FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5575, 462 aa 1>>>pF1KE5575 462 - 462 aa - 462 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6266+/-0.000897; mu= 15.6925+/- 0.054 mean_var=64.1750+/-13.615, 0's: 0 Z-trim(106.2): 30 B-trim: 312 in 1/50 Lambda= 0.160100 statistics sampled from 8837 (8861) to 8837 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.272), width: 16 Scan time: 3.050 The best scores are: opt bits E(32554) CCDS57974.1 CLCNKB gene_id:1188|Hs108|chr1 ( 517) 1598 377.9 1.3e-104 CCDS168.1 CLCNKB gene_id:1188|Hs108|chr1 ( 687) 1598 378.0 1.7e-104 CCDS57973.1 CLCNKA gene_id:1187|Hs108|chr1 ( 644) 1513 358.3 1.3e-98 CCDS41269.1 CLCNKA gene_id:1187|Hs108|chr1 ( 686) 1513 358.3 1.4e-98 CCDS167.1 CLCNKA gene_id:1187|Hs108|chr1 ( 687) 1513 358.3 1.4e-98 CCDS54690.1 CLCN2 gene_id:1181|Hs108|chr3 ( 854) 794 192.3 1.7e-48 CCDS54692.1 CLCN2 gene_id:1181|Hs108|chr3 ( 869) 794 192.3 1.7e-48 CCDS3263.1 CLCN2 gene_id:1181|Hs108|chr3 ( 898) 794 192.3 1.7e-48 CCDS5881.1 CLCN1 gene_id:1180|Hs108|chr7 ( 988) 740 179.8 1.1e-44 CCDS54691.1 CLCN2 gene_id:1181|Hs108|chr3 ( 881) 528 130.9 5.4e-30 >>CCDS57974.1 CLCNKB gene_id:1188|Hs108|chr1 (517 aa) initn: 1593 init1: 1593 opt: 1598 Z-score: 1991.4 bits: 377.9 E(32554): 1.3e-104 Smith-Waterman score: 1598; 91.6% identity (95.4% similar) in 262 aa overlap (179-439:137-398) 150 160 170 180 190 200 pF1KE5 VGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPE-NKSKPVYSALATLVL ..: .:.. .. ::::::::::::: CCDS57 PFDLPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVL 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE5 ASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS57 ASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPR 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE5 FTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS57 FTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAG 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE5 GITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS57 GITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSC 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE5 QPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQ :::::::::::::::::::::::::::::::::::::::::::: . .:. CCDS57 QPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTD 350 360 370 380 390 400 450 460 pF1KE5 AQMASGVVWFPVRGS CCDS57 VAKYPLVESTESQILVGIVRRAQLVQALKAEPPSWAPGHQCLQDILAAGCPTEPVTLKLS 410 420 430 440 450 460 >>CCDS168.1 CLCNKB gene_id:1188|Hs108|chr1 (687 aa) initn: 1593 init1: 1593 opt: 1598 Z-score: 1989.5 bits: 378.0 E(32554): 1.7e-104 Smith-Waterman score: 1958; 71.3% identity (72.0% similar) in 471 aa overlap (97-439:97-567) 70 80 90 100 110 120 pF1KE5 MDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEV :::::::::::::::::::::::::::::: CCDS16 MDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 KTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 KTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTT 130 140 150 160 170 180 190 pF1KE5 TIGEPENKSK-------------------------------------------------- :::::::::: CCDS16 TIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGFFAATCG 190 200 210 220 230 240 pF1KE5 ------------------------------------------------------------ CCDS16 AFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYLFCQRIF 250 260 270 280 290 300 200 210 220 230 pF1KE5 ------------------PVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHS :::::::::::::::::::::::::::::::::::::::::: CCDS16 FGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHS 310 320 330 340 350 360 240 250 260 270 280 290 pF1KE5 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF 370 380 390 400 410 420 300 310 320 330 340 350 pF1KE5 MPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 MPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTAL 430 440 450 460 470 480 360 370 380 390 400 410 pF1KE5 LAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 LAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVR 490 500 510 520 530 540 420 430 440 450 460 pF1KE5 VEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS ::::::::::::: . .:. CCDS16 VEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLVQALKAE 550 560 570 580 590 600 >-- initn: 672 init1: 672 opt: 672 Z-score: 833.5 bits: 164.1 E(32554): 4.2e-40 Smith-Waterman score: 672; 100.0% identity (100.0% similar) in 96 aa overlap (1-96:1-96) 10 20 30 40 50 60 pF1KE5 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG :::::::::::::::::::::::::::::::::::: CCDS16 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL CCDS16 SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL 130 140 150 160 170 180 >>CCDS57973.1 CLCNKA gene_id:1187|Hs108|chr1 (644 aa) initn: 1935 init1: 1513 opt: 1513 Z-score: 1883.8 bits: 358.3 E(32554): 1.3e-98 Smith-Waterman score: 1719; 64.9% identity (69.5% similar) in 459 aa overlap (101-431:60-516) 80 90 100 110 120 130 pF1KE5 VESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTML .::::.. .: .: ::::::.:::: CCDS57 RAIQGGLEWLKQKVFRLGEDWYFLMTLGVLMALVSYAMNF--AIGCVVRGSGIPELKTML 30 40 50 60 70 80 140 150 160 170 180 190 pF1KE5 AGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGE :::.:::::::::::::::::::::: ::::::::::::::::::.:::::::::::::: CCDS57 AGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGE 90 100 110 120 130 140 pF1KE5 PENKSK------------------------------------------------------ :::::: CCDS57 PENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIF 150 160 170 180 190 200 pF1KE5 ------------------------------------------------------------ CCDS57 RLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFI 210 220 230 240 250 260 200 210 220 230 240 pF1KE5 --------------PVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALM :::::::::.::::::::..:.:::::::::::::::::::::::: CCDS57 KTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHSWALM 270 280 290 300 310 320 250 260 270 280 290 300 pF1KE5 TQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS57 TQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIF 330 340 350 360 370 380 310 320 330 340 350 360 pF1KE5 VYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLAFE . :::::::.::.:. ::::::.::.::::::::::::::::::::::::::::::::: CCDS57 ILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTALLAFE 390 400 410 420 430 440 370 380 390 400 410 420 pF1KE5 VTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHF .::::::::::::::::::::::::::::::::.:::::::::::::::::::.:::::: CCDS57 LTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHF 450 460 470 480 490 500 430 440 450 460 pF1KE5 MNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS ::::::::: CCDS57 MNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAEPPSR 510 520 530 540 550 560 >-- initn: 375 init1: 375 opt: 375 Z-score: 463.2 bits: 95.5 E(32554): 1.8e-19 Smith-Waterman score: 375; 88.1% identity (98.3% similar) in 59 aa overlap (1-59:1-59) 10 20 30 40 50 60 pF1KE5 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM :::.:::::: ::.::::::::::::.:::.:.:::::::::.:::::::::::::::: CCDS57 MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG CCDS57 ALVSYAMNFAIGCVVRGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFL 70 80 90 100 110 120 >>CCDS41269.1 CLCNKA gene_id:1187|Hs108|chr1 (686 aa) initn: 1513 init1: 1513 opt: 1513 Z-score: 1883.4 bits: 358.3 E(32554): 1.4e-98 Smith-Waterman score: 1850; 68.0% identity (71.5% similar) in 463 aa overlap (97-431:97-559) 70 80 90 100 110 120 pF1KE5 MDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEV :::::::::::::::::::::::::::::. CCDS41 MNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 KTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTT :::::::.:::::::::::::::::::::: ::::::::::::::::::.:::::::::: CCDS41 KTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTT 130 140 150 160 170 180 190 pF1KE5 TIGEPENKSK-------------------------------------------------- :::::::::: CCDS41 TIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCG 190 200 210 220 230 240 pF1KE5 ------------------------------------------------------------ CCDS41 AFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTF 250 260 270 280 290 300 200 210 220 230 pF1KE5 ------------------PVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHS :::::::::.::::::::..:.:::::::::::::::::::: CCDS41 LSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHS 310 320 330 340 350 360 240 250 260 270 280 290 pF1KE5 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF 370 380 390 400 410 420 300 310 320 330 340 350 pF1KE5 MPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTAL ::::. :::::::.::.:. ::::::.::.::::::::::::::::::::::::::::: CCDS41 MPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTAL 430 440 450 460 470 480 360 370 380 390 400 410 pF1KE5 LAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVR ::::.::::::::::::::::::::::::::::::::.:::::::::::::::::::.:: CCDS41 LAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVR 490 500 510 520 530 540 420 430 440 450 460 pF1KE5 VEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS ::::::::::::: CCDS41 VEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAE 550 560 570 580 590 600 >-- initn: 585 init1: 585 opt: 585 Z-score: 724.9 bits: 144.0 E(32554): 4.7e-34 Smith-Waterman score: 585; 86.5% identity (95.8% similar) in 96 aa overlap (1-96:1-96) 10 20 30 40 50 60 pF1KE5 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM :::.:::::: ::.::::::::::::.:::.:.:::::::::.::::::::::::::::: CCDS41 MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG :::: ::..:. ::::::::::::::::::::::: CCDS41 ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL CCDS41 SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL 130 140 150 160 170 180 >>CCDS167.1 CLCNKA gene_id:1187|Hs108|chr1 (687 aa) initn: 1513 init1: 1513 opt: 1513 Z-score: 1883.3 bits: 358.3 E(32554): 1.4e-98 Smith-Waterman score: 1850; 68.0% identity (71.5% similar) in 463 aa overlap (97-431:97-559) 70 80 90 100 110 120 pF1KE5 MDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEV :::::::::::::::::::::::::::::. CCDS16 MNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 KTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTT :::::::.:::::::::::::::::::::: ::::::::::::::::::.:::::::::: CCDS16 KTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTT 130 140 150 160 170 180 190 pF1KE5 TIGEPENKSK-------------------------------------------------- :::::::::: CCDS16 TIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCG 190 200 210 220 230 240 pF1KE5 ------------------------------------------------------------ CCDS16 AFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTF 250 260 270 280 290 300 200 210 220 230 pF1KE5 ------------------PVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHS :::::::::.::::::::..:.:::::::::::::::::::: CCDS16 LSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHS 310 320 330 340 350 360 240 250 260 270 280 290 pF1KE5 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 WALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYF 370 380 390 400 410 420 300 310 320 330 340 350 pF1KE5 MPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTAL ::::. :::::::.::.:. ::::::.::.::::::::::::::::::::::::::::: CCDS16 MPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTAL 430 440 450 460 470 480 360 370 380 390 400 410 pF1KE5 LAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVR ::::.::::::::::::::::::::::::::::::::.:::::::::::::::::::.:: CCDS16 LAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVR 490 500 510 520 530 540 420 430 440 450 460 pF1KE5 VEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS ::::::::::::: CCDS16 VEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAE 550 560 570 580 590 600 >-- initn: 585 init1: 585 opt: 585 Z-score: 724.9 bits: 144.0 E(32554): 4.7e-34 Smith-Waterman score: 585; 86.5% identity (95.8% similar) in 96 aa overlap (1-96:1-96) 10 20 30 40 50 60 pF1KE5 MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM :::.:::::: ::.::::::::::::.:::.:.:::::::::.::::::::::::::::: CCDS16 MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG :::: ::..:. ::::::::::::::::::::::: CCDS16 ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL CCDS16 SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL 130 140 150 160 170 180 >>CCDS54690.1 CLCN2 gene_id:1181|Hs108|chr3 (854 aa) initn: 1111 init1: 655 opt: 794 Z-score: 984.3 bits: 192.3 E(32554): 1.7e-48 Smith-Waterman score: 894; 36.7% identity (58.2% similar) in 490 aa overlap (90-450:87-567) 60 70 80 90 100 110 pF1KE5 MALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG ::.::.:..:::.:..::.::.: ..:.. CCDS54 AAPELLEYGRSRCARCRAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 GSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAY ::::::.::.: ::::..:: .:.: :::.::.:.: :: . ::: :::::.. : :: CCDS54 GSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMPLGKEGPFVHIASMCAAL 120 130 140 150 160 170 180 190 pF1KE5 LGRVRTTTIGEPENKSK-------------------PV---------------------- :.. . : ::.:. :. CCDS54 LSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRG 180 190 200 210 220 230 pF1KE5 ------------------------------------------------------------ CCDS54 FFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALF 240 250 260 270 280 290 200 210 220 230 pF1KE5 ---------------------------YSALATLVLASITYPPSAGRFLASRLSMKQHLD . ::.::.....:.::. :.:.:..::.:. : CCDS54 VYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLV 300 310 320 330 340 350 240 250 260 270 280 290 pF1KE5 SLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTI .::::..: . :. :::.: : :: ..: ::..:..::::: ::::: CCDS54 TLFDNRTW--VRQGLV----EELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTI 360 370 380 390 400 300 310 320 330 340 350 pF1KE5 PMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVT :.: : :::.:: :::.::: ::... ::.:: . . : :.:::::..::::..:::: CCDS54 PVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVT 410 420 430 440 450 460 360 370 380 390 400 410 pF1KE5 HTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI-LGR ::.:::...::.::::.: :::..::. :::.::: :::.::. . .:::::::.. :: CCDS54 HTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGR 470 480 490 500 510 520 420 430 440 450 460 pF1KE5 NIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS . ..::::: .: ... .:.. .. . :. ...: CCDS54 H-QQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQ 530 540 550 560 570 580 CCDS54 VVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGET 590 600 610 620 630 640 >>CCDS54692.1 CLCN2 gene_id:1181|Hs108|chr3 (869 aa) initn: 1218 init1: 655 opt: 794 Z-score: 984.2 bits: 192.3 E(32554): 1.7e-48 Smith-Waterman score: 894; 36.7% identity (58.2% similar) in 490 aa overlap (90-450:131-611) 60 70 80 90 100 110 pF1KE5 MALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG ::.::.:..:::.:..::.::.: ..:.. CCDS54 MALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAV 110 120 130 140 150 160 120 130 140 150 160 170 pF1KE5 GSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAY ::::::.::.: ::::..:: .:.: :::.::.:.: :: . ::: :::::.. : :: CCDS54 GSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMPLGKEGPFVHIASMCAAL 170 180 190 200 210 180 190 pF1KE5 LGRVRTTTIGEPENKSK-------------------PV---------------------- :.. . : ::.:. :. CCDS54 LSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRG 220 230 240 250 260 270 pF1KE5 ------------------------------------------------------------ CCDS54 FFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALF 280 290 300 310 320 330 200 210 220 230 pF1KE5 ---------------------------YSALATLVLASITYPPSAGRFLASRLSMKQHLD . ::.::.....:.::. :.:.:..::.:. : CCDS54 VYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLV 340 350 360 370 380 390 240 250 260 270 280 290 pF1KE5 SLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTI .::::..: . :. :::.: : :: ..: ::..:..::::: ::::: CCDS54 TLFDNRTW--VRQGLV----EELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTI 400 410 420 430 440 450 300 310 320 330 340 350 pF1KE5 PMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVT :.: : :::.:: :::.::: ::... ::.:: . . : :.:::::..::::..:::: CCDS54 PVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVT 460 470 480 490 500 510 360 370 380 390 400 410 pF1KE5 HTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI-LGR ::.:::...::.::::.: :::..::. :::.::: :::.::. . .:::::::.. :: CCDS54 HTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGR 520 530 540 550 560 570 420 430 440 450 460 pF1KE5 NIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS . ..::::: .: ... .:.. .. . :. ...: CCDS54 H-QQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQ 580 590 600 610 620 630 CCDS54 VVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGET 640 650 660 670 680 690 >>CCDS3263.1 CLCN2 gene_id:1181|Hs108|chr3 (898 aa) initn: 1218 init1: 655 opt: 794 Z-score: 983.9 bits: 192.3 E(32554): 1.7e-48 Smith-Waterman score: 894; 36.7% identity (58.2% similar) in 490 aa overlap (90-450:131-611) 60 70 80 90 100 110 pF1KE5 MALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSG ::.::.:..:::.:..::.::.: ..:.. CCDS32 MALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAV 110 120 130 140 150 160 120 130 140 150 160 170 pF1KE5 GSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAY ::::::.::.: ::::..:: .:.: :::.::.:.: :: . ::: :::::.. : :: CCDS32 GSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMPLGKEGPFVHIASMCAAL 170 180 190 200 210 180 190 pF1KE5 LGRVRTTTIGEPENKSK-------------------PV---------------------- :.. . : ::.:. :. CCDS32 LSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRG 220 230 240 250 260 270 pF1KE5 ------------------------------------------------------------ CCDS32 FFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALF 280 290 300 310 320 330 200 210 220 230 pF1KE5 ---------------------------YSALATLVLASITYPPSAGRFLASRLSMKQHLD . ::.::.....:.::. :.:.:..::.:. : CCDS32 VYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLV 340 350 360 370 380 390 240 250 260 270 280 290 pF1KE5 SLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTI .::::..: . :. :::.: : :: ..: ::..:..::::: ::::: CCDS32 TLFDNRTW--VRQGLV----EELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTI 400 410 420 430 440 450 300 310 320 330 340 350 pF1KE5 PMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVT :.: : :::.:: :::.::: ::... ::.:: . . : :.:::::..::::..:::: CCDS32 PVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVT 460 470 480 490 500 510 360 370 380 390 400 410 pF1KE5 HTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI-LGR ::.:::...::.::::.: :::..::. :::.::: :::.::. . .:::::::.. :: CCDS32 HTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGR 520 530 540 550 560 570 420 430 440 450 460 pF1KE5 NIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS . ..::::: .: ... .:.. .. . :. ...: CCDS32 H-QQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQ 580 590 600 610 620 630 CCDS32 VVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGET 640 650 660 670 680 690 >>CCDS5881.1 CLCN1 gene_id:1180|Hs108|chr7 (988 aa) initn: 1122 init1: 600 opt: 740 Z-score: 915.9 bits: 179.8 E(32554): 1.1e-44 Smith-Waterman score: 769; 40.7% identity (70.9% similar) in 302 aa overlap (139-439:343-625) 110 120 130 140 150 160 pF1KE5 GFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGA-KVVGLSCTLACGSTLFLGKVG .:.:.. : ..:. : :: .:: : CCDS58 AFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGI-C---CG---LLGAVF 320 330 340 350 360 170 180 190 200 210 220 pF1KE5 PFVHLSVMMAAYLGRVRTTTIGEPENKSKPVYSALATLVLASITYPPSAGRFLASRLSMK ..: .:: :: . .... : . .: ...:.:.::.:.::. :.:.:..: . CCDS58 VYLHRQVM----LGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMPR 370 380 390 400 410 420 230 240 250 260 270 280 pF1KE5 QHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLIL . ...::::..:. . . :: : . .: ::: .. . .:.:::::: :. CCDS58 EAISTLFDNNTWVKHAGD-----PESLGQSAVW---IHPRVNVVIIIFLFFVMKFWMSIV 430 440 450 460 470 290 300 310 320 330 340 pF1KE5 ATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFS :::.:.: : :::.:: :::.::: :: ....::.::. : :.:::::. ::::.. CCDS58 ATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALT 480 490 500 510 520 530 350 360 370 380 390 400 pF1KE5 GAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRI :::.::.:::.. ::.::::.: ::...::. :: .::: :::.::. . :::::::: . CCDS58 GAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDL 540 550 560 570 580 590 410 420 430 440 450 460 pF1KE5 LGRNIGSHRVRVEHFMNHSITTLAITLMNDEIGVHCHQGQAQMASGVVWFPVRGS ..... . :: .: ... .. . :. CCDS58 GWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVE 600 610 620 630 640 650 CCDS58 RSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDE 660 670 680 690 700 710 >-- initn: 414 init1: 338 opt: 406 Z-score: 498.9 bits: 102.7 E(32554): 1.8e-21 Smith-Waterman score: 406; 44.5% identity (71.6% similar) in 155 aa overlap (45-199:113-262) 20 30 40 50 60 70 pF1KE5 PVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESV .:::: ::. ::.:::::: .:: . . CCDS58 GSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDGIFLVLLGLLMALVSWSMDYVSAKS 90 100 110 120 130 140 80 90 100 110 120 130 pF1KE5 VRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVV ..:..: : .. : :..: :...:..:. ::. : . :.:.. ::::::.::.: ::: CCDS58 LQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVV 150 160 170 180 190 200 140 150 160 170 180 190 pF1KE5 LEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENK :..:: .: : ::::.:. : :: . .:: :::::.. . :: :.. .. : : CCDS58 LKEYLTMKAFVAKVVALTAGL--GSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYE-- 210 220 230 240 250 200 210 220 230 240 250 pF1KE5 SKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEEL .: : CCDS58 -QPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFR 260 270 280 290 300 310 >>CCDS54691.1 CLCN2 gene_id:1181|Hs108|chr3 (881 aa) initn: 1134 init1: 439 opt: 528 Z-score: 652.0 bits: 130.9 E(32554): 5.4e-30 Smith-Waterman score: 825; 36.4% identity (55.6% similar) in 475 aa overlap (45-391:86-535) 20 30 40 50 60 70 pF1KE5 PVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESV :.:::: ::. ::.:::::: .:: :. . CCDS54 RAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAAC 60 70 80 90 100 110 80 90 100 110 120 130 pF1KE5 VRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVV ..:.::. : .. : ::.::.:..:::.:..::.::.: ..:.. ::::::.::.: ::: CCDS54 LQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVV 120 130 140 150 160 170 140 150 160 170 180 190 pF1KE5 LEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEPENK :..:: .:.: :::.::.:.: :: . ::: :::::.. : :: :.. . : ::. CCDS54 LKEYLTLKTFIAKVIGLTCAL--GSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENE 180 190 200 210 220 230 pF1KE5 SK-------------------PV------------------------------------- :. :. CCDS54 SRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLA 240 250 260 270 280 290 pF1KE5 ------------------------------------------------------------ CCDS54 VWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQK 300 310 320 330 340 350 200 210 220 230 240 pF1KE5 ------------YSALATLVLASITYPPSAGRFLASRLSMKQHLDSLFDNHSWALMTQNS . ::.::.....:.::. :.:.:..::.:. : .::::..: . :. CCDS54 TINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTW--VRQG- 360 370 380 390 400 410 250 260 270 280 290 300 pF1KE5 SPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFVYGA :::.: : :: ..: ::..:..::::: ::::::.: : :::.:: CCDS54 ---LVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVI-- 420 430 440 450 460 310 320 330 340 350 360 pF1KE5 AIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLAFEVTGQ .:: . . : :.:::::..::::..::::::.:::...::.::: CCDS54 ---------------DGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQ 470 480 490 500 510 370 380 390 400 410 420 pF1KE5 IVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNHS :.: :::..::. :::.::: :::. CCDS54 IAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRD 520 530 540 550 560 570 462 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 01:59:20 2016 done: Tue Nov 8 01:59:20 2016 Total Scan time: 3.050 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]