FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5687, 562 aa 1>>>pF1KE5687 562 - 562 aa - 562 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.8549+/-0.000531; mu= -13.8822+/- 0.033 mean_var=496.1118+/-103.036, 0's: 0 Z-trim(121.4): 283 B-trim: 1534 in 1/61 Lambda= 0.057582 statistics sampled from 37711 (38001) to 37711 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.446), width: 16 Scan time: 9.690 The best scores are: opt bits E(85289) NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 3845 334.1 7.4e-91 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 3801 330.4 9.2e-90 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 2962 260.7 8.5e-69 NP_001193719 (OMIM: 610050) transmembrane protease ( 491) 2842 250.7 8e-66 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 995 97.3 1.2e-19 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 995 97.3 1.2e-19 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 995 97.3 1.3e-19 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 976 95.6 3.1e-19 NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 935 92.2 3.6e-18 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 919 90.9 9.3e-18 XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 918 90.9 1e-17 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 914 90.5 1.2e-17 NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 900 89.3 2.7e-17 NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 900 89.3 2.7e-17 NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 897 89.1 3.1e-17 NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 888 88.3 5e-17 XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 883 88.0 7.8e-17 XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 883 88.0 7.8e-17 XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 871 86.9 1.5e-16 XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 871 86.9 1.5e-16 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 823 82.9 2.2e-15 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 819 82.5 2.3e-15 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 823 82.9 2.3e-15 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 823 83.0 2.3e-15 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 819 82.6 2.9e-15 NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 788 79.9 1.3e-14 XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 757 77.5 1e-13 NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 757 77.5 1e-13 NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 757 77.6 1.3e-13 XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 757 77.6 1.4e-13 XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 757 77.6 1.4e-13 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 735 75.9 5.6e-13 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 735 75.9 5.7e-13 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 728 75.4 1e-12 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 727 75.3 1.1e-12 XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 727 75.3 1.1e-12 XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 727 75.3 1.1e-12 XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 727 75.3 1.1e-12 XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 727 75.3 1.1e-12 XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 727 75.3 1.1e-12 XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 717 74.2 1.2e-12 XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 717 74.3 1.3e-12 XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 717 74.3 1.3e-12 NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 704 72.9 1.7e-12 NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 709 73.6 2.1e-12 XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 700 72.6 2.3e-12 XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 700 72.6 2.3e-12 XP_011530198 (OMIM: 610399) PREDICTED: transmembra ( 345) 692 72.0 3.6e-12 NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 703 73.2 3.7e-12 NP_054777 (OMIM: 610399) transmembrane protease se ( 423) 692 72.0 4.2e-12 >>NP_001070731 (OMIM: 610050) transmembrane protease ser (567 aa) initn: 3547 init1: 3547 opt: 3845 Z-score: 1752.2 bits: 334.1 E(85289): 7.4e-91 Smith-Waterman score: 3845; 99.1% identity (99.1% similar) in 567 aa overlap (1-562:1-567) 10 20 30 40 50 60 pF1KE5 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 PAGTPPGRASPGRASPAQASPA-----RASPALASLSRSSSGRSSSARSASVTTSPTRVY :::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK 490 500 510 520 530 540 540 550 560 pF1KE5 PGVYTKVTEVLPWIYSKMESEVRFRKS ::::::::::::::::::::::::::: NP_001 PGVYTKVTEVLPWIYSKMESEVRFRKS 550 560 >>NP_001231924 (OMIM: 610050) transmembrane protease ser (563 aa) initn: 3503 init1: 3503 opt: 3801 Z-score: 1732.5 bits: 330.4 E(85289): 9.2e-90 Smith-Waterman score: 3801; 99.1% identity (99.1% similar) in 560 aa overlap (1-555:1-560) 10 20 30 40 50 60 pF1KE5 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 PAGTPPGRASPGRASPAQASPA-----RASPALASLSRSSSGRSSSARSASVTTSPTRVY :::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK 490 500 510 520 530 540 540 550 560 pF1KE5 PGVYTKVTEVLPWIYSKMESEVRFRKS :::::::::::::::::::: NP_001 PGVYTKVTEVLPWIYSKMESSAG 550 560 >>NP_001193718 (OMIM: 610050) transmembrane protease ser (532 aa) initn: 2900 init1: 2900 opt: 2962 Z-score: 1356.1 bits: 260.7 E(85289): 8.5e-69 Smith-Waterman score: 3532; 92.8% identity (92.8% similar) in 567 aa overlap (1-562:1-532) 10 20 30 40 50 60 pF1KE5 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 PAGTPPGRASPGRASPAQASPA-----RASPALASLSRSSSGRSSSARSASVTTSPTRVY :::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV :::::::::::::::::::::::::::::: NP_001 LVRATPVGAVPIRSSPARSAPATRATRESP------------------------------ 130 140 150 180 190 200 210 220 230 pF1KE5 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 -----VQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS 160 170 180 190 200 240 250 260 270 280 290 pF1KE5 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH 210 220 230 240 250 260 300 310 320 330 340 350 pF1KE5 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW 270 280 290 300 310 320 360 370 380 390 400 410 pF1KE5 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL 330 340 350 360 370 380 420 430 440 450 460 470 pF1KE5 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC 390 400 410 420 430 440 480 490 500 510 520 530 pF1KE5 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK 450 460 470 480 490 500 540 550 560 pF1KE5 PGVYTKVTEVLPWIYSKMESEVRFRKS ::::::::::::::::::::::::::: NP_001 PGVYTKVTEVLPWIYSKMESEVRFRKS 510 520 530 >>NP_001193719 (OMIM: 610050) transmembrane protease ser (491 aa) initn: 2539 init1: 2539 opt: 2842 Z-score: 1302.7 bits: 250.7 E(85289): 8e-66 Smith-Waterman score: 2842; 97.2% identity (97.7% similar) in 436 aa overlap (1-431:1-434) 10 20 30 40 50 60 pF1KE5 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 PAGTPPGRASPGRASPAQASPA-----RASPALASLSRSSSGRSSSARSASVTTSPTRVY :::::::::::::::::::::: ::::::::::::::::::::::::::::::::: NP_001 PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC :::::::.. : : NP_001 SKPLTLSGE--GICTPRSPAPQPQHPLQPSHLSASVNSYPGPKASAGQKSKTLKDPYMEH 430 440 450 460 470 >>XP_011528033 (OMIM: 602060) PREDICTED: transmembrane p (492 aa) initn: 882 init1: 497 opt: 995 Z-score: 473.5 bits: 97.3 E(85289): 1.2e-19 Smith-Waterman score: 1009; 35.4% identity (63.4% similar) in 492 aa overlap (86-556:9-491) 60 70 80 90 100 110 pF1KE5 PAQASPAGTPPGRASPGRASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY ::.. .. . . . :. :. :: :: XP_011 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPT-VY 10 20 30 120 130 140 150 160 pF1KE5 LVRA-----TPVGAVPIRSSPARSAPATRATRESP-GTSLPKFTWREGQKQLPLIGCVLL :. .:: : : :.. . .:: :: . : . : : : :. XP_011 EVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTL-GTFLV 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE5 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK ::...:. :. . ...::. .. .: . . :::: : :: :::. . XP_011 GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE5 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS .:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... :. XP_011 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT 160 170 180 190 200 210 290 300 310 320 330 pF1KE5 T-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGALASDSKWPWQVSLH . : ..:..:. : :. .::.: ::. ..: :::: : . :::::::: XP_011 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE5 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE ..:.:::..: .:..::::: :: :.. : ..:: . .:. . . XP_011 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE5 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET .: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.: XP_011 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE5 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ ::: : ..: ::. ..::. :::. .:: :.::: :.:. :::::::::::: . XP_011 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK 400 410 420 430 440 520 530 540 550 560 pF1KE5 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS :: :.: : ::::.::.. .:::: .: ::: .:... XP_011 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG 450 460 470 480 490 >>NP_005647 (OMIM: 602060) transmembrane protease serine (492 aa) initn: 882 init1: 497 opt: 995 Z-score: 473.5 bits: 97.3 E(85289): 1.2e-19 Smith-Waterman score: 1009; 35.4% identity (63.4% similar) in 492 aa overlap (86-556:9-491) 60 70 80 90 100 110 pF1KE5 PAQASPAGTPPGRASPGRASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY ::.. .. . . . :. :. :: :: NP_005 MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPT-VY 10 20 30 120 130 140 150 160 pF1KE5 LVRA-----TPVGAVPIRSSPARSAPATRATRESP-GTSLPKFTWREGQKQLPLIGCVLL :. .:: : : :.. . .:: :: . : . : : : :. NP_005 EVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTL-GTFLV 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE5 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK ::...:. :. . ...::. .. .: . . :::: : :: :::. . NP_005 GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE5 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS .:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... :. NP_005 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT 160 170 180 190 200 210 290 300 310 320 330 pF1KE5 T-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGALASDSKWPWQVSLH . : ..:..:. : :. .::.: ::. ..: :::: : . :::::::: NP_005 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE5 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE ..:.:::..: .:..::::: :: :.. : ..:: . .:. . . NP_005 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE5 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET .: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.: NP_005 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE5 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ ::: : ..: ::. ..::. :::. .:: :.::: :.:. :::::::::::: . NP_005 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK 400 410 420 430 440 520 530 540 550 560 pF1KE5 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS :: :.: : ::::.::.. .:::: .: ::: .:... NP_005 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG 450 460 470 480 490 >>NP_001128571 (OMIM: 602060) transmembrane protease ser (529 aa) initn: 882 init1: 497 opt: 995 Z-score: 473.1 bits: 97.3 E(85289): 1.3e-19 Smith-Waterman score: 1009; 35.4% identity (63.4% similar) in 492 aa overlap (86-556:46-528) 60 70 80 90 100 110 pF1KE5 PAQASPAGTPPGRASPGRASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY ::.. .. . . . :. :. :: :: NP_001 GAAGHIEHSRYLSLLDAVDNSKMALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPT-VY 20 30 40 50 60 70 120 130 140 150 160 pF1KE5 LVRA-----TPVGAVPIRSSPARSAPATRATRESP-GTSLPKFTWREGQKQLPLIGCVLL :. .:: : : :.. . .:: :: . : . : : : :. NP_001 EVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTL-GTFLV 80 90 100 110 120 130 170 180 190 200 210 220 pF1KE5 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK ::...:. :. . ...::. .. .: . . :::: : :: :::. . NP_001 GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN 140 150 160 170 180 190 230 240 250 260 270 280 pF1KE5 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS .:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... :. NP_001 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT 200 210 220 230 240 250 290 300 310 320 330 pF1KE5 T-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGALASDSKWPWQVSLH . : ..:..:. : :. .::.: ::. ..: :::: : . :::::::: NP_001 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH 260 270 280 290 300 310 340 350 360 370 380 390 pF1KE5 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE ..:.:::..: .:..::::: :: :.. : ..:: . .:. . . NP_001 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK 320 330 340 350 360 400 410 420 430 440 450 pF1KE5 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET .: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.: NP_001 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK 370 380 390 400 410 420 460 470 480 490 500 510 pF1KE5 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ ::: : ..: ::. ..::. :::. .:: :.::: :.:. :::::::::::: . NP_001 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK 430 440 450 460 470 480 520 530 540 550 560 pF1KE5 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS :: :.: : ::::.::.. .:::: .: ::: .:... NP_001 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG 490 500 510 520 >>XP_011528035 (OMIM: 602060) PREDICTED: transmembrane p (384 aa) initn: 866 init1: 497 opt: 976 Z-score: 466.4 bits: 95.6 E(85289): 3.1e-19 Smith-Waterman score: 982; 38.9% identity (67.8% similar) in 373 aa overlap (198-556:17-383) 170 180 190 200 210 220 pF1KE5 LLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWD .: . . :::: : :: :::. XP_011 MGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGP 10 20 30 40 230 240 250 260 270 280 pF1KE5 KSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYN . .:..::.. ..: :.:...::..:.. .:...:... ... : ..: :... : XP_011 NFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLN 50 60 70 80 90 100 290 300 310 320 330 pF1KE5 ST-----IQESLHRSE-CPSQRYISLQCSHCGLRAMTGR---IVGGALASDSKWPWQVSL .. : ..:..:. : :. .::.: ::. ..: :::: : . ::::::: XP_011 TSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSL 110 120 130 140 150 160 340 350 360 370 380 390 pF1KE5 HFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IA : ..:.:::..: .:..::::: :: :.. : ..:: . .:. . XP_011 HVQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVE 170 180 190 200 210 220 400 410 420 430 440 450 pF1KE5 EIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRE ..: . :: .. . :::::.:.::::.. ..:.::: :. .. .. :::.:.: :.: XP_011 KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEE 230 240 250 260 270 280 460 470 480 490 500 510 pF1KE5 TDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCE ::: : ..: ::. ..::. :::. .:: :.::: :.:. :::::::::::: XP_011 KG-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTS 290 300 310 320 330 340 520 530 540 550 560 pF1KE5 QNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS .:: :.: : ::::.::.. .:::: .: ::: .:... XP_011 KNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG 350 360 370 380 >>NP_001077416 (OMIM: 606565) transmembrane protease ser (432 aa) initn: 819 init1: 323 opt: 935 Z-score: 447.3 bits: 92.2 E(85289): 3.6e-18 Smith-Waterman score: 935; 35.2% identity (64.5% similar) in 420 aa overlap (149-557:24-432) 120 130 140 150 160 170 pF1KE5 ATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVVSLI .: :.: . .:.: .:: .: .. .. NP_001 MLQDPDSDQPLNSLDVKPLRKPRIPMETFR--KVGIPII-IALLSLASIIIVV 10 20 30 40 50 180 190 200 210 220 pF1KE5 ILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCV-----------RFDWD .:.. . . . . :.. . ::: .:: : :: :: :.. : NP_001 VLIKVILDKYYFLCGQPLHFIPRKQL-CDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKD 60 70 80 90 100 230 240 250 260 270 280 pF1KE5 KSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYN .: :.. .... .:. : .:.... .: .:.:.:. :..:.. . . : . . NP_001 RSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYS---RAVEIGPDQDLDVVEITENS 110 120 130 140 150 160 290 300 310 320 330 340 pF1KE5 STIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICG . .. . : : .::.: :: : :.::: :: ..::::::... :.:: NP_001 QELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCG 170 180 190 200 210 220 350 360 370 380 390 400 pF1KE5 GTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDD :...: .::::::::: .. . .::: ::...: ..: : :::. : .:. NP_001 GSILDPHWVLTAAHCF--RKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN 230 240 250 260 270 280 410 420 430 440 450 460 pF1KE5 YDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQV :::::.:. :::.:. ..: :::. . .. :: :.: :... : : .: ...: NP_001 -DIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASV 290 300 310 320 330 340 470 480 490 500 510 520 pF1KE5 NLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWG ..:: .:: .:.. .: .::::: .:: :.:::::::::. :...:...:..::: NP_001 QVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLM-YQSDQWHVVGIVSWG 350 360 370 380 390 400 530 540 550 560 pF1KE5 TGCGQRNKPGVYTKVTEVLPWIYSKMESEVRFRKS ::: . :::::::. : :::. ..:. NP_001 YGCGGPSTPGVYTKVSAYLNWIYNVWKAEL 410 420 430 >>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa) initn: 927 init1: 388 opt: 919 Z-score: 439.8 bits: 90.9 E(85289): 9.3e-18 Smith-Waterman score: 1007; 37.9% identity (65.8% similar) in 409 aa overlap (163-558:53-452) 140 150 160 170 180 190 pF1KE5 RSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVVSLIILFQFWQGHTGIRY .:: . :..::...: : :. .: NP_001 DLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDC----SGKYR 30 40 50 60 70 200 210 220 230 240 250 pF1KE5 KEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDS .. .: . .::::: ::: :: ::: ....:......: : .::..:. NP_001 CRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAAS--WKTMCSDDWKGH 80 90 100 110 120 130 260 270 280 290 300 pF1KE5 YSEKTCQQLGFESAHRTTEVAHRDFANSFS--ILRYNSTIQE----SLH-----RSECPS :.. .: :::: : . .. .. ..: .. . . . .:: : : : NP_001 YANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCAS 140 150 160 170 180 190 310 320 330 340 350 360 pF1KE5 QRYISLQCSHCGLR-AMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAA . ..:::. :: : ....::::: .. :.::::.::.: :.:::..: :..::: NP_001 GHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAA 200 210 220 230 240 250 370 380 390 400 410 pF1KE5 HCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAE-IIINSNYTDEEDDYDIALMRLSKPL :: . . ..: . .: .: . : . ..: :. .:.: .. :::::.:. :: NP_001 HCVYDLY--LPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPL 260 270 280 290 300 310 420 430 440 450 460 470 pF1KE5 TLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYL :.. :.:.::: ..: ...:: .:.: :.. : .:: : .. : ::. : :: NP_001 TFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGD-ASPVLNHAAVPLISNKICNHRD 320 330 340 350 360 370 480 490 500 510 520 530 pF1KE5 VYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVY :: . ..: :.::: : :: :::::::::::::.. : :.:.::.: ::.. :::::: NP_001 VYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVY 380 390 400 410 420 430 540 550 560 pF1KE5 TKVTEVLPWIYSKMESEVRFRKS :.:: : ::. .:: ... NP_001 TRVTSFLDWIHEQMERDLKT 440 450 562 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:51:57 2016 done: Tue Nov 8 05:51:59 2016 Total Scan time: 9.690 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]