1310 1320 1330 530 540 550 560 570 pF1KE5 LAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF-AEKE---GMVSSGQN- :::. ....:::... . .: . ::: : :::.: . . :: : .. .: XP_005 SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNG 1340 1350 1360 1370 1380 1390 580 pF1KE5 --LLAVESQ :.: :: XP_005 AVLIADESDPAESMESLV 1400 1410 >>NP_002832 (OMIM: 176886) receptor-type tyrosine-protei (1445 aa) initn: 629 init1: 307 opt: 592 Z-score: 622.4 bits: 126.4 E(85289): 6.3e-28 Smith-Waterman score: 668; 36.7% identity (64.7% similar) in 343 aa overlap (258-575:806-1131) 230 240 250 260 270 280 pF1KE5 YVKIDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHV-PGP---HAMTIQELVD : : .. .:. . : : .:. ....: NP_002 RFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVK 780 790 800 810 820 830 290 300 310 320 330 pF1KE5 YVN---ARQKQGIYEEYEDIRR---ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLT ... . ...:. :..:...: . . . : : : : .:::: .. :..:::: NP_002 HIGELYSNNQHGFSEDFEEVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLR 840 850 860 870 880 890 340 350 360 370 380 390 pF1KE5 KRSGHT--QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE :. ..:::::...:::.. .:::.:::::..:..::: :.:::.. .::: : . NP_002 PLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLV 900 910 920 930 940 950 400 410 420 430 440 pF1KE5 EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER--QK-----R : ::::: :::: :.. . .: . :: ... : . :.::. . :: : NP_002 EKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR 960 970 980 990 1000 1010 450 460 470 480 490 500 pF1KE5 Q----VTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVV : : .... .:::.::: : .. :.: :. : .. :: :..: NP_002 QNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RS------------SAARMPETGPVLV 1020 1030 1040 1050 510 520 530 540 550 560 pF1KE5 HCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE :::::.:::::. .: : :... .:.::. ....:::: . .:: ::: : . :.:: NP_002 HCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE 1060 1070 1080 1090 1100 1110 570 580 pF1KE5 -FAEKEGMVSSGQNLLAVESQ . :: :::.: NP_002 AILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEK 1120 1130 1140 1150 1160 1170 >-- initn: 381 init1: 218 opt: 371 Z-score: 390.6 bits: 83.5 E(85289): 5.1e-15 Smith-Waterman score: 371; 31.3% identity (57.6% similar) in 278 aa overlap (317-582:1175-1435) 290 300 310 320 330 340 pF1KE5 ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTD : :::: ..: ...:: :. : :: NP_002 GGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTD 1150 1160 1170 1180 1190 1200 350 360 370 380 390 400 pF1KE5 YINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW :::::.. :: ..: .: :: :: .: .::: :.:.... .::: . .. . :: NP_002 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF-VYW 1210 1220 1230 1240 1250 1260 410 420 430 440 450 460 pF1KE5 PLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN-----TEERQKRQVTHFQFLSWPDY : ...: .: ::: .. . . .. . ::. :.. .: ::: .::. NP_002 PSREESMNCEAF-TVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP 1270 1280 1290 1300 1310 1320 470 480 490 500 510 520 pF1KE5 GVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDIC .: : : .... :.... :.. : : .:: : .: .:.: NP_002 DAPIS--STFELINVIKEE---ALTRDG----------PTIVHDEYGAVSAGMLCALTTL 1330 1340 1350 1360 530 540 550 560 570 pF1KE5 LAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF-AEKE---GMVSSGQN- :::. ....:::... . .: . ::: : :::.: . . :: : .. .: NP_002 SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNG 1370 1380 1390 1400 1410 1420 580 pF1KE5 --LLAVESQ :.: :: NP_002 AVLIADESDPAESMESLV 1430 1440 >>XP_016862452 (OMIM: 176886) PREDICTED: receptor-type t (1456 aa) initn: 629 init1: 307 opt: 592 Z-score: 622.4 bits: 126.4 E(85289): 6.3e-28 Smith-Waterman score: 668; 36.7% identity (64.7% similar) in 343 aa overlap (258-575:817-1142) 230 240 250 260 270 280 pF1KE5 YVKIDLATWNFQFLPQVNGHPDRFDEIILFSLPPALDWDSVHV-PGP---HAMTIQELVD : : .. .:. . : : .:. ....: XP_016 LTFVCLILLIAVLVYWRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVK 790 800 810 820 830 840 290 300 310 320 330 pF1KE5 YVN---ARQKQGIYEEYEDIRR---ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLT ... . ...:. :..:...: . . . : : : : .:::: .. :..:::: XP_016 HIGELYSNNQHGFSEDFEEVQRCTADMNITAEH-SNHPENKHKNRYINILAYDHSRVKLR 850 860 870 880 890 900 340 350 360 370 380 390 pF1KE5 KRSGHT--QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE :. ..:::::...:::.. .:::.:::::..:..::: :.:::.. .::: : . XP_016 PLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLV 910 920 930 940 950 960 400 410 420 430 440 pF1KE5 EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEER--QK-----R : ::::: :::: :.. . .: . :: ... : . :.::. . :: : XP_016 EKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGR 970 980 990 1000 1010 1020 450 460 470 480 490 500 pF1KE5 Q----VTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEP-PIVV : : .... .:::.::: : .. :.: :. : .. :: :..: XP_016 QNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RS------------SAARMPETGPVLV 1030 1040 1050 1060 510 520 530 540 550 560 pF1KE5 HCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE :::::.:::::. .: : :... .:.::. ....:::: . .:: ::: : . :.:: XP_016 HCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE 1070 1080 1090 1100 1110 1120 570 580 pF1KE5 -FAEKEGMVSSGQNLLAVESQ . :: :::.: XP_016 AILGKETEVSSNQLHSYVNSILIPGVGGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEK 1130 1140 1150 1160 1170 1180 >-- initn: 381 init1: 218 opt: 371 Z-score: 390.5 bits: 83.5 E(85289): 5.1e-15 Smith-Waterman score: 371; 31.3% identity (57.6% similar) in 278 aa overlap (317-582:1186-1446) 290 300 310 320 330 340 pF1KE5 ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTD : :::: ..: ...:: :. : :: XP_016 GGKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTD 1160 1170 1180 1190 1200 1210 350 360 370 380 390 400 pF1KE5 YINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW :::::.. :: ..: .: :: :: .: .::: :.:.... .::: . .. . :: XP_016 YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF-VYW 1220 1230 1240 1250 1260 1270 410 420 430 440 450 460 pF1KE5 PLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN-----TEERQKRQVTHFQFLSWPDY : ...: .: ::: .. . . .. . ::. :.. .: ::: .::. XP_016 PSREESMNCEAF-TVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNP 1280 1290 1300 1310 1320 1330 470 480 490 500 510 520 pF1KE5 GVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDIC .: : : .... :.... :.. : : .:: : .: .:.: XP_016 DAPIS--STFELINVIKEE---ALTRDG----------PTIVHDEYGAVSAGMLCALTTL 1340 1350 1360 1370 530 540 550 560 570 pF1KE5 LAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF-AEKE---GMVSSGQN- :::. ....:::... . .: . ::: : :::.: . . :: : .. .: XP_016 SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGPMTVDKNG 1380 1390 1400 1410 1420 1430 580 pF1KE5 --LLAVESQ :.: :: XP_016 AVLIADESDPAESMESLV 1440 1450 583 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:27:47 2016 done: Tue Nov 8 05:27:48 2016 Total Scan time: 8.880 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]