FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6287, 296 aa 1>>>pF1KE6287 296 - 296 aa - 296 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.3340+/-0.000436; mu= 21.1030+/- 0.027 mean_var=65.9762+/-13.725, 0's: 0 Z-trim(110.5): 32 B-trim: 0 in 0/49 Lambda= 0.157899 statistics sampled from 18798 (18830) to 18798 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.57), E-opt: 0.2 (0.221), width: 16 Scan time: 5.260 The best scores are: opt bits E(85289) NP_001306596 (OMIM: 249270,603941) thiamine transp ( 296) 1933 449.3 4e-126 NP_008927 (OMIM: 249270,603941) thiamine transport ( 497) 1479 346.2 7.8e-95 XP_005246931 (OMIM: 606152,607483) PREDICTED: thia ( 492) 767 184.0 5.2e-46 XP_011510235 (OMIM: 606152,607483) PREDICTED: thia ( 496) 767 184.0 5.2e-46 NP_079519 (OMIM: 606152,607483) thiamine transport ( 496) 767 184.0 5.2e-46 XP_011510234 (OMIM: 606152,607483) PREDICTED: thia ( 496) 767 184.0 5.2e-46 XP_011510233 (OMIM: 606152,607483) PREDICTED: thia ( 508) 767 184.0 5.3e-46 XP_016860523 (OMIM: 606152,607483) PREDICTED: thia ( 564) 767 184.0 5.7e-46 XP_016860522 (OMIM: 606152,607483) PREDICTED: thia ( 564) 767 184.0 5.7e-46 XP_016860521 (OMIM: 606152,607483) PREDICTED: thia ( 564) 767 184.0 5.7e-46 XP_016860520 (OMIM: 606152,607483) PREDICTED: thia ( 569) 767 184.0 5.8e-46 XP_016860519 (OMIM: 606152,607483) PREDICTED: thia ( 576) 767 184.0 5.8e-46 XP_011528011 (OMIM: 600424) PREDICTED: folate tran ( 473) 578 140.9 4.6e-33 XP_005261221 (OMIM: 600424) PREDICTED: folate tran ( 473) 578 140.9 4.6e-33 XP_011528008 (OMIM: 600424) PREDICTED: folate tran ( 545) 578 141.0 5.1e-33 NP_001192136 (OMIM: 600424) folate transporter 1 i ( 551) 578 141.0 5.1e-33 NP_919231 (OMIM: 600424) folate transporter 1 isof ( 591) 578 141.0 5.4e-33 XP_011528006 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33 XP_011528004 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33 XP_011528003 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33 XP_011528002 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33 XP_011528005 (OMIM: 600424) PREDICTED: folate tran ( 591) 578 141.0 5.4e-33 XP_011528000 (OMIM: 600424) PREDICTED: folate tran ( 613) 578 141.0 5.5e-33 XP_016883932 (OMIM: 600424) PREDICTED: folate tran ( 659) 578 141.0 5.8e-33 XP_011527998 (OMIM: 600424) PREDICTED: folate tran ( 688) 578 141.1 6e-33 XP_016883935 (OMIM: 600424) PREDICTED: folate tran ( 489) 508 125.0 3e-28 NP_001192135 (OMIM: 600424) folate transporter 1 i ( 489) 508 125.0 3e-28 XP_016883934 (OMIM: 600424) PREDICTED: folate tran ( 541) 508 125.0 3.2e-28 XP_016883933 (OMIM: 600424) PREDICTED: folate tran ( 586) 508 125.0 3.4e-28 >>NP_001306596 (OMIM: 249270,603941) thiamine transporte (296 aa) initn: 1933 init1: 1933 opt: 1933 Z-score: 2385.2 bits: 449.3 E(85289): 4e-126 Smith-Waterman score: 1933; 100.0% identity (100.0% similar) in 296 aa overlap (1-296:1-296) 10 20 30 40 50 60 pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 KVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWSTWGEMTLSLFSLLIAAAVYIMD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLI 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 VVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSSQVTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSSQVTTS 250 260 270 280 290 >>NP_008927 (OMIM: 249270,603941) thiamine transporter 1 (497 aa) initn: 1479 init1: 1479 opt: 1479 Z-score: 1823.5 bits: 346.2 E(85289): 7.8e-95 Smith-Waterman score: 1479; 99.1% identity (99.6% similar) in 231 aa overlap (66-296:267-497) 40 50 60 70 80 90 pF1KE6 LLCAYGFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLL :. ::::::::::::::::::::::::::: NP_008 IVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWNDFLMCYSSRPLL 240 250 260 270 280 290 100 110 120 130 140 150 pF1KE6 CWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 CWSVWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKI 300 310 320 330 340 350 160 170 180 190 200 210 pF1KE6 SWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 SWSTWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLS 360 370 380 390 400 410 220 230 240 250 260 270 pF1KE6 MERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MERYALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAV 420 430 440 450 460 470 280 290 pF1KE6 SVMKKCRKLEDPQSSSQVTTS ::::::::::::::::::::: NP_008 SVMKKCRKLEDPQSSSQVTTS 480 490 >-- initn: 494 init1: 459 opt: 486 Z-score: 601.0 bits: 120.0 E(85289): 9.8e-27 Smith-Waterman score: 486; 44.8% identity (64.2% similar) in 232 aa overlap (1-223:1-217) 10 20 30 40 50 60 pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE :::::::: . . .:. :: :: . :. : . : :: ::: NP_008 DKNLTEREVFNE-----IYPVWT-----YSYLVLL-FPVFLATDYLRYKPVV-LLQGL-- 70 80 90 100 130 140 150 160 170 pF1KE6 KVMPSRYAAIYNGGVEAVSTL---LGAVAVFAVGYIKISWSTWGE-MTLSLFSLLIAAAV ... . . .: :. :.. : : ... ..: . .:. : .. : .:.. NP_008 SLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYSVVDLGMYQKVTSYCRSATL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 Y---IMDTVGNIWVCYASYVVFR--IIYMLLITIATFQIAANLSMERYALVFGVNTFIAL . ...:.: : :.. .: .: . ...: : .: : : . .: : NP_008 VGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVA-FAVAWFLPMPQKSLFFHHIPSTCQ 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS NP_008 RVNGIKVQNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPEPKPDRLLVLKVLWND 230 240 250 260 270 280 >>XP_005246931 (OMIM: 606152,607483) PREDICTED: thiamine (492 aa) initn: 747 init1: 747 opt: 767 Z-score: 947.0 bits: 184.0 E(85289): 5.2e-46 Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:249-468) 50 60 70 80 90 pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS ::. . : . : : .:. ::::. :. :: XP_005 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS 220 230 240 250 260 270 100 110 120 130 140 150 pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS .:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:. XP_005 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD 280 290 300 310 320 330 160 170 180 190 200 210 pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER ::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..:: XP_005 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER 340 350 360 370 380 390 220 230 240 250 260 270 pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM ::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. . XP_005 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT 400 410 420 430 440 450 280 290 pF1KE6 KKCRKLEDPQSSSQVTTS . .. .: :: XP_005 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL 460 470 480 490 >>XP_011510235 (OMIM: 606152,607483) PREDICTED: thiamine (496 aa) initn: 918 init1: 747 opt: 767 Z-score: 947.0 bits: 184.0 E(85289): 5.2e-46 Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:253-472) 50 60 70 80 90 pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS ::. . : . : : .:. ::::. :. :: XP_011 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS 230 240 250 260 270 280 100 110 120 130 140 150 pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS .:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:. XP_011 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD 290 300 310 320 330 340 160 170 180 190 200 210 pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER ::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..:: XP_011 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER 350 360 370 380 390 400 220 230 240 250 260 270 pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM ::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. . XP_011 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT 410 420 430 440 450 460 280 290 pF1KE6 KKCRKLEDPQSSSQVTTS . .. .: :: XP_011 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL 470 480 490 >-- initn: 227 init1: 185 opt: 206 Z-score: 256.3 bits: 56.2 E(85289): 1.5e-07 Smith-Waterman score: 206; 26.6% identity (53.7% similar) in 203 aa overlap (30-223:12-199) 10 20 30 40 50 60 pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP :. ::..:: .:::. .::::::: ::: :: XP_011 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP 10 20 30 40 70 80 90 100 110 120 pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE ::::: : . :... .. :. ..:. .. : ::. XP_011 DKNLTSAE------------ITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGI-- 50 60 70 80 130 140 150 160 170 pF1KE6 KVMPSRYAAIYNGGV---EAVSTLLGAVAVFAVGYIKISWSTWGE---MTLSLFSLLIAA . . . ... :: ..: . : :.. :.: .:. . . .: . .. XP_011 SFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTL 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE6 AVYIMDTV-GNIWVCYA--SYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIAL :.: .: ... : : :: . .: . ...: : .. : : . .. : XP_011 AAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVA-FLFSLFLPMPKKSMFFHAKPSREI 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS XP_011 KKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQ 210 220 230 240 250 260 >>NP_079519 (OMIM: 606152,607483) thiamine transporter 2 (496 aa) initn: 918 init1: 747 opt: 767 Z-score: 947.0 bits: 184.0 E(85289): 5.2e-46 Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:253-472) 50 60 70 80 90 pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS ::. . : . : : .:. ::::. :. :: NP_079 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS 230 240 250 260 270 280 100 110 120 130 140 150 pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS .:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:. NP_079 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD 290 300 310 320 330 340 160 170 180 190 200 210 pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER ::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..:: NP_079 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER 350 360 370 380 390 400 220 230 240 250 260 270 pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM ::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. . NP_079 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT 410 420 430 440 450 460 280 290 pF1KE6 KKCRKLEDPQSSSQVTTS . .. .: :: NP_079 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL 470 480 490 >-- initn: 227 init1: 185 opt: 206 Z-score: 256.3 bits: 56.2 E(85289): 1.5e-07 Smith-Waterman score: 206; 26.6% identity (53.7% similar) in 203 aa overlap (30-223:12-199) 10 20 30 40 50 60 pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP :. ::..:: .:::. .::::::: ::: :: NP_079 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP 10 20 30 40 70 80 90 100 110 120 pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE ::::: : . :... .. :. ..:. .. : ::. NP_079 DKNLTSAE------------ITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGI-- 50 60 70 80 130 140 150 160 170 pF1KE6 KVMPSRYAAIYNGGV---EAVSTLLGAVAVFAVGYIKISWSTWGE---MTLSLFSLLIAA . . . ... :: ..: . : :.. :.: .:. . . .: . .. NP_079 SFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTL 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE6 AVYIMDTV-GNIWVCYA--SYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIAL :.: .: ... : : :: . .: . ...: : .. : : . .. : NP_079 AAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVA-FLFSLFLPMPKKSMFFHAKPSREI 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS NP_079 KKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQ 210 220 230 240 250 260 >>XP_011510234 (OMIM: 606152,607483) PREDICTED: thiamine (496 aa) initn: 918 init1: 747 opt: 767 Z-score: 947.0 bits: 184.0 E(85289): 5.2e-46 Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:253-472) 50 60 70 80 90 pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS ::. . : . : : .:. ::::. :. :: XP_011 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS 230 240 250 260 270 280 100 110 120 130 140 150 pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS .:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:. XP_011 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD 290 300 310 320 330 340 160 170 180 190 200 210 pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER ::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..:: XP_011 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER 350 360 370 380 390 400 220 230 240 250 260 270 pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM ::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. . XP_011 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT 410 420 430 440 450 460 280 290 pF1KE6 KKCRKLEDPQSSSQVTTS . .. .: :: XP_011 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL 470 480 490 >-- initn: 227 init1: 185 opt: 206 Z-score: 256.3 bits: 56.2 E(85289): 1.5e-07 Smith-Waterman score: 206; 26.6% identity (53.7% similar) in 203 aa overlap (30-223:12-199) 10 20 30 40 50 60 pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP :. ::..:: .:::. .::::::: ::: :: XP_011 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP 10 20 30 40 70 80 90 100 110 120 pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE ::::: : . :... .. :. ..:. .. : ::. XP_011 DKNLTSAE------------ITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGI-- 50 60 70 80 130 140 150 160 170 pF1KE6 KVMPSRYAAIYNGGV---EAVSTLLGAVAVFAVGYIKISWSTWGE---MTLSLFSLLIAA . . . ... :: ..: . : :.. :.: .:. . . .: . .. XP_011 SFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTL 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE6 AVYIMDTV-GNIWVCYA--SYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIAL :.: .: ... : : :: . .: . ...: : .. : : . .. : XP_011 AAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVA-FLFSLFLPMPKKSMFFHAKPSREI 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS XP_011 KKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQ 210 220 230 240 250 260 >>XP_011510233 (OMIM: 606152,607483) PREDICTED: thiamine (508 aa) initn: 918 init1: 747 opt: 767 Z-score: 946.8 bits: 184.0 E(85289): 5.3e-46 Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:265-484) 50 60 70 80 90 pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS ::. . : . : : .:. ::::. :. :: XP_011 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS 240 250 260 270 280 290 100 110 120 130 140 150 pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS .:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:. XP_011 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD 300 310 320 330 340 350 160 170 180 190 200 210 pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER ::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..:: XP_011 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER 360 370 380 390 400 410 220 230 240 250 260 270 pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM ::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. . XP_011 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT 420 430 440 450 460 470 280 290 pF1KE6 KKCRKLEDPQSSSQVTTS . .. .: :: XP_011 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL 480 490 500 >-- initn: 227 init1: 185 opt: 206 Z-score: 256.2 bits: 56.2 E(85289): 1.6e-07 Smith-Waterman score: 206; 26.6% identity (53.7% similar) in 203 aa overlap (30-223:24-211) 10 20 30 40 50 60 pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP :. ::..:: .:::. .::::::: ::: :: XP_011 MKGKGKHLAFTAMDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE ::::: : . :... .. :. ..:. .. : ::. XP_011 DKNLTSAE------------ITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGI-- 60 70 80 90 100 130 140 150 160 170 pF1KE6 KVMPSRYAAIYNGGV---EAVSTLLGAVAVFAVGYIKISWSTWGE---MTLSLFSLLIAA . . . ... :: ..: . : :.. :.: .:. . . .: . .. XP_011 SFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 AVYIMDTV-GNIWVCYA--SYVVFRIIYMLLITIATFQIAANLSMERYALVFGVNTFIAL :.: .: ... : : :: . .: . ...: : .. : : . .. : XP_011 AAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVA-FLFSLFLPMPKKSMFFHAKPSREI 170 180 190 200 210 240 250 260 270 280 290 pF1KE6 ALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVMKKCRKLEDPQSSS XP_011 KKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQ 220 230 240 250 260 270 >>XP_016860523 (OMIM: 606152,607483) PREDICTED: thiamine (564 aa) initn: 932 init1: 747 opt: 767 Z-score: 946.3 bits: 184.0 E(85289): 5.7e-46 Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:321-540) 50 60 70 80 90 pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS ::. . : . : : .:. ::::. :. :: XP_016 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS 300 310 320 330 340 350 100 110 120 130 140 150 pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS .:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:. XP_016 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD 360 370 380 390 400 410 160 170 180 190 200 210 pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER ::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..:: XP_016 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER 420 430 440 450 460 470 220 230 240 250 260 270 pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM ::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. . XP_016 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT 480 490 500 510 520 280 290 pF1KE6 KKCRKLEDPQSSSQVTTS . .. .: :: XP_016 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL 530 540 550 560 >-- initn: 241 init1: 199 opt: 199 Z-score: 247.0 bits: 54.6 E(85289): 5.1e-07 Smith-Waterman score: 199; 66.7% identity (82.1% similar) in 39 aa overlap (30-68:12-50) 10 20 30 40 50 60 pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP :. ::..:: .:::. .::::::: ::: :: XP_016 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP 10 20 30 40 70 80 90 100 110 120 pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE ::::: : XP_016 DKNLTSAELLRLKHATIKTTKDRCRVRSNSMNPLGSASRATVDQLTDLPSKEQLSCVVFA 50 60 70 80 90 100 >>XP_016860522 (OMIM: 606152,607483) PREDICTED: thiamine (564 aa) initn: 932 init1: 747 opt: 767 Z-score: 946.3 bits: 184.0 E(85289): 5.7e-46 Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:321-540) 50 60 70 80 90 pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS ::. . : . : : .:. ::::. :. :: XP_016 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS 300 310 320 330 340 350 100 110 120 130 140 150 pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS .:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:. XP_016 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD 360 370 380 390 400 410 160 170 180 190 200 210 pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER ::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..:: XP_016 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER 420 430 440 450 460 470 220 230 240 250 260 270 pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM ::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. . XP_016 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT 480 490 500 510 520 280 290 pF1KE6 KKCRKLEDPQSSSQVTTS . .. .: :: XP_016 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL 530 540 550 560 >-- initn: 241 init1: 199 opt: 199 Z-score: 247.0 bits: 54.6 E(85289): 5.1e-07 Smith-Waterman score: 199; 66.7% identity (82.1% similar) in 39 aa overlap (30-68:12-50) 10 20 30 40 50 60 pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP :. ::..:: .:::. .::::::: ::: :: XP_016 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP 10 20 30 40 70 80 90 100 110 120 pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE ::::: : XP_016 DKNLTSAELLRLKHATIKTTKDRCRVRSNSMNPLGSASRATVDQLTDLPSKEQLSCVVFA 50 60 70 80 90 100 >>XP_016860521 (OMIM: 606152,607483) PREDICTED: thiamine (564 aa) initn: 932 init1: 747 opt: 767 Z-score: 946.3 bits: 184.0 E(85289): 5.7e-46 Smith-Waterman score: 767; 51.6% identity (81.9% similar) in 221 aa overlap (71-289:321-540) 50 60 70 80 90 pF1KE6 GFFASLRPSEPFLTPYLLGPDKNLTEREEPKPDRLLV-LKVLW-NDFLMCYSSRPLLCWS ::. . : . : : .:. ::::. :. :: XP_016 GEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWS 300 310 320 330 340 350 100 110 120 130 140 150 pF1KE6 VWWALSTCGYFQVVNYTQGLWEKVMPSRYAAIYNGGVEAVSTLLGAVAVFAVGYIKISWS .:::..: :. ::.::.: ::. ::. ..::::.:::..:. ::::.:::::.:..:. XP_016 LWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWD 360 370 380 390 400 410 160 170 180 190 200 210 pF1KE6 TWGEMTLSLFSLLIAAAVYIMDTVGNIWVCYASYVVFRIIYMLLITIATFQIAANLSMER ::..: .::.. :.....: ..:::.:::.:..:. ::::::::.::::.::..:: XP_016 LLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVER 420 430 440 450 460 470 220 230 240 250 260 270 pF1KE6 YALVFGVNTFIALALQTLLTLIVVDASGLGLEITTQFLIYASYFALIAVVFLASGAVSVM ::::::.::::::..::..:.:::: ::.: .. :::.:.::::.:: .:: .. . XP_016 YALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMR-SMYIT 480 490 500 510 520 280 290 pF1KE6 KKCRKLEDPQSSSQVTTS . .. .: :: XP_016 YSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKL 530 540 550 560 >-- initn: 241 init1: 199 opt: 199 Z-score: 247.0 bits: 54.6 E(85289): 5.1e-07 Smith-Waterman score: 199; 66.7% identity (82.1% similar) in 39 aa overlap (30-68:12-50) 10 20 30 40 50 60 pF1KE6 MDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPFLTPYLLGP :. ::..:: .:::. .::::::: ::: :: XP_016 MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGP 10 20 30 40 70 80 90 100 110 120 pF1KE6 DKNLTEREEPKPDRLLVLKVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYTQGLWE ::::: : XP_016 DKNLTSAELLRLKHATIKTTKDRCRVRSNSMNPLGSASRATVDQLTDLPSKEQLSCVVFA 50 60 70 80 90 100 296 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:48:12 2016 done: Tue Nov 8 11:48:13 2016 Total Scan time: 5.260 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]