FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5754, 736 aa 1>>>pF1KE5754 736 - 736 aa - 736 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.1353+/-0.000461; mu= 6.0185+/- 0.029 mean_var=134.1959+/-27.021, 0's: 0 Z-trim(113.1): 23 B-trim: 501 in 2/56 Lambda= 0.110715 statistics sampled from 22204 (22223) to 22204 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.617), E-opt: 0.2 (0.261), width: 16 Scan time: 11.370 The best scores are: opt bits E(85289) NP_075045 (OMIM: 616865) poly(A) polymerase gamma ( 736) 4845 786.2 0 XP_005264558 (OMIM: 616865) PREDICTED: poly(A) pol ( 692) 4565 741.4 2.8e-213 XP_005264557 (OMIM: 616865) PREDICTED: poly(A) pol ( 714) 4392 713.8 6e-205 XP_016860212 (OMIM: 616865) PREDICTED: poly(A) pol ( 498) 3288 537.4 5.2e-152 XP_011531343 (OMIM: 616865) PREDICTED: poly(A) pol ( 498) 3288 537.4 5.2e-152 XP_016860213 (OMIM: 616865) PREDICTED: poly(A) pol ( 476) 2835 465.0 3e-130 NP_001280556 (OMIM: 605553) poly(A) polymerase alp ( 744) 2827 463.8 1.1e-129 NP_116021 (OMIM: 605553) poly(A) polymerase alpha ( 745) 2817 462.2 3.3e-129 XP_016876424 (OMIM: 605553) PREDICTED: poly(A) pol ( 723) 2782 456.6 1.6e-127 XP_005267338 (OMIM: 605553) PREDICTED: poly(A) pol ( 724) 2780 456.3 2e-127 XP_016876425 (OMIM: 605553) PREDICTED: poly(A) pol ( 698) 2775 455.5 3.3e-127 XP_005267339 (OMIM: 605553) PREDICTED: poly(A) pol ( 699) 2773 455.2 4.1e-127 NP_064529 (OMIM: 607436) poly(A) polymerase beta [ ( 637) 2540 418.0 6e-116 NP_001280561 (OMIM: 605553) poly(A) polymerase alp ( 495) 1549 259.6 2.1e-68 NP_001280557 (OMIM: 605553) poly(A) polymerase alp ( 495) 1549 259.6 2.1e-68 NP_001238935 (OMIM: 605553) poly(A) polymerase alp ( 285) 1457 244.9 3.5e-64 NP_001238936 (OMIM: 605553) poly(A) polymerase alp ( 238) 994 170.9 5.4e-42 >>NP_075045 (OMIM: 616865) poly(A) polymerase gamma [Hom (736 aa) initn: 4845 init1: 4845 opt: 4845 Z-score: 4191.3 bits: 786.2 E(85289): 0 Smith-Waterman score: 4845; 100.0% identity (100.0% similar) in 736 aa overlap (1-736:1-736) 10 20 30 40 50 60 pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE5 VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_075 VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA 670 680 690 700 710 720 730 pF1KE5 NNIRVIKNSIRLTLNR :::::::::::::::: NP_075 NNIRVIKNSIRLTLNR 730 >>XP_005264558 (OMIM: 616865) PREDICTED: poly(A) polymer (692 aa) initn: 4565 init1: 4565 opt: 4565 Z-score: 3950.0 bits: 741.4 E(85289): 2.8e-213 Smith-Waterman score: 4565; 100.0% identity (100.0% similar) in 692 aa overlap (45-736:1-692) 20 30 40 50 60 70 pF1KE5 QQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHRLVVLGKLNNLVKEW :::::::::::::::::::::::::::::: XP_005 MKPFGVFEDEEELNHRLVVLGKLNNLVKEW 10 20 30 80 90 100 110 120 130 pF1KE5 ISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVERSDFFQSFFE 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE5 KLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDNLDLRDDSRLRSLDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDNLDLRDDSRLRSLDI 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE5 RCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVAR 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE5 TCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPI 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE5 ITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYI 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE5 VLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVS 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE5 MWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHH 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE5 YLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPS 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE5 VGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNV 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE5 IPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDP 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE5 RTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTL 640 650 660 670 680 690 pF1KE5 NR :: XP_005 NR >>XP_005264557 (OMIM: 616865) PREDICTED: poly(A) polymer (714 aa) initn: 4693 init1: 4381 opt: 4392 Z-score: 3800.5 bits: 713.8 E(85289): 6e-205 Smith-Waterman score: 4653; 97.0% identity (97.0% similar) in 736 aa overlap (1-736:1-714) 10 20 30 40 50 60 pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE5 VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA ::: ::::::::::::::::::::::::::::::::::: XP_005 VEK----------------------DAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA 670 680 690 730 pF1KE5 NNIRVIKNSIRLTLNR :::::::::::::::: XP_005 NNIRVIKNSIRLTLNR 700 710 >>XP_016860212 (OMIM: 616865) PREDICTED: poly(A) polymer (498 aa) initn: 3288 init1: 3288 opt: 3288 Z-score: 2850.0 bits: 537.4 E(85289): 5.2e-152 Smith-Waterman score: 3288; 100.0% identity (100.0% similar) in 498 aa overlap (239-736:1-498) 210 220 230 240 250 260 pF1KE5 ILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLV :::::::::::::::::::::::::::::: XP_016 MLGFLGGVSWAMLVARTCQLYPNAAASTLV 10 20 30 270 280 290 300 310 320 pF1KE5 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV 40 50 60 70 80 90 330 340 350 360 370 380 pF1KE5 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE 100 110 120 130 140 150 390 400 410 420 430 440 pF1KE5 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA 160 170 180 190 200 210 450 460 470 480 490 500 pF1KE5 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS 220 230 240 250 260 270 510 520 530 540 550 560 pF1KE5 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV 280 290 300 310 320 330 570 580 590 600 610 620 pF1KE5 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ 340 350 360 370 380 390 630 640 650 660 670 680 pF1KE5 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI 400 410 420 430 440 450 690 700 710 720 730 pF1KE5 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR 460 470 480 490 >>XP_011531343 (OMIM: 616865) PREDICTED: poly(A) polymer (498 aa) initn: 3288 init1: 3288 opt: 3288 Z-score: 2850.0 bits: 537.4 E(85289): 5.2e-152 Smith-Waterman score: 3288; 100.0% identity (100.0% similar) in 498 aa overlap (239-736:1-498) 210 220 230 240 250 260 pF1KE5 ILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLV :::::::::::::::::::::::::::::: XP_011 MLGFLGGVSWAMLVARTCQLYPNAAASTLV 10 20 30 270 280 290 300 310 320 pF1KE5 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV 40 50 60 70 80 90 330 340 350 360 370 380 pF1KE5 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE 100 110 120 130 140 150 390 400 410 420 430 440 pF1KE5 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA 160 170 180 190 200 210 450 460 470 480 490 500 pF1KE5 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS 220 230 240 250 260 270 510 520 530 540 550 560 pF1KE5 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV 280 290 300 310 320 330 570 580 590 600 610 620 pF1KE5 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ 340 350 360 370 380 390 630 640 650 660 670 680 pF1KE5 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI 400 410 420 430 440 450 690 700 710 720 730 pF1KE5 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR 460 470 480 490 >>XP_016860213 (OMIM: 616865) PREDICTED: poly(A) polymer (476 aa) initn: 3136 init1: 2824 opt: 2835 Z-score: 2459.3 bits: 465.0 E(85289): 3e-130 Smith-Waterman score: 3096; 95.6% identity (95.6% similar) in 498 aa overlap (239-736:1-476) 210 220 230 240 250 260 pF1KE5 ILHLVPNKETFRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLV :::::::::::::::::::::::::::::: XP_016 MLGFLGGVSWAMLVARTCQLYPNAAASTLV 10 20 30 270 280 290 300 310 320 pF1KE5 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKFFLVFSKWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNV 40 50 60 70 80 90 330 340 350 360 370 380 pF1KE5 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STSTRTVMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLE 100 110 120 130 140 150 390 400 410 420 430 440 pF1KE5 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WVGLVESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENA 160 170 180 190 200 210 450 460 470 480 490 500 pF1KE5 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESVNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS 220 230 240 250 260 270 510 520 530 540 550 560 pF1KE5 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPAAV 280 290 300 310 320 330 570 580 590 600 610 620 pF1KE5 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNPAQGQ 340 350 360 370 380 390 630 640 650 660 670 680 pF1KE5 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAI ::::::::::::::::::::::::::::::::::: ::: XP_016 PHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEK----------------------DAI 400 410 420 690 700 710 720 730 pF1KE5 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR 430 440 450 460 470 >>NP_001280556 (OMIM: 605553) poly(A) polymerase alpha i (744 aa) initn: 2792 init1: 2677 opt: 2827 Z-score: 2449.2 bits: 463.8 E(85289): 1.1e-129 Smith-Waterman score: 2846; 61.1% identity (78.8% similar) in 746 aa overlap (12-736:13-744) 10 20 30 40 50 pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH .: :::::::::::::.::: : . :::::...:::::::.::::.. NP_001 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA :...:::::::::::: ..::::::: ::. .:::::::::::::::::::::::::::: NP_001 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD ::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: . NP_001 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM .::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::. NP_001 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW ::::::::::::::::::::::: :::::::::::::::::::::::::::: ::::::: NP_001 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK ::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..::: NP_001 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS :.: :::::::.::::: ::: ::...::::::::::::.:::.::.::::::::::::: NP_001 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG ::. ::. ... .:: .:..:...::.:....::::::::::::::::: : .:.. NP_001 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN ::: : :::.::::. :: ..::::::.: : : .:..: :: : :.:: NP_001 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN 490 500 510 520 530 540 550 560 570 580 pF1KE5 GTPFNSPASKSD-SP--SVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVI-------GA . ::.: . :: : : .. :: :: ... .. : .:.: . :. NP_001 SMSVPSPTSATKTSPLNSSGSSQGNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGGT 540 550 560 570 580 590 600 610 620 630 640 pF1KE5 KVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP---- . .: .:.. :.. : .:.: : :...: ..:. .: . :: :: NP_001 SSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVGV 590 600 610 620 630 640 650 660 670 680 690 pF1KE5 KRSHSPSIDGTPKRLKDVEKFIR-----LESTFKDPRTAEERKRKSVDAIGGESMPIPTI ::. :: . .::. : : : . .: :.:. ... .:.. . NP_001 KRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAAS 650 660 670 680 690 700 700 710 720 730 pF1KE5 DTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR . .: : .: : . .::: : ::::::.: ::: NP_001 LLASQKT-SSTDLSDIPA-LPANPIPVIKNSIKLRLNR 710 720 730 740 >>NP_116021 (OMIM: 605553) poly(A) polymerase alpha isof (745 aa) initn: 2784 init1: 2669 opt: 2817 Z-score: 2440.6 bits: 462.2 E(85289): 3.3e-129 Smith-Waterman score: 2844; 61.2% identity (78.8% similar) in 747 aa overlap (12-736:13-745) 10 20 30 40 50 pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH .: :::::::::::::.::: : . :::::...:::::::.::::.. NP_116 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA :...:::::::::::: ..::::::: ::. .:::::::::::::::::::::::::::: NP_116 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD ::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: . NP_116 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM .::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::. NP_116 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW ::::::::::::::::::::::: :::::::::::::::::::::::::::: ::::::: NP_116 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK ::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..::: NP_116 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS :.: :::::::.::::: ::: ::...::::::::::::.:::.::.::::::::::::: NP_116 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG ::. ::. ... .:: .:..:...::.:....::::::::::::::::: : .:.. NP_116 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN ::: : :::.::::. :: ..::::::.: : : .:..: :: : :.:: NP_116 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN 490 500 510 520 530 540 550 560 570 580 pF1KE5 GTPFNSPASKSD-SP--SVGETE-RNSAEPAAVIVEKPLSVPPAQGLSIPVI-------G . ::.: . :: : : .. ::: :: ... .. : .:.: . : NP_116 SMSVPSPTSATKTSPLNSSGSSQGRNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGG 540 550 560 570 580 590 600 610 620 630 640 pF1KE5 AKVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP--- .. .: .:.. :.. : .:.: : :...: ..:. .: . :: :: NP_116 TSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVG 590 600 610 620 630 640 650 660 670 680 690 pF1KE5 -KRSHSPSIDGTPKRLKDVEKFIR-----LESTFKDPRTAEERKRKSVDAIGGESMPIPT ::. :: . .::. : : : . .: :.:. ... .:.. . NP_116 VKRTSSPHKEESPKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAA 650 660 670 680 690 700 700 710 720 730 pF1KE5 IDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR . .: : .: : . .::: : ::::::.: ::: NP_116 SLLASQKT-SSTDLSDIPA-LPANPIPVIKNSIKLRLNR 710 720 730 740 >>XP_016876424 (OMIM: 605553) PREDICTED: poly(A) polymer (723 aa) initn: 2828 init1: 2677 opt: 2782 Z-score: 2410.6 bits: 456.6 E(85289): 1.6e-127 Smith-Waterman score: 2833; 61.3% identity (78.8% similar) in 741 aa overlap (12-736:13-723) 10 20 30 40 50 pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH .: :::::::::::::.::: : . :::::...:::::::.::::.. XP_016 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA :...:::::::::::: ..::::::: ::. .:::::::::::::::::::::::::::: XP_016 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD ::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: . XP_016 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM .::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::. XP_016 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW ::::::::::::::::::::::: :::::::::::::::::::::::::::: ::::::: XP_016 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK ::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..::: XP_016 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS :.: :::::::.::::: ::: ::...::::::::::::.:::.::.::::::::::::: XP_016 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG ::. ::. ... .:: .:..:...::.:....::::::::::::::::: : .:.. XP_016 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN ::: : :::.::::. :: ..::::::.: : : .:..: :: : :.:: XP_016 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN 490 500 510 520 530 540 550 560 570 580 pF1KE5 GTPFNSPASKSD-SP--SVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVI-------GA . ::.: . :: : : .. :: :: ... .. : .:.: . :. XP_016 SMSVPSPTSATKTSPLNSSGSSQGNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGGT 540 550 560 570 580 590 600 610 620 630 640 pF1KE5 KVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP---- . .: .:.. :.. : .:.: : :...: ..:. .: . :: :: XP_016 SSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVGV 590 600 610 620 630 640 650 660 670 680 690 700 pF1KE5 KRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRK ::. :: . .::. : :. . :.. . .: . .. .:.: XP_016 KRTSSPHKEESPKKTKTEEEQLDTETSTTQSETIQT---------------AASLLASQK 650 660 670 680 690 710 720 730 pF1KE5 KRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR : .: : . .::: : ::::::.: ::: XP_016 TS--STDLSDIPA-LPANPIPVIKNSIKLRLNR 700 710 720 >>XP_005267338 (OMIM: 605553) PREDICTED: poly(A) polymer (724 aa) initn: 2779 init1: 2669 opt: 2780 Z-score: 2408.8 bits: 456.3 E(85289): 2e-127 Smith-Waterman score: 2831; 61.3% identity (78.8% similar) in 742 aa overlap (12-736:13-724) 10 20 30 40 50 pF1KE5 MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNH .: :::::::::::::.::: : . :::::...:::::::.::::.. XP_005 MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 RLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVA :...:::::::::::: ..::::::: ::. .:::::::::::::::::::::::::::: XP_005 RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE5 PRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISD ::::.::::: ::..::: :. ...:::::.:::::::. :::::::..:::::.::: . XP_005 PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE5 NLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNM .::::::: :..:::::::::::::::::::::::: ..:::::::.::::::..::::. XP_005 DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 LGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVW ::::::::::::::::::::::: :::::::::::::::::::::::::::: ::::::: XP_005 LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSK ::::::::::::::::::::::::::::::.::: :::::::::::.::::: .:..::: XP_005 DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 LLEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQS :.: :::::::.::::: ::: ::...::::::::::::.:::.::.::::::::::::: XP_005 LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 FPGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEG ::. ::. ... .:: .:..:...::.:....::::::::::::::::: : .:.. XP_005 FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE5 MKIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDN ::: : :::.::::. :: ..::::::.: : : .:..: :: : :.:: XP_005 MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGV---------KLTALNDSSLDLSMDSDN 490 500 510 520 530 540 550 560 570 580 pF1KE5 GTPFNSPASKSD-SP--SVGETE-RNSAEPAAVIVEKPLSVPPAQGLSIPVI-------G . ::.: . :: : : .. ::: :: ... .. : .:.: . : XP_005 SMSVPSPTSATKTSPLNSSGSSQGRNS--PAPAVTAASVTNIQATEVSVPQVNSSESSGG 540 550 560 570 580 590 600 610 620 630 640 pF1KE5 AKVDSTVKTVSPPTVCTIPT-VVGRNVIP-RITTPHNPAQGQPHLNGMSNITKTVTP--- .. .: .:.. :.. : .:.: : :...: ..:. .: . :: :: XP_005 TSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSG-NAATKIPTPIVG 590 600 610 620 630 640 650 660 670 680 690 700 pF1KE5 -KRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSR ::. :: . .::. : :. . :.. . .: . .. .:. XP_005 VKRTSSPHKEESPKKTKTEEEQLDTETSTTQSETIQT---------------AASLLASQ 650 660 670 680 690 710 720 730 pF1KE5 KKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR : : .: : . .::: : ::::::.: ::: XP_005 KTS--STDLSDIPA-LPANPIPVIKNSIKLRLNR 700 710 720 736 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:22:27 2016 done: Tue Nov 8 06:22:29 2016 Total Scan time: 11.370 Total Display time: 0.170 Function used was FASTA [36.3.4 Apr, 2011]