FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5750, 692 aa 1>>>pF1KE5750 692 - 692 aa - 692 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2962+/-0.000336; mu= 11.2621+/- 0.021 mean_var=168.4362+/-32.659, 0's: 0 Z-trim(121.1): 218 B-trim: 130 in 1/59 Lambda= 0.098823 statistics sampled from 36942 (37195) to 36942 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.766), E-opt: 0.2 (0.436), width: 16 Scan time: 12.250 The best scores are: opt bits E(85289) NP_001269376 (OMIM: 607114) disintegrin and metall ( 812) 3264 477.9 6.6e-134 XP_006723702 (OMIM: 607114) PREDICTED: disintegrin ( 825) 3264 477.9 6.6e-134 XP_011527675 (OMIM: 607114) PREDICTED: disintegrin ( 492) 3252 476.0 1.5e-133 XP_011527669 (OMIM: 607114) PREDICTED: disintegrin ( 812) 3252 476.2 2.1e-133 NP_079496 (OMIM: 607114) disintegrin and metallopr ( 813) 3252 476.2 2.1e-133 XP_006723703 (OMIM: 607114) PREDICTED: disintegrin ( 823) 3252 476.2 2.2e-133 XP_011527668 (OMIM: 607114) PREDICTED: disintegrin ( 825) 3252 476.2 2.2e-133 XP_005260900 (OMIM: 607114) PREDICTED: disintegrin ( 826) 3252 476.2 2.2e-133 NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787) 1907 284.4 1.1e-75 XP_011527670 (OMIM: 607114) PREDICTED: disintegrin ( 800) 1907 284.4 1.1e-75 XP_016883570 (OMIM: 607114) PREDICTED: disintegrin ( 547) 1891 282.0 4.2e-75 XP_016865498 (OMIM: 603640) PREDICTED: disintegrin ( 651) 1352 205.2 6.4e-52 XP_011532984 (OMIM: 603640) PREDICTED: disintegrin ( 651) 1352 205.2 6.4e-52 NP_150377 (OMIM: 603640) disintegrin and metallopr ( 918) 1352 205.4 8.2e-52 XP_005266060 (OMIM: 603640) PREDICTED: disintegrin ( 955) 1352 205.4 8.4e-52 XP_016872195 (OMIM: 602714) PREDICTED: disintegrin ( 520) 1209 184.7 7.5e-46 XP_016872194 (OMIM: 602714) PREDICTED: disintegrin ( 753) 1209 184.9 9.8e-46 NP_001275902 (OMIM: 602714) disintegrin and metall ( 906) 1209 185.0 1.1e-45 NP_003465 (OMIM: 602714) disintegrin and metallopr ( 909) 1209 185.0 1.1e-45 NP_001275904 (OMIM: 602714) disintegrin and metall ( 735) 1174 179.9 3e-44 NP_067673 (OMIM: 602714) disintegrin and metallopr ( 738) 1174 179.9 3.1e-44 NP_001275903 (OMIM: 602714) disintegrin and metall ( 737) 1169 179.2 5e-44 XP_011527672 (OMIM: 607114) PREDICTED: disintegrin ( 635) 1148 176.1 3.6e-43 XP_016883572 (OMIM: 607114) PREDICTED: disintegrin ( 396) 1111 170.7 9.9e-42 XP_016883571 (OMIM: 607114) PREDICTED: disintegrin ( 435) 1111 170.7 1.1e-41 XP_006723707 (OMIM: 607114) PREDICTED: disintegrin ( 489) 1111 170.7 1.1e-41 XP_016883569 (OMIM: 607114) PREDICTED: disintegrin ( 560) 1111 170.8 1.3e-41 XP_011527673 (OMIM: 607114) PREDICTED: disintegrin ( 560) 1111 170.8 1.3e-41 NP_997079 (OMIM: 605548) disintegrin and metallopr ( 862) 1110 170.8 1.9e-41 NP_997078 (OMIM: 605548) disintegrin and metallopr ( 838) 1105 170.1 3.1e-41 NP_997077 (OMIM: 605548) disintegrin and metallopr ( 839) 1105 170.1 3.1e-41 NP_997080 (OMIM: 605548) disintegrin and metallopr ( 863) 1099 169.3 5.7e-41 NP_003806 (OMIM: 605548) disintegrin and metallopr ( 814) 1073 165.5 7.1e-40 NP_001248393 (OMIM: 605548) disintegrin and metall ( 824) 1073 165.5 7.2e-40 NP_997074 (OMIM: 605548) disintegrin and metallopr ( 772) 1059 163.5 2.7e-39 NP_001248394 (OMIM: 605548) disintegrin and metall ( 796) 1057 163.2 3.4e-39 XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801) 988 153.4 3.1e-36 NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819) 988 153.4 3.2e-36 XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821) 988 153.4 3.2e-36 NP_068566 (OMIM: 604779) disintegrin and metallopr ( 790) 919 143.6 2.8e-33 NP_003804 (OMIM: 603713) disintegrin and metallopr ( 722) 911 142.4 5.8e-33 NP_003805 (OMIM: 603712) disintegrin and metallopr ( 776) 873 137.0 2.6e-31 XP_005268208 (OMIM: 603712) PREDICTED: disintegrin ( 776) 873 137.0 2.6e-31 NP_001248395 (OMIM: 605548) disintegrin and metall ( 633) 860 135.1 8.2e-31 NP_001124177 (OMIM: 604778) disintegrin and metall ( 820) 854 134.3 1.8e-30 NP_001265055 (OMIM: 604778) disintegrin and metall ( 820) 854 134.3 1.8e-30 NP_055084 (OMIM: 604778) disintegrin and metallopr ( 820) 854 134.3 1.8e-30 XP_011529859 (OMIM: 604778) PREDICTED: disintegrin ( 820) 854 134.3 1.8e-30 NP_001124176 (OMIM: 604778) disintegrin and metall ( 820) 854 134.3 1.8e-30 XP_011529863 (OMIM: 604778) PREDICTED: disintegrin ( 820) 854 134.3 1.8e-30 >>NP_001269376 (OMIM: 607114) disintegrin and metallopro (812 aa) initn: 3264 init1: 3264 opt: 3264 Z-score: 2525.1 bits: 477.9 E(85289): 6.6e-134 Smith-Waterman score: 4280; 83.4% identity (83.4% similar) in 724 aa overlap (89-692:89-812) 60 70 80 90 100 110 pF1KE5 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG :::::::::::::::::::::::::::::: NP_001 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL 180 190 200 210 220 230 240 250 260 270 pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR---------------------------- :::::::::::::::::::::::::::::::: NP_001 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA 240 250 260 270 280 290 pF1KE5 ------------------------------------------------------------ NP_001 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD 300 310 320 330 340 350 280 290 pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::: NP_001 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 360 370 380 390 400 410 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH 600 610 620 630 640 650 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 660 670 680 690 700 710 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 720 730 740 750 760 770 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW :::::::::::::::::::::::::::::::::: NP_001 PENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW 780 790 800 810 >-- initn: 613 init1: 613 opt: 613 Z-score: 482.5 bits: 100.0 E(85289): 3.9e-20 Smith-Waterman score: 613; 100.0% identity (100.0% similar) in 88 aa overlap (1-88:1-88) 10 20 30 40 50 60 pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV :::::::::::::::::::::::::::: NP_001 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV 70 80 90 100 110 120 >>XP_006723702 (OMIM: 607114) PREDICTED: disintegrin and (825 aa) initn: 4041 init1: 3264 opt: 3264 Z-score: 2525.0 bits: 477.9 E(85289): 6.6e-134 Smith-Waterman score: 4145; 81.6% identity (81.6% similar) in 724 aa overlap (102-692:102-825) 80 90 100 110 pF1KE5 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCHYQG :::::::::: ::::::: XP_006 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQG 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 140 150 160 170 180 190 180 190 200 210 220 230 pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL 200 210 220 230 240 250 240 250 260 270 pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR---------------------------- :::::::::::::::::::::::::::::::: XP_006 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA 260 270 280 290 300 310 pF1KE5 ------------------------------------------------------------ XP_006 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD 320 330 340 350 360 370 280 290 pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::: XP_006 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 380 390 400 410 420 430 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 440 450 460 470 480 490 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 500 510 520 530 540 550 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 560 570 580 590 600 610 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH 620 630 640 650 660 670 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 680 690 700 710 720 730 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 740 750 760 770 780 790 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW :::::::::::::::::::::::::::::::::: XP_006 PENSHEPSSHPEKPLPAVSPDPQDQVQMPRSCLW 800 810 820 >-- initn: 712 init1: 712 opt: 712 Z-score: 558.6 bits: 114.1 E(85289): 2.2e-24 Smith-Waterman score: 712; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101) 10 20 30 40 50 60 pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV ::::::::::::::::::::::::::::::::::::::::: XP_006 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG XP_006 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF 130 140 150 160 170 180 >>XP_011527675 (OMIM: 607114) PREDICTED: disintegrin and (492 aa) initn: 3250 init1: 3175 opt: 3252 Z-score: 2518.7 bits: 476.0 E(85289): 1.5e-133 Smith-Waterman score: 3252; 99.8% identity (99.8% similar) in 425 aa overlap (269-692:68-492) 240 250 260 270 280 290 pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRRQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::::: XP_011 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 40 50 60 70 80 90 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 100 110 120 130 140 150 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 160 170 180 190 200 210 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 220 230 240 250 260 270 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH 280 290 300 310 320 330 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 340 350 360 370 380 390 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 400 410 420 430 440 450 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW ::::::::::::::::::::::: ::::::::::: XP_011 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 460 470 480 490 >>XP_011527669 (OMIM: 607114) PREDICTED: disintegrin and (812 aa) initn: 3825 init1: 3175 opt: 3252 Z-score: 2515.9 bits: 476.2 E(85289): 2.1e-133 Smith-Waterman score: 4268; 83.3% identity (83.3% similar) in 725 aa overlap (89-692:88-812) 60 70 80 90 100 110 pF1KE5 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG :::::::::::::::::::::::::::::: XP_011 EPVSKPDMGLVALEAEGQELLLELEKNQLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL 180 190 200 210 220 230 240 250 260 270 pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR---------------------------- :::::::::::::::::::::::::::::::: XP_011 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA 240 250 260 270 280 290 pF1KE5 ------------------------------------------------------------ XP_011 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD 300 310 320 330 340 350 280 290 pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::: XP_011 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 360 370 380 390 400 410 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH 600 610 620 630 640 650 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 660 670 680 690 700 710 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 720 730 740 750 760 770 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW ::::::::::::::::::::::: ::::::::::: XP_011 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 780 790 800 810 >-- initn: 620 init1: 589 opt: 589 Z-score: 464.0 bits: 96.5 E(85289): 4.2e-19 Smith-Waterman score: 589; 97.7% identity (98.9% similar) in 87 aa overlap (1-87:1-87) 10 20 30 40 50 60 pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV ::::::::::::::::::::::::. : XP_011 SKPDMGLVALEAEGQELLLELEKNQLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVR 70 80 90 100 110 120 >>NP_079496 (OMIM: 607114) disintegrin and metalloprotei (813 aa) initn: 3250 init1: 3175 opt: 3252 Z-score: 2515.8 bits: 476.2 E(85289): 2.1e-133 Smith-Waterman score: 4268; 83.3% identity (83.3% similar) in 725 aa overlap (89-692:89-813) 60 70 80 90 100 110 pF1KE5 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG :::::::::::::::::::::::::::::: NP_079 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL 180 190 200 210 220 230 240 250 260 270 pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR---------------------------- :::::::::::::::::::::::::::::::: NP_079 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA 240 250 260 270 280 290 pF1KE5 ------------------------------------------------------------ NP_079 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD 300 310 320 330 340 350 280 290 pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::: NP_079 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 360 370 380 390 400 410 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH 600 610 620 630 640 650 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 660 670 680 690 700 710 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 720 730 740 750 760 770 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW ::::::::::::::::::::::: ::::::::::: NP_079 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 780 790 800 810 >-- initn: 613 init1: 613 opt: 613 Z-score: 482.4 bits: 100.0 E(85289): 3.9e-20 Smith-Waterman score: 613; 100.0% identity (100.0% similar) in 88 aa overlap (1-88:1-88) 10 20 30 40 50 60 pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV :::::::::::::::::::::::::::: NP_079 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV 70 80 90 100 110 120 >>XP_006723703 (OMIM: 607114) PREDICTED: disintegrin and (823 aa) initn: 4027 init1: 3175 opt: 3252 Z-score: 2515.8 bits: 476.2 E(85289): 2.2e-133 Smith-Waterman score: 4165; 81.9% identity (81.9% similar) in 725 aa overlap (99-692:99-823) 70 80 90 100 110 pF1KE5 ALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCH ::::::::::::: :::: XP_006 ALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCH 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 YQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTW 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 KGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQ 190 200 210 220 230 240 240 250 260 270 pF1KE5 RLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSR------------------------- ::::::::::::::::::::::::::::::::::: XP_006 RLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPH 250 260 270 280 290 300 pF1KE5 ------------------------------------------------------------ XP_006 DSAQLLTGRAFQGATVGLAPVEGMCRAESSGGDHSELPIGAAATMAHEIGHSLGLSHDPD 310 320 330 340 350 360 280 290 pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::: XP_006 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 370 380 390 400 410 420 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 430 440 450 460 470 480 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 490 500 510 520 530 540 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 550 560 570 580 590 600 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH 610 620 630 640 650 660 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 670 680 690 700 710 720 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 730 740 750 760 770 780 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW ::::::::::::::::::::::: ::::::::::: XP_006 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 790 800 810 820 >-- initn: 686 init1: 686 opt: 686 Z-score: 538.6 bits: 110.4 E(85289): 2.9e-23 Smith-Waterman score: 686; 100.0% identity (100.0% similar) in 98 aa overlap (1-98:1-98) 10 20 30 40 50 60 pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV :::::::::::::::::::::::::::::::::::::: XP_006 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG XP_006 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF 130 140 150 160 170 180 >>XP_011527668 (OMIM: 607114) PREDICTED: disintegrin and (825 aa) initn: 4003 init1: 3175 opt: 3252 Z-score: 2515.8 bits: 476.2 E(85289): 2.2e-133 Smith-Waterman score: 4133; 81.5% identity (81.5% similar) in 725 aa overlap (102-692:101-825) 80 90 100 110 pF1KE5 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCHYQG :::::::::: ::::::: XP_011 EAEGQELLLELEKNQLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQG 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 140 150 160 170 180 190 180 190 200 210 220 230 pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL 200 210 220 230 240 250 240 250 260 270 pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR---------------------------- :::::::::::::::::::::::::::::::: XP_011 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA 260 270 280 290 300 310 pF1KE5 ------------------------------------------------------------ XP_011 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD 320 330 340 350 360 370 280 290 pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::: XP_011 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 380 390 400 410 420 430 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 440 450 460 470 480 490 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 500 510 520 530 540 550 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 560 570 580 590 600 610 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH 620 630 640 650 660 670 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 680 690 700 710 720 730 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 740 750 760 770 780 790 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW ::::::::::::::::::::::: ::::::::::: XP_011 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 800 810 820 >-- initn: 620 init1: 589 opt: 684 Z-score: 537.1 bits: 110.1 E(85289): 3.5e-23 Smith-Waterman score: 684; 98.0% identity (99.0% similar) in 101 aa overlap (1-101:1-100) 10 20 30 40 50 60 pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV ::::::::::::::::::::::::. ::::::::::::::: XP_011 SKPDMGLVALEAEGQELLLELEKNQ-LLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG XP_011 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF 120 130 140 150 160 170 >>XP_005260900 (OMIM: 607114) PREDICTED: disintegrin and (826 aa) initn: 4027 init1: 3175 opt: 3252 Z-score: 2515.8 bits: 476.2 E(85289): 2.2e-133 Smith-Waterman score: 4133; 81.5% identity (81.5% similar) in 725 aa overlap (102-692:102-826) 80 90 100 110 pF1KE5 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCHYQG :::::::::: ::::::: XP_005 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQG 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 140 150 160 170 180 190 180 190 200 210 220 230 pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL 200 210 220 230 240 250 240 250 260 270 pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR---------------------------- :::::::::::::::::::::::::::::::: XP_005 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA 260 270 280 290 300 310 pF1KE5 ------------------------------------------------------------ XP_005 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD 320 330 340 350 360 370 280 290 pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::: XP_005 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 380 390 400 410 420 430 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 440 450 460 470 480 490 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 500 510 520 530 540 550 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 560 570 580 590 600 610 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH 620 630 640 650 660 670 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 680 690 700 710 720 730 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 740 750 760 770 780 790 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW ::::::::::::::::::::::: ::::::::::: XP_005 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 800 810 820 >-- initn: 712 init1: 712 opt: 712 Z-score: 558.6 bits: 114.1 E(85289): 2.2e-24 Smith-Waterman score: 712; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101) 10 20 30 40 50 60 pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV ::::::::::::::::::::::::::::::::::::::::: XP_005 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG XP_005 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF 130 140 150 160 170 180 >>NP_694882 (OMIM: 607114) disintegrin and metalloprotei (787 aa) initn: 3047 init1: 1907 opt: 1907 Z-score: 1479.7 bits: 284.4 E(85289): 1.1e-75 Smith-Waterman score: 4010; 79.7% identity (79.7% similar) in 725 aa overlap (89-692:89-787) 60 70 80 90 100 110 pF1KE5 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG :::::::::::::::::::::::::::::: NP_694 PVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL 180 190 200 210 220 230 240 250 260 270 pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR---------------------------- :::::::::::::::::::::::::::::::: NP_694 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA 240 250 260 270 280 290 pF1KE5 ------------------------------------------------------------ NP_694 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD 300 310 320 330 340 350 280 290 pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::: NP_694 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 360 370 380 390 400 410 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH ::::::::::::::::::::::::::::::::::::: NP_694 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRM----------------------- 600 610 620 630 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 ---VCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 640 650 660 670 680 690 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 700 710 720 730 740 750 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW ::::::::::::::::::::::: ::::::::::: NP_694 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 760 770 780 >-- initn: 613 init1: 613 opt: 613 Z-score: 482.6 bits: 99.9 E(85289): 3.8e-20 Smith-Waterman score: 613; 100.0% identity (100.0% similar) in 88 aa overlap (1-88:1-88) 10 20 30 40 50 60 pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV :::::::::::::::::::::::::::: NP_694 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV 70 80 90 100 110 120 >>XP_011527670 (OMIM: 607114) PREDICTED: disintegrin and (800 aa) initn: 2759 init1: 1907 opt: 1907 Z-score: 1479.6 bits: 284.4 E(85289): 1.1e-75 Smith-Waterman score: 3875; 77.9% identity (77.9% similar) in 725 aa overlap (102-692:102-800) 80 90 100 110 pF1KE5 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHT-------------DHCHYQG :::::::::: ::::::: XP_011 AEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPEDHCHYQG 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE5 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGT 140 150 160 170 180 190 180 190 200 210 220 230 pF1KE5 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLL 200 210 220 230 240 250 240 250 260 270 pF1KE5 EVANYVDQLLRTLDIQVALTGLEVWTERDRSR---------------------------- :::::::::::::::::::::::::::::::: XP_011 EVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSA 260 270 280 290 300 310 pF1KE5 ------------------------------------------------------------ XP_011 QLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPD 320 330 340 350 360 370 280 290 pF1KE5 --------------------------------RQLRAFFRKGGGACLSNAPDPGLPVPPA :::::::::::::::::::::::::::: XP_011 GCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPA 380 390 400 410 420 430 300 310 320 330 340 350 pF1KE5 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQA 440 450 460 470 480 490 360 370 380 390 400 410 pF1KE5 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAP 500 510 520 530 540 550 420 430 440 450 460 470 pF1KE5 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVH 560 570 580 590 600 610 480 490 500 510 520 530 pF1KE5 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACH ::::::::::::::::::::::::::::::::::::::: XP_011 LDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVC--------------------- 620 630 640 650 540 550 560 570 580 590 pF1KE5 SHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -----NSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGA 660 670 680 690 700 600 610 620 630 640 650 pF1KE5 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLD 710 720 730 740 750 760 660 670 680 690 pF1KE5 PENSHEPSSHPEKPLPAVSPDPQ-DQVQMPRSCLW ::::::::::::::::::::::: ::::::::::: XP_011 PENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW 770 780 790 800 >-- initn: 712 init1: 712 opt: 712 Z-score: 558.8 bits: 114.1 E(85289): 2.2e-24 Smith-Waterman score: 712; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101) 10 20 30 40 50 60 pF1KE5 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRV ::::::::::::::::::::::::::::::::::::::::: XP_011 SKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTVRCFHGLWD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCG XP_011 APPEDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIF 130 140 150 160 170 180 692 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:20:24 2016 done: Tue Nov 8 06:20:26 2016 Total Scan time: 12.250 Total Display time: 0.200 Function used was FASTA [36.3.4 Apr, 2011]